Ammon Posey

Research Scientist, Washington University in St. Louis

Research Expertise

intrinsically disordered proteins
protein aggregation
phase transitions
phase separation
Cell Biology
Molecular Biology
Biochemistry
Colloid and Surface Chemistry
Catalysis
Bioengineering
Biotechnology
Condensed Matter Physics
Biomedical Engineering
Biophysics
Structural Biology
Physical and Theoretical Chemistry
Atomic and Molecular Physics, and Optics

About

Protein Biophysics, Experimental Design, Experimental Methods Development, Instrument Design, Data Analysis, Python Programming Language, Fluorescence Spectroscopy, Circular Dichroism, Static Light Scattering, Microfluidics, Capillary Electrophoresis, Electron Microscopy, Intrinsically Disordered Proteins, Phase Separation

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Publications

A Lethal de Novo Mutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division
Journal of Biological Chemistry
2010
Phase Separation of Intrinsically Disordered Proteins
Methods in Enzymology
2018
Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation
Molecular Cell
2020
Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers
Journal of Biological Chemistry
2018
Self-Assembly of Block Heterochiral Peptides into Helical Tapes
Journal of the American Chemical Society
2020
Inhibition of amyloid beta fibril formation by monomeric human transthyretin
Protein Science
2018
Molecular Motor Dnm1 Synergistically Induces Membrane Curvature To Facilitate Mitochondrial Fission
ACS Central Science
2017
GADIS: Algorithm for designing sequences to achieve target secondary structure profiles of intrinsically disordered proteins
Protein Engineering Design and Selection
2016
Dilute phase oligomerization can oppose phase separation and modulate material properties of a ribonucleoprotein condensate
Unknown Venue
2021
A Targeted Mutation Identified through pK Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission
Journal of Biological Chemistry
2016
Gold Nanoshell Assembly on a Ferritin Protein Employed as a Bio-Template
Journal of Nanoscience and Nanotechnology
2010
Mechanistic Inferences From Analysis of Measurements of Protein Phase Transitions in Live Cells
Journal of Molecular Biology
2021
A First Glimpse of Nucleation of Phase Transitions in Living Cells
Molecular Cell
2018
Basin Mapping Method for Extracting Comparative Assessments of Protein Phase Behavior from In Vivo Measurements
Biophysical Journal
2020
Increasing the Accuracy in All-Atom Simulations of Intrinsically Disordered Proteins based on the Absinth Model
Biophysical Journal
2018
The Variable Domain from the Mitochondrial Fission Mechanoenzyme Drp1 Promotes Liquid-Liquid Phase Separation
Biophysical Journal
2020
Quantitative analysis of intracellular protein phase transitions
Biophysical Journal
2023
How does sequence influence charge regulation of disordered proteins?
Biophysical Journal
2023
Demixing of distinct ribonucleoprotein condensates is under dynamical control
Biophysical Journal
2023
Dynamical control enables the formation of demixed biomolecular condensates
Unknown Venue
2023
Quantifying Coexistence Concentrations in Multi-Component Phase-Separating Systems Using Analytical HPLC
Biomolecules
2022
Heterogeneous distributions of charge states determine the apparent net charge of intrinsically disordered proteins
Biophysical Journal
2022
The variable domain from the mitochondrial fission mechanoenzyme Drp1 promotes liquid-liquid phase separation
Biophysical Journal
2022
Charge state heterogeneity in single alpha helices helps maintain helicity over a large range of pH values
Biophysical Journal
2022
The soluble N-termini of mechanosensitive ion channels MSL8, MSL9, and MSL10 are environmentally sensitive intrinsically disordered regions with distinct biophysical characteristics
Unknown Venue
2022
Uncovering the Physical Basis for Selective Mixing Versus Unmixing of Protein-RNA Condensates
Biophysical Journal
2021
Phase Separation of the Variable Domain of Dynamin Related Protein 1 in TMAO Suggests a Role in Assembly
Biophysical Journal
2018
Heuristics for the Effects of Sequence and Conformational Contexts on pKA Values of Ionizable Residues Inferred from Q-Canonical Monte Carlo Simulations
Biophysical Journal
2020
Principles of Ligand Modulation of Phase Behavior in Multicomponent Systems
Biophysical Journal
2020
Quantifying the Effects of Charge Regulation on Disorder-Order Transitions of Highly Charged Protein Sequences
Biophysical Journal
2020
Introducing a Novel Multi-Level Method for Simulating the pH Dependence of Charge State Fluctuations and Conformational Ensembles of Intrinsically Disordered Proteins
Biophysical Journal
2019
Modeling the Effects of Ligand Binding on the Phase Behavior of Aggregation-Prone Proteins
Biophysical Journal
2019
Experimental and Theoretical Methods for Mapping Coexistence Curves of Phase-Separating Biological Macromolecules
Biophysical Journal
2019
Advances in Quantitative Analysis of Intracellular Protein Phase Separation Kinetics and its Modulation by Cellular Interactions
Biophysical Journal
2018
Sequence-Encoded Charge Patterning of the Intrinsically Disordered Tail of FtsZ Impacts Polymerization and Bacterial Cell Division
Biophysical Journal
2018
The Intrinsically Disordered Tail of FtsZ Impacts Polymerization and Bacterial Cell Division Through Sequence-Encoded Charge Patterning
Biophysical Journal
2017
Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1
Biophysical Journal
2017
Charge Neutralization, Not Salt Bridges, Stabilizes Alpha Helices in Repeating Blocks of Acidic and Basic Residues
Biophysical Journal
2017
Profilin Binding Modulates the Aggregation and Phase Separation of Huntingtin N-Terminal Fragments via Polyphasic Linkage
Biophysical Journal
2016
Molecular Mechanisms Behind Mitochondrial Fission
Biophysical Journal
2012
Dynamical control enables the formation of demixed biomolecular condensates
Unknown Venue
2023
Uncovering the Contributions of Charge Regulation to the Stability of Single Alpha Helices**
ChemPhysChem
2023
Uncovering the contributions of charge regulation to the stability of single alpha helices
Unknown Venue
2022
Quantifying charge state heterogeneity for proteins with multiple ionizable residues
Biophysical Journal
2021
Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils
Biochemistry
2021
Quantifying charge state heterogeneity for proteins with multiple ionizable residues
Unknown Venue
2021
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
Unknown Venue
2020
Evolved sequence features within the intrinsically disordered tail influence FtsZ assembly and bacterial cell division
Unknown Venue
2018

Education

Johns Hopkins University

PhD, Molecular Biophysics / 2014

Baltimore, Maryland, United States of America

Brigham Young University

BS, Biophysics / 2006

Provo, Utah, United States of America

Experience

Washington University in St. Louis

Senior Research Scientist / 2014Present

Johns Hopkins University

Doctoral Researcher / 20082014

Dissertation: Intrinsic disorder and amphitropism in the mitochondrial fission mechanoenzyme Drp1

NASA Langley Research Center

Research Scholar / 20042005

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