Michael Kluppel, PhD

Senior Research Scientist (PhD) with 35 years of experience in biomedical research and publication/grant writing and peer-review. Experience as Professor and Principal Investigator in major US medical schools.

Chicago, Illinois, United States of America

Research Expertise

Stem cell biology, cancer biology, cardiovascular, intestinal and bone/cartilage biology, pathology, signaling pathways and extracellular matrix.

About

Senior Research Scientist (PhD) with 35 years of experience in biomedical research and publication/grant writing and peer-review. Experience as Professor and Principal Investigator in major US medical schools. Sole Proprietor of MKPhD Scientific Consulting, providing manuscript and grant proposal editing and peer-review services for international clients in academia and industry. Areas of expertise include stem cell biology, cancer biology, cardiovascular, intestinal and bone/cartilage biology, pathology, signaling pathways and extracellular matrix.

Publications

W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity

Nature

1995

Developmental origin and kit‐dependent development of the interstitial cells of cajal in the mammalian small intestine

Developmental Dynamics

1998

Reporter constructs with low background activity utilizing the cat gene

Gene

1992

Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis

Development

2005

An Immunological Renal Disease in Transgenic Mice That Overexpress Fli-1, a Member of the ets Family of Transcription Factor Genes

Molecular and Cellular Biology

1995

Turning it up a Notch: cross-talk between TGFβ and Notch signaling

BioEssays

2005

The mouse tyrosinase promoter is sufficient for expression in melanocytes and in the pigmented epithelium of the retina.

Proceedings of the National Academy of Sciences

1991

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

Genes & Development

2003

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

Proceedings of the National Academy of Sciences

2004

Chondroitin Sulfate-E Is a Negative Regulator of a Pro-Tumorigenic Wnt/Beta-Catenin-Collagen 1 Axis in Breast Cancer Cells

PLoS ONE

2014

The Roles of Chondroitin-4-Sulfotransferase-1 in Development and Disease

Progress in Molecular Biology and Translational Science

2010

Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W 57 and W banded mice and interfere with distinct steps in melanocyte development

Development

1997

Aquarius, a novel gene isolated by gene trapping with an RNA‐dependent RNA polymerase motif

Developmental Dynamics

1998

Myocardial storage of chondroitin sulfate-containing moieties in Costello syndrome patients with severe hypertrophic cardiomyopathy

American Journal of Medical Genetics Part A

2005

Elimination of breast tumor-associated chondroitin sulfate promotes metastasis

Genetics and Molecular Research

2011

A high-throughput induction gene trap approach defines C4ST as a target of BMP signaling

Mechanisms of Development

2002

Overexpression of Human Stem Cell Factor Impairs Melanocyte, Mast Cell, and Thymocyte Development: A Role for Receptor Tyrosine Kinase-Mediated Mitogen Activated Protein Kinase Activation in Cell Differentiation

Blood

1997

Mechanisms and biology of signalling by serine/threonine kinase receptors for the TGFP superfamily

Protein Kinase Functions

2000

Molecular Characterization of the Mouse Tyrosinase Gene:Pigment Cell‐Specific Expression in Transgenic Mice

Pigment Cell Research

1992

Alterations in the bone microarchitecture in Psen1 L166P KI mice depicting pathogenesis of Alzheimer’s disease

Alzheimer's & Dementia

2020

1509 - IGF1 Signaling Play A Critical Role In Fracture Repair And Bone Homeostasis By Regulating Osteogenic Differentiation Of Bone Lining Cells Through CXCL12 Expression

Unknown Venue

2019

CXCR4 Mediates the Effects of IGF-1R Signaling in Rodent Bone Homeostasis and Fracture Repair

SSRN Electronic Journal

2022

Novel roles of Atrogin‐1 in cardiac disease, lipid metabolism and bone microstructure

The FASEB Journal

2020

Functional analysis of cardiac‐specific loss of MuRF1 in diabetic cardiomyopathy

The FASEB Journal

2020

CHST11 (carbohydrate (chondroitin 4) sulfotransferase 11)

Atlas of Genetics and Cytogenetics in Oncology and Haematology

2014

Abstract 3250: Chondroitin sulfate-mediated regulation of Wnt/β-catenin signaling in breast cancer

Cancer Research

2012

C4St-1 and Chondroitin Sulfate in Stromal Control of wht Signaling in Breast Cancer

Unknown Venue

2012

Reviewer #3 (Public Review): Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells

Unknown Venue

2024

A085 Effect of Sclerostin on Bone Health and Glucose Homeostasis after Roux-en-Y Gastric Bypass in Mice

Surgery for Obesity and Related Diseases

2023

CXCR4 mediates the effects of IGF-1R signaling in rodent bone homeostasis and fracture repair

Bone

2023

The Unraveling

The American Journal of Pathology

2020

Lentivirus-mediated transfection of chondroitinase ABC gene without the bacterial leader sequence enables long-term secretion of functional chondroitinase ABC in human bone marrow stromal cells

Biotechnology Letters

2016

Biphasic Role of Chondroitin Sulfate in Cardiac Differentiation of Embryonic Stem Cells through Inhibition of Wnt/β-Catenin Signaling

PLoS ONE

2014

Inhibition by Chondroitin Sulfate E Can Specify Functional Wnt/β-Catenin Signaling Thresholds in NIH3T3 Fibroblasts

Journal of Biological Chemistry

2012

C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome

European Journal of Human Genetics

2012

Efficient secretion of biologically active Chondroitinase ABC from mammalian cells in the absence of an N-terminal signal peptide

Molecular and Cellular Biochemistry

2011

Identification and characterization of TGFβ-dependent and -independent cis-regulatory modules in the C4ST-1/CHST11 locus

Genetics and Molecular Research

2009

Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif

Developmental Dynamics

1998

recessive spotting: a linked locus that interacts with W/Kit but is not allelic

Genes to Cells

1998

Developmental origin andkit-dependent development of the interstitial cells of cajal in the mammalian small intestine

Developmental Dynamics

1998

Education

University of Toronto

PhD, Molecular and Medical Genetics / December, 1997

Toronto

Ruprecht-Karls-Universität Heidelberg

Diplom (MSc), Biology / June, 1990

Heidelberg

Experience

Rush University Medical Center

Senior Research Scientist / July, 2020 — Present

Indiana University School of Medicine

Research Assistant Professor / January, 2018 — June, 2020

Northwestern University

Assistant Professor / July, 2007 — December, 2017

Mount Sinai Hospital

Postdoctoral fellow, Research Associate / January, 1998 — June, 2007

Links & Social Media

Michael Kluppel LinkedIn

Michael Kluppel Orcid

Michael Kluppel Google Scholar

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