Ramy Ayoub

PhD Medical Biophysics

Toronto, Ontario, Canada

Research Expertise

neuro-oncology

mouse imaging

cancer therapy

normal tissue toxicity

Radiology, Nuclear Medicine and imaging

Radiation

Biophysics

Cancer Research

Neurology (clinical)

Oncology

Experimental and Cognitive Psychology

About

Ramy Ayoub obtained his Ph.D. in Medical Biophysics from the University of Toronto in 2023, where he developed a strong foundation in the principles and applications in neuroscience, statistics, machine learning, imaging & radiation physics. During his time at the University of Toronto, Ramy has been involved in conducting cutting-edge research in the field, with a focus on developing new technologies and pharmacological interventions to improve healthcare outcomes. He is passionate about using his skills and expertise to make a positive impact in the medical field and is dedicated to advancing the field through his ongoing research and contributions.

Publications

Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin

Nature Medicine / Jul 27, 2020

Ayoub, R., Ruddy, R. M., Cox, E., Oyefiade, A., Derkach, D., Laughlin, S., Ades-aron, B., Shirzadi, Z., Fieremans, E., MacIntosh, B. J., de Medeiros, C. B., Skocic, J., Bouffet, E., Miller, F. D., Morshead, C. M., & Mabbott, D. J. (2020). Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin. Nature Medicine, 26(8), 1285–1294. https://doi.org/10.1038/s41591-020-0985-2

Unified rhombic lip origins of group 3 and group 4 medulloblastoma

Nature / Sep 21, 2022

Smith, K. S., Bihannic, L., Gudenas, B. L., Haldipur, P., Tao, R., Gao, Q., Li, Y., Aldinger, K. A., Iskusnykh, I. Y., Chizhikov, V. V., Scoggins, M., Zhang, S., Edwards, A., Deng, M., Glass, I. A., Overman, L. M., Millman, J., Sjoboen, A. H., Hadley, J., … Northcott, P. A. (2022). Unified rhombic lip origins of group 3 and group 4 medulloblastoma. Nature, 609(7929), 1012–1020. https://doi.org/10.1038/s41586-022-05208-9

Out of sight, out of mind: mechanisms of social choice in fish

Animal Behaviour / Sep 01, 2019

Ayoub, R., Armstrong, E., & Miller, N. Y. (2019). Out of sight, out of mind: mechanisms of social choice in fish. Animal Behaviour, 155, 163–169. https://doi.org/10.1016/j.anbehav.2019.05.025

Spatiotemporal Mapping of Early Volume Loss in the Mouse Brain after Cranial Irradiation

Radiation Research / Jul 16, 2021

Ayoub, R., Lau, K., Yuen, N., Fernandes, D., Elder, M., Yeung, J., Wong, S. C., & Nieman, B. J. (2021). Spatiotemporal Mapping of Early Volume Loss in the Mouse Brain after Cranial Irradiation. Radiation Research, 196(4). https://doi.org/10.1667/rade-21-00013.1

QOL-53. METFORMIN RESULTS IN HIPPOCAMPAL REMODELING AND IMPROVED MEMORY ENCODING IN PAEDIATRIC BRAIN TUMOR SURVIVORS TREATED WITH CRANIAL RADIATION: A PILOT RANDOMIZED CONTROLLED CROSSOVER STUDY

Neuro-Oncology / Jun 01, 2018

Ayoub, R., Miller, F., Beera, K., de Medeiros, C., Laughlin, S., Bouffet, E., & Mabbott, D. (2018). QOL-53. METFORMIN RESULTS IN HIPPOCAMPAL REMODELING AND IMPROVED MEMORY ENCODING IN PAEDIATRIC BRAIN TUMOR SURVIVORS TREATED WITH CRANIAL RADIATION: A PILOT RANDOMIZED CONTROLLED CROSSOVER STUDY. Neuro-Oncology, 20(suppl_2), i168–i168. https://doi.org/10.1093/neuonc/noy059.634

MEDB-78. Unified rhombic lip origins of Group 3 and Group 4 medulloblastoma

Neuro-Oncology / Jun 01, 2022

Smith, K., Bihannic, L., Gudenas, B., Gao, Q., Haldipur, P., Tao, R., Iskusnykh, I., Chizhikov, V., Scoggins, M., Zhang, S., Edwards, A., Deng, M., Glass, I., Overman, L., Millman, J., Sjoboen, A., Hadley, J., Mankad, K., Onar-Thomas, A., … Northcott, P. (2022). MEDB-78. Unified rhombic lip origins of Group 3 and Group 4 medulloblastoma. Neuro-Oncology, 24(Supplement_1), i124–i125. https://doi.org/10.1093/neuonc/noac079.452

Behavioral evidence for two distinct memory systems in rats

Animal Cognition / Jun 22, 2022

Miller, N., Ayoub, R., Sentinathan, G., & Mallet, P. E. (2022). Behavioral evidence for two distinct memory systems in rats. Animal Cognition, 25(6), 1599–1608. https://doi.org/10.1007/s10071-022-01645-1

Education

University of Toronto

Ph.D., Medical Biophysics / October, 2023 (anticipated)

Toronto, Ontario, Canada

Experience

The Hospital for Sick Children

PhD Scientific Researcher / September, 2018 — October, 2023

Designed strategies to limit negative complications experienced by brain tumour survivors treated with radiation; Conducted genetic and pharmacological interventions in mouse models to determine translatability of strategies; Assessed the efficacy of treatment strategies using multi-modal imaging approaches (MRI, serial two-photon imaging); Published findings in peer-reviewed journals Nature, and Radiation Research

Links & Social Media

Google scholar

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