Dr. Shilpa Patil, Ph.D

PhD & Postdoc level expertise in Cancer Research

Vancouver, British Columbia, Canada

Research Expertise

Cancer
epigenetics
development
Oncology
Cancer Research
Biophysics
Biochemistry
Molecular Biology
Gastroenterology
Surgery
Hepatology
Endocrinology, Diabetes and Metabolism

About

Dr. Shilpa Patil is a highly experienced cancer researcher with a strong background in Preclinical studies. She received her Ph.D. in Molecular Medicine from the University of Göttingen in 2020, where she focused on developing novel treatments for pancreatic cancer. Prior to that, she completed her MSc in Regenerative Medicine from Manipal University in 2014 and her BSc in Biotechnology from the same institution in 2012. With over 6 years of research experience, Dr. Patil has worked at prestigious institutions such as the University of British Columbia, University of Göttingen and JNCASR. Her expertise lies in the areas of cancer biology, epigenetics, cell and molecular biology, and regenerative medicine. She has published numerous research articles in reputed journals and has presented her work at various international conferences. Dr. Patil is a dedicated and passionate scientist, committed to using her knowledge and skills to contribute to the fight against cancer. She is driven by her curiosity to unravel complex biological processes and her desire to make a positive impact in the field of cancer research. She is also driven to bridge the academia-industry gap.

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Publications

EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6
Cancer Research
2020
Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
EBioMedicine
2019
Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models
Journal of Visualized Experiments
2018
Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation
iScience
2018
TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer
Cancers
2022
HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells
Cancers
2021
Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation
Biochimica et Biophysica Acta (BBA) - General Subjects
2018
Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer
Cells
2019
Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes
Visceral Medicine
2021
Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer
Cells
2021
NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming
Cellular and Molecular Gastroenterology and Hepatology
2023
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation
Unknown Venue
2022
Acvr1bloss promotes formation of precancerous lesions from acinar and ductal cells of origin
Unknown Venue
2023
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
Unknown Venue
Kombinierte Radiochemotherapeutika zur Behandlung von endogenen Pankreaskarzinomen im KPC-Modell – eine feasibility Studie
Zeitschrift für Gastroenterologie
2019
EZH2 controls PDAC plasticity by regulating differentiation genes
Pancreatology
2019
Impact of cytosolic 5'-nucleotidase 1A on chemotherapeutic resistance in pancreatic cancer
Pancreatology
2018
The Wild-type and Gain-of-function Mutant p53 Enhance p300 Autoacetylation through Conformational Switching
Unknown Venue
2017
Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity
Pancreatology
2017
Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models
Journal of Visualized Experiments
2018

Education

University of Göttingen

Ph.D, Cancer Research / June, 2020

Göttingen

Manipal Academy of Higher Education

MSc, Regenerative Medicine / August, 2014

Manipal

Manipal Academy of Higher Education

BSc, Biotechnology / August, 2012

Manipal

Experience

University of British Columbia

Postdoctoral Research Fellow / January, 2021July, 2023

University of Gottingen

Postdoctoral Researcher / July, 2020December, 2020

JNCASR

Research Assistant / September, 2014February, 2016

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