Work with thought leaders and academic experts in Electrophysiology

Companies can benefit from working with Electrophysiology experts in several ways. These experts can provide valuable insights and expertise in the development of new medical devices and technologies. They can also help in conducting preclinical and clinical trials, ensuring the safety and efficacy of products. Additionally, Electrophysiology experts can contribute to research and development, helping companies stay at the forefront of scientific advancements. Collaborating with these experts can lead to breakthrough discoveries, improved patient outcomes, and a competitive advantage in the market.

Researchers on NotedSource with backgrounds in Electrophysiology include Matthew Scarnati, Mohsen Omrani, Shruti Muralidhar, Guillaume Duret, and Koraly Pérez-Edgar.

Matthew Scarnati

Old Bridge, New Jersey, United States of America
Neuroscientist driving preclinical drug development programs to combat neurological disease.
Most Relevant Research Expertise
Other Research Expertise (4)
Stem Cell Biology
Disease Modeling
Neuropsychiatric Disorders
I am a seasoned and perseverent pre-clinical drug development neuroscientist with over 12 years of research experience covering NEUROSCIENCE, Biochemistry, Molecular and Cellular Biology, Synaptic Physiology and Stem Cell Biology. My "never give up" attitude and vast experience in many disciplines adopts me the ability to address scientific questions in creative and unique ways. I have experience in pre-clinical small molecule drug development to support chemistry SAR to identify lead therapeutic candidates for neurology related targets. Experience in design, optimization and execution of both cell based and biochemical assays. I can provide expertise in synaptic physiology, and neuropsychiatric disease modeling. I have comprehensively studied the biological basis of addiction utilizing human stem cell biology and cellular reprogramming techniques. I am well versed in cutting edge induced neuronal (iN) cell technology. My main roles at PTC as a preclinical drug development Neuroscientist: -Provide subject matter expertise and leadership in the expansion of neuroscience and neurological disease understanding -Design and execute high-throughput in-vitro cell-based assays to screen 100s of small molecules to assist in driving chemistry SAR -Validation of new drug targets accomplished through elegant experimental design (both cell-based and biochemical) -My main focus was elucidating the mechanism(s) of action of one of PTCs lead small molecule drug candidates for a rare neurological disorder -Comprehensively screened primary mouse neuronal cultures (as well as human cell lines) to identify disease specific biomarkers for pharmacodynamic studies -Mentored and trained associate level scientists on both the technical and conceptual framework of our teams small molecule pipeline -Translating in-vitro cell based findings into in-vivo rodent models to better understand the PK/PD relationship of our lead small molecule -Team lead for a gene-therapy focused project to combat a devastating rare pediatric indication ➢ Scientific communication is a great strength of mine. My experience has provided me with excellent presentation skills and the ability to convey my work to diverse audiences. EMAIL: [email protected] SKILLS: Pre\-Clinical Drug Discovery I Electrophysiology \| Human Stem Cell Biology \| Mammalian Tissue Culture \| Cell Signaling Pathways \| Confocal Microscopy \| Protein Purification and Expression \| qPCR \| Cellular Assays \| Science Writing \| Problem Solving \| ELISA

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Example Electrophysiology projects

How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on Electrophysiology?

Development of Advanced Cardiac Monitoring Systems

An Electrophysiology expert can collaborate with a medical device company to develop advanced cardiac monitoring systems. This can include the design and implementation of innovative sensors and algorithms to accurately detect and analyze cardiac electrical signals. The collaboration can result in the creation of cutting-edge devices that improve the diagnosis and treatment of cardiac conditions.

Optimization of Neural Stimulation Techniques

Companies working on neural stimulation technologies can benefit from collaborating with Electrophysiology experts. These experts can provide insights into the optimal parameters and techniques for stimulating specific neural pathways. By leveraging their expertise, companies can develop more effective and targeted therapies for neurological disorders such as Parkinson's disease and epilepsy.

Evaluation of Drug Effects on Cardiac Electrophysiology

Pharmaceutical companies can collaborate with Electrophysiology experts to evaluate the effects of drugs on cardiac electrophysiology. These experts can conduct in vitro and in vivo studies to assess the impact of drugs on cardiac ion channels, action potentials, and arrhythmias. The collaboration can help companies identify potential cardiac safety issues early in the drug development process and optimize the therapeutic efficacy of their products.

Investigation of Brain-Computer Interfaces

Electrophysiology experts can contribute to the development of brain-computer interfaces (BCIs) by collaborating with companies in the field. They can provide insights into the recording and analysis of neural signals, as well as the design of algorithms for decoding and translating these signals into commands. The collaboration can lead to the creation of more accurate and efficient BCIs, enabling individuals with disabilities to regain motor control and improve their quality of life.

Enhancement of Neuroimaging Techniques

Companies involved in neuroimaging can collaborate with Electrophysiology experts to enhance their imaging techniques. These experts can provide expertise in the recording and analysis of neural activity, which can complement the spatial information obtained from imaging modalities such as fMRI and PET. The collaboration can result in improved understanding of brain function and the development of more precise diagnostic tools for neurological disorders.