Work with thought leaders and academic experts from University of Chile

Javier O. Morales is a highly accomplished and experienced pharmaceutical professional with a strong academic background and extensive practical experience. He obtained his Bachelor of Science degree in Pharmacy in 2006 and the Pharmaceutical Chemist degree in 2008 from the University of Chile. He then went on to obtain his Ph.D. in Pharmaceutics from The University of Texas at Austin in 2012. Dr. Morales has since worked as an Assistant Professor and later as an Associate Professor at the University of Chile. He has also served as the Director of the Center of New Drugs for Hypertension (CENDHY), where he led a team of researchers in developing new and innovative pharmaceutical treatments for hypertension. Dr. Morales has a strong passion for research and has published numerous articles in international journals and has patented his developed technologies. His expertise in pharmaceuticals, nano and microstructured drug delivery systems, implants, and peptide drug discovery has made him a sought-after speaker at conferences and symposiums around the world. In addition to his academic and research achievements, Dr. Morales is also a dedicated mentor and has supervised and mentored several students in their research projects. He is known for his commitment to excellence and his ability to motivate and inspire others. Overall, Dr. Morales is a highly respected and accomplished pharmaceutical professional with a strong track record of success in academia. His contributions to the field of pharmaceutical sciences have made a significant impact, and he continues to be a leader in the industry.

Felipe Oyarzún Ampuero graduated as a Pharmaceutical Chemist in the Austral University of Chile (2004). He obtained a “Diploma of Advanced Studies” (year 2007) and the degree of “Doctor in Research and Development of Medicines” (year 2011) at the University of Santiago de Compostela (Spain). Later he developed postdoctoral studies (2011-2013) at the Polymer Laboratory of the Universidad Austral de Chile. To carry out these studies he has received scholarships from MINEDUC (undergraduate) and CONICYT (postgraduate). In 2013 he joined to the University of Chile as an academic with a project on “Insertion of Advanced Human Capital in the Academy”. He is currently the Director of the Department of Pharmaceutical Sciences and Technology. In the teaching field he teaches to undergraduate and graduate students (Master's and Doctorate). He has been a researcher responsible for projects related to basic science (1 Fondecyt startup, 3 Fondecyt Regular, 2 Fondecyt postdoctoral) and several technological and/or applied science projects (Fondequip, Fondef and Corfo, among others). He has also been principal investigator in projects of different kinds (Fondap, Fondef, Fondequip, Anillo, Fondecyt regular, among others). The laboratory directed by Dr. Oyarzún has the necessary equipment to characterize liquid and solid formulations of different sizes (from nanometers to millimeters), their stability and the release profile of the active molecule contained. His main lines of research are: Encapsulation of active molecules (drugs and nutrients) in nano- and microsystems mediated by non-covalent interactions. Study of chemical interactions for the formation of nano and microsystems. Development of new materials for the pharmaceutical and food industries. Dr. Oyarzún has published more than 50 ISI publications, almost all of them from the first quartile. Below are the patents in which he appears as an inventor: **Accepted patents:** Application for USA: A new and green methodology to create polymeric nanocarriers containig hydrophilic low molecular-weight drugs and providing a very high drug loading and a very high prolonged release” (US/16/888,438). Felipe Oyarzún, Gabriela Villamizar, Ignacio Moreno, Elton Molina (**GRANTED**). Application for Spain: Nanocapsules with a polimeric Shell (ES2385995B2). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED AND LICENSED**). Application for USA:Nanocapsules with a polimeric Shell (US 9415019, B2). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED**). Application for Europe: Nanocapsules with a polymeric Shell (EP2664324(B1). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED**). Application for Chile: Biomaterial que comprende quitosano y al menos un glicosaminoglicano” (PCT/CL2012/000023). Miguel Concha Murray, Ignacio Moreno Villoslada, Sandra Lorena Orellana Donoso, Felipe Oyarzun Ampuero, María Alejandra Vidal Villa, Annesi Gisela Giacaman Fonseca, María Francisca Pavicic Rojas, Carlos Morales Hernandez, Marcos Ruminot Bascur, Sandra Pamela Jofre Rivas (**GRANTED**). **Application patents:** M.P. Ocaranza, J.E. Jalil, J.O. Morales, F. Oyarzun-Ampuero, E. Soto-Bustamante, F. Gonzalez-Nilo. Composición farmacéutica que comprende un péptido o una combinación de péptidos agonistas de los receptores Mas, AT1 y AT2. Chilean Patent Application PCT/CL2023/050084. PCT Application: Compositions (PCT/IB2022/051550). Verónica Palma, Daniela Carrillo, Fernando Valenzuela, Felipe Oyarzún, María Gabriela Villamizar (**LICENCED**). PCT Application: Nanoparticle of chitosan and cyclodextrin containing encapsulated interferon and pharmaceutical compositions that contain it" (PCT/IB2019/052510). Rodrigo Naves, Luis González Felipe Oyarzún. PCT Application: Método para obtener nanoestructuras con carotenoides y nanoestructuras obtenidas (PCT/CL2017/0550046). Felipe Oyarzún, Javier Morales, Matías Silva, Mariela Inostroza, Andrew Quest, Marcelo Kogan, Simón Guerrero, Ignacio Moreno, Carlos Alarcón, Mario Flores, César Torres (**LICENCED**). PCT Application: Curcumin-Loaded nanoemulsions, method of manufacture, and method of preventive treatment using the same (PCT) (15/856,786). Felipe Oyarzún, Andrew Quest, Simón Guerrero, Marcelo Kogan, Pamela Contreras, Víctor Díaz, Pablo Lara, Areli Cárdenas, Lisette Leyton, Andrea Vivanco, Víctor Miranda. Application for Chile: Microdieta para especies marinas de cultivo, incluyendo peces en etapas de desarrollo, la que una vez deshidratada y reconstituida toma una forma alargada similar a un alimento vivo, y método de preparación (201603279). Felipe Andrés Oyarzún Ampuero, Ignacio Moreno-Villoslada, Mariela Inostroza Riquelme. Application for Brazil: Nanocapsules with a polymeric Shell (PI98213). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes. Application for China: Nanocapsules with a polymeric Shell (CN103596558). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes.