Work with thought leaders and academic experts in Biochemistry

Companies can greatly benefit from working with experts in the field of Biochemistry. These researchers bring a deep understanding of molecular processes, biochemical reactions, and the structure and function of biomolecules. They can provide valuable insights and solutions for various industries, including pharmaceuticals, biotechnology, agriculture, food science, and environmental science. By collaborating with Biochemistry experts, companies can enhance their research and development efforts, accelerate innovation, improve product quality, optimize production processes, and address complex challenges. Their expertise can also contribute to the discovery of new drugs, the development of sustainable technologies, and the improvement of health and well-being.

Researchers on NotedSource with backgrounds in Biochemistry include Ping Luo, Gwendolyn Thomas, Ph.D., CSCS, USAW-L1, Luciano Dibona, Ph.D, Ajay Badhan, Dr. David Siderovski, Ph.D., Martin Tsui, and Boris Leibovitch.

Ping Luo

Toronto, Ontario, Canada
8 Years Experience
Assistant Professor at Algoma University
Education

University of Saskatchewan

Ph.D., Biomedical Engineering / September, 2019

Saskatoon, Saskatchewan, Canada

Beijing Institute of Technology

M.Eng., Biomedical Engineering / June, 2015

Beijing

Hunan University

B.Eng., Computer Science / June, 2010

Changsha
Experience

Princess Margaret Cancer Centre

Postdoctoral Researcher / November, 2019 — Present

I work in Dr. Trevor Pugh's lab and design cancer diagnosis and treatment strategies by analyze cell-free DNA and single cell sequencing data

Princess Margaret Cancer Centre

Bioinformatics Specialist / September, 2023 — Present

I work in Dr. Tak Mak's lab and study tumor immunology using single cell and TCR sequencing data.

Most Relevant Research Expertise
Biochemistry
Other Research Expertise (21)
single-cell genomics
deep learning
complex network analysis
Genetics (clinical)
Genetics
And 16 more
About
8 years of science and engineering experience integrating multi-omics data to identify biomarkers for cancer studies. Seeking to apply data analytics expertise to develop new diagnosis and treatment strategies.
Most Relevant Publications (6+)

23 total publications

Enhancing the prediction of disease–gene associations with multimodal deep learning

Bioinformatics / Mar 02, 2019

Luo, P., Li, Y., Tian, L.-P., & Wu, F.-X. (2019). Enhancing the prediction of disease–gene associations with multimodal deep learning. Bioinformatics, 35(19), 3735–3742. https://doi.org/10.1093/bioinformatics/btz155

Identifying cell types from single-cell data based on similarities and dissimilarities between cells

BMC Bioinformatics / May 01, 2021

Li, Y., Luo, P., Lu, Y., & Wu, F.-X. (2021). Identifying cell types from single-cell data based on similarities and dissimilarities between cells. BMC Bioinformatics, 22(S3). https://doi.org/10.1186/s12859-020-03873-z

Ensemble disease gene prediction by clinical sample-based networks

BMC Bioinformatics / Mar 01, 2020

Luo, P., Tian, L.-P., Chen, B., Xiao, Q., & Wu, F.-X. (2020). Ensemble disease gene prediction by clinical sample-based networks. BMC Bioinformatics, 21(S2). https://doi.org/10.1186/s12859-020-3346-8

A Novel Core-Attachment-Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks

PROTEOMICS / Feb 20, 2019

Xiao, Q., Luo, P., Li, M., Wang, J., & Wu, F.-X. (2019). A Novel Core-Attachment-Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks. PROTEOMICS, 19(5), 1800129. Portico. https://doi.org/10.1002/pmic.201800129

Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma

Blood / Nov 05, 2021

Coffey, D. G., Maura, F., Gonzalez-Kozlova, E., Diaz-Mejia3, J., Luo, P., Zhang, Y., Xu, Y., Warren, E. H., Smith, E. L., Cho, H. J., Lesokhin, A., Diamond, B., Kazandjian, D., Pugh, T. J., Green, D. J., Gnjatic, S., & Landgren, O. (2021). Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma. Blood, 138(Supplement 1), 329–329. https://doi.org/10.1182/blood-2021-154506

Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets

Computational and Structural Biotechnology Journal / Jan 01, 2022

Mahalanabis, A., Turinsky, A. L., Husić, M., Christensen, E., Luo, P., Naidas, A., Brudno, M., Pugh, T., Ramani, A. K., & Shooshtari, P. (2022). Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets. Computational and Structural Biotechnology Journal, 20, 6375–6387. https://doi.org/10.1016/j.csbj.2022.10.029

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Gwendolyn Thomas, Ph.D., CSCS, USAW-L1

Philadelphia, Pennsylvania, United States of America
17 Years Experience
Resistance Exercise Physiologist/Performance Enhancement/Optimizing RE Prescription
Education

University of Connecticut

Ph.D., Kinesiology (Exercise Endocrinology, Exercise Physiology, Resistance Exercise) / May, 2010

Storrs, Connecticut, United States of America

University of Connecticut

M.A., Strength and Conditioning / May, 2007

Storrs, Connecticut, United States of America
Experience

Penn State University

Assistant Research Professor / September, 2019 — August, 2023

Principal Investigator of the Exercise Prescription Lab. The lab (PI: Thomas) conducts interdisciplinary and translational research on chronic diseases, publishing in peer-reviewed journals. Transform population health outcomes through data, analytics, and actionable insights. Chair the regulatory review board, overseeing IRB Administration, running meetings, and approving research protocols. Expertise in institutional, FDA, and Federal regulatory work.

Penn State Integrative Physiology

Faculty Member / September, 2019 — Present

Faculty Member In Integrative Physiology

Syracuse University

Assistant Professor / August, 2016 — August, 2019

Independent Principal Investigator: Assumed responsibility for all research studies conducted in my lab, including but not limited to oversight and training of research assistants (25), training of research assistants (30), and generating independent, high quality, reproducible results. Responsible for the management and integrity of design, conduct and reporting of the research project and for managing, monitoring and ensuring the integrity of collaborative relationships. Curriculum Committee Chair:Led Curriculum Committee and Departmental Leadership to develop Master’s Degree in Strength and Conditioning through certifying agency, the National Strength and Conditioning Association (NSCA).

Most Relevant Research Expertise
Biochemistry
Other Research Expertise (30)
resistance exercise
obesity
breast cancer
chronic disease
inflammation
And 25 more
About
My work has focused on how we can use data to support decisions to individualize monitoring to optimize human performance.  My work has demonstrated that a one size fits all approach is not the way to optimize performance in any setting.  My monitoring approach is one that utilizes a network physiology paradigm, which focuses on nonlinear dynamic interactions. In my athlete monitoring I focus on leveraging EMA and wearables; biological sampling and resistance exercise and conditioning prescribed to elicit a specific biological response.    Additionally, as a practitioner it is important to understand the limitations of athlete monitoring, which is another area research and practice has focused.  This is an important skillset that is currently being utilized by the in a project entitled “Integrating mHealth and Physical Function to Develop a Predictors of Injury and Optimal Performance Model in Special Military Operators “with the Rangers in the 3/75 Ranger Battalion.  This approach is one that quantifies factors such as dosage variables of training and lifestyle factors (sleep, nutrition, life stress).  Using this data, we are working on individualizing acute training sessions to optimize readiness and performance enhancement.   During my time at Syracuse University, I was the professor of record to teach the NSCA CSCS preparation course and lead the strength and conditioning program.  We were developing a master’s in exercise science and I was in the process of working on certification with the NSCA.  We also worked closely with athletics to secure strength and conditioning assistantships to allow for student funding.  I am currently on several NSCA committees, which include the Education and Women’s Committee (next certification cycle).    I am particularly adept at all phases of the athletic performance enhancement and these experiences have given me expertise in evidence based program design, linear and non-linear periodization, exercise endocrinology, resistance exercise physiology and acute and chronic training readiness and non-training parameters
Most Relevant Publications (2+)

51 total publications

Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women

Steroids / Nov 01, 2009

Vingren, J. L., Kraemer, W. J., Hatfield, D. L., Volek, J. S., Ratamess, N. A., Anderson, J. M., Häkkinen, K., Ahtiainen, J., Fragala, M. S., & Thomas, G. A. (2009). Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women. Steroids, 74(13–14), 1033–1039. https://doi.org/10.1016/j.steroids.2009.08.002

Endogenous opioid peptide responses to opioid and anti-inflammatory medications following eccentric exercise-induced muscle damage

Peptides / Jan 01, 2010

Kraemer, W. J., Joseph, M. F., Volek, J. S., Hoffman, J. R., Ratamess, N. A., Newton, R. U., Fragala, M. S., French, D. N., Rubin, M. A., Scheett, T. P., McGuigan, M. R., Thomas, G. A., Gomez, A. L., Häkkinen, K., & Maresh, C. M. (2010). Endogenous opioid peptide responses to opioid and anti-inflammatory medications following eccentric exercise-induced muscle damage. Peptides, 31(1), 88–93. https://doi.org/10.1016/j.peptides.2009.09.031

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Luciano Dibona, Ph.D

Santiago
7 Years Experience
Highly motivated young professional with a PhD in Chemistry and specialized in Photobiological aspects of Life Sciences and Agriculture on Crop protection.
Education

Pontificia Universidad Católica de Chile

PhD Chemistry, Facultad de Química y de Farmacia

Santiago

Universidad de Tarapaca - Campus Saucache

Químico/Licenciado en Química, Departamento de Química

Arica
Experience

IQS

Postdoctoral Researcher / March, 2022 — Present

Pontificia Universidad Católica de Chile

R+D Project Director / January, 2021 — April, 2023

R&D Project director in VIU Project: “Development of fungicidal formulations based on photoactive polymers (LEAPs) for application in Agriculture”. Pontificia Universidad Católica de Chile.

Pontificia Universidad Católica de Chile

Researcher / January, 2021 — June, 2023

Researcher in COPEC UC 2019.J.1273 “Photoactive biofungicides for use citrus and postharvest table grapes” Pontificia Universidad Católica de Chile

Most Relevant Research Expertise
Biochemistry
Other Research Expertise (5)
Antimicrobial Photodynamic Therapy
Physical and Theoretical Chemistry
Plant Science
Horticulture
Photobiology
About
With more than 5 years of background in the field, I'm committed to drive scientific advances into impactful innovation for the industry and the market through knowledge and technology transfer. Experience as a consultant in formulation of R&D projects with a focus on teamwork, collaboration, and communication skills. Works with an analytical mindset to deliver meaningful results. Experience in designing and evaluating industry-driven scientific research and intellectual property protection processes involved.
Most Relevant Publications (1+)

7 total publications

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†

Photochemistry and Photobiology / Dec 20, 2022

Mariño‐Ocampo, N., Dibona‐Villanueva, L., Escobar‐Álvarez, E., Guerra‐Díaz, D., Zúñiga‐Núñez, D., Fuentealba, D., & Robinson‐Duggon, J. (2022). Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†. Photochemistry and Photobiology, 99(2), 469–497. Portico. https://doi.org/10.1111/php.13749

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Ajay Badhan

Lethbridge, Alberta, Canada
15 Years Experience
Research Biologist, Lethbridge Research Center, Canada
Education

Ph.D., Microbiology

Experience

Agriculture Agri-food Canada

Biologist / May, 2015 — Present

Most Relevant Research Expertise
Biochemistry
Other Research Expertise (26)
Animal nutrition
cell wall biosynthesis and its deconstruction
biofuels
Waste Management and Disposal
Renewable Energy, Sustainability and the Environment
And 21 more
About
I am a proficient researcher with valuable research and teaching experience acquired at distinguished institutes like Complex Carbohydrate Research Center, US, University of Alberta, Canada, and Lethbridge Research Center (AAFC), Canada. I have been working for past 15 years on multiple projects focused on the economical, environmental and social sustainability of agricultural production. Improvement in livestock performance, productivity, and health by unlocking the microbiome, development of clean technologies, improving agriculture environmental performance, and Increase agro-ecosystem resilience are prime objectives for my research.
Most Relevant Publications (2+)

29 total publications

Functionally diverse multiple xylanases of thermophilic fungus Myceliophthora sp. IMI 387099

Enzyme and Microbial Technology / Oct 01, 2004

Badhan, A. K., Chadha, B. S., Sonia, K. G., Saini, H. S., & Bhat, M. K. (2004). Functionally diverse multiple xylanases of thermophilic fungus Myceliophthora sp. IMI 387099. Enzyme and Microbial Technology, 35(5), 460–466. https://doi.org/10.1016/j.enzmictec.2004.07.002

Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses

Computational and Structural Biotechnology Journal / Jan 01, 2022

Badhan, A., Low, K. E., Jones, D. R., Xing, X., Milani, M. R. M., Polo, R. O., Klassen, L., Venketachalam, S., Hahn, M. G., Abbott, D. W., & McAllister, T. A. (2022). Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses. Computational and Structural Biotechnology Journal, 20, 148–164. https://doi.org/10.1016/j.csbj.2021.12.009

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Dr. David Siderovski, Ph.D.

Fort Worth
25 Years Experience
Professor of Computational Pharmacology; Chair of HSC SBS Dept. of Pharmacology & Neuroscience
Education

University of Toronto

Ph.D., Medical Biophysics / November, 1997

Toronto, Ontario, Canada
Experience

University of North Carolina at Chapel Hill

Professor / January, 1999 — June, 2012

West Virginia University School of Medicine

E.J. Van Liere Endowed Medicine Professor and Chairman / July, 2012 — February, 2020

Chair of the Dept. of Physiology and Pharmacology

University of North Texas Health Science Center

Professor & Chair / March, 2020 — Present

Most Relevant Research Expertise
Biochemistry
Other Research Expertise (25)
Regulator of G protein Signaling (RGS) proteins
Pharmacology
Molecular Biology
Cellular and Molecular Neuroscience
Molecular Medicine
And 20 more
About
Dr. David Siderovski is a renowned scientist and academic, with a career spanning over two decades. He received his Ph.D. in Medical Biophysics from the University of Toronto in 1997, where he specialized in signal transduction and cellular signaling pathways. After completing his doctorate, Dr. Siderovski held various faculty positions at prestigious universities, including the University of North Carolina at Chapel Hill, West Virginia University School of Medicine, and the University of North Texas Health Science Center. At these institutions, Dr. Siderovski has made significant contributions to the field of pharmacology through his research on G protein-coupled receptors (GPCRs) and RGS proteins, which are key regulators of GPCR cellular signaling. His work has helped to advance the understanding of RGS proteins and their roles in various diseases, including cancer, cardiovascular disorders, and neurological disorders. In addition to his research, Dr. Siderovski is also a dedicated educator and mentor. He has taught and mentored numerous undergraduate, graduate, and medical students, and has served as a mentor for postdoctoral fellows and junior faculty members. He is known for his passion and enthusiasm for science and his ability to inspire and guide the next generation of scientists. Dr. Siderovski has received numerous awards and honors for his contributions to the scientific community. He was the recipient of the Abel Award in 2004 from the American Society of Pharmacology & Experimental Therapeutics for his pioneering discoveries of the RGS proteins and the GoLoco motif. He has also served on editorial boards of several scientific journals (including a decade at *J.Biol.Chem.*) and has been a member of various scientific committees, NIH study section panels, and pharma/biotech advisory boards, including for Inspire, Wyeth, and BellBrook Labs. Overall, Dr. David Siderovski is a highly accomplished and respected scientist and educator, whose research has had a significant impact on the field of pharmacology. His dedication and passion for science continue to inspire and influence the next generation of researchers in this field.
Most Relevant Publications (24+)

94 total publications

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Nature Structural Biology / May 13, 2002

Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., & Sondek, J. (2002). Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Structural Biology, 9(6), 468–475. https://doi.org/10.1038/nsb796

RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity

Journal of Biological Chemistry / Aug 01, 2001

Kimple, R. J., De Vries, L., Tronchère, H., Behe, C. I., Morris, R. A., Farquhar, M. G., & Siderovski, D. P. (2001). RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity. Journal of Biological Chemistry, 276(31), 29275–29281. https://doi.org/10.1074/jbc.m103208200

GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain

Journal of Biological Chemistry / Jul 01, 1998

Snow, B. E., Hall, R. A., Krumins, A. M., Brothers, G. M., Bouchard, D., Brothers, C. A., Chung, S., Mangion, J., Gilman, A. G., Lefkowitz, R. J., & Siderovski, D. P. (1998). GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain. Journal of Biological Chemistry, 273(28), 17749–17755. https://doi.org/10.1074/jbc.273.28.17749

Return of the GDI: The GoLoco Motif in Cell Division

Annual Review of Biochemistry / Jun 01, 2004

Willard, F. S., Kimple, R. J., & Siderovski, D. P. (2004). Return of the GDI: The GoLoco Motif in Cell Division. Annual Review of Biochemistry, 73(1), 925–951. https://doi.org/10.1146/annurev.biochem.73.011303.073756

The GoLoco motif: a Gαi/o binding motif and potential guanine-nucleotide exchange factor

Trends in Biochemical Sciences / Sep 01, 1999

Siderovski, D. P., Diversé-Pierluissi, M. A., & De Vries, L. (1999). The GoLoco motif: a Gαi/o binding motif and potential guanine-nucleotide exchange factor. Trends in Biochemical Sciences, 24(9), 340–341. https://doi.org/10.1016/s0968-0004(99)01441-3

Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits

Journal of Biological Chemistry / Dec 01, 2001

Wing, M. R., Houston, D., Kelley, G. G., Der, C. J., Siderovski, D. P., & Harden, T. K. (2001). Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits. Journal of Biological Chemistry, 276(51), 48257–48261. https://doi.org/10.1074/jbc.c100574200

Whither Goest the RGS Proteins?

Critical Reviews in Biochemistry and Molecular Biology / Jan 01, 1999

Siderovski, D. P., Strockbine, B., & Behe, C. I. (1999). Whither Goest the RGS Proteins? Critical Reviews in Biochemistry and Molecular Biology, 34(4), 215–251. https://doi.org/10.1080/10409239991209273

Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells

Journal of Biological Chemistry / Jul 01, 2002

Wang, Q., Liu, M., Mullah, B., Siderovski, D. P., & Neubig, R. R. (2002). Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells. Journal of Biological Chemistry, 277(28), 24949–24958. https://doi.org/10.1074/jbc.m203802200

PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation

Journal of Biological Chemistry / Jan 01, 2010

Nakamura, K., Kimple, A. J., Siderovski, D. P., & Johnson, G. L. (2010). PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation. Journal of Biological Chemistry, 285(3), 2077–2089. https://doi.org/10.1074/jbc.m109.065102

Molecular Cloning and Expression Analysis of RatRgs12andRgs14

Biochemical and Biophysical Research Communications / Apr 01, 1997

Snow, B. E., Antonio, L., Suggs, S., Gutstein, H. B., & Siderovski, D. P. (1997). Molecular Cloning and Expression Analysis of RatRgs12andRgs14. Biochemical and Biophysical Research Communications, 233(3), 770–777. https://doi.org/10.1006/bbrc.1997.6537

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

Journal of Biological Chemistry / Dec 01, 2001

Snyder, J. T., Rossman, K. L., Baumeister, M. A., Pruitt, W. M., Siderovski, D. P., Der, C. J., Lemmon, M. A., & Sondek, J. (2001). Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins. Journal of Biological Chemistry, 276(49), 45868–45875. https://doi.org/10.1074/jbc.m106731200

Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq

Journal of Biological Chemistry / Jun 01, 2001

Evanko, D. S., Thiyagarajan, M. M., Siderovski, D. P., & Wedegaertner, P. B. (2001). Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq. Journal of Biological Chemistry, 276(26), 23945–23953. https://doi.org/10.1074/jbc.m101154200

Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

Journal of Biological Chemistry / Jul 01, 2009

Kimple, A. J., Soundararajan, M., Hutsell, S. Q., Roos, A. K., Urban, D. J., Setola, V., Temple, B. R. S., Roth, B. L., Knapp, S., Willard, F. S., & Siderovski, D. P. (2009). Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2). Journal of Biological Chemistry, 284(29), 19402–19411. https://doi.org/10.1074/jbc.m109.024711

Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif

Biochemical Journal / Mar 15, 2004

KIMPLE, R. J., WILLARD, F. S., HAINS, M. D., JONES, M. B., NWEKE, G. K., & SIDEROVSKI, D. P. (2004). Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. Biochemical Journal, 378(3), 801–808. https://doi.org/10.1042/bj20031686

D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi‐specific GoLoco motif peptides

Journal of Neurochemistry / Feb 17, 2005

Webb, C. K., McCudden, C. R., Willard, F. S., Kimple, R. J., Siderovski, D. P., & Oxford, G. S. (2005). D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi‐specific GoLoco motif peptides. Journal of Neurochemistry, 92(6), 1408–1418. Portico. https://doi.org/10.1111/j.1471-4159.2004.02997.x

G protein signaling in the parasite Entamoeba histolytica

Experimental & Molecular Medicine / Mar 22, 2013

Bosch, D. E., & Siderovski, D. P. (2013). G protein signaling in the parasite Entamoeba histolytica. Experimental & Molecular Medicine, 45(3), e15–e15. https://doi.org/10.1038/emm.2013.30

Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13

Journal of Biological Chemistry / Dec 01, 2001

Blake, B. L., Wing, M. R., Zhou, J. Y., Lei, Q., Hillmann, J. R., Behe, C. I., Morris, R. A., Harden, T. K., Bayliss, D. A., Miller, R. J., & Siderovski, D. P. (2001). Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13. Journal of Biological Chemistry, 276(52), 49267–49274. https://doi.org/10.1074/jbc.m106565200

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics / Sep 01, 2007

Kimple, A. J., Willard, F. S., Giguère, P. M., Johnston, C. A., Mocanu, V., & Siderovski, D. P. (2007). The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1774(9), 1213–1220. https://doi.org/10.1016/j.bbapap.2007.06.002

Computational Design of the Sequence and Structure of a Protein-Binding Peptide

Journal of the American Chemical Society / Mar 09, 2011

Sammond, D. W., Bosch, D. E., Butterfoss, G. L., Purbeck, C., Machius, M., Siderovski, D. P., & Kuhlman, B. (2011). Computational Design of the Sequence and Structure of a Protein-Binding Peptide. Journal of the American Chemical Society, 133(12), 4190–4192. https://doi.org/10.1021/ja110296z

A direct fluorescence-based assay for RGS domain GTPase accelerating activity

Analytical Biochemistry / May 01, 2005

Willard, F. S., Kimple, A. J., Johnston, C. A., & Siderovski, D. P. (2005). A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Analytical Biochemistry, 340(2), 341–351. https://doi.org/10.1016/j.ab.2005.02.015

A Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding

Journal of Biological Chemistry / Dec 01, 2008

Willard, F. S., Zheng, Z., Guo, J., Digby, G. J., Kimple, A. J., Conley, J. M., Johnston, C. A., Bosch, D., Willard, M. D., Watts, V. J., Lambert, N. A., Ikeda, S. R., Du, Q., & Siderovski, D. P. (2008). A Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding. Journal of Biological Chemistry, 283(52), 36698–36710. https://doi.org/10.1074/jbc.m804936200

Minimal Determinants for Binding Activated Gα from the Structure of a Gαi1−Peptide Dimer,

Biochemistry / Aug 30, 2006

Johnston, C. A., Lobanova, E. S., Shavkunov, A. S., Low, J., Ramer, J. K., Blaesius, R., Fredericks, Z., Willard, F. S., Kuhlman, B., Arshavsky, V. Y., & Siderovski, D. P. (2006). Minimal Determinants for Binding Activated Gα from the Structure of a Gαi1−Peptide Dimer,. Biochemistry, 45(38), 11390–11400. https://doi.org/10.1021/bi0613832

Covalent immobilization of histidine-tagged proteins for surface plasmon resonance

Analytical Biochemistry / Jun 01, 2006

Willard, F. S., & Siderovski, D. P. (2006). Covalent immobilization of histidine-tagged proteins for surface plasmon resonance. Analytical Biochemistry, 353(1), 147–149. https://doi.org/10.1016/j.ab.2006.02.004

Regulator of G-protein Signaling-21 (RGS21) Is an Inhibitor of Bitter Gustatory Signaling Found in Lingual and Airway Epithelia

Journal of Biological Chemistry / Dec 01, 2012

Cohen, S. P., Buckley, B. K., Kosloff, M., Garland, A. L., Bosch, D. E., Cheng, G., Radhakrishna, H., Brown, M. D., Willard, F. S., Arshavsky, V. Y., Tarran, R., Siderovski, D. P., & Kimple, A. J. (2012). Regulator of G-protein Signaling-21 (RGS21) Is an Inhibitor of Bitter Gustatory Signaling Found in Lingual and Airway Epithelia. Journal of Biological Chemistry, 287(50), 41706–41719. https://doi.org/10.1074/jbc.m112.423806

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Martin Tsui

San Francisco, California, United States of America
7 Years Experience
University of California, San Francisco
Education

Florida State University

Ph.D., Molecular Biophysics / July, 2017

Tallahassee, Florida, United States of America

University of California, San Diego

B.S., Chemistry / June, 2012

San Diego, California, United States of America
Experience

Stealth

Founder & CEO / January, 2023 — Present

Genome engineering

Amazon

Senior Scientist / December, 2021 — February, 2023

Molecular Diagnostics

Van Andel Institute

Postdoctoral Fellow / September, 2020 — April, 2021

Cryo-EM of membrane proteins

Most Relevant Research Expertise
Biochemistry
Other Research Expertise (15)
Structural Biology
Cryo-EM
CRISPR
Molecular Assembly and Interaction
Molecular Biology
And 10 more
About
Martin Tsui is an accomplished scientist with a strong background in biochemistry. He received his Ph.D. in Molecular Biophysics from Florida State University in 2017, where he conducted research on the structure and function of CRISPR proteins. Prior to that, he obtained his B.S. in Chemistry from the University of California, San Diego in 2012. After completing his graduate studies, Martin founded his own company, Stealth, where he serves as a Founder & CEO. Under his leadership, the company has developed innovative solutions for the biotech industry and has gained recognition for its groundbreaking research. Before starting his company, Martin worked as a Senior Scientist at Amazon, where he applied his expertise in protein biochemistry and CRISPR to improve the company's product development processes and creating new products. He also gained valuable experience as a Postdoctoral Scholar at the University of California, San Francisco and Postdoctoral Fellow at the Van Andel Institute, where he studied cancer proteins, SARS-CoV-2, HIV proteins, and the role of proteins in neurodegenerative diseases, respectively. Martin is a highly driven and passionate individual who is dedicated to advancing the field of biotechnology. His impressive education and diverse experience have equipped him with the skills and knowledge to make significant contributions to the scientific community. He continues to pursue new opportunities to further his research and make a positive impact in the world of science.
Most Relevant Publications (1+)

16 total publications

Structure Principles of CRISPR-Cas Surveillance and Effector Complexes

Annual Review of Biophysics / Jun 22, 2015

Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939

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Boris Leibovitch

New York, New York, United States of America
30 Years Experience
Experienced wet lab and in teaching Molecular Cell biologist, geneticist, cancer biologist in Academia
Education

Moscow Region State University

PhD, Molecular Biology / April, 1978

Moscow

Moscow Region State University

MS, Genetics / July, 1972

Moscow

Moscow Region State University

BS, Genetics / April, 1971

Moscow
Experience

NYU Langone Medical Center

Associate Research Scientist / June, 2021 — September, 2022

Wet lab research and teaching Molecular and Cell Biology in MD program

Icahn School of Medicine at Mount Sinai

Assistant Professor / July, 2004 — June, 2021

Wet lab research and teaching Molecular and Cell Biology in MD program

Washington University in St. Louis

Post-doctoral Research Associate / June, 1994 — June, 2004

Wet lab research and teaching Molecular and Cell Biology in MS program

Most Relevant Research Expertise
Biochemistry
Other Research Expertise (8)
Cancer Research
Cell Biology
Developmental Biology
Molecular Biology
Hematology
And 3 more
About
I am experienced molecular and cell biologist with deep genetics background who worked many years in USA and Russia on the bench and as teacher. Both types of work had demanded extremely broad knowledge and understanding of developments in the fields. Participation in grant writing, editorial/reviewer work for scientific journals and consulting colleagues on these subjects added a lot to my broad experience as the scientist.
Most Relevant Publications (2+)

22 total publications

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

Blood / Mar 15, 2008

Marango, J., Shimoyama, M., Nishio, H., Meyer, J. A., Min, D.-J., Sirulnik, A., Martinez-Martinez, Y., Chesi, M., Bergsagel, P. L., Zhou, M.-M., Waxman, S., Leibovitch, B. A., Walsh, M. J., & Licht, J. D. (2008). The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood, 111(6), 3145–3154. https://doi.org/10.1182/blood-2007-06-092122

Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster

Cold Spring Harbor Symposia on Quantitative Biology / Jan 01, 2004

HAYNES, K. A., LEIBOVITCH, B. A., RANGWALA, S. H., CRAIG, C., & ELGIN, S. C. R. (2004). Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster. Cold Spring Harbor Symposia on Quantitative Biology, 69(0), 267–272. https://doi.org/10.1101/sqb.2004.69.267

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Example Biochemistry projects

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Drug Discovery and Development

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Biotechnology Advancements

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Crop Improvement and Agriculture

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Food Science and Nutrition

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Environmental Remediation

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