Work with thought leaders and academic experts in Structural Biology
Companies can greatly benefit from collaborating with academic researchers in the field of Structural Biology. These experts can provide valuable insights and expertise in understanding the structure and function of biological molecules. Here are some ways companies can collaborate with them: 1. Drug Discovery and Development: Structural biologists can help in identifying potential drug targets and designing new drugs by studying the structure of target molecules. 2. Protein Engineering: They can assist in modifying and optimizing proteins for various applications, such as enzyme engineering, biocatalysis, and protein therapeutics. 3. Biomolecular Interactions: Structural biologists can investigate the interactions between proteins, nucleic acids, and other biomolecules, providing insights into molecular recognition and signaling pathways. 4. Structural Analysis: They can determine the three-dimensional structures of biomolecules using techniques like X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy. 5. Biotechnology and Biomedical Research: Collaborating with structural biologists can enhance research in areas like protein engineering, drug delivery systems, and understanding disease mechanisms. By partnering with academic researchers in Structural Biology, companies can leverage their expertise to drive innovation, develop new products, and stay ahead in the competitive market.
Researchers on NotedSource with backgrounds in Structural Biology include Mohammad Imran Khan, Dr. David Siderovski, Ph.D., Ajay Badhan, Ping Luo, Martin Tsui, Aimee Eggler, and john kerry.
Mohammad Imran Khan
Postdoctoral Associate at University of Maryland College Park in the Department of Nutrition and Food Science
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Other Research Expertise (22)
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Most Relevant Publications (1+)
11 total publications
Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy
International Journal of Biological Macromolecules / Jul 01, 2020
Praveen, M. A., Parvathy, K. R. K., Patra, S., Khan, I., Natarajan, P., & Balasubramanian, P. (2020). Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy. International Journal of Biological Macromolecules, 154, 557–566. https://doi.org/10.1016/j.ijbiomac.2020.03.086
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Dr. David Siderovski, Ph.D.
Professor of Computational Pharmacology; Chair of HSC SBS Dept. of Pharmacology & Neuroscience
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Other Research Expertise (25)
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Most Relevant Publications (7+)
94 total publications
Structural and Evolutionary Division of Phosphotyrosine Binding (PTB) Domains
Journal of Molecular Biology / Jan 01, 2005
Uhlik, M. T., Temple, B., Bencharit, S., Kimple, A. J., Siderovski, D. P., & Johnson, G. L. (2005). Structural and Evolutionary Division of Phosphotyrosine Binding (PTB) Domains. Journal of Molecular Biology, 345(1), 1–20. https://doi.org/10.1016/j.jmb.2004.10.038
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
Nature Structural Biology / May 13, 2002
Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., & Sondek, J. (2002). Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Structural Biology, 9(6), 468–475. https://doi.org/10.1038/nsb796
Crystal structure of the multifunctional Gβ5–RGS9 complex
Nature Structural & Molecular Biology / Jan 20, 2008
Cheever, M. L., Snyder, J. T., Gershburg, S., Siderovski, D. P., Harden, T. K., & Sondek, J. (2008). Crystal structure of the multifunctional Gβ5–RGS9 complex. Nature Structural & Molecular Biology, 15(2), 155–162. https://doi.org/10.1038/nsmb.1377
Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities
Journal of Molecular Biology / Aug 01, 2007
Sammond, D. W., Eletr, Z. M., Purbeck, C., Kimple, R. J., Siderovski, D. P., & Kuhlman, B. (2007). Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities. Journal of Molecular Biology, 371(5), 1392–1404. https://doi.org/10.1016/j.jmb.2007.05.096
Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange
Structure / Jul 01, 2005
Johnston, C. A., Willard, F. S., Jezyk, M. R., Fredericks, Z., Bodor, E. T., Jones, M. B., Blaesius, R., Watts, V. J., Harden, T. K., Sondek, J., Ramer, J. K., & Siderovski, D. P. (2005). Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange. Structure, 13(7), 1069–1080. https://doi.org/10.1016/j.str.2005.04.007
Integrating energy calculations with functional assays to decipher the specificity of G protein–RGS protein interactions
Nature Structural & Molecular Biology / Jun 19, 2011
Kosloff, M., Travis, A. M., Bosch, D. E., Siderovski, D. P., & Arshavsky, V. Y. (2011). Integrating energy calculations with functional assays to decipher the specificity of G protein–RGS protein interactions. Nature Structural & Molecular Biology, 18(7), 846–853. https://doi.org/10.1038/nsmb.2068
Cooperative interaction between the DNA-binding domains of PU.1 and IRF4
Journal of Molecular Biology / Jun 01, 1998
Yee, A. A., Yin, P., Siderovski, D. P., Mak, T. W., Litchfield, D. W., & Arrowsmith, C. H. (1998). Cooperative interaction between the DNA-binding domains of PU.1 and IRF4. Journal of Molecular Biology, 279(5), 1075–1083. https://doi.org/10.1006/jmbi.1998.1838
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Ajay Badhan
Research Biologist, Lethbridge Research Center, Canada
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Other Research Expertise (26)
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Most Relevant Publications (1+)
29 total publications
Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses
Computational and Structural Biotechnology Journal / Jan 01, 2022
Badhan, A., Low, K. E., Jones, D. R., Xing, X., Milani, M. R. M., Polo, R. O., Klassen, L., Venketachalam, S., Hahn, M. G., Abbott, D. W., & McAllister, T. A. (2022). Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses. Computational and Structural Biotechnology Journal, 20, 148–164. https://doi.org/10.1016/j.csbj.2021.12.009
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Ping Luo
Bioinformatics Specialist at Princess Margaret Cancer Centre with experience in deep learning
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Other Research Expertise (21)
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Most Relevant Publications (3+)
23 total publications
Identifying cell types from single-cell data based on similarities and dissimilarities between cells
BMC Bioinformatics / May 01, 2021
Li, Y., Luo, P., Lu, Y., & Wu, F.-X. (2021). Identifying cell types from single-cell data based on similarities and dissimilarities between cells. BMC Bioinformatics, 22(S3). https://doi.org/10.1186/s12859-020-03873-z
Ensemble disease gene prediction by clinical sample-based networks
BMC Bioinformatics / Mar 01, 2020
Luo, P., Tian, L.-P., Chen, B., Xiao, Q., & Wu, F.-X. (2020). Ensemble disease gene prediction by clinical sample-based networks. BMC Bioinformatics, 21(S2). https://doi.org/10.1186/s12859-020-3346-8
Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets
Computational and Structural Biotechnology Journal / Jan 01, 2022
Mahalanabis, A., Turinsky, A. L., Husić, M., Christensen, E., Luo, P., Naidas, A., Brudno, M., Pugh, T., Ramani, A. K., & Shooshtari, P. (2022). Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets. Computational and Structural Biotechnology Journal, 20, 6375–6387. https://doi.org/10.1016/j.csbj.2022.10.029
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Martin Tsui
University of California, San Francisco
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Other Research Expertise (15)
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Most Relevant Publications (2+)
16 total publications
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes
Annual Review of Biophysics / Jun 22, 2015
Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Structure / Mar 01, 2023
Remesh, S. G., Merz, G. E., Brilot, A. F., Chio, U. S., Rizo, A. N., Pospiech, T. H., Lui, I., Laurie, M. T., Glasgow, J., Le, C. Q., Zhang, Y., Diwanji, D., Hernandez, E., Lopez, J., Mehmood, H., Pawar, K. I., Pourmal, S., Smith, A. M., Zhou, F., … Verba, K. A. (2023). Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31(3), 253-264.e6. https://doi.org/10.1016/j.str.2023.01.009
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Aimee Eggler
Professor of Chemistry and Biochemistry at Villanova University
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Other Research Expertise (18)
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Most Relevant Publications (1+)
25 total publications
Sites of alkylation of human Keap1 by natural chemoprevention agents
Journal of the American Society for Mass Spectrometry / Dec 01, 2007
Luo, Y., Eggler, A. L., Liu, D., Liu, G., Mesecar, A. D., & van Breemen, R. B. (2007). Sites of alkylation of human Keap1 by natural chemoprevention agents. Journal of the American Society for Mass Spectrometry, 18(12), 2226–2232. https://doi.org/10.1016/j.jasms.2007.09.015
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john kerry
Food Consultant PhD in Food Science & Technology
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Other Research Expertise (10)
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Most Relevant Publications (1+)
43 total publications
Use and application of gelatin as potential biodegradable packaging materials for food products
International Journal of Biological Macromolecules / Nov 01, 2014
Nur Hanani, Z. A., Roos, Y. H., & Kerry, J. P. (2014). Use and application of gelatin as potential biodegradable packaging materials for food products. International Journal of Biological Macromolecules, 71, 94–102. https://doi.org/10.1016/j.ijbiomac.2014.04.027
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Example Structural Biology projects
How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on Structural Biology?
Structure-Based Drug Design
A pharmaceutical company can collaborate with a structural biologist to design new drugs by studying the structure of target molecules and identifying potential binding sites for drug molecules.
Protein Engineering for Industrial Applications
A biotechnology company can work with a structural biologist to engineer proteins with improved properties for industrial applications, such as enzyme engineering for biofuel production.
Understanding Protein-Protein Interactions
A biopharmaceutical company can partner with a structural biologist to study the interactions between proteins involved in disease pathways, aiding in the development of targeted therapies.
Structural Analysis of Viral Proteins
A vaccine development company can collaborate with a structural biologist to determine the three-dimensional structures of viral proteins, facilitating the design of effective vaccines.
Structural Biology in Agriculture
An agricultural company can work with a structural biologist to understand the structure and function of plant proteins, leading to the development of improved crop varieties with enhanced traits.