Work with thought leaders and academic experts in Structural Biology

Companies can greatly benefit from collaborating with academic researchers in the field of Structural Biology. These experts can provide valuable insights and expertise in understanding the structure and function of biological molecules. Here are some ways companies can collaborate with them: 1. Drug Discovery and Development: Structural biologists can help in identifying potential drug targets and designing new drugs by studying the structure of target molecules. 2. Protein Engineering: They can assist in modifying and optimizing proteins for various applications, such as enzyme engineering, biocatalysis, and protein therapeutics. 3. Biomolecular Interactions: Structural biologists can investigate the interactions between proteins, nucleic acids, and other biomolecules, providing insights into molecular recognition and signaling pathways. 4. Structural Analysis: They can determine the three-dimensional structures of biomolecules using techniques like X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy. 5. Biotechnology and Biomedical Research: Collaborating with structural biologists can enhance research in areas like protein engineering, drug delivery systems, and understanding disease mechanisms. By partnering with academic researchers in Structural Biology, companies can leverage their expertise to drive innovation, develop new products, and stay ahead in the competitive market.

Researchers on NotedSource with backgrounds in Structural Biology include Ajay Badhan, Dr. David Siderovski, Ph.D., Aimee Eggler, Mohammad Imran Khan, Ping Luo, Martin Tsui, and David Proctor.

Ajay Badhan

Lethbridge, Alberta, Canada
15 Years Experience
Research Biologist, Lethbridge Research Center, Canada
Education

Ph.D., Microbiology

Experience

Agriculture Agri-food Canada

Biologist / May, 2015 — Present

Most Relevant Research Expertise
Structural Biology
Other Research Expertise (26)
Animal nutrition
cell wall biosynthesis and its deconstruction
biofuels
Waste Management and Disposal
Renewable Energy, Sustainability and the Environment
And 21 more
About
I am a proficient researcher with valuable research and teaching experience acquired at distinguished institutes like Complex Carbohydrate Research Center, US, University of Alberta, Canada, and Lethbridge Research Center (AAFC), Canada. I have been working for past 15 years on multiple projects focused on the economical, environmental and social sustainability of agricultural production. Improvement in livestock performance, productivity, and health by unlocking the microbiome, development of clean technologies, improving agriculture environmental performance, and Increase agro-ecosystem resilience are prime objectives for my research.
Most Relevant Publications (1+)

29 total publications

Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses

Computational and Structural Biotechnology Journal / Jan 01, 2022

Badhan, A., Low, K. E., Jones, D. R., Xing, X., Milani, M. R. M., Polo, R. O., Klassen, L., Venketachalam, S., Hahn, M. G., Abbott, D. W., & McAllister, T. A. (2022). Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses. Computational and Structural Biotechnology Journal, 20, 148–164. https://doi.org/10.1016/j.csbj.2021.12.009

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Dr. David Siderovski, Ph.D.

Fort Worth
25 Years Experience
Professor of Computational Pharmacology; Chair of HSC SBS Dept. of Pharmacology & Neuroscience
Education

University of Toronto

Ph.D., Medical Biophysics / November, 1997

Toronto, Ontario, Canada
Experience

University of North Carolina at Chapel Hill

Professor / January, 1999 — June, 2012

West Virginia University School of Medicine

E.J. Van Liere Endowed Medicine Professor and Chairman / July, 2012 — February, 2020

Chair of the Dept. of Physiology and Pharmacology

University of North Texas Health Science Center

Professor & Chair / March, 2020 — Present

Most Relevant Research Expertise
Structural Biology
Other Research Expertise (25)
Regulator of G protein Signaling (RGS) proteins
Pharmacology
Molecular Biology
Cellular and Molecular Neuroscience
Molecular Medicine
And 20 more
About
Dr. David Siderovski is a renowned scientist and academic, with a career spanning over two decades. He received his Ph.D. in Medical Biophysics from the University of Toronto in 1997, where he specialized in signal transduction and cellular signaling pathways. After completing his doctorate, Dr. Siderovski held various faculty positions at prestigious universities, including the University of North Carolina at Chapel Hill, West Virginia University School of Medicine, and the University of North Texas Health Science Center. At these institutions, Dr. Siderovski has made significant contributions to the field of pharmacology through his research on G protein-coupled receptors (GPCRs) and RGS proteins, which are key regulators of GPCR cellular signaling. His work has helped to advance the understanding of RGS proteins and their roles in various diseases, including cancer, cardiovascular disorders, and neurological disorders. In addition to his research, Dr. Siderovski is also a dedicated educator and mentor. He has taught and mentored numerous undergraduate, graduate, and medical students, and has served as a mentor for postdoctoral fellows and junior faculty members. He is known for his passion and enthusiasm for science and his ability to inspire and guide the next generation of scientists. Dr. Siderovski has received numerous awards and honors for his contributions to the scientific community. He was the recipient of the Abel Award in 2004 from the American Society of Pharmacology & Experimental Therapeutics for his pioneering discoveries of the RGS proteins and the GoLoco motif. He has also served on editorial boards of several scientific journals (including a decade at *J.Biol.Chem.*) and has been a member of various scientific committees, NIH study section panels, and pharma/biotech advisory boards, including for Inspire, Wyeth, and BellBrook Labs. Overall, Dr. David Siderovski is a highly accomplished and respected scientist and educator, whose research has had a significant impact on the field of pharmacology. His dedication and passion for science continue to inspire and influence the next generation of researchers in this field.
Most Relevant Publications (7+)

94 total publications

Structural and Evolutionary Division of Phosphotyrosine Binding (PTB) Domains

Journal of Molecular Biology / Jan 01, 2005

Uhlik, M. T., Temple, B., Bencharit, S., Kimple, A. J., Siderovski, D. P., & Johnson, G. L. (2005). Structural and Evolutionary Division of Phosphotyrosine Binding (PTB) Domains. Journal of Molecular Biology, 345(1), 1–20. https://doi.org/10.1016/j.jmb.2004.10.038

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Nature Structural Biology / May 13, 2002

Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., & Sondek, J. (2002). Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Structural Biology, 9(6), 468–475. https://doi.org/10.1038/nsb796

Crystal structure of the multifunctional Gβ5–RGS9 complex

Nature Structural & Molecular Biology / Jan 20, 2008

Cheever, M. L., Snyder, J. T., Gershburg, S., Siderovski, D. P., Harden, T. K., & Sondek, J. (2008). Crystal structure of the multifunctional Gβ5–RGS9 complex. Nature Structural & Molecular Biology, 15(2), 155–162. https://doi.org/10.1038/nsmb.1377

Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities

Journal of Molecular Biology / Aug 01, 2007

Sammond, D. W., Eletr, Z. M., Purbeck, C., Kimple, R. J., Siderovski, D. P., & Kuhlman, B. (2007). Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities. Journal of Molecular Biology, 371(5), 1392–1404. https://doi.org/10.1016/j.jmb.2007.05.096

Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange

Structure / Jul 01, 2005

Johnston, C. A., Willard, F. S., Jezyk, M. R., Fredericks, Z., Bodor, E. T., Jones, M. B., Blaesius, R., Watts, V. J., Harden, T. K., Sondek, J., Ramer, J. K., & Siderovski, D. P. (2005). Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange. Structure, 13(7), 1069–1080. https://doi.org/10.1016/j.str.2005.04.007

Integrating energy calculations with functional assays to decipher the specificity of G protein–RGS protein interactions

Nature Structural & Molecular Biology / Jun 19, 2011

Kosloff, M., Travis, A. M., Bosch, D. E., Siderovski, D. P., & Arshavsky, V. Y. (2011). Integrating energy calculations with functional assays to decipher the specificity of G protein–RGS protein interactions. Nature Structural & Molecular Biology, 18(7), 846–853. https://doi.org/10.1038/nsmb.2068

Cooperative interaction between the DNA-binding domains of PU.1 and IRF4

Journal of Molecular Biology / Jun 01, 1998

Yee, A. A., Yin, P., Siderovski, D. P., Mak, T. W., Litchfield, D. W., & Arrowsmith, C. H. (1998). Cooperative interaction between the DNA-binding domains of PU.1 and IRF4. Journal of Molecular Biology, 279(5), 1075–1083. https://doi.org/10.1006/jmbi.1998.1838

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Aimee Eggler

Villanova, Pennsylvania, United States of America
20 Years Experience
Professor of Chemistry and Biochemistry at Villanova University
Education

University of California, Santa Cruz

BS, Chemistry / May, 1996

Santa Cruz, California, United States of America

University of Wisconsin–Madison

Ph.D., Biochemistry / May, 2002

Madison, Wisconsin, United States of America
Experience

Villanova University

Associate Professor of Chemistry / 2019 — Present

Villanova University

Assistant Professor / 2012 — 2019

Purdue University

Research Assistant Professor / 2010 — 2012

Most Relevant Research Expertise
Structural Biology
Other Research Expertise (18)
Biochemistry
Physiology (medical)
Toxicology
Organic Chemistry
Clinical Biochemistry
And 13 more
About
Dr. Eggler has 20 years of experience in the field of redox biology, with a focus on the Nrf2 transcription factor, a master regulator of antioxidant, detoxification and anti-inflammatory genes. She is also an award-winning educator and the recipient of the Villanova University Junior Faculty Excellence in Teaching award. Her interests in education include innovation in teaching metabolism from a logic-based perspective.
Most Relevant Publications (1+)

25 total publications

Sites of alkylation of human Keap1 by natural chemoprevention agents

Journal of the American Society for Mass Spectrometry / Dec 01, 2007

Luo, Y., Eggler, A. L., Liu, D., Liu, G., Mesecar, A. D., & van Breemen, R. B. (2007). Sites of alkylation of human Keap1 by natural chemoprevention agents. Journal of the American Society for Mass Spectrometry, 18(12), 2226–2232. https://doi.org/10.1016/j.jasms.2007.09.015

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Mohammad Imran Khan

College Park, Maryland, United States of America
3 Years Experience
Postdoctoral Associate at University of Maryland College Park in the Department of Nutrition and Food Science
Education

Kalinga Institute of Industrial Technology

PhD, School of Biotechnology / February, 2021

Bhubaneswar

Kalinga Institute of Industrial Technology

M.Sc., Biotechnology / July, 2014

Bhubaneswar
Experience

Columbia University Irving Medical Center, New York

Postdoctoral Research Scientist / August, 2021 — October, 2021

The George Washington University, Washington D.C.

Postdoctoral Associate / May, 2022 — March, 2023

University of Maryland College Park

Postdoctoral Associate / April, 2023 — Present

Most Relevant Research Expertise
Structural Biology
Other Research Expertise (22)
Biomedical Engineering
Nanotechology
Wound healing
Infection and Immunity
Bioengineering
And 17 more
About
Research work is focused on the formulation of nanoparticles encapsulated materials which could be useful for tissue engineering, stem cells, drug delivery and biomechanics to create biologically inspired tissue and organ constructs. Furthermore, 3D material may play significant role in the healing of complex tissues and organs in vitro and in vivo.
Most Relevant Publications (1+)

11 total publications

Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy

International Journal of Biological Macromolecules / Jul 01, 2020

Praveen, M. A., Parvathy, K. R. K., Patra, S., Khan, I., Natarajan, P., & Balasubramanian, P. (2020). Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy. International Journal of Biological Macromolecules, 154, 557–566. https://doi.org/10.1016/j.ijbiomac.2020.03.086

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Ping Luo

Toronto, Ontario, Canada
8 Years Experience
Assistant Professor at Algoma University
Education

University of Saskatchewan

Ph.D., Biomedical Engineering / September, 2019

Saskatoon, Saskatchewan, Canada

Beijing Institute of Technology

M.Eng., Biomedical Engineering / June, 2015

Beijing

Hunan University

B.Eng., Computer Science / June, 2010

Changsha
Experience

Princess Margaret Cancer Centre

Postdoctoral Researcher / November, 2019 — Present

I work in Dr. Trevor Pugh's lab and design cancer diagnosis and treatment strategies by analyze cell-free DNA and single cell sequencing data

Princess Margaret Cancer Centre

Bioinformatics Specialist / September, 2023 — Present

I work in Dr. Tak Mak's lab and study tumor immunology using single cell and TCR sequencing data.

Most Relevant Research Expertise
Structural Biology
Other Research Expertise (21)
single-cell genomics
deep learning
complex network analysis
Genetics (clinical)
Genetics
And 16 more
About
8 years of science and engineering experience integrating multi-omics data to identify biomarkers for cancer studies. Seeking to apply data analytics expertise to develop new diagnosis and treatment strategies.
Most Relevant Publications (3+)

23 total publications

Identifying cell types from single-cell data based on similarities and dissimilarities between cells

BMC Bioinformatics / May 01, 2021

Li, Y., Luo, P., Lu, Y., & Wu, F.-X. (2021). Identifying cell types from single-cell data based on similarities and dissimilarities between cells. BMC Bioinformatics, 22(S3). https://doi.org/10.1186/s12859-020-03873-z

Ensemble disease gene prediction by clinical sample-based networks

BMC Bioinformatics / Mar 01, 2020

Luo, P., Tian, L.-P., Chen, B., Xiao, Q., & Wu, F.-X. (2020). Ensemble disease gene prediction by clinical sample-based networks. BMC Bioinformatics, 21(S2). https://doi.org/10.1186/s12859-020-3346-8

Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets

Computational and Structural Biotechnology Journal / Jan 01, 2022

Mahalanabis, A., Turinsky, A. L., Husić, M., Christensen, E., Luo, P., Naidas, A., Brudno, M., Pugh, T., Ramani, A. K., & Shooshtari, P. (2022). Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets. Computational and Structural Biotechnology Journal, 20, 6375–6387. https://doi.org/10.1016/j.csbj.2022.10.029

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Martin Tsui

San Francisco, California, United States of America
7 Years Experience
University of California, San Francisco
Education

Florida State University

Ph.D., Molecular Biophysics / July, 2017

Tallahassee, Florida, United States of America

University of California, San Diego

B.S., Chemistry / June, 2012

San Diego, California, United States of America
Experience

Stealth

Founder & CEO / January, 2023 — Present

Genome engineering

Amazon

Senior Scientist / December, 2021 — February, 2023

Molecular Diagnostics

Van Andel Institute

Postdoctoral Fellow / September, 2020 — April, 2021

Cryo-EM of membrane proteins

Most Relevant Research Expertise
Structural Biology
Other Research Expertise (15)
Biochemistry
Cryo-EM
CRISPR
Molecular Assembly and Interaction
Molecular Biology
And 10 more
About
Martin Tsui is an accomplished scientist with a strong background in biochemistry. He received his Ph.D. in Molecular Biophysics from Florida State University in 2017, where he conducted research on the structure and function of CRISPR proteins. Prior to that, he obtained his B.S. in Chemistry from the University of California, San Diego in 2012. After completing his graduate studies, Martin founded his own company, Stealth, where he serves as a Founder & CEO. Under his leadership, the company has developed innovative solutions for the biotech industry and has gained recognition for its groundbreaking research. Before starting his company, Martin worked as a Senior Scientist at Amazon, where he applied his expertise in protein biochemistry and CRISPR to improve the company's product development processes and creating new products. He also gained valuable experience as a Postdoctoral Scholar at the University of California, San Francisco and Postdoctoral Fellow at the Van Andel Institute, where he studied cancer proteins, SARS-CoV-2, HIV proteins, and the role of proteins in neurodegenerative diseases, respectively. Martin is a highly driven and passionate individual who is dedicated to advancing the field of biotechnology. His impressive education and diverse experience have equipped him with the skills and knowledge to make significant contributions to the scientific community. He continues to pursue new opportunities to further his research and make a positive impact in the world of science.
Most Relevant Publications (2+)

16 total publications

Structure Principles of CRISPR-Cas Surveillance and Effector Complexes

Annual Review of Biophysics / Jun 22, 2015

Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

Structure / Mar 01, 2023

Remesh, S. G., Merz, G. E., Brilot, A. F., Chio, U. S., Rizo, A. N., Pospiech, T. H., Lui, I., Laurie, M. T., Glasgow, J., Le, C. Q., Zhang, Y., Diwanji, D., Hernandez, E., Lopez, J., Mehmood, H., Pawar, K. I., Pourmal, S., Smith, A. M., Zhou, F., … Verba, K. A. (2023). Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31(3), 253-264.e6. https://doi.org/10.1016/j.str.2023.01.009

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David Proctor

Midland, Michigan, United States of America
27 Years Experience
PhD biochemist with expertise in higher education, applied microbiology R&D, and science policy
Education

Pennsylvania State University

PhD, Chemistry / August, 2004

University Park, Pennsylvania, United States of America

Commonwealth University-Lock Haven

BS, Biology, Chemistry / May, 1998

Lock Haven
Experience

Mid Michigan College

Adjunct Faculty / 2017 — Present

Saginaw Valley State University

Adjunct Faculty / August, 2015 — August, 2020

CSRA Inc

Scientific Review Officer / 2015 — 2018

Most Relevant Research Expertise
Structural biology
Other Research Expertise (3)
Biochemistry
Biophysics
Microbiology
About
David Proctor is the Technical Director at the International Antimicrobial Council (IAC) and Adjunct Faculty in Chemistry and Biology at Mid Michigan College. As Technical Director at the International Antimicrobial Council, David promotes the responsible use of microbial and odor control technologies through research, education, and community building. His research interests include the development of test methods for multi-functional finishes and the impact of microbial and odor control finishes on the establishment of circular economies for textiles and other sectors. Previously, David was Adjunct Faculty at Saginaw Valley State University. He was also a Scientific Review Officer with CSRA Inc. David served as a AAAS Science & Technology Policy Fellow in the Office of Advanced Cyberinfrastructure at the National Science Foundation and was a Research Associate and a Christine Mirzayan Science and Technology Policy Graduate Fellow with the Committee on Science, Engineering, Medicine, and Public Policy at the National Academies of Sciences, Engineering and Medicine. David was a postdoctoral researcher in structural biology at the University of Dundee, where he helped to establish the UK Research Staff Association to provide a collective voice for UK researchers. He completed a doctorate in chemistry at the Pennsylvania State University.

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Example Structural Biology projects

How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on Structural Biology?

Structure-Based Drug Design

A pharmaceutical company can collaborate with a structural biologist to design new drugs by studying the structure of target molecules and identifying potential binding sites for drug molecules.

Protein Engineering for Industrial Applications

A biotechnology company can work with a structural biologist to engineer proteins with improved properties for industrial applications, such as enzyme engineering for biofuel production.

Understanding Protein-Protein Interactions

A biopharmaceutical company can partner with a structural biologist to study the interactions between proteins involved in disease pathways, aiding in the development of targeted therapies.

Structural Analysis of Viral Proteins

A vaccine development company can collaborate with a structural biologist to determine the three-dimensional structures of viral proteins, facilitating the design of effective vaccines.

Structural Biology in Agriculture

An agricultural company can work with a structural biologist to understand the structure and function of plant proteins, leading to the development of improved crop varieties with enhanced traits.