Work with thought leaders and academic experts in Cell Biology

Companies can greatly benefit from working with experts in the field of Cell Biology. These researchers can provide valuable insights and expertise to enhance research and development efforts. They can help in developing innovative solutions and technologies, improving product quality and safety, and optimizing manufacturing processes. Additionally, collaborating with Cell Biology experts can lead to the discovery of new applications and opportunities in various industries such as pharmaceuticals, biotechnology, agriculture, and environmental sciences. By leveraging their knowledge and skills, companies can gain a competitive edge, accelerate scientific advancements, and drive business growth.

Researchers on NotedSource with backgrounds in Cell Biology include Boris Leibovitch, Michael W Harman, Regan Hamel, Sheed Itaman, Dr. Hannah Actor-Engel, Ph.D., Luca Delfinis, Burcu Vitrinel, Ph.D., John M Baust, Ph.D, Denver Ncube, Ph.D., THANGASAMY SAMINATHAN, Dr. David Siderovski, Ph.D., Martin Tsui, and Odion Ikhimiukor.

Boris Leibovitch

New York, New York, United States of America
Experienced wet lab and in teaching Molecular Cell biologist, geneticist, cancer biologist in Academia
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (8)
Cancer Research
Developmental Biology
Molecular Biology
Hematology
Immunology
And 3 more
About
I am experienced molecular and cell biologist with deep genetics background who worked many years in USA and Russia on the bench and as teacher. Both types of work had demanded extremely broad knowledge and understanding of developments in the fields. Participation in grant writing, editorial/reviewer work for scientific journals and consulting colleagues on these subjects added a lot to my broad experience as the scientist.
Most Relevant Publications (3+)

22 total publications

Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors

Developmental Biology / Jan 01, 2011

Marzan, C. V., Kupumbati, T. S., Bertran, S. P., Samuels, T., Leibovitch, B., Mira-y-Lopez, R., Ossowski, L., & Farias, E. F. (2011). Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors. Developmental Biology, 349(2), 125–136. https://doi.org/10.1016/j.ydbio.2010.10.018

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

Blood / Mar 15, 2008

Marango, J., Shimoyama, M., Nishio, H., Meyer, J. A., Min, D.-J., Sirulnik, A., Martinez-Martinez, Y., Chesi, M., Bergsagel, P. L., Zhou, M.-M., Waxman, S., Leibovitch, B. A., Walsh, M. J., & Licht, J. D. (2008). The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood, 111(6), 3145–3154. https://doi.org/10.1182/blood-2007-06-092122

GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter

Molecular and Cellular Biology / Sep 01, 2002

Leibovitch, B. A., Lu, Q., Benjamin, L. R., Liu, Y., Gilmour, D. S., & Elgin, S. C. R. (2002). GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter. Molecular and Cellular Biology, 22(17), 6148–6157. https://doi.org/10.1128/mcb.22.17.6148-6157.2002

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Michael W Harman

East Greenwich, RI, Rhode Island, United States of America
Distinguished Subject Matter Expert & Leader in Medical Technologies.
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (13)
Bacteria & Cell Bio-Physics
Biomechanics
Infectious Diseases
Immunology
Microbiology
And 8 more
About
Highly skilled, energetic, and motivated professional empowered by over a decade of cross-disciplinary engineering and scientific applications experience. Presenting elegant solutions to prevalent biomedical challenges. Motivated by driving deliverable outcomes from complex research studies through effective leadership, active consulting work, and innovative problem-solving techniques. Seeking to make an immediate impact in a fast-paced biotechnology environment capitalizing on my advanced comprehension, continued professional growth, strategic product development expertise, and active network of personal connections across all areas of science, engineering, medicine, manufacturing and healthcare.
Most Relevant Publications (1+)

15 total publications

Measuring DNA content in live cells by fluorescence microscopy

Cell Division / Sep 04, 2018

Gomes, C. J., Harman, M. W., Centuori, S. M., Wolgemuth, C. W., & Martinez, J. D. (2018). Measuring DNA content in live cells by fluorescence microscopy. Cell Division, 13(1). https://doi.org/10.1186/s13008-018-0039-z

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Regan Hamel

Cambridge
Senior bioinformatics scientist, specializing in single cell omics in the context of cellular reprogramming and neuroinflammation
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (12)
single cell biology
transcriptomics
Cellular and Molecular Neuroscience
Developmental Biology
Immunology
And 7 more
About
Regan Hamel has an MPhil and PhD in Clinical Neurosciences from University of Cambridge. She also has a Bachelor of Science in Neurosciences from McGill University. Her PhD with Stefano Pluchino and John Marioni focused on single cell transcriptomics in the context of neuroinflammation. Since 2021 she has worked as a Bioinformatics scientist at Mogrify Ltd, applying a multitude of computational biology techniques (including single cell omics, bulk RNAseq, and predictive modelling) in the context of cell reprogramming
Most Relevant Publications (1+)

12 total publications

Stem Cell Therapies for Progressive Multiple Sclerosis

Frontiers in Cell and Developmental Biology / Jul 09, 2021

Smith, J. A., Nicaise, A. M., Ionescu, R.-B., Hamel, R., Peruzzotti-Jametti, L., & Pluchino, S. (2021). Stem Cell Therapies for Progressive Multiple Sclerosis. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.696434

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Sheed Itaman

New York, New York, United States of America
Neurobiologist | Biopharma Consultant | Let's Connect!
Research Expertise (0)
About
1. Eight years of wet laboratory and lab management experience 2. Excellent organizational, analytical and technical skills to execute effectively on complex projects and meet tight timelines 3. Outstanding interpersonal and communication skills; multiple awards for presentations and writing # TECHNICAL SKILLS 1. **Animal Handling:** Mouse handling, tissue harvest, IV/IP/IM/SC injections 2. **Cell Biology:** Cell culture, Cell assays, Cell fractionation 3. **Microscopy/Imaging:** Confocal microscopy, Cell imaging and analysis 4. **Tissue Culture:** Primary cell isolation and culture 5. **Biochemistry:** Western Blotting, BCA protein assay, Bradford assay, IHC, IP 6. **Molecular biology:** PCR, transfection, transduction, mini prep, DNA/RNA isolation

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Dr. Hannah Actor-Engel, Ph.D.

Brooklyn, New York, United States of America
University of Colorado Anschutz
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (5)
Molecular neuroscience
Histology
Anatomy
Molecular Biology
Cellular and Molecular Neuroscience
About
Biomedical scientist with Ph.D. in Neuroscience. Expertise in neuroscience, molecular biology, neurodegeneration, and fluorescence microscopy. Experienced researcher, problem-solver, and medical writer.
Most Relevant Publications (1+)

8 total publications

α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males

Molecular and Cellular Neuroscience / Jul 01, 2018

Chen, Y.-W., Actor-Engel, H., & Aoki, C. (2018). α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males. Molecular and Cellular Neuroscience, 90, 33–48. https://doi.org/10.1016/j.mcn.2018.04.008

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Luca Delfinis

Toronto, Ontario, Canada
PhD candidate in physiology researching the mechanisms that drive muscle dysfunction in cancer
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (2)
Physiology
Physiology (medical)
About
Luca Delfinis is a PhD candidate at York University where his research focuses on muscle dysfunction in cancer. Luca has been a part of several research collaborations both nationally and internationally throughout his PhD that has helped him gain unique perspectives in physiology, especially in the context of metabolism. He has also presented at several conferences where he has discussed data with leaders in cachexia, metabolism, exercise and more.
Most Relevant Publications (1+)

4 total publications

Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime

American Journal of Physiology-Cell Physiology / May 01, 2023

Bellissimo, C. A., Delfinis, L. J., Hughes, M. C., Turnbull, P. C., Gandhi, S., DiBenedetto, S. N., Rahman, F. A., Tadi, P., Amaral, C. A., Dehghani, A., Cobley, J. N., Quadrilatero, J., Schlattner, U., & Perry, C. G. R. (2023). Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime. American Journal of Physiology-Cell Physiology, 324(5), C1141–C1157. https://doi.org/10.1152/ajpcell.00377.2022

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Burcu Vitrinel, Ph.D.

San Francisco
Cross-functional life sciences strategy professional with a Ph.D. in genetics
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (15)
Molecular Biology
Biochemistry
Aging
Computer Science Applications
Virology
And 10 more
About
Cross-functional life sciences **strategy** professional with a doctoral degree in **genetics**; worked on 16+ projects in collaboration with 7+ big pharma clients as the lead consultant in a **client-facing** role. Exceptional understanding of current life sciences **market trends**. Scientist with 10+ years of wet-lab with hands-on **CRISPR-Cas9 gene** **editing and tandem mass-spectrometry** experience with 3 first-author papers. Experienced primary market researcher for pharmaceutical companies. Award-winning science communicator for a wide range of audiences tailored to different internal and external stakeholders.
Most Relevant Publications (2+)

10 total publications

Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity

Cell Systems / Dec 01, 2020

Shim, W. J., Sinniah, E., Xu, J., Vitrinel, B., Alexanian, M., Andreoletti, G., Shen, S., Sun, Y., Balderson, B., Boix, C., Peng, G., Jing, N., Wang, Y., Kellis, M., Tam, P. P. L., Smith, A., Piper, M., Christiaen, L., Nguyen, Q., … Palpant, N. J. (2020). Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity. Cell Systems, 11(6), 625-639.e13. https://doi.org/10.1016/j.cels.2020.11.001

The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans

Aging Cell / Aug 09, 2019

Müthel, S., Uyar, B., He, M., Krause, A., Vitrinel, B., Bulut, S., Vasiljevic, D., Marchal, I., Kempa, S., Akalin, A., & Tursun, B. (2019). The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Aging Cell, 18(6). Portico. https://doi.org/10.1111/acel.13012

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John M Baust, Ph.D

Ithaca, New York, United States of America
Proven success in delivering best-in-class services across scientific, commercial and education environments.
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (16)
Biotechnology
Biomedical Engineering
Transplantation
Surgery
Management of Technology and Innovation
And 11 more
About
***Proven success in delivering best-in-class services across highly regulated scientific and commercial environments.*** * Resourceful, dynamic, and future-focused professional; equipped with strategic leadership, business, research, and academic expertise with career excellence in conducting in-depth research, leading multi-faceted R&D projects, and developing new products and treatments. * Dedicated, driven self-starter focused on developing innovative life changing technologies and procedures advancing the areas of cancer treatment, regenerative medicine and cell therapy.   * Substantial experience in providing oversight for medical device development, pre-clinical studies, cancer therapy, stem cell preservation, cell therapy, tissue engineering, and organ transplantation, etc. * Astute at establishing solid relationships with stakeholders and industry leaders to drive innovative ideas and lead collaborative efforts in pursuit of accomplishing long-term milestones. * Successful in delivering interactive academic instruction across higher education settings offering captivating lectures on Biology and Entrepreneurship courses in accordance with the organizational mission. * Accredited with authoring, managing, and executing multi-million dollar grants, corporate contracts * Accomplished author of numerous patents and high profile publications to disseminate essential research findings.
Most Relevant Publications (18+)

68 total publications

Molecular Mechanisms of Cellular Demise Associated with Cryopreservation Failure

Cell Preservation Technology / May 01, 2002

Baust, J. M. (2002). Molecular Mechanisms of Cellular Demise Associated with Cryopreservation Failure. Cell Preservation Technology, 1(1), 17–31. https://doi.org/10.1089/15383440260073266

Gene Activation of the Apoptotic Caspase Cascade Following Cryogenic Storage

Cell Preservation Technology / May 01, 2002

Baust, J. M., Van Buskirk, R., & Baust, J. G. (2002). Gene Activation of the Apoptotic Caspase Cascade Following Cryogenic Storage. Cell Preservation Technology, 1(1), 63–80. https://doi.org/10.1089/15383440260073301

Transplantation Diagnostics: A Preliminary Analysis Using Protein Microarray to Determine Kidney Status Prior To and Following Implantation

Cell Preservation Technology / Jun 01, 2004

Baust, J. M., Mathew, A. J., Snyder, K. K., Liu, E. H., van Buskirk, R. G., Hardy, M. A., & Baust, J. G. (2004). Transplantation Diagnostics: A Preliminary Analysis Using Protein Microarray to Determine Kidney Status Prior To and Following Implantation. Cell Preservation Technology, 2(2), 81–90. https://doi.org/10.1089/153834404774101936

Long-Term Function of Cryopreserved Rat Hepatocytes in a Coculture System

Cell Transplantation / Mar 01, 2004

Sugimachi, K., Sosef, M. N., Baust, J. M., Fowler, A., Tompkins, R. G., & Toner, M. (2004). Long-Term Function of Cryopreserved Rat Hepatocytes in a Coculture System. Cell Transplantation, 13(2), 187–195. https://doi.org/10.3727/000000004773301799

Cellular Components of the Coronary Vasculature Exhibit Differential Sensitivity to Low Temperature Insult

Cell Preservation Technology / Dec 01, 2002

Hollister, W. R., Baust, J. M., Van Buskirk, R. G., & Baust, J. G. (2002). Cellular Components of the Coronary Vasculature Exhibit Differential Sensitivity to Low Temperature Insult. Cell Preservation Technology, 1(4), 269–280. https://doi.org/10.1089/15383440260682099

Effect of Cell Substrate Interactions on the Desiccation Behavior of Human Fibroblasts

Cell Preservation Technology / Sep 01, 2004

Baust, J. M., Fowler, A., & Toner, M. (2004). Effect of Cell Substrate Interactions on the Desiccation Behavior of Human Fibroblasts. Cell Preservation Technology, 2(3), 188–197. https://doi.org/10.1089/cpt.2004.2.188

Enhanced Hypothermic Storage of Neonatal Cardiomyocytes

Cell Preservation Technology / Mar 01, 2005

Snyder, K. K., Baust, J. M., Van Buskirk, R. G., & Baust, J. G. (2005). Enhanced Hypothermic Storage of Neonatal Cardiomyocytes. Cell Preservation Technology, 3(1), 61–74. https://doi.org/10.1089/cpt.2005.3.61

Involvement of the Cysteine Protease Calpain Family in Cell Death After Cryopreservation

Cell Preservation Technology / Mar 01, 2006

Robilotto, A. T., Baust, J. M., Buskirk, R. V., & Baust, J. G. (2006). Involvement of the Cysteine Protease Calpain Family in Cell Death After Cryopreservation. Cell Preservation Technology, 4(1), 17–30. https://doi.org/10.1089/cpt.2006.4.17

Cardiomyocyte Responses to Thermal Excursions: Implications for Electrophysiological Cardiac Mapping

Cell Preservation Technology / Jun 01, 2007

Snyder, K. K., Baust, J. M., Van Buskirk, R. G., & Baust, J. G. (2007). Cardiomyocyte Responses to Thermal Excursions: Implications for Electrophysiological Cardiac Mapping. Cell Preservation Technology, 5(2), 116–128. https://doi.org/10.1089/cpt.2007.9995

Activation of Mitochondrial-Associated Apoptosis Contributes to Cryopreservation Failure

Cell Preservation Technology / Sep 01, 2007

Baust, J. M., Vogel, M. J., Snyder, K. K., Van Buskirk, R. G., & Baust, J. G. (2007). Activation of Mitochondrial-Associated Apoptosis Contributes to Cryopreservation Failure. Cell Preservation Technology, 5(3), 155–164. https://doi.org/10.1089/cpt.2007.9990

Preliminary Report: Evaluation of Storage Conditions and Cryococktails during Peripheral Blood Mononuclear Cell Cryopreservation

Cell Preservation Technology / Dec 01, 2007

Cosentino, L. M., Corwin, W., Baust, J. M., Diaz-Mayoral, N., Cooley, H., Shao, W., van Buskirk, R., & Baust, J. G. (2007). Preliminary Report: Evaluation of Storage Conditions and Cryococktails during Peripheral Blood Mononuclear Cell Cryopreservation. Cell Preservation Technology, 5(4), 189–204. https://doi.org/10.1089/cpt.2007.9987

Changing Paradigms in Biopreservation

Biopreservation and Biobanking / Mar 01, 2009

Baust, J. M., Snyder, K. K., VanBuskirk, R. G., & Baust, J. G. (2009). Changing Paradigms in Biopreservation. Biopreservation and Biobanking, 7(1), 3–12. https://doi.org/10.1089/bio.2009.0701.jmb

In VitroAssessment of Apoptosis and Necrosis Following Cold Storage in a Human Airway Cell Model

Biopreservation and Biobanking / Mar 01, 2009

Corwin, W. L., Baust, J. M., VanBuskirk, R. G., & Baust, J. G. (2009). In VitroAssessment of Apoptosis and Necrosis Following Cold Storage in a Human Airway Cell Model. Biopreservation and Biobanking, 7(1), 19–27. https://doi.org/10.1089/bio.2009.0002

How Much Will the Biobanking Industry Come to Rely on Private Companies?

Biopreservation and Biobanking / Dec 01, 2010

Clark, B. J., Baust, J. M., & Stacey, G. (2010). How Much Will the Biobanking Industry Come to Rely on Private Companies? Biopreservation and Biobanking, 8(4), 179–180. https://doi.org/10.1089/bio.2010.8415

Implications of Differential Stress Response Activation Following Non-Frozen Hepatocellular Storage

Biopreservation and Biobanking / Feb 01, 2013

Corwin, W. L., Baust, J. M., Baust, J. G., & Van Buskirk, R. G. (2013). Implications of Differential Stress Response Activation Following Non-Frozen Hepatocellular Storage. Biopreservation and Biobanking, 11(1), 33–44. https://doi.org/10.1089/bio.2012.0045

Integrating Molecular Control to Improve Cryopreservation Outcome

Biopreservation and Biobanking / Apr 01, 2017

Baust, J. G., Snyder, K. K., Van Buskirk, R., & Baust, J. M. (2017). Integrating Molecular Control to Improve Cryopreservation Outcome. Biopreservation and Biobanking, 15(2), 134–141. https://doi.org/10.1089/bio.2016.0119

Best practices in cell culture: an overview

In Vitro Cellular & Developmental Biology - Animal / Aug 14, 2017

Baust, J. M., Buehring, G. C., Campbell, L., Elmore, E., Harbell, J. W., Nims, R. W., Price, P., Reid, Y. A., & Simione, F. (2017). Best practices in cell culture: an overview. In Vitro Cellular & Developmental Biology - Animal, 53(8), 669–672. https://doi.org/10.1007/s11626-017-0177-7

Best practices for cryopreserving, thawing, recovering, and assessing cells

In Vitro Cellular & Developmental Biology - Animal / Nov 02, 2017

Baust, J. M., Campbell, L. H., & Harbell, J. W. (2017). Best practices for cryopreserving, thawing, recovering, and assessing cells. In Vitro Cellular & Developmental Biology - Animal, 53(10), 855–871. https://doi.org/10.1007/s11626-017-0201-y

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Denver Ncube, Ph.D.

Morrisville, North Carolina, United States of America
Computational biologist/bioinformatician with a passion for extracting meaningful insight from complex biological data.
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (4)
Neuroscience
Anatomy
Pharmacology
Toxicology
About
With over 8 years of experience in neuroscience and bioinformatics, I am a computational biologist who is passionate about applying data science and machine learning to unravel the molecular and cellular mechanisms of complex diseases, such as cancer and neurodegenerative disorders.

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THANGASAMY SAMINATHAN

Charleston, West Virginia, United States of America
I have mix of expertise in Molecular Biology, Mapping and Functional Genomics, and Groundwater Remediation
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (10)
Genetics
Molecular biology
Groundwater remediation
Biotechnology
Plant Science
And 5 more
About
Dr. Thangasamy Saminathan is a highly educated and experienced scientist with a passion for biotechnology and agriculture. He completed his PhD in Biotechnology at the prestigious Taiwan International Graduate Program at Academia Sinica in 2011. He has a diverse range of experience in the field of biotechnology and agriculture. He works as an Environmental Resource Analyst at the West Virginia Department of Environmental Protection, where he utilized his knowledge and skills to analyze and assess environmental resources. He also serves as an Associate Adjunct Faculty at West Virginia State University, teaching biotechnology and agriculture courses to students. His research experience includes a postdoctoral position at Academia Sinica, where he worked on projects related to plant biotechnology and genetics. He gained hands-on experience in plant breeding and genetics. Dr. Saminathan's education and experience have equipped him with a strong foundation in biotechnology and agriculture, and he continues to be actively involved in research and teaching in these fields. He is a dedicated scientist who is committed to finding innovative solutions to challenges in agriculture and utilizing biotechnology for sustainable development.
Most Relevant Publications (1+)

29 total publications

Rice LGD1 containing RNA binding activity affects growth and development through alternative promoters

The Plant Journal / May 25, 2012

Thangasamy, S., Chen, P., Lai, M., Chen, J., & Jauh, G. (2012). Rice LGD1 containing RNA binding activity affects growth and development through alternative promoters. The Plant Journal, 71(2), 288–302. Portico. https://doi.org/10.1111/j.1365-313x.2012.04989.x

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Dr. David Siderovski, Ph.D.

Fort Worth
Professor of Computational Pharmacology; Chair of HSC SBS Dept. of Pharmacology & Neuroscience
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (25)
Regulator of G protein Signaling (RGS) proteins
Pharmacology
Molecular Biology
Cellular and Molecular Neuroscience
Molecular Medicine
And 20 more
About
Dr. David Siderovski is a renowned scientist and academic, with a career spanning over two decades. He received his Ph.D. in Medical Biophysics from the University of Toronto in 1997, where he specialized in signal transduction and cellular signaling pathways. After completing his doctorate, Dr. Siderovski held various faculty positions at prestigious universities, including the University of North Carolina at Chapel Hill, West Virginia University School of Medicine, and the University of North Texas Health Science Center. At these institutions, Dr. Siderovski has made significant contributions to the field of pharmacology through his research on G protein-coupled receptors (GPCRs) and RGS proteins, which are key regulators of GPCR cellular signaling. His work has helped to advance the understanding of RGS proteins and their roles in various diseases, including cancer, cardiovascular disorders, and neurological disorders. In addition to his research, Dr. Siderovski is also a dedicated educator and mentor. He has taught and mentored numerous undergraduate, graduate, and medical students, and has served as a mentor for postdoctoral fellows and junior faculty members. He is known for his passion and enthusiasm for science and his ability to inspire and guide the next generation of scientists. Dr. Siderovski has received numerous awards and honors for his contributions to the scientific community. He was the recipient of the Abel Award in 2004 from the American Society of Pharmacology & Experimental Therapeutics for his pioneering discoveries of the RGS proteins and the GoLoco motif. He has also served on editorial boards of several scientific journals (including a decade at *J.Biol.Chem.*) and has been a member of various scientific committees, NIH study section panels, and pharma/biotech advisory boards, including for Inspire, Wyeth, and BellBrook Labs. Overall, Dr. David Siderovski is a highly accomplished and respected scientist and educator, whose research has had a significant impact on the field of pharmacology. His dedication and passion for science continue to inspire and influence the next generation of researchers in this field.
Most Relevant Publications (27+)

94 total publications

G-protein signaling: back to the future

Cellular and Molecular Life Sciences / Mar 01, 2005

McCudden, C. R., Hains, M. D., Kimple, R. J., Siderovski, D. P., & Willard, F. S. (2005). G-protein signaling: back to the future. Cellular and Molecular Life Sciences, 62(5), 551–577. https://doi.org/10.1007/s00018-004-4462-3

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

International Journal of Biological Sciences / Jan 01, 2005

Siderovski, D. P., & Willard, F. S. (2005). The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. International Journal of Biological Sciences, 51–66. https://doi.org/10.7150/ijbs.1.51

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

Nature Cell Biology / Jul 22, 2002

Lambert, J. M., Lambert, Q. T., Reuther, G. W., Malliri, A., Siderovski, D. P., Sondek, J., Collard, J. G., & Der, C. J. (2002). Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nature Cell Biology, 4(8), 621–625. https://doi.org/10.1038/ncb833

RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity

Journal of Biological Chemistry / Aug 01, 2001

Kimple, R. J., De Vries, L., Tronchère, H., Behe, C. I., Morris, R. A., Farquhar, M. G., & Siderovski, D. P. (2001). RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity. Journal of Biological Chemistry, 276(31), 29275–29281. https://doi.org/10.1074/jbc.m103208200

GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain

Journal of Biological Chemistry / Jul 01, 1998

Snow, B. E., Hall, R. A., Krumins, A. M., Brothers, G. M., Bouchard, D., Brothers, C. A., Chung, S., Mangion, J., Gilman, A. G., Lefkowitz, R. J., & Siderovski, D. P. (1998). GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain. Journal of Biological Chemistry, 273(28), 17749–17755. https://doi.org/10.1074/jbc.273.28.17749

LGN regulates mitotic spindle orientation during epithelial morphogenesis

Journal of Cell Biology / Apr 12, 2010

Zheng, Z., Zhu, H., Wan, Q., Liu, J., Xiao, Z., Siderovski, D. P., & Du, Q. (2010). LGN regulates mitotic spindle orientation during epithelial morphogenesis. Journal of Cell Biology, 189(2), 275–288. https://doi.org/10.1083/jcb.200910021

A Human Gene Encoding a Putative Basic Helix–Loop–Helix Phosphoprotein Whose mRNA Increases Rapidly in Cycloheximide-Treated Blood Mononuclear Cells

DNA and Cell Biology / Feb 01, 1994

SIDEROVSKI, D. P., HEXIMER, S. P., & FORSDYKE, D. R. (1994). A Human Gene Encoding a Putative Basic Helix–Loop–Helix Phosphoprotein Whose mRNA Increases Rapidly in Cycloheximide-Treated Blood Mononuclear Cells. DNA and Cell Biology, 13(2), 125–147. https://doi.org/10.1089/dna.1994.13.125

Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits

Journal of Biological Chemistry / Dec 01, 2001

Wing, M. R., Houston, D., Kelley, G. G., Der, C. J., Siderovski, D. P., & Harden, T. K. (2001). Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits. Journal of Biological Chemistry, 276(51), 48257–48261. https://doi.org/10.1074/jbc.c100574200

Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins

Nature Cell Biology / Oct 16, 2005

Wang, H., Ng, K. H., Qian, H., Siderovski, D. P., Chia, W., & Yu, F. (2005). Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nature Cell Biology, 7(11), 1091–1098. https://doi.org/10.1038/ncb1317

Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells

Journal of Biological Chemistry / Jul 01, 2002

Wang, Q., Liu, M., Mullah, B., Siderovski, D. P., & Neubig, R. R. (2002). Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells. Journal of Biological Chemistry, 277(28), 24949–24958. https://doi.org/10.1074/jbc.m203802200

PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation

Journal of Biological Chemistry / Jan 01, 2010

Nakamura, K., Kimple, A. J., Siderovski, D. P., & Johnson, G. L. (2010). PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation. Journal of Biological Chemistry, 285(3), 2077–2089. https://doi.org/10.1074/jbc.m109.065102

Molecular Cloning and Expression Analysis of RatRgs12andRgs14

Biochemical and Biophysical Research Communications / Apr 01, 1997

Snow, B. E., Antonio, L., Suggs, S., Gutstein, H. B., & Siderovski, D. P. (1997). Molecular Cloning and Expression Analysis of RatRgs12andRgs14. Biochemical and Biophysical Research Communications, 233(3), 770–777. https://doi.org/10.1006/bbrc.1997.6537

Clathrin Adaptor AP2 Regulates Thrombin Receptor Constitutive Internalization and Endothelial Cell Resensitization

Molecular and Cellular Biology / Apr 01, 2006

Paing, M. M., Johnston, C. A., Siderovski, D. P., & Trejo, J. (2006). Clathrin Adaptor AP2 Regulates Thrombin Receptor Constitutive Internalization and Endothelial Cell Resensitization. Molecular and Cellular Biology, 26(8), 3231–3242. https://doi.org/10.1128/mcb.26.8.3231-3242.2006

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

Journal of Biological Chemistry / Dec 01, 2001

Snyder, J. T., Rossman, K. L., Baumeister, M. A., Pruitt, W. M., Siderovski, D. P., Der, C. J., Lemmon, M. A., & Sondek, J. (2001). Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins. Journal of Biological Chemistry, 276(49), 45868–45875. https://doi.org/10.1074/jbc.m106731200

Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo

Molecular and Cellular Biology / Nov 01, 2000

Liu, Y., Snow, B. E., Hande, M. P., Baerlocher, G., Kickhoefer, V. A., Yeung, D., Wakeham, A., Itie, A., Siderovski, D. P., Lansdorp, P. M., Robinson, M. O., & Harrington, L. (2000). Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo. Molecular and Cellular Biology, 20(21), 8178–8184. https://doi.org/10.1128/mcb.20.21.8178-8184.2000

Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq

Journal of Biological Chemistry / Jun 01, 2001

Evanko, D. S., Thiyagarajan, M. M., Siderovski, D. P., & Wedegaertner, P. B. (2001). Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq. Journal of Biological Chemistry, 276(26), 23945–23953. https://doi.org/10.1074/jbc.m101154200

A Set of Human Putative Lymphocyte G0/G1Switch Genes Includes Genes Homologous to Rodent Cytokine and Zinc Finger Protein-Encoding Genes

DNA and Cell Biology / Oct 01, 1990

SIDEROVSKI, D. P., BLUM, S., FORSDYKE, R. E., & FORSDYKE, D. R. (1990). A Set of Human Putative Lymphocyte G0/G1Switch Genes Includes Genes Homologous to Rodent Cytokine and Zinc Finger Protein-Encoding Genes. DNA and Cell Biology, 9(8), 579–587. https://doi.org/10.1089/dna.1990.9.579

Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

Journal of Biological Chemistry / Jul 01, 2009

Kimple, A. J., Soundararajan, M., Hutsell, S. Q., Roos, A. K., Urban, D. J., Setola, V., Temple, B. R. S., Roth, B. L., Knapp, S., Willard, F. S., & Siderovski, D. P. (2009). Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2). Journal of Biological Chemistry, 284(29), 19402–19411. https://doi.org/10.1074/jbc.m109.024711

Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif

Biochemical Journal / Mar 15, 2004

KIMPLE, R. J., WILLARD, F. S., HAINS, M. D., JONES, M. B., NWEKE, G. K., & SIDEROVSKI, D. P. (2004). Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. Biochemical Journal, 378(3), 801–808. https://doi.org/10.1042/bj20031686

Dynamic Regulation of Mammalian Numb by G Protein-coupled Receptors and Protein Kinase C Activation: Structural Determinants of Numb Association with the Cortical Membrane

Molecular Biology of the Cell / Sep 01, 2006

Dho, S. E., Trejo, J., Siderovski, D. P., & McGlade, C. J. (2006). Dynamic Regulation of Mammalian Numb by G Protein-coupled Receptors and Protein Kinase C Activation: Structural Determinants of Numb Association with the Cortical Membrane. Molecular Biology of the Cell, 17(9), 4142–4155. https://doi.org/10.1091/mbc.e06-02-0097

Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13

Journal of Biological Chemistry / Dec 01, 2001

Blake, B. L., Wing, M. R., Zhou, J. Y., Lei, Q., Hillmann, J. R., Behe, C. I., Morris, R. A., Harden, T. K., Bayliss, D. A., Miller, R. J., & Siderovski, D. P. (2001). Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13. Journal of Biological Chemistry, 276(52), 49267–49274. https://doi.org/10.1074/jbc.m106565200

A direct fluorescence-based assay for RGS domain GTPase accelerating activity

Analytical Biochemistry / May 01, 2005

Willard, F. S., Kimple, A. J., Johnston, C. A., & Siderovski, D. P. (2005). A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Analytical Biochemistry, 340(2), 341–351. https://doi.org/10.1016/j.ab.2005.02.015

A Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding

Journal of Biological Chemistry / Dec 01, 2008

Willard, F. S., Zheng, Z., Guo, J., Digby, G. J., Kimple, A. J., Conley, J. M., Johnston, C. A., Bosch, D., Willard, M. D., Watts, V. J., Lambert, N. A., Ikeda, S. R., Du, Q., & Siderovski, D. P. (2008). A Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding. Journal of Biological Chemistry, 283(52), 36698–36710. https://doi.org/10.1074/jbc.m804936200

Gα selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research / Sep 01, 2005

McCudden, C. R., Willard, F. S., Kimple, R. J., Johnston, C. A., Hains, M. D., Jones, M. B., & Siderovski, D. P. (2005). Gα selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1745(2), 254–264. https://doi.org/10.1016/j.bbamcr.2005.05.002

The effect of RGS12 on PDGFβ receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells

Cellular Signalling / Jul 01, 2006

Sambi, B. S., Hains, M. D., Waters, C. M., Connell, M. C., Willard, F. S., Kimple, A. J., Pyne, S., Siderovski, D. P., & Pyne, N. J. (2006). The effect of RGS12 on PDGFβ receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. Cellular Signalling, 18(7), 971–981. https://doi.org/10.1016/j.cellsig.2005.08.003

Covalent immobilization of histidine-tagged proteins for surface plasmon resonance

Analytical Biochemistry / Jun 01, 2006

Willard, F. S., & Siderovski, D. P. (2006). Covalent immobilization of histidine-tagged proteins for surface plasmon resonance. Analytical Biochemistry, 353(1), 147–149. https://doi.org/10.1016/j.ab.2006.02.004

Regulator of G-protein Signaling-21 (RGS21) Is an Inhibitor of Bitter Gustatory Signaling Found in Lingual and Airway Epithelia

Journal of Biological Chemistry / Dec 01, 2012

Cohen, S. P., Buckley, B. K., Kosloff, M., Garland, A. L., Bosch, D. E., Cheng, G., Radhakrishna, H., Brown, M. D., Willard, F. S., Arshavsky, V. Y., Tarran, R., Siderovski, D. P., & Kimple, A. J. (2012). Regulator of G-protein Signaling-21 (RGS21) Is an Inhibitor of Bitter Gustatory Signaling Found in Lingual and Airway Epithelia. Journal of Biological Chemistry, 287(50), 41706–41719. https://doi.org/10.1074/jbc.m112.423806

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Martin Tsui

San Francisco, California, United States of America
University of California, San Francisco
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (15)
Biochemistry
Structural Biology
Cryo-EM
CRISPR
Molecular Assembly and Interaction
And 10 more
About
Martin Tsui is an accomplished scientist with a strong background in biochemistry. He received his Ph.D. in Molecular Biophysics from Florida State University in 2017, where he conducted research on the structure and function of CRISPR proteins. Prior to that, he obtained his B.S. in Chemistry from the University of California, San Diego in 2012. After completing his graduate studies, Martin founded his own company, Stealth, where he serves as a Founder & CEO. Under his leadership, the company has developed innovative solutions for the biotech industry and has gained recognition for its groundbreaking research. Before starting his company, Martin worked as a Senior Scientist at Amazon, where he applied his expertise in protein biochemistry and CRISPR to improve the company's product development processes and creating new products. He also gained valuable experience as a Postdoctoral Scholar at the University of California, San Francisco and Postdoctoral Fellow at the Van Andel Institute, where he studied cancer proteins, SARS-CoV-2, HIV proteins, and the role of proteins in neurodegenerative diseases, respectively. Martin is a highly driven and passionate individual who is dedicated to advancing the field of biotechnology. His impressive education and diverse experience have equipped him with the skills and knowledge to make significant contributions to the scientific community. He continues to pursue new opportunities to further his research and make a positive impact in the world of science.
Most Relevant Publications (2+)

16 total publications

Structure Principles of CRISPR-Cas Surveillance and Effector Complexes

Annual Review of Biophysics / Jun 22, 2015

Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Nature Chemical Biology / Oct 20, 2020

Bracken, C. J., Lim, S. A., Solomon, P., Rettko, N. J., Nguyen, D. P., Zha, B. S., Schaefer, K., Byrnes, J. R., Zhou, J., Lui, I., Liu, J., Pance, K., Azumaya, C. M., Braxton, J. R., Brilot, A. F., Gupta, M., Li, F., Lopez, K. E., … Melo, A. (2020). Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nature Chemical Biology, 17(1), 113–121. https://doi.org/10.1038/s41589-020-00679-1

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Odion Ikhimiukor

Albany, New York, United States of America
Postdoctoral Research Scientist at University at Albany, State University of New York
Most Relevant Research Expertise
Cell Biology
Other Research Expertise (23)
Pathogen Genomics
Bioinformatics
Molecular Biology
Epidemiology
Environmental Microbiology
And 18 more
About
A postdoctoral research scientist with over 9 years experience in bacterial genomics, microbiology, bioinformatics and antimicrobial resistance research. I’m seeking a Research Scientist or Epidemiologist role at public health genomics laboratories and I am the perfect fit for these roles because I have the following skills: molecular biology, research & development, strategic planning, project management, documentation, outbreak investigation, and cross-functional collaboration skills. I have leveraged my skills to work in a collaborative team-oriented environment to accomplish project goals related to examining the evolution of antimicrobial resistance as evidenced by over 7 national and international collaborations including the New York State Department of Health. I am also a proactive problem-solver adopting innovative and scientific thinking strategies in molecular biology to fulfill project objectives resulting in scientific discoveries including uncovering 1 novel hotspot for the dissemination of resistance in bacteria. I have gained mentorship expertise in promoting data reproducibility, and innovative research methodology in antimicrobial resistance research as evidenced by mentoring 10 professionals on evolutionary genomics, epidemiological statistics, and antimicrobial stewardship. I have also worked collaboratively with a team to apply pathogen genomics, bioinformatics, and leadership skills as demonstrated by working with over 10 highly collaborative teams including the Africa CDC. In addition, I have the following qualifications: Cross-functional collaborator and experience elucidating methods and frequencies of horizontal gene transfer and antimicrobial resistance spread in bacterial species, as demonstrated by 26 peer-reviewed publications including 1 in Nature Microbiology. Experience in leading and managing project details and tasks as evidenced by over 20 projects in pathogen genomics, epidemiology, antimicrobial resistance surveillance, and global health. Astute communication skills in bacterial epidemiology and antimicrobial resistance research resulting in 20 presentations and 6 travel awards to deliver such presentations, including the Bill and Melinda Gates Foundation. I want to serve an organization that prizes community, collaboration and humility among its employees. I’m excited to be on a team built around impact, innovation and a strong, positive reputation. I know I will thrive at a company where responsibility is valued, as well as self-improvement and time-management. I want to be a part of an organization that infuses growth into their brand, culture and market and who I can help make a difference in the world.
Most Relevant Publications (2+)

27 total publications

A bottom-up view of antimicrobial resistance transmission in developing countries

Nature Microbiology / May 30, 2022

Ikhimiukor, O. O., Odih, E. E., Donado-Godoy, P., & Okeke, I. N. (2022). A bottom-up view of antimicrobial resistance transmission in developing countries. Nature Microbiology, 7(6), 757–765. https://doi.org/10.1038/s41564-022-01124-w

Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales

Microbiology Spectrum / Oct 17, 2023

Ikhimiukor, O. O., Souza, S. S. R., Akintayo, I. J., Marcovici, M. M., Workman, A., Martin, I. W., & Andam, C. P. (2023). Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales. Microbiology Spectrum, 11(5). https://doi.org/10.1128/spectrum.00549-23

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Example Cell Biology projects

How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on Cell Biology?

Drug Discovery and Development

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Cancer Research and Treatment

Cell Biology experts can contribute to cancer research and treatment by studying the molecular mechanisms of cancer development, identifying biomarkers for early detection, and developing targeted therapies. Collaborating with these experts can lead to the development of personalized medicine approaches and more effective treatment strategies for different types of cancer.

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Cell Biology researchers can contribute to environmental monitoring and remediation efforts by studying the impact of pollutants on living organisms, developing bioindicators for pollution assessment, and designing bioremediation strategies. Companies can collaborate with these experts to ensure compliance with environmental regulations and develop sustainable solutions for pollution control and remediation.