Work with thought leaders and academic experts in Physiology

Companies can greatly benefit from working with academic researchers in the field of Physiology. These experts can provide valuable insights and expertise to enhance product development, improve customer experience, and drive innovation. By collaborating with Physiology researchers, companies can gain a deeper understanding of human physiology, develop more effective healthcare solutions, optimize athletic performance, and improve workplace ergonomics. Additionally, academic researchers can help companies stay up-to-date with the latest scientific advancements, conduct clinical trials, and provide evidence-based recommendations. Overall, partnering with Physiology researchers can give companies a competitive edge and contribute to their success.

Researchers on NotedSource with backgrounds in Physiology include Fayth Tan, Ph.D., Karina van de Voorde, Luca Delfinis, Gwendolyn Thomas, Ph.D., CSCS, USAW-L1, Elvira Forte, THANGASAMY SAMINATHAN, Odion Ikhimiukor, John M Baust, Ph.D, Shariq Usmani, PhD, Dushani L. Palliyaguru, Ph.D., Daniel Milej, Ph.D., and Dr. Everson A Nunes, Ph.D..

Fayth Tan, Ph.D.

Pasadena, California, United States of America
7 Years Experience
Science Communicator · Biologist
Education

California Institute of Technology

Ph.D. Biology, Biology and Bioengineering / June, 2023

Pasadena, California, United States of America

University of California San Diego

B.S Marine Biology, Scripps Institution of Oceanography / June, 2018

La Jolla, California, United States of America
Experience

California Institute of Technology

Graduate Researcher / September, 2018 — June, 2023

Independent/Freelance

Science Writer / December, 2021 — Present

Write features, profiles, essay, reportage and creative non-fiction. Bylines in Nature, Electric Literature, The Xylom etc.

Schmidt Sciences

Science Writer / October, 2023 — Present

Interview and profile Schmidt Sciences AI 2050 Initiative Fellows, collectively elevating research agendas in the use, development or impacts of AI worth >$12 million

Most Relevant Research Expertise
Physiology
Other Research Expertise (7)
Regeneration Biology
Developmental Biology
Evolutionary Biology
Molecular Biology
Science Communication
And 2 more
About
Award-winning science writer and communicator with >7 years of experience as an academic biologist. Available for opportunities to consult on topics including regeneration biology, inflammation and fibrosis, aging, stem cell biology, metabolic disease, and animal physiology—or how best to communicate them to your target audience. I can also speak on effective science communication for researchers. My graduate research was in animal regeneration, using mouse models to investigate how physiology affects regenerative ability in the mouse digit tip and the neonatal mouse heart. I've published on novel methods to induce mouse digit regeneration, and analyzed the single-cell transcriptome of neonatal cardiac stem cells to identify potential developmental changes that may cause the loss of regenerative ability in older mice. As a science writer and communicator, I write about how science and technology impact and are impacted by society and culture. My work was recognized by the National Academy of Sciences in 2022, winning the Schmidt Prize for Excellence in Science Communication—an award of $20,000 that was given to 24 scientists and journalists from over 550 submissions. I've been commissioned by companies and non-profits to write about subjects from AI-powered drug discovery to the use of metaphor in neuroscience—my work doesn't shy away from niche, interdisciplinary and unexpected topics. <br> <br> <br> <br>

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Karina van de Voorde

Tilburg
12 Years Experience
Associate Professor of Behavioral Sciences at Tilburg University
Education

Tilburg University

PhD student, Human Resource Studies / May, 2010

Tilburg
Experience

Tilburg University

Assistant Professor (tenured 2015) / May, 2012 — Present

Radboud University Nijmegen

Assistant Professor / May, 2010 — May, 2012

Most Relevant Research Expertise
Physiology
Other Research Expertise (11)
Organizational Behavior and Human Resource Management
Management of Technology and Innovation
Strategy and Management
Business and International Management
Industrial relations
And 6 more
About
Karina van de Voorde's research is focused on aligning the Organizational Behavior/Occupational Health Psychology orientation towards the topic of organizational performance. Karina was the lead author of the publication "Employee Well-Being and the HRM - Organizational Performance Relationship: A Review of Quantitative Studies"
Most Relevant Publications (1+)

20 total publications

Effects of new ways of working on work hours and work location, health and job-related outcomes

Chronobiology International / May 25, 2016

Nijp, H. H., Beckers, D. G. J., van de Voorde, K., Geurts, S. A. E., & Kompier, M. A. J. (2016). Effects of new ways of working on work hours and work location, health and job-related outcomes. Chronobiology International, 33(6), 604–618. https://doi.org/10.3109/07420528.2016.1167731

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Luca Delfinis

Toronto, Ontario, Canada
6 Years Experience
PhD candidate in physiology researching the mechanisms that drive muscle dysfunction in cancer
Education

Wilfrid Laurier University

BSc, Kinesiology & Physical Education / April, 2018

Waterloo, Ontario, Canada

York University

MSc, Molecular, Cellular and Integrative Physiology / August, 2020

Toronto, Ontario, Canada

York University

PhD, Molecular, Cellular and Integrative Physiology / August, 2024 (anticipated)

Toronto, Ontario, Canada
Experience

York University

Teaching Assistant / September, 2018 — Present

KINE 2049 (Research Methods in Kinesiology) and KINE 3012 (Human Physiology II)

Wilfrid Laurier University

Supplemental Instruction Senior Mentor / April, 2017 — April, 2018

Oversee teaching assistants with their teaching programs

Most Relevant Research Expertise
Physiology
Other Research Expertise (2)
Physiology (medical)
Cell Biology
About
Luca Delfinis is a PhD candidate at York University where his research focuses on muscle dysfunction in cancer. Luca has been a part of several research collaborations both nationally and internationally throughout his PhD that has helped him gain unique perspectives in physiology, especially in the context of metabolism. He has also presented at several conferences where he has discussed data with leaders in cachexia, metabolism, exercise and more.
Most Relevant Publications (1+)

4 total publications

Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime

American Journal of Physiology-Cell Physiology / May 01, 2023

Bellissimo, C. A., Delfinis, L. J., Hughes, M. C., Turnbull, P. C., Gandhi, S., DiBenedetto, S. N., Rahman, F. A., Tadi, P., Amaral, C. A., Dehghani, A., Cobley, J. N., Quadrilatero, J., Schlattner, U., & Perry, C. G. R. (2023). Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime. American Journal of Physiology-Cell Physiology, 324(5), C1141–C1157. https://doi.org/10.1152/ajpcell.00377.2022

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Gwendolyn Thomas, Ph.D., CSCS, USAW-L1

Philadelphia, Pennsylvania, United States of America
17 Years Experience
Resistance Exercise Physiologist/Performance Enhancement/Optimizing RE Prescription
Education

University of Connecticut

Ph.D., Kinesiology (Exercise Endocrinology, Exercise Physiology, Resistance Exercise) / May, 2010

Storrs, Connecticut, United States of America

University of Connecticut

M.A., Strength and Conditioning / May, 2007

Storrs, Connecticut, United States of America
Experience

Penn State University

Assistant Research Professor / September, 2019 — August, 2023

Principal Investigator of the Exercise Prescription Lab. The lab (PI: Thomas) conducts interdisciplinary and translational research on chronic diseases, publishing in peer-reviewed journals. Transform population health outcomes through data, analytics, and actionable insights. Chair the regulatory review board, overseeing IRB Administration, running meetings, and approving research protocols. Expertise in institutional, FDA, and Federal regulatory work.

Penn State Integrative Physiology

Faculty Member / September, 2019 — Present

Faculty Member In Integrative Physiology

Syracuse University

Assistant Professor / August, 2016 — August, 2019

Independent Principal Investigator: Assumed responsibility for all research studies conducted in my lab, including but not limited to oversight and training of research assistants (25), training of research assistants (30), and generating independent, high quality, reproducible results. Responsible for the management and integrity of design, conduct and reporting of the research project and for managing, monitoring and ensuring the integrity of collaborative relationships. Curriculum Committee Chair:Led Curriculum Committee and Departmental Leadership to develop Master’s Degree in Strength and Conditioning through certifying agency, the National Strength and Conditioning Association (NSCA).

Most Relevant Research Expertise
Physiology
Other Research Expertise (30)
resistance exercise
obesity
breast cancer
chronic disease
inflammation
And 25 more
About
My work has focused on how we can use data to support decisions to individualize monitoring to optimize human performance.  My work has demonstrated that a one size fits all approach is not the way to optimize performance in any setting.  My monitoring approach is one that utilizes a network physiology paradigm, which focuses on nonlinear dynamic interactions. In my athlete monitoring I focus on leveraging EMA and wearables; biological sampling and resistance exercise and conditioning prescribed to elicit a specific biological response.    Additionally, as a practitioner it is important to understand the limitations of athlete monitoring, which is another area research and practice has focused.  This is an important skillset that is currently being utilized by the in a project entitled “Integrating mHealth and Physical Function to Develop a Predictors of Injury and Optimal Performance Model in Special Military Operators “with the Rangers in the 3/75 Ranger Battalion.  This approach is one that quantifies factors such as dosage variables of training and lifestyle factors (sleep, nutrition, life stress).  Using this data, we are working on individualizing acute training sessions to optimize readiness and performance enhancement.   During my time at Syracuse University, I was the professor of record to teach the NSCA CSCS preparation course and lead the strength and conditioning program.  We were developing a master’s in exercise science and I was in the process of working on certification with the NSCA.  We also worked closely with athletics to secure strength and conditioning assistantships to allow for student funding.  I am currently on several NSCA committees, which include the Education and Women’s Committee (next certification cycle).    I am particularly adept at all phases of the athletic performance enhancement and these experiences have given me expertise in evidence based program design, linear and non-linear periodization, exercise endocrinology, resistance exercise physiology and acute and chronic training readiness and non-training parameters
Most Relevant Publications (4+)

51 total publications

Effect of resistance exercise on muscle steroidogenesis

Journal of Applied Physiology / Dec 01, 2008

Vingren, J. L., Kraemer, W. J., Hatfield, D. L., Anderson, J. M., Volek, J. S., Ratamess, N. A., Thomas, G. A., Ho, J.-Y., Fragala, M. S., & Maresh, C. M. (2008). Effect of resistance exercise on muscle steroidogenesis. Journal of Applied Physiology, 105(6), 1754–1760. https://doi.org/10.1152/japplphysiol.91235.2008

Immunoreactive and bioactive growth hormone responses to resistance exercise in men who are lean or obese

Journal of Applied Physiology / Aug 01, 2011

Thomas, G. A., Kraemer, W. J., Kennett, M. J., Comstock, B. A., Maresh, C. M., Denegar, C. R., Volek, J. S., & Hymer, W. C. (2011). Immunoreactive and bioactive growth hormone responses to resistance exercise in men who are lean or obese. Journal of Applied Physiology, 111(2), 465–472. https://doi.org/10.1152/japplphysiol.00157.2011

Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight

European Journal of Applied Physiology / Dec 02, 2008

Fragala, M. S., Kraemer, W. J., Volek, J. S., Maresh, C. M., Puglisi, M. J., Vingren, J. L., Ho, J.-Y., Hatfield, D. L., Spiering, B. A., Forsythe, C. E., Thomas, G. A., Quann, E. E., Anderson, J. M., & Hesslink, R. L. (2008). Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight. European Journal of Applied Physiology, 105(5). https://doi.org/10.1007/s00421-008-0944-y

Endogenous opioid peptide responses to opioid and anti-inflammatory medications following eccentric exercise-induced muscle damage

Peptides / Jan 01, 2010

Kraemer, W. J., Joseph, M. F., Volek, J. S., Hoffman, J. R., Ratamess, N. A., Newton, R. U., Fragala, M. S., French, D. N., Rubin, M. A., Scheett, T. P., McGuigan, M. R., Thomas, G. A., Gomez, A. L., Häkkinen, K., & Maresh, C. M. (2010). Endogenous opioid peptide responses to opioid and anti-inflammatory medications following eccentric exercise-induced muscle damage. Peptides, 31(1), 88–93. https://doi.org/10.1016/j.peptides.2009.09.031

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Elvira Forte

New York, New York, United States of America
15 Years Experience
Scientific strategist • Senior Scientist • Senior Scientific Editor
Education

Sapienza University of Rome

PhD, Pasteurian Sciences / January, 2011

Rome

Sapienza University of Rome

Master, Medical, Molecular and Cellular Biotechnology / October, 2006

Rome

Sapienza University of Rome

Bachelor, Biotechnology / October, 2004

Rome
Experience

Springer Nature

Associate/Senior Editor / June, 2021 — February, 2024

Helped shape and launch a new journal, Nature Cardiovascular Research, which publishes exceptional advances in the fields of cardiac, vascular, and blood biology, covering fundamental, translational, clinical, and public health research. • Assessed the novelty and impact of manuscripts within all the topics covered by the journal and chaperoned the whole revision process until acceptance for over 40% of all the content published by the journal since its start, with optimal processing times and excellent feedback from the authors. • Interfaced with scientists around the World, provided scientific guidance on how to improve manuscripts, or recommended more appropriate journals to publish with. Commissioned Comments, Reviews, News and Views on current topics, and summarized novel scientific findings in meaningful snippets and Research Highlights. • Contributed to the training and supervision of 2 Associate Editors; covered the Chief Editor's functions when needed.

Research Fellow/Associate Research Scientist / January, 2017 — June, 2021

• Analyzed the dynamic cellular changes during the fibrotic repair post-myocardial infarction, using cutting-edge techniques such as single-cell RNAseq with 10xChromium. Learned how to perform myocardial infarction in mice and assess the cardiac function via echography; analyze scRNAseq data using the Seurat package on R studio. • Completed a project aimed to characterize similarities and differences among fibroblasts from different organs cultured in the same conditions. Through cytometric, transcriptomic analysis, functional assays, shRNA and CRISPR-Cas9-mediated in vitro gene knockdowns we showed that fibroblasts isolated from different organs retain the expression of key transcription factors reflecting their embryological origin. • Collaborated with other laboratories in the Institute to design new mice models that could possibly recapitulate the symptoms of COVID-19; to analyze the response of mice with diverse genetic backgrounds to stressors.

Post-doctoral fellow/ Co-joint lecturer / May, 2013 — November, 2016

Developed projects aimed at understanding the embryological origin and function of a population of putative progenitor cells, cardiac colony forming unit fibroblasts cCFU-F, identified 2 years before in the lab (PMID: 22136928). • Performed cell lineage tracing and designed in vitro and in vivo cellular assays to assess the functional and immunomodulatory properties of PDGFRa+ fibroblasts in homeostasis and post-myocardial infarction with or without treatment with the PDGF-AB ligands. The data, presented in 3 international conferences and included in a preprint manuscript, have supported the use of a short-term treatment with PDGF-AB in a preclinical model of acute myocardial infarction in pigs. • Co-supervised 2 Ph.D. students at University of New South Wales

Scientific Editor / March, 2024 — Present

Consultant freelancer position within a team of former journal editors and grants specialists • Helped scientists increase the impact of their science by providing advice, in-depth editing, and feedback on manuscripts.

Most Relevant Research Expertise
Physiology
Other Research Expertise (26)
fibrosis
inflammation
cardiomyopathies
Cardiology and Cardiovascular Medicine
Physiology (medical)
And 21 more
About
Motivated and growth-driven biomedical scientist with over 15 years of experience in the cardiovascular field. Strong background in cell and molecular biology, data analysis, and interpretation. Seeking #newopportunities to deliver value as a Senior Scientist, Associate Principal Scientist, Scientific Liaison, or Scientific Consultant within a company that combines new technologies such as single-cell omics and AI for drug discovery and personalized medicine. <br> Throughout my career, I've used various in vivo and in vitro models to investigate the molecular and cellular mechanisms of fibrosis and inflammation in the heart, and how these mechanisms are affected in mice with different genetic backgrounds. My experience includes project management and mentoring. I completed three projects involving international collaborations, supervised two junior researchers, and taught cellular and molecular techniques to at least six professionals. As one of the launching editors and senior editor at Nature Cardiovascular Research, I oversaw the quality of the content published in the journal and the editorial process. I collaborated with authors, reviewers, and editors to ensure the highest standards of scientific rigor, relevance, and innovation. I also contributed to the journal's vision, strategy, and outreach, promoting the latest advances and discoveries in the cardiovascular and hematology fields. This experience has sharpened my analytical and communication skills and broadened my understanding of the field, covering a wide range of studies, from basic research to clinical, epidemiological, and public health research. My mission is to advance the knowledge and practice of cardiovascular medicine and to bridge the gap between research and clinical applications. Keywords: cardiovascular, #fibrosis, inflammation, cardioimmunology, RNA, single-cell biology, #transcriptomics, imaging, animal models, small animal surgery, and scientific writing.
Most Relevant Publications (4+)

63 total publications

Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields

Cardiovascular Research / Feb 19, 2009

Gaetani, R., Ledda, M., Barile, L., Chimenti, I., De Carlo, F., Forte, E., Ionta, V., Giuliani, L., D’Emilia, E., Frati, G., Miraldi, F., Pozzi, D., Messina, E., Grimaldi, S., Giacomello, A., & Lisi, A. (2009). Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields. Cardiovascular Research, 82(3), 411–420. https://doi.org/10.1093/cvr/cvp067

Editorial: Fibrosis and Inflammation in Tissue Pathophysiology

Frontiers in Physiology / Jan 21, 2022

Chimenti, I., Sattler, S., del Monte-Nieto, G., & Forte, E. (2022). Editorial: Fibrosis and Inflammation in Tissue Pathophysiology. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.830683

Abstract 704: Profiling Differential Response to Myocardial Infarction by Single Cell Analysis of the Cardiac Interstitium

Circulation Research / Aug 02, 2019

Forte, E. (2019). Abstract 704: Profiling Differential Response to Myocardial Infarction by Single Cell Analysis of the Cardiac Interstitium. Circulation Research, 125(Suppl_1). https://doi.org/10.1161/res.125.suppl_1.704

Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts

Circulation Research / Jul 17, 2015

Forte, E., Janbandhu, V., Asli, N. S., Cornwell, J., Abeygunawardena, D., Xaymardan, M., & Harvey, R. P. (2015). Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts. Circulation Research, 117(suppl_1). https://doi.org/10.1161/res.117.suppl_1.12

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THANGASAMY SAMINATHAN

Charleston, West Virginia, United States of America
24 Years Experience
I have mix of expertise in Molecular Biology, Mapping and Functional Genomics, and Groundwater Remediation
Education

Academia Sinica

PhD Biotechnology, Taiwan International Graduate Program / January, 2011

Taipei

Tamil Nadu Agricultural University

MSc Agriculture (Plant Breeding and Genetics), Center for Plant Breeding and Genetics / August, 2000

Coimbatore

Tamil Nadu Agricultural University

BSc Agriculture, Anbil Dharmalingam Agricultural College and Research Institute / November, 1996

Coimbatore
Experience

West Virginia Department of Environmental Protection

Environmental Resource Analyst / February, 2018 — Present

West Virginia State University

Associate Adjunct Faculty / May, 2013 — Present

Academia Sinica

Postdoctoral Research Fellow / February, 2011 — April, 2013

Most Relevant Research Expertise
Physiology
Other Research Expertise (10)
Genetics
Molecular biology
Groundwater remediation
Biotechnology
Plant Science
And 5 more
About
Dr. Thangasamy Saminathan is a highly educated and experienced scientist with a passion for biotechnology and agriculture. He completed his PhD in Biotechnology at the prestigious Taiwan International Graduate Program at Academia Sinica in 2011. He has a diverse range of experience in the field of biotechnology and agriculture. He works as an Environmental Resource Analyst at the West Virginia Department of Environmental Protection, where he utilized his knowledge and skills to analyze and assess environmental resources. He also serves as an Associate Adjunct Faculty at West Virginia State University, teaching biotechnology and agriculture courses to students. His research experience includes a postdoctoral position at Academia Sinica, where he worked on projects related to plant biotechnology and genetics. He gained hands-on experience in plant breeding and genetics. Dr. Saminathan's education and experience have equipped him with a strong foundation in biotechnology and agriculture, and he continues to be actively involved in research and teaching in these fields. He is a dedicated scientist who is committed to finding innovative solutions to challenges in agriculture and utilizing biotechnology for sustainable development.
Most Relevant Publications (2+)

29 total publications

Rice SIZ1, a SUMO E3 ligase, controls spikelet fertility through regulation of anther dehiscence

New Phytologist / Nov 16, 2010

Thangasamy, S., Guo, C., Chuang, M., Lai, M., Chen, J., & Jauh, G. (2010). Rice SIZ1, a SUMO E3 ligase, controls spikelet fertility through regulation of anther dehiscence. New Phytologist, 189(3), 869–882. Portico. https://doi.org/10.1111/j.1469-8137.2010.03538.x

Differential gene expression and alternative splicing between diploid and tetraploid watermelon

Journal of Experimental Botany / Dec 17, 2014

Saminathan, T., Nimmakayala, P., Manohar, S., Malkaram, S., Almeida, A., Cantrell, R., Tomason, Y., Abburi, L., Rahman, M. A., Vajja, V. G., Khachane, A., Kumar, B., Rajasimha, H. K., Levi, A., Wehner, T., & Reddy, U. K. (2014). Differential gene expression and alternative splicing between diploid and tetraploid watermelon. Journal of Experimental Botany, 66(5), 1369–1385. https://doi.org/10.1093/jxb/eru486

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Odion Ikhimiukor

Albany, New York, United States of America
6 Years Experience
Postdoctoral Research Scientist at University at Albany, State University of New York
Education

University of Ibadan

PhD Microbiology, Bacterial genomics, Bioinformatics, Microbiology

Ibadan

University of Ibadan

Master of Science (M. Sc.), Environmental Microbiology / April, 2015

Ibadan

University of Abuja

Bachelor of Science (B.Sc.), Microbiology / March, 2011

Abuja
Experience

University at Albany, State University of New York

Postdoctoral Associate

National Institute for Pharmaceutical Research and Development

FCT Emergency Services, Asokoro District Hospital

Most Relevant Research Expertise
Physiology
Other Research Expertise (23)
Pathogen Genomics
Bioinformatics
Molecular Biology
Epidemiology
Environmental Microbiology
And 18 more
About
A postdoctoral research scientist with over 9 years experience in bacterial genomics, microbiology, bioinformatics and antimicrobial resistance research. I’m seeking a Research Scientist or Epidemiologist role at public health genomics laboratories and I am the perfect fit for these roles because I have the following skills: molecular biology, research & development, strategic planning, project management, documentation, outbreak investigation, and cross-functional collaboration skills. I have leveraged my skills to work in a collaborative team-oriented environment to accomplish project goals related to examining the evolution of antimicrobial resistance as evidenced by over 7 national and international collaborations including the New York State Department of Health. I am also a proactive problem-solver adopting innovative and scientific thinking strategies in molecular biology to fulfill project objectives resulting in scientific discoveries including uncovering 1 novel hotspot for the dissemination of resistance in bacteria. I have gained mentorship expertise in promoting data reproducibility, and innovative research methodology in antimicrobial resistance research as evidenced by mentoring 10 professionals on evolutionary genomics, epidemiological statistics, and antimicrobial stewardship. I have also worked collaboratively with a team to apply pathogen genomics, bioinformatics, and leadership skills as demonstrated by working with over 10 highly collaborative teams including the Africa CDC. In addition, I have the following qualifications: Cross-functional collaborator and experience elucidating methods and frequencies of horizontal gene transfer and antimicrobial resistance spread in bacterial species, as demonstrated by 26 peer-reviewed publications including 1 in Nature Microbiology. Experience in leading and managing project details and tasks as evidenced by over 20 projects in pathogen genomics, epidemiology, antimicrobial resistance surveillance, and global health. Astute communication skills in bacterial epidemiology and antimicrobial resistance research resulting in 20 presentations and 6 travel awards to deliver such presentations, including the Bill and Melinda Gates Foundation. I want to serve an organization that prizes community, collaboration and humility among its employees. I’m excited to be on a team built around impact, innovation and a strong, positive reputation. I know I will thrive at a company where responsibility is valued, as well as self-improvement and time-management. I want to be a part of an organization that infuses growth into their brand, culture and market and who I can help make a difference in the world.
Most Relevant Publications (1+)

27 total publications

Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales

Microbiology Spectrum / Oct 17, 2023

Ikhimiukor, O. O., Souza, S. S. R., Akintayo, I. J., Marcovici, M. M., Workman, A., Martin, I. W., & Andam, C. P. (2023). Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales. Microbiology Spectrum, 11(5). https://doi.org/10.1128/spectrum.00549-23

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John M Baust, Ph.D

Ithaca, New York, United States of America
25 Years Experience
Proven success in delivering best-in-class services across scientific, commercial and education environments.
Education

Harvard Medical School

Post Doc

Boston, Massachusetts, United States of America

Binghamton University

Ph.D.

Binghamton, New York, United States of America

Cornell University

BS

Ithaca, New York, United States of America
Experience

Cell Preservation Services (United States)

President

Most Relevant Research Expertise
Physiology
Other Research Expertise (16)
Cell Biology
Biotechnology
Biomedical Engineering
Transplantation
Surgery
And 11 more
About
***Proven success in delivering best-in-class services across highly regulated scientific and commercial environments.*** * Resourceful, dynamic, and future-focused professional; equipped with strategic leadership, business, research, and academic expertise with career excellence in conducting in-depth research, leading multi-faceted R&D projects, and developing new products and treatments. * Dedicated, driven self-starter focused on developing innovative life changing technologies and procedures advancing the areas of cancer treatment, regenerative medicine and cell therapy.   * Substantial experience in providing oversight for medical device development, pre-clinical studies, cancer therapy, stem cell preservation, cell therapy, tissue engineering, and organ transplantation, etc. * Astute at establishing solid relationships with stakeholders and industry leaders to drive innovative ideas and lead collaborative efforts in pursuit of accomplishing long-term milestones. * Successful in delivering interactive academic instruction across higher education settings offering captivating lectures on Biology and Entrepreneurship courses in accordance with the organizational mission. * Accredited with authoring, managing, and executing multi-million dollar grants, corporate contracts * Accomplished author of numerous patents and high profile publications to disseminate essential research findings.
Most Relevant Publications (1+)

68 total publications

Cryoablation: physical and molecular basis with putative immunological consequences

International Journal of Hyperthermia / Nov 29, 2019

Baust, J. G., Snyder, K. K., Santucci, K. L., Robilotto, A. T., Van Buskirk, R. G., & Baust, J. M. (2019). Cryoablation: physical and molecular basis with putative immunological consequences. International Journal of Hyperthermia, 36(sup1), 10–16. https://doi.org/10.1080/02656736.2019.1647355

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Shariq Usmani, PhD

Boston, Massachusetts, United States of America
15 Years Experience
Massachusetts General Hospital, Harvard Medical School
Education

University of Konstanz

PhD, Molecular and Cell Biology / May, 2011

Konstanz

Harvard University

Postdoctoral fellow, Virology/Immunology / 2019

Cambridge, Massachusetts, United States of America
Experience

Cabaletta Bio

Scientific Director / 2024 — Present

I lead a research team in the preclinical R&D organization at Cabaletta bio. I directly manage a talented group of Senior Scientists, Scientists and Research Associates to spearhead and drive innovation in cell therapies and biologics in autoimmune disease indications.

Sana Biotechnology

Principal Scientist / 2022 — 2023

As a team lead, I led efforts to establish in vivo genome editing platform, vector design/engineering and optimization, with a broader goal to develop innovative and effective genomic medicine for unmet medical needs.

Zohdan Bio

Consultant / 2024 — Present

Providing strategic support for all aspects of preclinical, R&D programs in gene therapy, genome editing and virology and immunology space.

Most Relevant Research Expertise
Physiology
Other Research Expertise (9)
Microbiology
Virology
Immunology
Molecular Biology
Genetics
And 4 more
About
Dr. Shariq Usmani is scientific director at Cabaletta bio, a leader in cell therapy for autoimmune diseases (https://www.cabalettabio.com). He leads a research team in preclinical R&D organization at Cabaletta bio. He directly manage a talented group of Senior Scientists, Scientists and Research Associates to spearhead and drive innovation in cell therapies and biologics in autoimmune disease indications. <br> He is also serves as consultant at Zohdan Bio, where he provides strategic support for preclinical R&D programs focused on gene therapy, genome editing, and virology. With a deep foundation in oncology and biologics, Dr. Usmani has led groundbreaking work in both academia and industry, including his tenures at Sana Biotechnology, Harvard Medical School and Massachusetts General Hospital. He's led and spearheaded the development of innovative in vivo genome editing platforms, optimized viral vectors, and engineered cutting-edge reporter assays.
Most Relevant Publications (2+)

22 total publications

2-APB and Capsazepine-induced Ca<sup>2+</sup> Influx Stimulates Clathrin-dependent Endocytosis in Alveolar Epithelial Cells

Cellular Physiology and Biochemistry / Jan 01, 2010

Usmani, S., Fois, G., Albrecht, S., von Aulock, S., Dietl, P., & Wittekindt, O. (2010). 2-APB and Capsazepine-induced Ca&lt;sup&gt;2+&lt;/sup&gt; Influx Stimulates Clathrin-dependent Endocytosis in Alveolar Epithelial Cells. Cellular Physiology and Biochemistry, 25(001), 091–102. https://doi.org/10.1159/000272064

Plasma Membrane Trafficking in Alveolar Type II Cells

Cellular Physiology and Biochemistry / Jan 01, 2010

Albrecht, S., Usmani, S., Dietl, P., & Wittekindt, O. (2010). Plasma Membrane Trafficking in Alveolar Type II Cells. Cellular Physiology and Biochemistry, 25(001), 081–090. https://doi.org/10.1159/000272053

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Dushani L. Palliyaguru, Ph.D.

Baltimore, MD, Maryland, United States of America
16 Years Experience
Toxicologist | Aging, Nutrition and Metabolism Research Scientist | Systems Biologist
Education

University of Pittsburgh

Ph.D., Environmental and Occupational Health (Toxicology) / May, 2016

Pittsburgh, Pennsylvania, United States of America

Clark University

B.A., Biochemistry and Molecular Biology, Mathematics / May, 2009

Worcester, Massachusetts, United States of America
Experience

National Institute on Aging Intramural Research Program, Translational Gerontology Branch

IRTA Postdoctoral Fellow, K99/R00 Grant Recipient / September, 2018 — Present

-Leading, managing and coordinating large population longitudinal studies within US Federal Government and Industry partnerships - Successfully writing, submitting, and managing grants and manuscripts to ensure continuity of research initiatives -Hiring, mentoring, and supervising research fellows and technicians -Applying epidemiological, machine learning and data science methods to multi-omics data to characterize biomarkers of aging and aging-related diseases -Testing nutritional and pharmacological compounds for lifespan extension, and prevention of chronic diseases (eg. Alzheimer’s)

University of Pittsburgh, Department of Pharmacology and Chemical Biology

Postdoctoral Fellow / May, 2016 — September, 2018

Identified a novel urinary biomarker of cruciferous vegetable intake in cancer prevention clinical trials using liquid chromatography mass spectrometry -Led and managed project that showed broccoli-derived sulforaphane prevented breast cancer through altering gene expression and lipidomics profiles

Healthcare Ready

Health Policy Fellow / January, 2017 — January, 2018

-Synthesized data, mined literature and wrote Toolkits/ Issue Brief on “Pharmacy and Emergency Preparedness: A Landscape Analysis”

Most Relevant Research Expertise
Physiology
Other Research Expertise (16)
Nutrition
aging
Oncology
Hematology
Molecular Biology
And 11 more
About
·   Highly productive scientist with 13 years of multidisciplinary experience in toxicology, molecular nutrition, and aging/ disease biomarkers ·   Excellent communicator with proven record of advanced writing and presentation skills - manuscripts, conference presentations, and grants ·   Extensive experience in large study design, supervision and coordination, big data analysis, and management of junior scientists
Most Relevant Publications (2+)

20 total publications

Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice

American Journal of Physiology-Endocrinology and Metabolism / Aug 01, 2018

Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Fazzari, M., Khoo, N. K. H., Schopfer, F. J., Sipula, I., Yagishita, Y., Michalopoulos, G. K., O’Doherty, R. M., & Kensler, T. W. (2018). Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. American Journal of Physiology-Endocrinology and Metabolism, 315(2), E180–E195. https://doi.org/10.1152/ajpendo.00311.2017

Fasting blood glucose as a predictor of mortality: Lost in translation

Cell Metabolism / Nov 01, 2021

Palliyaguru, D. L., Shiroma, E. J., Nam, J. K., Duregon, E., Vieira Ligo Teixeira, C., Price, N. L., Bernier, M., Camandola, S., Vaughan, K. L., Colman, R. J., Deighan, A., Korstanje, R., Peters, L. L., Dickinson, S. L., Ejima, K., Simonsick, E. M., Launer, L. J., Chia, C. W., Egan, J., … de Cabo, R. (2021). Fasting blood glucose as a predictor of mortality: Lost in translation. Cell Metabolism, 33(11), 2189-2200.e3. https://doi.org/10.1016/j.cmet.2021.08.013

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Daniel Milej, Ph.D.

London, Ontario, Canada
15 Years Experience
Ph.D. in biomedical engineering
Education

Western University

Post-doctorate fellowship, Department of Medical Biophysics / June, 2019

London

Polish Academy of Science

PhD, Nalecz Institute of Biocybernetics and Biomedical Engineering / June, 2014

Warsaw

Military Univeristy of Technology

MSc, Department of Electronics / June, 2008

Warsaw
Experience

Lawson Research Institute

Research Associate / July, 2019 — July, 2025

Scientist / August, 2024 — Present

Western University

Postdoctoral fellow / September, 2014 — June, 2019

Assistant Professor / September, 2024 — Present

Polish Academy of Science

Researcher/PhD Student / June, 2008 — September, 2014

Research Expertise (32)
Biomedical Optics
NIRS
fNIRS
Diffuse Correlation Spectroscopy
CBF
And 27 more
About
Dr. Daniel Milej is a multidisciplinary researcher with experience in medical biophysics, electronics, biocybernetics, biomedical optics and engineering. He is highly knowledgeable and experienced in a range of research techniques. He is a Scientist at the Lawson Research Institute, leading the transition of multimodal optical imaging systems from a research setting to clinical use in an ICU and OR environment, working closely with teams of nurses, surgeons, doctors and respiratory therapists. Previously, he was a Postdoctoral Fellow and Research Associate working on developing noninvasive modalities for brain activity monitoring in the Department of Medical Biophysics at Western University. Before that, Dr. Milej worked as a Researcher at the Nalecz Institute of Biocybernetics and Biomedical Engineering. He obtained his Ph.D. in 2014 from the Polish Academy of Science, specializing in Biocybernetics and Biomedical Engineering. He received his MSc in Electronics/Optoelectronics from the Military University of Technology, Warsaw, Poland, in 2008.

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Dr. Everson A Nunes, Ph.D.

Hamilton, Ontario, Canada
19 Years Experience
Post-Doctoral Fellow at McMaster University | former Associate Professor - Physiological Sciences
Education

Universidade Federal do Paraná - Campus Centro Politécnico

PhD, Physiological Sciences / December, 2009

Curitiba

Universidade Federal do Paraná - Campus Centro Politécnico

BSc - Human Nutrition / December, 2007

Curitiba

Universidade Federal do Paraná - Campus Centro Politécnico

MSc, Physiological Sciences / March, 2005

Curitiba
Experience

McMaster University

Post Doctoral Fellow / September, 2019 — Present

Post-Doctoral Research Fellow / September, 2015 — August, 2016

Universidade Federal de Santa Catarina

Associate professor / October, 2013 — April, 2022

Assistant Professor / October, 2010 — September, 2013

Universidade Federal do Paraná

Post-Doctoral Fellow / December, 2009 — September, 2010

Most Relevant Research Expertise
Physiology
Other Research Expertise (39)
skeletal muscle
nutrition
physical activity
obesity
cancer
And 34 more
About
Dr. Everson A Nunes is a highly accomplished researcher and educator in the field of physiological sciences. He received his Ph.D. in Cellular and Molecular Biology with a focus on Physiological Sciences from Universidade Federal do Paraná in 2009, after completing a BSc in Human Nutrition and an MSc in Physiological Sciences. He also holds a specialization in Exercise Physiology and a BSc in Biological Sciences from Universidade Federal do Paraná. Dr. Nunes has a strong background in research, having completed two post-doctoral fellowships at McMaster University and Universidade Federal do Paraná. He has also held positions as an associate professor and assistant professor at Universidade Federal de Santa Catarina. He has published numerous articles in peer-reviewed journals, and his research focuses on the effects of exercise and nutrition on physiological processes in the human body. In addition to his research, Dr. Nunes is also a dedicated educator. He has taught at various universities in Brazil, including Universidade Federal de Santa Catarina, Universidade Gama Filho, Faculdades Integradas Espírita, Pontificia Universidade Católica do Paraná, and Faculdade do Litoral Sul. He is known for his dynamic teaching style and his ability to engage students in complex physiological concepts. Dr. Nunes is a member of several professional organizations, including the American Society for Nutrition, the Canadian Society of Exercise Physiology, the Canadian Nutrition Society and the Brazilian Society of Physiology. He is also a regular speaker at national and international conferences, sharing his expertise and research findings with colleagues and students. Overall, Dr. Nunes is a highly qualified and experienced professional in physiological sciences, metabolism, cancer and nutrition. His dedication to research and education makes him a valuable asset to any institution.
Most Relevant Publications (16+)

97 total publications

Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats

European Journal of Applied Physiology / Aug 08, 2008

de Lima, C., Alves, L. E., Iagher, F., Machado, A. F., Bonatto, S. J., Kuczera, D., de Souza, C. F., Pequito, D. C., Muritiba, A. L., Nunes, E. A., & Fernandes, L. C. (2008). Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats. European Journal of Applied Physiology, 104(6), 957–964. https://doi.org/10.1007/s00421-008-0849-9

In vitro ketone‐supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle

The Journal of Physiology / Aug 19, 2020

Petrick, H. L., Brunetta, H. S., Pignanelli, C., Nunes, E. A., van Loon, L. J. C., Burr, J. F., & Holloway, G. P. (2020). In vitro ketone‐supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle. The Journal of Physiology, 598(21), 4869–4885. Portico. https://doi.org/10.1113/jp280032

Decrement in resting and insulin‐stimulated soleus muscle mitochondrial respiration is an early event in diet‐induced obesity in mice

Experimental Physiology / Jan 24, 2019

Brunetta, H. S., de Paula, G. C., de Oliveira, J., Martins, E. L., dos Santos, G. J., Galina, A., Rafacho, A., de Bem, A. F., & Nunes, E. A. (2019). Decrement in resting and insulin‐stimulated soleus muscle mitochondrial respiration is an early event in diet‐induced obesity in mice. Experimental Physiology, 104(3), 306–321. Portico. https://doi.org/10.1113/ep087317

Nitrate attenuates high fat diet‐induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission

The Journal of Physiology / Jun 16, 2020

Brunetta, H. S., Politis‐Barber, V., Petrick, H. L., Dennis, K. M. J. H., Kirsh, A. J., Barbeau, P., Nunes, E. A., & Holloway, G. P. (2020). Nitrate attenuates high fat diet‐induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission. The Journal of Physiology, 598(16), 3357–3371. Portico. https://doi.org/10.1113/jp279455

Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats

Canadian Journal of Physiology and Pharmacology / Oct 01, 2014

dos Santos, C., Ferreira, F. B. D., Gonçalves-Neto, L. M., Taboga, S. R., Boschero, A. C., & Rafacho, A. (2014). Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats. Canadian Journal of Physiology and Pharmacology, 92(10), 867–878. https://doi.org/10.1139/cjpp-2014-0259

Increased protein intake derived from leucine-enriched protein enhances the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women: a 4-day randomized controlled trial

Applied Physiology, Nutrition, and Metabolism / Nov 01, 2022

Lim, C., Traylor, D. A., McGlory, C., Joanisse, S., McKendry, J., Grewal, T., Mcleod, J. C., Prior, T., Nunes, E. A., Lees, M., & Phillips, S. M. (2022). Increased protein intake derived from leucine-enriched protein enhances the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women: a 4-day randomized controlled trial. Applied Physiology, Nutrition, and Metabolism, 47(11), 1104–1114. https://doi.org/10.1139/apnm-2022-0164

Associação da atividade física, consumo de álcool e índice de massa corporal com a qualidade de vida de adolescentes

Revista Brasileira de Cineantropometria e Desempenho Humano / Jul 18, 2008

Gordia, A. P. (2008). Associação da atividade física, consumo de álcool e índice de massa corporal com a qualidade de vida de adolescentes. Revista Brasileira de Cineantropometria e Desempenho Humano, 10(3), 313. https://doi.org/10.5007/1980-0037.2008v10n3p313

Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies

American Journal of Physiology-Cell Physiology / Jun 01, 2022

Nunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022). Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies. American Journal of Physiology-Cell Physiology, 322(6), C1068–C1084. https://doi.org/10.1152/ajpcell.00425.2021

Association of physical activity and sedentary behavior at school with cardiovascular risk factors in adolescents

Revista Brasileira de Cineantropometria &amp; Desempenho Humano / Jan 01, 2020

Santos, P. C. dos, Lima, L. R. A. de, Costa, B. G. G. da, Martins, C. R., Minatto, G., Berria, J., Nunes, E. A., Petroski, E. L., & Silva, K. S. da. (2020). Association of physical activity and sedentary behavior at school with cardiovascular risk factors in adolescents. Revista Brasileira de Cineantropometria &amp; Desempenho Humano, 22. https://doi.org/10.1590/1980-0037.2020v22e72397

Assessing the mechanistic target of rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay

Applied Physiology, Nutrition, and Metabolism / Sep 01, 2018

McGlory, C., Nunes, E. A., Oikawa, S. Y., Tsakiridis, E., & Phillips, S. M. (2018). Assessing the mechanistic target of rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay. Applied Physiology, Nutrition, and Metabolism, 43(9), 945–949. https://doi.org/10.1139/apnm-2017-0852

Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats

Stress / Feb 10, 2018

Simas, B. B., Nunes, E. A., Crestani, C. C., & Speretta, G. F. (2018). Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats. Stress, 21(3), 247–256. https://doi.org/10.1080/10253890.2018.1437413

Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats

Applied Physiology, Nutrition, and Metabolism / Apr 01, 2016

Barbosa, A. M., Francisco, P. de C., Motta, K., Chagas, T. R., dos Santos, C., Rafacho, A., & Nunes, E. A. (2016). Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats. Applied Physiology, Nutrition, and Metabolism, 41(4), 382–390. https://doi.org/10.1139/apnm-2015-0487

Glucose homoeostasis in rats exposed to acute intermittent hypoxia

Acta Physiologica / Jun 08, 2013

Rafacho, A., Gonçalves-Neto, L. M., Ferreira, F. B. D., Protzek, A. O. P., Boschero, A. C., Nunes, E. A., & Zoccal, D. B. (2013). Glucose homoeostasis in rats exposed to acute intermittent hypoxia. Acta Physiologica, 209(1), 77–89. https://doi.org/10.1111/apha.12118

Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats

Applied Physiology, Nutrition, and Metabolism / Nov 01, 2013

Nunes, E. A., Gonçalves-Neto, L. M., Ferreira, F. B. D., dos Santos, C., Fernandes, L. C., Boschero, A. C., Calder, P. C., & Rafacho, A. (2013). Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats. Applied Physiology, Nutrition, and Metabolism, 38(11), 1137–1146. https://doi.org/10.1139/apnm-2012-0456

Neutrophil response of anaerobic jump trained diabetic rats

European Journal of Applied Physiology / Sep 10, 2008

de Souza, C. F., Machado, A. F., Bonatto, S. J. R., Grando, F. C. C., Pessini, C., Alves, L. E., de Lima, C., de Brito, G. A. P., Nunes, E. A., & Fernandes, L. C. (2008). Neutrophil response of anaerobic jump trained diabetic rats. European Journal of Applied Physiology, 104(6), 1079–1086. https://doi.org/10.1007/s00421-008-0865-9

Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation

Applied Physiology, Nutrition, and Metabolism / Aug 01, 2011

de Lima, C., Alves, L., Iagher, F., Machado, A. F., Kryczyk, M., Yamazaki, R. K., Brito, G. A. P., Nunes, E. A., Naliwaiko, K., & Fernandes, L. C. (2011). Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation. Applied Physiology, Nutrition, and Metabolism, 36(4), 533–538. https://doi.org/10.1139/h11-047

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Example Physiology projects

How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on Physiology?

Developing Advanced Medical Devices

By collaborating with a Physiology researcher, a medical device company can develop advanced devices that are tailored to the physiological needs of patients. This can include wearable devices for monitoring vital signs, implantable devices for targeted drug delivery, or rehabilitation devices for improving motor function.

Optimizing Sports Performance

Sports companies can benefit from working with Physiology researchers to optimize athletes' performance. Researchers can analyze physiological data, design training programs based on individual needs, and provide insights on nutrition and recovery strategies to enhance athletic performance and reduce the risk of injuries.

Improving Workplace Ergonomics

Companies can collaborate with Physiology researchers to improve workplace ergonomics and employee well-being. Researchers can assess the physiological impact of work environments, recommend ergonomic adjustments, and develop strategies to prevent musculoskeletal disorders, fatigue, and stress.

Enhancing Pharmaceutical Development

Pharmaceutical companies can partner with Physiology researchers to enhance drug development processes. Researchers can conduct preclinical studies, evaluate drug efficacy and safety, and provide insights on drug metabolism and pharmacokinetics, leading to the development of more effective and targeted medications.

Designing Personalized Health Interventions

By collaborating with Physiology researchers, companies can design personalized health interventions. Researchers can analyze individual physiological data, identify risk factors, and develop tailored interventions for chronic diseases, mental health conditions, and lifestyle management, leading to improved health outcomes.