Experts and Thought Leaders in Biomedicine
Ping Luo
Bioinformatics Specialist at Princess Margaret Cancer Centre with experience in deep learning
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23 total publications
Enhancing the prediction of disease–gene associations with multimodal deep learning
Bioinformatics / Mar 02, 2019
Luo, P., Li, Y., Tian, L.-P., & Wu, F.-X. (2019). Enhancing the prediction of disease–gene associations with multimodal deep learning. Bioinformatics, 35(19), 3735–3742. https://doi.org/10.1093/bioinformatics/btz155
Identifying cell types from single-cell data based on similarities and dissimilarities between cells
BMC Bioinformatics / May 01, 2021
Li, Y., Luo, P., Lu, Y., & Wu, F.-X. (2021). Identifying cell types from single-cell data based on similarities and dissimilarities between cells. BMC Bioinformatics, 22(S3). https://doi.org/10.1186/s12859-020-03873-z
Ensemble disease gene prediction by clinical sample-based networks
BMC Bioinformatics / Mar 01, 2020
Luo, P., Tian, L.-P., Chen, B., Xiao, Q., & Wu, F.-X. (2020). Ensemble disease gene prediction by clinical sample-based networks. BMC Bioinformatics, 21(S2). https://doi.org/10.1186/s12859-020-3346-8
A Novel Core-Attachment-Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks
PROTEOMICS / Feb 20, 2019
Xiao, Q., Luo, P., Li, M., Wang, J., & Wu, F.-X. (2019). A Novel Core-Attachment-Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks. PROTEOMICS, 19(5), 1800129. Portico. https://doi.org/10.1002/pmic.201800129
Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma
Blood / Nov 05, 2021
Coffey, D. G., Maura, F., Gonzalez-Kozlova, E., Diaz-Mejia3, J., Luo, P., Zhang, Y., Xu, Y., Warren, E. H., Smith, E. L., Cho, H. J., Lesokhin, A., Diamond, B., Kazandjian, D., Pugh, T. J., Green, D. J., Gnjatic, S., & Landgren, O. (2021). Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma. Blood, 138(Supplement 1), 329–329. https://doi.org/10.1182/blood-2021-154506
Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets
Computational and Structural Biotechnology Journal / Jan 01, 2022
Mahalanabis, A., Turinsky, A. L., Husić, M., Christensen, E., Luo, P., Naidas, A., Brudno, M., Pugh, T., Ramani, A. K., & Shooshtari, P. (2022). Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets. Computational and Structural Biotechnology Journal, 20, 6375–6387. https://doi.org/10.1016/j.csbj.2022.10.029
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Mohammad Imran Khan
Postdoctoral Associate at University of Maryland College Park in the Department of Nutrition and Food Science
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11 total publications
Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition
Biochemical Engineering Journal / Jan 01, 2016
Mishra, P., Ray, S., Sinha, S., Das, B., Khan, Md. I., Behera, S. K., Yun, S.-I., Tripathy, S. K., & Mishra, A. (2016). Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition. Biochemical Engineering Journal, 105, 264–272. https://doi.org/10.1016/j.bej.2015.09.021
Biosynthesis of magnesium oxide (MgO) nanoflakes by using leaf extract of Bauhinia purpurea and evaluation of its antibacterial property against Staphylococcus aureus
Materials Science and Engineering: C / Oct 01, 2018
Das, B., Moumita, S., Ghosh, S., Khan, M. I., Indira, D., Jayabalan, R., Tripathy, S. K., Mishra, A., & Balasubramanian, P. (2018). Biosynthesis of magnesium oxide (MgO) nanoflakes by using leaf extract of Bauhinia purpurea and evaluation of its antibacterial property against Staphylococcus aureus. Materials Science and Engineering: C, 91, 436–444. https://doi.org/10.1016/j.msec.2018.05.059
Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells
Frontiers in Bioengineering and Biotechnology / Dec 15, 2021
Berehu, H. M., S, A., Khan, M. I., Chakraborty, R., Lavudi, K., Penchalaneni, J., Mohapatra, B., Mishra, A., & Patnaik, S. (2021). Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells. Frontiers in Bioengineering and Biotechnology, 9. https://doi.org/10.3389/fbioe.2021.788527
Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy
International Journal of Biological Macromolecules / Jul 01, 2020
Praveen, M. A., Parvathy, K. R. K., Patra, S., Khan, I., Natarajan, P., & Balasubramanian, P. (2020). Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy. International Journal of Biological Macromolecules, 154, 557–566. https://doi.org/10.1016/j.ijbiomac.2020.03.086
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Luciano Dibona, Ph.D
Highly motivated young professional with a PhD in Chemistry and specialized in Photobiological aspects of Life Sciences and Agriculture on Crop protection.
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7 total publications
Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†
Photochemistry and Photobiology / Dec 20, 2022
Mariño‐Ocampo, N., Dibona‐Villanueva, L., Escobar‐Álvarez, E., Guerra‐Díaz, D., Zúñiga‐Núñez, D., Fuentealba, D., & Robinson‐Duggon, J. (2022). Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†. Photochemistry and Photobiology, 99(2), 469–497. Portico. https://doi.org/10.1111/php.13749
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Dr. Fantai Kong, Ph.D.
Hunt Energy
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31 total publications
Stable and Active Oxidation Catalysis by Cooperative Lattice Oxygen Redox on SmMn2O5 Mullite Surface
Journal of the American Chemical Society / Jun 18, 2019
Zheng, Y., Thampy, S., Ashburn, N., Dillon, S., Wang, L., Jangjou, Y., Tan, K., Kong, F., Nie, Y., Kim, M. J., Epling, W. S., Chabal, Y. J., Hsu, J. W. P., & Cho, K. (2019). Stable and Active Oxidation Catalysis by Cooperative Lattice Oxygen Redox on SmMn2O5 Mullite Surface. Journal of the American Chemical Society, 141(27), 10722–10728. https://doi.org/10.1021/jacs.9b03334
Atomic Insights into Phase Evolution in Ternary Transition‐Metal Dichalcogenides Nanostructures
Small / May 01, 2018
Zou, Y., Chen, Z., Liu, S., Aso, K., Zhang, C., Kong, F., Hong, M., Matsumura, S., Cho, K., & Zou, J. (2018). Atomic Insights into Phase Evolution in Ternary Transition‐Metal Dichalcogenides Nanostructures. Small, 14(22). Portico. https://doi.org/10.1002/smll.201800780
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Ajay Badhan
Research Biologist, Lethbridge Research Center, Canada
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29 total publications
Production of multiple xylanolytic and cellulolytic enzymes by thermophilic fungus Myceliophthora sp. IMI 387099
Bioresource Technology / Feb 01, 2007
Badhan, A. K., Chadha, B. S., Kaur, J., Saini, H. S., & Bhat, M. K. (2007). Production of multiple xylanolytic and cellulolytic enzymes by thermophilic fungus Myceliophthora sp. IMI 387099. Bioresource Technology, 98(3), 504–510. https://doi.org/10.1016/j.biortech.2006.02.009
Purification and characterization of ß-glucosidase from Melanocarpus sp. MTCC 3922
Electronic Journal of Biotechnology / Apr 15, 2007
Kaur, J., Chadha, B. S., Kumar, B. A., Ghatora, S. K., & Saini, H. S. (2007). Purification and characterization of ß-glucosidase from Melanocarpus sp. MTCC 3922. Electronic Journal of Biotechnology, 10(2), 0–0. https://doi.org/10.2225/vol10-issue2-fulltext-4
Purification and characterization of two endoglucanases from Melanocarpus sp. MTCC 3922
Bioresource Technology / Jan 01, 2007
KAUR, J., CHADHA, B., KUMAR, B., & SAINI, H. (2007). Purification and characterization of two endoglucanases from Melanocarpus sp. MTCC 3922. Bioresource Technology, 98(1), 74–81. https://doi.org/10.1016/j.biortech.2005.11.019
Identification and characterization of diverse xylanases from thermophilic and thermotolerant fungi
BioResources / Jul 01, 2006
Ghatora, S. K., Chadha, B. S., Badhan, A. K., Saini, H. S., & Bhat, M. K. (2006). Identification and characterization of diverse xylanases from thermophilic and thermotolerant fungi. BioResources, 1(1), 18–33. https://doi.org/10.15376/biores.1.1.18-33
Functionally diverse multiple xylanases of thermophilic fungus Myceliophthora sp. IMI 387099
Enzyme and Microbial Technology / Oct 01, 2004
Badhan, A. K., Chadha, B. S., Sonia, K. G., Saini, H. S., & Bhat, M. K. (2004). Functionally diverse multiple xylanases of thermophilic fungus Myceliophthora sp. IMI 387099. Enzyme and Microbial Technology, 35(5), 460–466. https://doi.org/10.1016/j.enzmictec.2004.07.002
Expression of a fungal ferulic acid esterase in alfalfa modifies cell wall digestibility
Biotechnology for Biofuels / Mar 20, 2014
Badhan, A., Jin, L., Wang, Y., Han, S., Kowalczys, K., Brown, D. C., Ayala, C. J., Latoszek-Green, M., Miki, B., Tsang, A., & McAllister, T. (2014). Expression of a fungal ferulic acid esterase in alfalfa modifies cell wall digestibility. Biotechnology for Biofuels, 7(1). https://doi.org/10.1186/1754-6834-7-39
Identification of glucose tolerant acid active β-glucosidases from thermophilic and thermotolerant fungi
World Journal of Microbiology and Biotechnology / Aug 23, 2007
Sonia, K. G., Chadha, B. S., Badhan, A. K., Saini, H. S., & Bhat, M. K. (2007). Identification of glucose tolerant acid active β-glucosidases from thermophilic and thermotolerant fungi. World Journal of Microbiology and Biotechnology, 24(5), 599–604. https://doi.org/10.1007/s11274-007-9512-6
Two endoxylanases active and stable at alkaline pH from the newly isolated thermophilic fungus, Myceliophthora sp. IMI 387099
Journal of Biotechnology / Apr 01, 2004
Chadha, B. S., Ajay, B. K., Mellon, F., & Bhat, M. K. (2004). Two endoxylanases active and stable at alkaline pH from the newly isolated thermophilic fungus, Myceliophthora sp. IMI 387099. Journal of Biotechnology, 109(3), 227–237. https://doi.org/10.1016/j.jbiotec.2003.12.010
Identification of novel enzymes to enhance the ruminal digestion of barley straw
Bioresource Technology / Jul 01, 2018
Badhan, A., Ribeiro, G. O., Jones, D. R., Wang, Y., Abbott, D. W., Di Falco, M., Tsang, A., & McAllister, T. A. (2018). Identification of novel enzymes to enhance the ruminal digestion of barley straw. Bioresource Technology, 260, 76–84. https://doi.org/10.1016/j.biortech.2018.03.086
Role of Transglycosylation Products in the Expression of Multiple Xylanases in Myceliophthora sp. IMI 387099
Current Microbiology / May 14, 2007
Badhan, A. K., Chadha, B. S., Kaur, J., Sonia, K. G., Saini, H. S., & Bhat, M. K. (2007). Role of Transglycosylation Products in the Expression of Multiple Xylanases in Myceliophthora sp. IMI 387099. Current Microbiology, 54(6), 405–409. https://doi.org/10.1007/s00284-006-0204-5
Designer Plants for Biofuels: A Review
Current Metabolomics / Mar 02, 2016
Badhan, A., & McAllister, T. (2016). Designer Plants for Biofuels: A Review. Current Metabolomics, 4(1), 49–55. https://doi.org/10.2174/2213235x03666141226213656
Purification of the alkaliphilic xylanases from Myceliophthora sp. IMI 387099 using cellulose-binding domain as an affinity tag
World Journal of Microbiology and Biotechnology / Sep 19, 2007
Badhan, A. K., Chadha, B. S., & Saini, H. S. (2007). Purification of the alkaliphilic xylanases from Myceliophthora sp. IMI 387099 using cellulose-binding domain as an affinity tag. World Journal of Microbiology and Biotechnology, 24(7), 973–981. https://doi.org/10.1007/s11274-007-9561-x
Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses
Computational and Structural Biotechnology Journal / Jan 01, 2022
Badhan, A., Low, K. E., Jones, D. R., Xing, X., Milani, M. R. M., Polo, R. O., Klassen, L., Venketachalam, S., Hahn, M. G., Abbott, D. W., & McAllister, T. A. (2022). Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses. Computational and Structural Biotechnology Journal, 20, 148–164. https://doi.org/10.1016/j.csbj.2021.12.009
Saccharification efficiencies of multi-enzyme complexes produced by aerobic fungi
New Biotechnology / Nov 01, 2018
Badhan, A., Huang, J., Wang, Y., Abbott, D. W., Di Falco, M., Tsang, A., & McAllister, T. (2018). Saccharification efficiencies of multi-enzyme complexes produced by aerobic fungi. New Biotechnology, 46, 1–6. https://doi.org/10.1016/j.nbt.2018.05.003
Comparative analysis of functional diversity of rumen microbiome in bison and beef heifers
Applied and Environmental Microbiology / Dec 21, 2023
Nguyen, T. T. M., Badhan, A. K., Reid, I. D., Ribeiro, G., Gruninger, R., Tsang, A., Guan, L. L., & McAllister, T. (2023). Comparative analysis of functional diversity of rumen microbiome in bison and beef heifers. Applied and Environmental Microbiology, 89(12). https://doi.org/10.1128/aem.01320-23
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Elvira Forte
Scientific strategist • Senior Scientist • Senior Scientific Editor
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63 total publications
Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs
Biomaterials / Dec 01, 2011
Chimenti, I., Rizzitelli, G., Gaetani, R., Angelini, F., Ionta, V., Forte, E., Frati, G., Schussler, O., Barbetta, A., Messina, E., Dentini, M., & Giacomello, A. (2011). Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs. Biomaterials, 32(35), 9271–9281. https://doi.org/10.1016/j.biomaterials.2011.08.049
Biochemistry and biology: Heart-to-heart to investigate cardiac progenitor cells
Biochimica et Biophysica Acta (BBA) - General Subjects / Feb 01, 2013
Chimenti, I., Forte, E., Angelini, F., Messina, E., & Giacomello, A. (2013). Biochemistry and biology: Heart-to-heart to investigate cardiac progenitor cells. Biochimica et Biophysica Acta (BBA) - General Subjects, 1830(2), 2459–2469. https://doi.org/10.1016/j.bbagen.2012.08.004
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Keiran Thompson
Stanford University
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29 total publications
CH5+: Chemistry's Chameleon Unmasked
Journal of the American Chemical Society / Mar 12, 2005
Thompson, K. C., Crittenden, D. L., & Jordan, M. J. T. (2005). CH5+: Chemistry’s Chameleon Unmasked. Journal of the American Chemical Society, 127(13), 4954–4958. https://doi.org/10.1021/ja0482280
D-term scattering in the resonance Raman spectrum of C60
Journal of the American Chemical Society / Dec 01, 1994
Gallagher, S. H., Armstrong, R. S., Lay, P. A., & Reed, C. A. (1994). D-term scattering in the resonance Raman spectrum of C60. Journal of the American Chemical Society, 116(26), 12091–12092. https://doi.org/10.1021/ja00105a075
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Siddharth Maddali
Computational physicist with a specialization in X-ray and optical imaging and microscopy for condensed matter and materials systems.
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29 total publications
Comparison between diffraction contrast tomography and high-energy diffraction microscopy on a slightly deformed aluminium alloy
IUCrJ / Jan 01, 2016
Renversade, L., Quey, R., Ludwig, W., Menasche, D., Maddali, S., Suter, R. M., & Borbély, A. (2016). Comparison between diffraction contrast tomography and high-energy diffraction microscopy on a slightly deformed aluminium alloy. IUCrJ, 3(1), 32–42. https://doi.org/10.1107/s2052252515019995
Multimodal X-ray imaging of grain-level properties and performance in a polycrystalline solar cell
Journal of Synchrotron Radiation / May 14, 2019
Ulvestad, A., Hruszkewycz, S. O., Holt, M. V., Hill, M. O., Calvo-Almazán, I., Maddali, S., Huang, X., Yan, H., Nazaretski, E., Chu, Y. S., Lauhon, L. J., Rodkey, N., Bertoni, M. I., & Stuckelberger, M. E. (2019). Multimodal X-ray imaging of grain-level properties and performance in a polycrystalline solar cell. Journal of Synchrotron Radiation, 26(4), 1316–1321. https://doi.org/10.1107/s1600577519003606
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Dr. David Siderovski, Ph.D.
Professor of Computational Pharmacology; Chair of HSC SBS Dept. of Pharmacology & Neuroscience
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94 total publications
G-protein signaling: back to the future
Cellular and Molecular Life Sciences / Mar 01, 2005
McCudden, C. R., Hains, M. D., Kimple, R. J., Siderovski, D. P., & Willard, F. S. (2005). G-protein signaling: back to the future. Cellular and Molecular Life Sciences, 62(5), 551–577. https://doi.org/10.1007/s00018-004-4462-3
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
International Journal of Biological Sciences / Jan 01, 2005
Siderovski, D. P., & Willard, F. S. (2005). The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. International Journal of Biological Sciences, 51–66. https://doi.org/10.7150/ijbs.1.51
Regulators of G-Protein signalling as new central nervous system drug targets
Nature Reviews Drug Discovery / Mar 01, 2002
Neubig, R. R., & Siderovski, D. P. (2002). Regulators of G-Protein signalling as new central nervous system drug targets. Nature Reviews Drug Discovery, 1(3), 187–197. https://doi.org/10.1038/nrd747
Structural and Evolutionary Division of Phosphotyrosine Binding (PTB) Domains
Journal of Molecular Biology / Jan 01, 2005
Uhlik, M. T., Temple, B., Bencharit, S., Kimple, A. J., Siderovski, D. P., & Johnson, G. L. (2005). Structural and Evolutionary Division of Phosphotyrosine Binding (PTB) Domains. Journal of Molecular Biology, 345(1), 1–20. https://doi.org/10.1016/j.jmb.2004.10.038
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
Nature Structural Biology / May 13, 2002
Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., & Sondek, J. (2002). Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Structural Biology, 9(6), 468–475. https://doi.org/10.1038/nsb796
RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity
Journal of Biological Chemistry / Aug 01, 2001
Kimple, R. J., De Vries, L., Tronchère, H., Behe, C. I., Morris, R. A., Farquhar, M. G., & Siderovski, D. P. (2001). RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity. Journal of Biological Chemistry, 276(31), 29275–29281. https://doi.org/10.1074/jbc.m103208200
GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain
Journal of Biological Chemistry / Jul 01, 1998
Snow, B. E., Hall, R. A., Krumins, A. M., Brothers, G. M., Bouchard, D., Brothers, C. A., Chung, S., Mangion, J., Gilman, A. G., Lefkowitz, R. J., & Siderovski, D. P. (1998). GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain. Journal of Biological Chemistry, 273(28), 17749–17755. https://doi.org/10.1074/jbc.273.28.17749
Return of the GDI: The GoLoco Motif in Cell Division
Annual Review of Biochemistry / Jun 01, 2004
Willard, F. S., Kimple, R. J., & Siderovski, D. P. (2004). Return of the GDI: The GoLoco Motif in Cell Division. Annual Review of Biochemistry, 73(1), 925–951. https://doi.org/10.1146/annurev.biochem.73.011303.073756
The GoLoco motif: a Gαi/o binding motif and potential guanine-nucleotide exchange factor
Trends in Biochemical Sciences / Sep 01, 1999
Siderovski, D. P., Diversé-Pierluissi, M. A., & De Vries, L. (1999). The GoLoco motif: a Gαi/o binding motif and potential guanine-nucleotide exchange factor. Trends in Biochemical Sciences, 24(9), 340–341. https://doi.org/10.1016/s0968-0004(99)01441-3
Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits
Journal of Biological Chemistry / Dec 01, 2001
Wing, M. R., Houston, D., Kelley, G. G., Der, C. J., Siderovski, D. P., & Harden, T. K. (2001). Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits. Journal of Biological Chemistry, 276(51), 48257–48261. https://doi.org/10.1074/jbc.c100574200
Whither Goest the RGS Proteins?
Critical Reviews in Biochemistry and Molecular Biology / Jan 01, 1999
Siderovski, D. P., Strockbine, B., & Behe, C. I. (1999). Whither Goest the RGS Proteins? Critical Reviews in Biochemistry and Molecular Biology, 34(4), 215–251. https://doi.org/10.1080/10409239991209273
Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells
Journal of Biological Chemistry / Jul 01, 2002
Wang, Q., Liu, M., Mullah, B., Siderovski, D. P., & Neubig, R. R. (2002). Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells. Journal of Biological Chemistry, 277(28), 24949–24958. https://doi.org/10.1074/jbc.m203802200
PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation
Journal of Biological Chemistry / Jan 01, 2010
Nakamura, K., Kimple, A. J., Siderovski, D. P., & Johnson, G. L. (2010). PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation. Journal of Biological Chemistry, 285(3), 2077–2089. https://doi.org/10.1074/jbc.m109.065102
Molecular Cloning and Expression Analysis of RatRgs12andRgs14
Biochemical and Biophysical Research Communications / Apr 01, 1997
Snow, B. E., Antonio, L., Suggs, S., Gutstein, H. B., & Siderovski, D. P. (1997). Molecular Cloning and Expression Analysis of RatRgs12andRgs14. Biochemical and Biophysical Research Communications, 233(3), 770–777. https://doi.org/10.1006/bbrc.1997.6537
Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins
Journal of Biological Chemistry / Dec 01, 2001
Snyder, J. T., Rossman, K. L., Baumeister, M. A., Pruitt, W. M., Siderovski, D. P., Der, C. J., Lemmon, M. A., & Sondek, J. (2001). Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins. Journal of Biological Chemistry, 276(49), 45868–45875. https://doi.org/10.1074/jbc.m106731200
Crystal structure of the multifunctional Gβ5–RGS9 complex
Nature Structural & Molecular Biology / Jan 20, 2008
Cheever, M. L., Snyder, J. T., Gershburg, S., Siderovski, D. P., Harden, T. K., & Sondek, J. (2008). Crystal structure of the multifunctional Gβ5–RGS9 complex. Nature Structural & Molecular Biology, 15(2), 155–162. https://doi.org/10.1038/nsmb.1377
Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities
Journal of Molecular Biology / Aug 01, 2007
Sammond, D. W., Eletr, Z. M., Purbeck, C., Kimple, R. J., Siderovski, D. P., & Kuhlman, B. (2007). Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities. Journal of Molecular Biology, 371(5), 1392–1404. https://doi.org/10.1016/j.jmb.2007.05.096
Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange
Structure / Jul 01, 2005
Johnston, C. A., Willard, F. S., Jezyk, M. R., Fredericks, Z., Bodor, E. T., Jones, M. B., Blaesius, R., Watts, V. J., Harden, T. K., Sondek, J., Ramer, J. K., & Siderovski, D. P. (2005). Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange. Structure, 13(7), 1069–1080. https://doi.org/10.1016/j.str.2005.04.007
Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq
Journal of Biological Chemistry / Jun 01, 2001
Evanko, D. S., Thiyagarajan, M. M., Siderovski, D. P., & Wedegaertner, P. B. (2001). Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq. Journal of Biological Chemistry, 276(26), 23945–23953. https://doi.org/10.1074/jbc.m101154200
Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)
Journal of Biological Chemistry / Jul 01, 2009
Kimple, A. J., Soundararajan, M., Hutsell, S. Q., Roos, A. K., Urban, D. J., Setola, V., Temple, B. R. S., Roth, B. L., Knapp, S., Willard, F. S., & Siderovski, D. P. (2009). Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2). Journal of Biological Chemistry, 284(29), 19402–19411. https://doi.org/10.1074/jbc.m109.024711
Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif
Biochemical Journal / Mar 15, 2004
KIMPLE, R. J., WILLARD, F. S., HAINS, M. D., JONES, M. B., NWEKE, G. K., & SIDEROVSKI, D. P. (2004). Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. Biochemical Journal, 378(3), 801–808. https://doi.org/10.1042/bj20031686
D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi‐specific GoLoco motif peptides
Journal of Neurochemistry / Feb 17, 2005
Webb, C. K., McCudden, C. R., Willard, F. S., Kimple, R. J., Siderovski, D. P., & Oxford, G. S. (2005). D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi‐specific GoLoco motif peptides. Journal of Neurochemistry, 92(6), 1408–1418. Portico. https://doi.org/10.1111/j.1471-4159.2004.02997.x
G protein signaling in the parasite Entamoeba histolytica
Experimental & Molecular Medicine / Mar 22, 2013
Bosch, D. E., & Siderovski, D. P. (2013). G protein signaling in the parasite Entamoeba histolytica. Experimental & Molecular Medicine, 45(3), e15–e15. https://doi.org/10.1038/emm.2013.30
Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13
Journal of Biological Chemistry / Dec 01, 2001
Blake, B. L., Wing, M. R., Zhou, J. Y., Lei, Q., Hillmann, J. R., Behe, C. I., Morris, R. A., Harden, T. K., Bayliss, D. A., Miller, R. J., & Siderovski, D. P. (2001). Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13. Journal of Biological Chemistry, 276(52), 49267–49274. https://doi.org/10.1074/jbc.m106565200
The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics / Sep 01, 2007
Kimple, A. J., Willard, F. S., Giguère, P. M., Johnston, C. A., Mocanu, V., & Siderovski, D. P. (2007). The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1774(9), 1213–1220. https://doi.org/10.1016/j.bbapap.2007.06.002
Established and Emerging Fluorescence-Based Assays for G-Protein Function: Ras-Superfamily GTPases
Combinatorial Chemistry & High Throughput Screening / Jun 01, 2003
Rojas, R., Kimple, R., Rossman, K., Siderovski, D., & Sondek, J. (2003). Established and Emerging Fluorescence-Based Assays for G-Protein Function: Ras-Superfamily GTPases. Combinatorial Chemistry & High Throughput Screening, 6(4), 409–418. https://doi.org/10.2174/138620703106298509
Computational Design of the Sequence and Structure of a Protein-Binding Peptide
Journal of the American Chemical Society / Mar 09, 2011
Sammond, D. W., Bosch, D. E., Butterfoss, G. L., Purbeck, C., Machius, M., Siderovski, D. P., & Kuhlman, B. (2011). Computational Design of the Sequence and Structure of a Protein-Binding Peptide. Journal of the American Chemical Society, 133(12), 4190–4192. https://doi.org/10.1021/ja110296z
A direct fluorescence-based assay for RGS domain GTPase accelerating activity
Analytical Biochemistry / May 01, 2005
Willard, F. S., Kimple, A. J., Johnston, C. A., & Siderovski, D. P. (2005). A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Analytical Biochemistry, 340(2), 341–351. https://doi.org/10.1016/j.ab.2005.02.015
Integrating energy calculations with functional assays to decipher the specificity of G protein–RGS protein interactions
Nature Structural & Molecular Biology / Jun 19, 2011
Kosloff, M., Travis, A. M., Bosch, D. E., Siderovski, D. P., & Arshavsky, V. Y. (2011). Integrating energy calculations with functional assays to decipher the specificity of G protein–RGS protein interactions. Nature Structural & Molecular Biology, 18(7), 846–853. https://doi.org/10.1038/nsmb.2068
A Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding
Journal of Biological Chemistry / Dec 01, 2008
Willard, F. S., Zheng, Z., Guo, J., Digby, G. J., Kimple, A. J., Conley, J. M., Johnston, C. A., Bosch, D., Willard, M. D., Watts, V. J., Lambert, N. A., Ikeda, S. R., Du, Q., & Siderovski, D. P. (2008). A Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding. Journal of Biological Chemistry, 283(52), 36698–36710. https://doi.org/10.1074/jbc.m804936200
Minimal Determinants for Binding Activated Gα from the Structure of a Gαi1−Peptide Dimer,
Biochemistry / Aug 30, 2006
Johnston, C. A., Lobanova, E. S., Shavkunov, A. S., Low, J., Ramer, J. K., Blaesius, R., Fredericks, Z., Willard, F. S., Kuhlman, B., Arshavsky, V. Y., & Siderovski, D. P. (2006). Minimal Determinants for Binding Activated Gα from the Structure of a Gαi1−Peptide Dimer,. Biochemistry, 45(38), 11390–11400. https://doi.org/10.1021/bi0613832
Cooperative interaction between the DNA-binding domains of PU.1 and IRF4
Journal of Molecular Biology / Jun 01, 1998
Yee, A. A., Yin, P., Siderovski, D. P., Mak, T. W., Litchfield, D. W., & Arrowsmith, C. H. (1998). Cooperative interaction between the DNA-binding domains of PU.1 and IRF4. Journal of Molecular Biology, 279(5), 1075–1083. https://doi.org/10.1006/jmbi.1998.1838
Covalent immobilization of histidine-tagged proteins for surface plasmon resonance
Analytical Biochemistry / Jun 01, 2006
Willard, F. S., & Siderovski, D. P. (2006). Covalent immobilization of histidine-tagged proteins for surface plasmon resonance. Analytical Biochemistry, 353(1), 147–149. https://doi.org/10.1016/j.ab.2006.02.004
Established and Emerging Fluorescence-Based Assays for G-Protein Function: Heterotrimeric G-Protein Alpha Subunits and Regulator of G-Protein Signaling (RGS) Proteins
Combinatorial Chemistry & High Throughput Screening / Jun 01, 2003
Kimple, R., Jones, M., Shutes, A., Yerxa, B., Siderovski, D., & Willard, F. (2003). Established and Emerging Fluorescence-Based Assays for G-Protein Function: Heterotrimeric G-Protein Alpha Subunits and Regulator of G-Protein Signaling (RGS) Proteins. Combinatorial Chemistry & High Throughput Screening, 6(4), 399–407. https://doi.org/10.2174/138620703106298491
A High Throughput Fluorescence Polarization Assay for Inhibitors of the GoLoco Motif/G-alpha Interaction
Combinatorial Chemistry & High Throughput Screening / Jun 01, 2008
Kimple, A., Yasgar, A., Hughes, M., Jadhav, A., Willard, F., Muller, R., Austin, C., Inglese, J., Ibeanu, G., Siderovski, D., & Simeonov, A. (2008). A High Throughput Fluorescence Polarization Assay for Inhibitors of the GoLoco Motif/G-alpha Interaction. Combinatorial Chemistry & High Throughput Screening, 11(5), 396–409. https://doi.org/10.2174/138620708784534770
Regulator of G-protein Signaling-21 (RGS21) Is an Inhibitor of Bitter Gustatory Signaling Found in Lingual and Airway Epithelia
Journal of Biological Chemistry / Dec 01, 2012
Cohen, S. P., Buckley, B. K., Kosloff, M., Garland, A. L., Bosch, D. E., Cheng, G., Radhakrishna, H., Brown, M. D., Willard, F. S., Arshavsky, V. Y., Tarran, R., Siderovski, D. P., & Kimple, A. J. (2012). Regulator of G-protein Signaling-21 (RGS21) Is an Inhibitor of Bitter Gustatory Signaling Found in Lingual and Airway Epithelia. Journal of Biological Chemistry, 287(50), 41706–41719. https://doi.org/10.1074/jbc.m112.423806
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Martin Tsui
University of California, San Francisco
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Other Research Expertise (12)
About
Most Relevant Publications (3+)
16 total publications
The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9
ACS Synthetic Biology / Mar 20, 2017
Tsui, T. K. M., Hand, T. H., Duboy, E. C., & Li, H. (2017). The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9. ACS Synthetic Biology, 6(6), 1103–1113. https://doi.org/10.1021/acssynbio.7b00050
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes
Annual Review of Biophysics / Jun 22, 2015
Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Structure / Mar 01, 2023
Remesh, S. G., Merz, G. E., Brilot, A. F., Chio, U. S., Rizo, A. N., Pospiech, T. H., Lui, I., Laurie, M. T., Glasgow, J., Le, C. Q., Zhang, Y., Diwanji, D., Hernandez, E., Lopez, J., Mehmood, H., Pawar, K. I., Pourmal, S., Smith, A. M., Zhou, F., … Verba, K. A. (2023). Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31(3), 253-264.e6. https://doi.org/10.1016/j.str.2023.01.009
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Boris Leibovitch
Experienced wet lab and in teaching Molecular Cell biologist, geneticist, cancer biologist in Academia
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Other Research Expertise (8)
About
Most Relevant Publications (3+)
22 total publications
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor
Blood / Mar 15, 2008
Marango, J., Shimoyama, M., Nishio, H., Meyer, J. A., Min, D.-J., Sirulnik, A., Martinez-Martinez, Y., Chesi, M., Bergsagel, P. L., Zhou, M.-M., Waxman, S., Leibovitch, B. A., Walsh, M. J., & Licht, J. D. (2008). The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood, 111(6), 3145–3154. https://doi.org/10.1182/blood-2007-06-092122
Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster
Cold Spring Harbor Symposia on Quantitative Biology / Jan 01, 2004
HAYNES, K. A., LEIBOVITCH, B. A., RANGWALA, S. H., CRAIG, C., & ELGIN, S. C. R. (2004). Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster. Cold Spring Harbor Symposia on Quantitative Biology, 69(0), 267–272. https://doi.org/10.1101/sqb.2004.69.267
Mutations That Affect Ion Channels Change the Sensitivity ofDrosophila Melanogasterto Volatile Anesthetics
Journal of Neurogenetics / Jan 01, 1995
Leibovitch, B. A., Campbell, D. B., Krishnan, K. S., & Nash, H. A. (1995). Mutations That Affect Ion Channels Change the Sensitivity ofDrosophila Melanogasterto Volatile Anesthetics. Journal of Neurogenetics, 10(1), 1–13. https://doi.org/10.3109/01677069509083455
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neuroscience
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drug discovery
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otorhinolaryngology
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