Experts and Thought Leaders in Life Sciences

Dushani L. Palliyaguru, Ph.D.

Baltimore, MD, Maryland, United States of America
Toxicologist | Aging, Nutrition and Metabolism Research Scientist | Systems Biologist
Most Relevant Research Expertise
aging
Molecular Biology
Biotechnology
Toxicology
Physiology
Endocrinology, Diabetes and Metabolism
Geriatrics and Gerontology
Other Research Expertise (10)
Nutrition
Oncology
Hematology
Food Science
Biochemistry
And 5 more
About
·   Highly productive scientist with 13 years of multidisciplinary experience in toxicology, molecular nutrition, and aging/ disease biomarkers ·   Excellent communicator with proven record of advanced writing and presentation skills - manuscripts, conference presentations, and grants ·   Extensive experience in large study design, supervision and coordination, big data analysis, and management of junior scientists
Most Relevant Publications (12+)

20 total publications

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

Molecular and Cellular Biology / Feb 15, 2014

Wakabayashi, N., Skoko, J. J., Chartoumpekis, D. V., Kimura, S., Slocum, S. L., Noda, K., Palliyaguru, D. L., Fujimuro, M., Boley, P. A., Tanaka, Y., Shigemura, N., Biswal, S., Yamamoto, M., & Kensler, T. W. (2014). Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling. Molecular and Cellular Biology, 34(4), 653–663. https://doi.org/10.1128/mcb.01408-13

Isothiocyanates: Translating the Power of Plants to People

Molecular Nutrition & Food Research / Mar 26, 2018

Palliyaguru, D. L., Yuan, J.-M., Kensler, T. W., & Fahey, J. W. (2018). Isothiocyanates: Translating the Power of Plants to People. Molecular Nutrition & Food Research, 62(18), 1700965. Portico. https://doi.org/10.1002/mnfr.201700965

Withania somnifera : From prevention to treatment of cancer

Molecular Nutrition & Food Research / Jan 29, 2016

Palliyaguru, D. L., Singh, S. V., & Kensler, T. W. (2016). Withania somnifera : From prevention to treatment of cancer. Molecular Nutrition & Food Research, 60(6), 1342–1353. Portico. https://doi.org/10.1002/mnfr.201500756

Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions

Mechanisms of Ageing and Development / Jun 01, 2019

Palliyaguru, D. L., Moats, J. M., Di Germanio, C., Bernier, M., & de Cabo, R. (2019). Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions. Mechanisms of Ageing and Development, 180, 42–48. https://doi.org/10.1016/j.mad.2019.03.005

Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide

Food Additives & Contaminants: Part A / Mar 01, 2013

Palliyaguru, D. L., & Wu, F. (2013). Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide. Food Additives & Contaminants: Part A, 30(3), 534–540. https://doi.org/10.1080/19440049.2012.751630

Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice

American Journal of Physiology-Endocrinology and Metabolism / Aug 01, 2018

Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Fazzari, M., Khoo, N. K. H., Schopfer, F. J., Sipula, I., Yagishita, Y., Michalopoulos, G. K., O’Doherty, R. M., & Kensler, T. W. (2018). Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. American Journal of Physiology-Endocrinology and Metabolism, 315(2), E180–E195. https://doi.org/10.1152/ajpendo.00311.2017

Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice

Molecular Metabolism / Jul 01, 2015

Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Khoo, N. K. H., Schoiswohl, G., O’Doherty, R. M., & Kensler, T. W. (2015). Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice. Molecular Metabolism, 4(7), 543–550. https://doi.org/10.1016/j.molmet.2015.04.004

Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques

The Journals of Gerontology: Series A / Dec 18, 2020

Palliyaguru, D. L., Vieira Ligo Teixeira, C., Duregon, E., di Germanio, C., Alfaras, I., Mitchell, S. J., Navas-Enamorado, I., Shiroma, E. J., Studenski, S., Bernier, M., Camandola, S., Price, N. L., Ferrucci, L., & de Cabo, R. (2020). Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques. The Journals of Gerontology: Series A, 76(4), 552–560. https://doi.org/10.1093/gerona/glaa285

Fasting blood glucose as a predictor of mortality: Lost in translation

Cell Metabolism / Nov 01, 2021

Palliyaguru, D. L., Shiroma, E. J., Nam, J. K., Duregon, E., Vieira Ligo Teixeira, C., Price, N. L., Bernier, M., Camandola, S., Vaughan, K. L., Colman, R. J., Deighan, A., Korstanje, R., Peters, L. L., Dickinson, S. L., Ejima, K., Simonsick, E. M., Launer, L. J., Chia, C. W., Egan, J., … de Cabo, R. (2021). Fasting blood glucose as a predictor of mortality: Lost in translation. Cell Metabolism, 33(11), 2189-2200.e3. https://doi.org/10.1016/j.cmet.2021.08.013

Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet

The Journals of Gerontology: Series A / Jun 18, 2020

Palliyaguru, D. L., Minor, R. K., Mitchell, S. J., Palacios, H. H., Licata, J. J., Ward, T. M., Abulwerdi, G., Elliott, P., Westphal, C., Ellis, J. L., Sinclair, D. A., Price, N. L., Bernier, M., & de Cabo, R. (2020). Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet. The Journals of Gerontology: Series A, 75(11), 2037–2041. https://doi.org/10.1093/gerona/glaa148

Perinatal diet influences health and survival in a mouse model of leukemia

GeroScience / May 11, 2020

Palliyaguru, D. L., Rudderow, A. L., Sossong, A. M., Lewis, K. N., Younts, C., Pearson, K. J., Bernier, M., & de Cabo, R. (2020). Perinatal diet influences health and survival in a mouse model of leukemia. GeroScience, 42(4), 1147–1155. https://doi.org/10.1007/s11357-020-00199-9

Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake

Molecular Nutrition & Food Research / Nov 22, 2018

Palliyaguru, D. L., Salvatore, S. R., Schopfer, F. J., Cheng, X., Zhou, J., Kensler, T. W., & Wendell, S. G. (2018). Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake. Molecular Nutrition & Food Research, 63(3), 1801029. Portico. https://doi.org/10.1002/mnfr.201801029

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Elvira Forte

New York, New York, United States of America
Scientific strategist • Senior Scientist • Senior Scientific Editor
Most Relevant Research Expertise
Physiology
Developmental Biology
Molecular Biology
Cell Biology
Genetics
Genetics (clinical)
Medical Laboratory Technology
Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Other Research Expertise (18)
fibrosis
inflammation
cardiomyopathies
Cardiology and Cardiovascular Medicine
Physiology (medical)
And 13 more
About
Motivated and growth-driven biomedical scientist with over 15 years of experience in the cardiovascular field. Strong background in cell and molecular biology, data analysis, and interpretation. Seeking #newopportunities to deliver value as a Senior Scientist, Associate Principal Scientist, Scientific Liaison, or Scientific Consultant within a company that combines new technologies such as single-cell omics and AI for drug discovery and personalized medicine. <br> Throughout my career, I've used various in vivo and in vitro models to investigate the molecular and cellular mechanisms of fibrosis and inflammation in the heart, and how these mechanisms are affected in mice with different genetic backgrounds. My experience includes project management and mentoring. I completed three projects involving international collaborations, supervised two junior researchers, and taught cellular and molecular techniques to at least six professionals. As one of the launching editors and senior editor at Nature Cardiovascular Research, I oversaw the quality of the content published in the journal and the editorial process. I collaborated with authors, reviewers, and editors to ensure the highest standards of scientific rigor, relevance, and innovation. I also contributed to the journal's vision, strategy, and outreach, promoting the latest advances and discoveries in the cardiovascular and hematology fields. This experience has sharpened my analytical and communication skills and broadened my understanding of the field, covering a wide range of studies, from basic research to clinical, epidemiological, and public health research. My mission is to advance the knowledge and practice of cardiovascular medicine and to bridge the gap between research and clinical applications. Keywords: cardiovascular, #fibrosis, inflammation, cardioimmunology, RNA, single-cell biology, #transcriptomics, imaging, animal models, small animal surgery, and scientific writing.
Most Relevant Publications (27+)

63 total publications

Fibroblasts: Origins, definitions, and functions in health and disease

Cell / Jul 01, 2021

Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N., Biernaskie, J., & Horsley, V. (2021). Fibroblasts: Origins, definitions, and functions in health and disease. Cell, 184(15), 3852–3872. https://doi.org/10.1016/j.cell.2021.06.024

Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields

Cardiovascular Research / Feb 19, 2009

Gaetani, R., Ledda, M., Barile, L., Chimenti, I., De Carlo, F., Forte, E., Ionta, V., Giuliani, L., D’Emilia, E., Frati, G., Miraldi, F., Pozzi, D., Messina, E., Grimaldi, S., Giacomello, A., & Lisi, A. (2009). Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields. Cardiovascular Research, 82(3), 411–420. https://doi.org/10.1093/cvr/cvp067

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

Nature Communications / Jan 29, 2021

Tombor, L. S., John, D., Glaser, S. F., Luxán, G., Forte, E., Furtado, M., Rosenthal, N., Baumgarten, N., Schulz, M. H., Wittig, J., Rogg, E.-M., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Klee, K., Looso, M., Selignow, C., Acker, T., Bibli, S.-I., … Dimmeler, S. (2021). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-20905-1

Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice

Cell Reports / Mar 01, 2020

Forte, E., Skelly, D. A., Chen, M., Daigle, S., Morelli, K. A., Hon, O., Philip, V. M., Costa, M. W., Rosenthal, N. A., & Furtado, M. B. (2020). Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice. Cell Reports, 30(9), 3149-3163.e6. https://doi.org/10.1016/j.celrep.2020.02.008

Developmental origin and lineage plasticity of endogenous cardiac stem cells

Development / Apr 15, 2016

Santini, M. P., Forte, E., Harvey, R. P., & Kovacic, J. C. (2016). Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development, 143(8), 1242–1258. https://doi.org/10.1242/dev.111591

Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells

Stem Cell Research / Nov 01, 2014

Chong, J. J. H., Forte, E., & Harvey, R. P. (2014). Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells. Stem Cell Research, 13(3), 592–614. https://doi.org/10.1016/j.scr.2014.09.008

Serum and supplement optimization for EU GMP‐compliance in cardiospheres cell culture

Journal of Cellular and Molecular Medicine / Jan 20, 2014

Chimenti, I., Gaetani, R., Forte, E., Angelini, F., De Falco, E., Zoccai, G. B., Messina, E., Frati, G., & Giacomello, A. (2014). Serum and supplement optimization for <scp>EU GMP</scp>‐compliance in cardiospheres cell culture. Journal of Cellular and Molecular Medicine, 18(4), 624–634. Portico. https://doi.org/10.1111/jcmm.12210

Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application

Journal of Cellular and Molecular Medicine / May 01, 2010

Gaetani, R., Rizzitelli, G., Chimenti, I., Barile, L., Forte, E., Ionta, V., Angelini, F., Sluijter, J. P. G., Barbetta, A., Messina, E., & Frati, G. (2010). Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application. Journal of Cellular and Molecular Medicine, no-no. https://doi.org/10.1111/j.1582-4934.2010.01078.x

TGFβ-Dependent Epithelial-to-Mesenchymal Transition Is Required to Generate Cardiospheres from Human Adult Heart Biopsies

Stem Cells and Development / Nov 20, 2012

Forte, E., Miraldi, F., Chimenti, I., Angelini, F., Zeuner, A., Giacomello, A., Mercola, M., & Messina, E. (2012). TGFβ-Dependent Epithelial-to-Mesenchymal Transition Is Required to Generate Cardiospheres from Human Adult Heart Biopsies. Stem Cells and Development, 21(17), 3081–3090. https://doi.org/10.1089/scd.2012.0277

Different types of cultured human adult Cardiac Progenitor Cells have a high degree of transcriptome similarity

Journal of Cellular and Molecular Medicine / Oct 14, 2014

Gaetani, R., Feyen, D. A. M., Doevendans, P. A., Gremmels, H., Forte, E., Fledderus, J. O., Ramjankhan, F. Z., Messina, E., Sussman, M. A., Giacomello, A., & Sluijter, J. P. G. (2014). Different types of cultured human adult Cardiac Progenitor Cells have a high degree of transcriptome similarity. Journal of Cellular and Molecular Medicine, 18(11), 2147–2151. Portico. https://doi.org/10.1111/jcmm.12458

Cardiac Cell Therapy: The Next (Re)Generation

Stem Cell Reviews and Reports / Mar 25, 2011

Forte, E., Chimenti, I., Barile, L., Gaetani, R., Angelini, F., Ionta, V., Messina, E., & Giacomello, A. (2011). Cardiac Cell Therapy: The Next (Re)Generation. Stem Cell Reviews and Reports, 7(4), 1018–1030. https://doi.org/10.1007/s12015-011-9252-8

Bone marrow‐derived cells can acquire cardiac stem cells properties in damaged heart

Journal of Cellular and Molecular Medicine / Jan 01, 2011

Barile, L., Cerisoli, F., Frati, G., Gaetani, R., Chimenti, I., Forte, E., Cassinelli, L., Spinardi, L., Altomare, C., Kizana, E., Giacomello, A., Messina, E., Ottolenghi, S., & Magli, M. C. (2011). Bone marrow‐derived cells can acquire cardiac stem cells properties in damaged heart. Journal of Cellular and Molecular Medicine, 15(1), 63–71. Portico. https://doi.org/10.1111/j.1582-4934.2009.00968.x

A Chemical Biology Approach to Myocardial Regeneration

Journal of Cardiovascular Translational Research / Mar 22, 2011

Willems, E., Lanier, M., Forte, E., Lo, F., Cashman, J., & Mercola, M. (2011). A Chemical Biology Approach to Myocardial Regeneration. Journal of Cardiovascular Translational Research, 4(3), 340–350. https://doi.org/10.1007/s12265-011-9270-6

Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart

Journal of Cellular and Molecular Medicine / Nov 29, 2020

Forte, E., Panahi, M., Baxan, N., Ng, F. S., Boyle, J. J., Branca, J., Bedard, O., Hasham, M. G., Benson, L., Harding, S. E., Rosenthal, N., & Sattler, S. (2020). Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. Journal of Cellular and Molecular Medicine, 25(1), 229–243. Portico. https://doi.org/10.1111/jcmm.15937

Adult mouse fibroblasts retain organ-specific transcriptomic identity

eLife / Mar 16, 2022

Forte, E., Ramialison, M., Nim, H. T., Mara, M., Li, J. Y., Cohn, R., Daigle, S. L., Boyd, S., Stanley, E. G., Elefanty, A. G., Hinson, J. T., Costa, M. W., Rosenthal, N. A., & Furtado, M. B. (2022). Adult mouse fibroblasts retain organ-specific transcriptomic identity. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.71008

Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease

Molecular Metabolism / Feb 01, 2019

Wilmanns, J. C., Pandey, R., Hon, O., Chandran, A., Schilling, J. M., Forte, E., Wu, Q., Cagnone, G., Bais, P., Philip, V., Coleman, D., Kocalis, H., Archer, S. K., Pearson, J. T., Ramialison, M., Heineke, J., Patel, H. H., Rosenthal, N. A., Furtado, M. B., & Costa, M. W. (2019). Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Molecular Metabolism, 20, 102–114. https://doi.org/10.1016/j.molmet.2018.11.002

Continuous Subcutaneous Insulin Infusion in Italy: Third National Survey

Diabetes Technology &amp; Therapeutics / Feb 01, 2015

Bruttomesso, D., Laviola, L., Lepore, G., Bonfanti, R., Bozzetto, L., Corsi, A., Di Blasi, V., Girelli, A., Grassi, G., Iafusco, D., Rabbone, I., & Schiaffini, R. (2015). Continuous Subcutaneous Insulin Infusion in Italy: Third National Survey. Diabetes Technology &amp; Therapeutics, 17(2), 96–104. https://doi.org/10.1089/dia.2014.0242

Biochemistry and biology: Heart-to-heart to investigate cardiac progenitor cells

Biochimica et Biophysica Acta (BBA) - General Subjects / Feb 01, 2013

Chimenti, I., Forte, E., Angelini, F., Messina, E., & Giacomello, A. (2013). Biochemistry and biology: Heart-to-heart to investigate cardiac progenitor cells. Biochimica et Biophysica Acta (BBA) - General Subjects, 1830(2), 2459–2469. https://doi.org/10.1016/j.bbagen.2012.08.004

Editorial: Fibrosis and Inflammation in Tissue Pathophysiology

Frontiers in Physiology / Jan 21, 2022

Chimenti, I., Sattler, S., del Monte-Nieto, G., & Forte, E. (2022). Editorial: Fibrosis and Inflammation in Tissue Pathophysiology. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.830683

Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling

STAR Protocols / Sep 01, 2020

Forte, E., Daigle, S., & Rosenthal, N. A. (2020). Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling. STAR Protocols, 1(2), 100077. https://doi.org/10.1016/j.xpro.2020.100077

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

Nature Communications / Jul 25, 2023

Robertson, S. J., Bedard, O., McNally, K. L., Shaia, C., Clancy, C. S., Lewis, M., Broeckel, R. M., Chiramel, A. I., Shannon, J. G., Sturdevant, G. L., Rosenke, R., Anzick, S. L., Forte, E., Preuss, C., Baker, C. N., Harder, J. M., Brunton, C., Munger, S., Bruno, D. P., … Best, S. M. (2023). Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40076-5

HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice

The Journal of Immunology / Dec 15, 2023

Racine, J. J., Misherghi, A., Dwyer, J. R., Maser, R., Forte, E., Bedard, O., Sattler, S., Pugliese, A., Landry, L., Elso, C., Nakayama, M., Mannering, S., Rosenthal, N., & Serreze, D. V. (2023). HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice. The Journal of Immunology, 211(12), 1792–1805. https://doi.org/10.4049/jimmunol.2300303

Ex uno, plures–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology

International Journal of Molecular Sciences / Feb 19, 2021

Forte, E., McLellan, M. A., Skelly, D. A., & Rosenthal, N. A. (2021). Ex uno, plures–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology. International Journal of Molecular Sciences, 22(4), 2071. https://doi.org/10.3390/ijms22042071

Cardiac stem cells can be generated in damaged heart from bone marrow-derived cells

Journal of Molecular and Cellular Cardiology / Jun 01, 2007

Barile, L., Cerisoli, F., Gaetani, R., Forte, E., Ottolenghi, S., Magli, M. C., & Messina, E. (2007). Cardiac stem cells can be generated in damaged heart from bone marrow-derived cells. Journal of Molecular and Cellular Cardiology, 42(6), S100. https://doi.org/10.1016/j.yjmcc.2007.03.220

Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy

The Journal of Immunology / Mar 01, 2024

Racine, J. J., Bachman, J. F., Zhang, J.-G., Misherghi, A., Khadour, R., Kaisar, S., Bedard, O., Jenkins, C., Abbott, A., Forte, E., Rainer, P., Rosenthal, N., Sattler, S., & Serreze, D. V. (2024). Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy. The Journal of Immunology, 212(8), 1287–1306. https://doi.org/10.4049/jimmunol.2300841

Abstract 704: Profiling Differential Response to Myocardial Infarction by Single Cell Analysis of the Cardiac Interstitium

Circulation Research / Aug 02, 2019

Forte, E. (2019). Abstract 704: Profiling Differential Response to Myocardial Infarction by Single Cell Analysis of the Cardiac Interstitium. Circulation Research, 125(Suppl_1). https://doi.org/10.1161/res.125.suppl_1.704

Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts

Circulation Research / Jul 17, 2015

Forte, E., Janbandhu, V., Asli, N. S., Cornwell, J., Abeygunawardena, D., Xaymardan, M., & Harvey, R. P. (2015). Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts. Circulation Research, 117(suppl_1). https://doi.org/10.1161/res.117.suppl_1.12

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THANGASAMY SAMINATHAN

Charleston, West Virginia, United States of America
I have mix of expertise in Molecular Biology, Mapping and Functional Genomics, and Groundwater Remediation
Most Relevant Research Expertise
Genetics
Molecular biology
Biotechnology
Plant Science
Physiology
Cell Biology
Other Research Expertise (5)
Groundwater remediation
Environmental Chemistry
Pollution
Plant Breeding
Coal mine reclamation
About
Dr. Thangasamy Saminathan is a highly educated and experienced scientist with a passion for biotechnology and agriculture. He completed his PhD in Biotechnology at the prestigious Taiwan International Graduate Program at Academia Sinica in 2011. He has a diverse range of experience in the field of biotechnology and agriculture. He works as an Environmental Resource Analyst at the West Virginia Department of Environmental Protection, where he utilized his knowledge and skills to analyze and assess environmental resources. He also serves as an Associate Adjunct Faculty at West Virginia State University, teaching biotechnology and agriculture courses to students. His research experience includes a postdoctoral position at Academia Sinica, where he worked on projects related to plant biotechnology and genetics. He gained hands-on experience in plant breeding and genetics. Dr. Saminathan's education and experience have equipped him with a strong foundation in biotechnology and agriculture, and he continues to be actively involved in research and teaching in these fields. He is a dedicated scientist who is committed to finding innovative solutions to challenges in agriculture and utilizing biotechnology for sustainable development.
Most Relevant Publications (17+)

29 total publications

Single nucleotide polymorphisms generated by genotyping by sequencing to characterize genome-wide diversity, linkage disequilibrium, and selective sweeps in cultivated watermelon

BMC Genomics / Sep 08, 2014

Nimmakayala, P., Levi, A., Abburi, L., Abburi, V. L., Tomason, Y. R., Saminathan, T., Vajja, V. G., Malkaram, S., Reddy, R., Wehner, T. C., Mitchell, S. E., & Reddy, U. K. (2014). Single nucleotide polymorphisms generated by genotyping by sequencing to characterize genome-wide diversity, linkage disequilibrium, and selective sweeps in cultivated watermelon. BMC Genomics, 15(1). https://doi.org/10.1186/1471-2164-15-767

Rice SIZ1, a SUMO E3 ligase, controls spikelet fertility through regulation of anther dehiscence

New Phytologist / Nov 16, 2010

Thangasamy, S., Guo, C., Chuang, M., Lai, M., Chen, J., & Jauh, G. (2010). Rice SIZ1, a SUMO E3 ligase, controls spikelet fertility through regulation of anther dehiscence. New Phytologist, 189(3), 869–882. Portico. https://doi.org/10.1111/j.1469-8137.2010.03538.x

Metagenomic and Metatranscriptomic Analyses of Diverse Watermelon Cultivars Reveal the Role of Fruit Associated Microbiome in Carbohydrate Metabolism and Ripening of Mature Fruits

Frontiers in Plant Science / Jan 19, 2018

Saminathan, T., García, M., Ghimire, B., Lopez, C., Bodunrin, A., Nimmakayala, P., Abburi, V. L., Levi, A., Balagurusamy, N., & Reddy, U. K. (2018). Metagenomic and Metatranscriptomic Analyses of Diverse Watermelon Cultivars Reveal the Role of Fruit Associated Microbiome in Carbohydrate Metabolism and Ripening of Mature Fruits. Frontiers in Plant Science, 9. https://doi.org/10.3389/fpls.2018.00004

Genome-wide identification of microRNAs in pomegranate (Punica granatum L.) by high-throughput sequencing

BMC Plant Biology / May 26, 2016

Saminathan, T., Bodunrin, A., Singh, N. V., Devarajan, R., Nimmakayala, P., Jeff, M., Aradhya, M., & Reddy, U. K. (2016). Genome-wide identification of microRNAs in pomegranate (Punica granatum L.) by high-throughput sequencing. BMC Plant Biology, 16(1). https://doi.org/10.1186/s12870-016-0807-3

Differential gene expression and alternative splicing between diploid and tetraploid watermelon

Journal of Experimental Botany / Dec 17, 2014

Saminathan, T., Nimmakayala, P., Manohar, S., Malkaram, S., Almeida, A., Cantrell, R., Tomason, Y., Abburi, L., Rahman, M. A., Vajja, V. G., Khachane, A., Kumar, B., Rajasimha, H. K., Levi, A., Wehner, T., & Reddy, U. K. (2014). Differential gene expression and alternative splicing between diploid and tetraploid watermelon. Journal of Experimental Botany, 66(5), 1369–1385. https://doi.org/10.1093/jxb/eru486

Genetic diversity and association mapping of bacterial blight and other horticulturally important traits with microsatellite markers in pomegranate from India

Molecular Genetics and Genomics / Feb 13, 2015

Singh, N. V., Abburi, V. L., Ramajayam, D., Kumar, R., Chandra, R., Sharma, K. K., Sharma, J., Babu, K. D., Pal, R. K., Mundewadikar, D. M., Saminathan, T., Cantrell, R., Nimmakayala, P., & Reddy, U. K. (2015). Genetic diversity and association mapping of bacterial blight and other horticulturally important traits with microsatellite markers in pomegranate from India. Molecular Genetics and Genomics, 290(4), 1393–1402. https://doi.org/10.1007/s00438-015-1003-0

Genome-Wide Differentiation of Various Melon Horticultural Groups for Use in GWAS for Fruit Firmness and Construction of a High Resolution Genetic Map

Frontiers in Plant Science / Sep 22, 2016

Nimmakayala, P., Tomason, Y. R., Abburi, V. L., Alvarado, A., Saminathan, T., Vajja, V. G., Salazar, G., Panicker, G. K., Levi, A., Wechter, W. P., McCreight, J. D., Korol, A. B., Ronin, Y., Garcia-Mas, J., & Reddy, U. K. (2016). Genome-Wide Differentiation of Various Melon Horticultural Groups for Use in GWAS for Fruit Firmness and Construction of a High Resolution Genetic Map. Frontiers in Plant Science, 7. https://doi.org/10.3389/fpls.2016.01437

High-Resolution Genetic Map for Understanding the Effect of Genome-Wide Recombination Rate on Nucleotide Diversity in Watermelon

G3 Genes|Genomes|Genetics / Nov 01, 2014

Reddy, U. K., Nimmakayala, P., Levi, A., Abburi, V. L., Saminathan, T., Tomason, Y. R., Vajja, G., Reddy, R., Abburi, L., Wehner, T. C., Ronin, Y., & Karol, A. (2014). High-Resolution Genetic Map for Understanding the Effect of Genome-Wide Recombination Rate on Nucleotide Diversity in Watermelon. G3 Genes|Genomes|Genetics, 4(11), 2219–2230. https://doi.org/10.1534/g3.114.012815

A Genome-Wide Scan of Selective Sweeps and Association Mapping of Fruit Traits Using Microsatellite Markers in Watermelon

Journal of Heredity / Nov 25, 2014

Reddy, U. K., Abburi, L., Abburi, V. L., Saminathan, T., Cantrell, R., Vajja, V. G., Reddy, R., Tomason, Y. R., Levi, A., Wehner, T. C., & Nimmakayala, P. (2014). A Genome-Wide Scan of Selective Sweeps and Association Mapping of Fruit Traits Using Microsatellite Markers in Watermelon. Journal of Heredity, 106(2), 166–176. https://doi.org/10.1093/jhered/esu077

Rice LGD1 containing RNA binding activity affects growth and development through alternative promoters

The Plant Journal / May 25, 2012

Thangasamy, S., Chen, P., Lai, M., Chen, J., & Jauh, G. (2012). Rice LGD1 containing RNA binding activity affects growth and development through alternative promoters. The Plant Journal, 71(2), 288–302. Portico. https://doi.org/10.1111/j.1365-313x.2012.04989.x

Genome-Wide Divergence and Linkage Disequilibrium Analyses for Capsicum baccatum Revealed by Genome-Anchored Single Nucleotide Polymorphisms

Frontiers in Plant Science / Nov 03, 2016

Nimmakayala, P., Abburi, V. L., Saminathan, T., Almeida, A., Davenport, B., Davidson, J., Reddy, C. V. C. M., Hankins, G., Ebert, A., Choi, D., Stommel, J., & Reddy, U. K. (2016). Genome-Wide Divergence and Linkage Disequilibrium Analyses for Capsicum baccatum Revealed by Genome-Anchored Single Nucleotide Polymorphisms. Frontiers in Plant Science, 7. https://doi.org/10.3389/fpls.2016.01646

Elevated carbon dioxide and drought modulate physiology and storage-root development in sweet potato by regulating microRNAs

Functional &amp; Integrative Genomics / Sep 22, 2018

Saminathan, T., Alvarado, A., Lopez, C., Shinde, S., Gajanayake, B., Abburi, V. L., Vajja, V. G., Jagadeeswaran, G., Raja Reddy, K., Nimmakayala, P., & Reddy, U. K. (2018). Elevated carbon dioxide and drought modulate physiology and storage-root development in sweet potato by regulating microRNAs. Functional &amp; Integrative Genomics, 19(1), 171–190. https://doi.org/10.1007/s10142-018-0635-7

Genome-Wide Association Study of Natural Variation in Arabidopsis Exposed to Acid Mine Drainage Toxicity and Validation of Associated Genes with Reverse Genetics

Plants / Jan 20, 2021

Ghimire, B., Saminathan, T., Bodunrin, A., Abburi, V. L., Kshetry, A. O., Shinde, S., Nimmakayala, P., & Reddy, U. K. (2021). Genome-Wide Association Study of Natural Variation in Arabidopsis Exposed to Acid Mine Drainage Toxicity and Validation of Associated Genes with Reverse Genetics. Plants, 10(2), 191. https://doi.org/10.3390/plants10020191

Transcriptome Analysis of Cambium Tissue of Paulownia Collected during Winter and Spring

Diversity / Sep 01, 2021

Perry, Z. D., Saminathan, T., Arun, A., Vaidya, B. N., Basu, C., Reddy, U. K., & Joshee, N. (2021). Transcriptome Analysis of Cambium Tissue of Paulownia Collected during Winter and Spring. Diversity, 13(9), 423. https://doi.org/10.3390/d13090423

Stress responses and comparative transcriptome analysis of Arabidopsis thaliana ecotypes exposed to BTEX compounds

Environmental and Experimental Botany / Sep 01, 2022

Pacheco-Valenciana, A., Lopez-Ortiz, C., Natarajan, P., Saminathan, T., Nimmakayala, P., & Reddy, U. K. (2022). Stress responses and comparative transcriptome analysis of Arabidopsis thaliana ecotypes exposed to BTEX compounds. Environmental and Experimental Botany, 201, 104953. https://doi.org/10.1016/j.envexpbot.2022.104953

Northwestern Blot of Protein-RNA Interaction from Young Rice Panicles

BIO-PROTOCOL / Jan 01, 2013

Thangasamy, S., & Jauh, G.-Y. (2013). Northwestern Blot of Protein-RNA Interaction from Young Rice Panicles. BIO-PROTOCOL, 3(7). https://doi.org/10.21769/bioprotoc.625

Breeding behaviour for juice quality through selfing and progeny evaluation in hybrid clones and inbred derivatives of sugarcane (Saccharum sp.)

Sugar Tech / Sep 01, 2003

Hemaprabha, G., Natarajan, U. S., & Balasundaram, N. (2003). Breeding behaviour for juice quality through selfing and progeny evaluation in hybrid clones and inbred derivatives of sugarcane (Saccharum sp.). Sugar Tech, 5(3), 177–180. https://doi.org/10.1007/bf02943631

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Dawn Hancock

Vicksburg, Mississippi, United States of America
US Army Corps of Engineers Research and Development Center
Most Relevant Research Expertise
Biology
Microbiology
Molecular Biology
Other Research Expertise (5)
Biology, Microbiology, Molecular Biology, Toxicology, DNA, RNA
Data Analysis
Writing
Education
Artificial Intelligence
About
US Army Corps of Engineers Research and Development Center. Experienced Researcher with a demonstrated history of laboratory experience, management experience, proposal writing, and publications in the military industry. Strong research professional skilled in DNA Sequencing, Microbiology, Water Quality, Molecular Biology, Marine Biology, and Ecology.

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Brady O'Connor, Ph.D.

Columbus, Ohio, United States of America
Postdoctoral Researcher at The Ohio State University with expertise in microbiology, particularly in working with difficult and low biomass samples.
Most Relevant Research Expertise
Molecular Biology
Astrobiology
Science Communication
Other Research Expertise (9)
Environmental Microbiology
Extremophile Microbiology
Classical Microbiology
Next-Generation Sequencing
Genomic Analysis
And 4 more
About
I hold a PhD in Microbiology from McGill University and am a current Postdoctoral Fellow at The Ohio State University specializing in environmental microbiology, molecular biology, and genomic analyses. My work explores how microorganisms survive in extreme environments, with broad applications in climate science, biotechnology, and planetary exploration. Throughout my academic and research career, I have received numerous awards recognizing excellence in research and scientific communication. These honours reflect not only the quality of my work but also my commitment to delivering results that are innovative, rigorous, and impactful — qualities I bring to every client engagement. Beyond research, I have hands-on experience leading multidisciplinary projects, coordinating field expeditions in remote environments, and supporting teams with scientific writing, data analysis, and project management. I am particularly adept at designing experiments and planning sequencing projects and have extensive experience in 'omics data analysis. I am committed to delivering high-quality, actionable insights tailored to each client’s unique needs. I enjoy collaborating with partners across academia, industry, and startups to solve complex challenges, communicate scientific findings clearly, and accelerate innovation. Whether you need expert consulting, help with experimental design, scientific content development, or project management support, I bring a solution-focused approach with clear communication and a commitment to your goals. Let’s connect to see how I can help move your project forward.

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Regan Hamel

Cambridge
Senior bioinformatics scientist, specializing in single cell omics in the context of cellular reprogramming and neuroinflammation
Most Relevant Research Expertise
Cellular and Molecular Neuroscience
Cell Biology
Developmental Biology
Immunology and Allergy
Genetics
Molecular Biology
Other Research Expertise (7)
single cell biology
transcriptomics
Immunology
Drug Discovery
Pharmacology
And 2 more
About
Regan Hamel has an MPhil and PhD in Clinical Neurosciences from University of Cambridge. She also has a Bachelor of Science in Neurosciences from McGill University. Her PhD with Stefano Pluchino and John Marioni focused on single cell transcriptomics in the context of neuroinflammation. Since 2021 she has worked as a Bioinformatics scientist at Mogrify Ltd, applying a multitude of computational biology techniques (including single cell omics, bulk RNAseq, and predictive modelling) in the context of cell reprogramming
Most Relevant Publications (6+)

12 total publications

Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology

Frontiers in Cellular Neuroscience / Nov 05, 2020

Willis, C. M., Nicaise, A. M., Hamel, R., Pappa, V., Peruzzotti-Jametti, L., & Pluchino, S. (2020). Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology. Frontiers in Cellular Neuroscience, 14. https://doi.org/10.3389/fncel.2020.590960

Stem Cell Therapies for Progressive Multiple Sclerosis

Frontiers in Cell and Developmental Biology / Jul 09, 2021

Smith, J. A., Nicaise, A. M., Ionescu, R.-B., Hamel, R., Peruzzotti-Jametti, L., & Pluchino, S. (2021). Stem Cell Therapies for Progressive Multiple Sclerosis. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.696434

Metabolic Control of Smoldering Neuroinflammation

Frontiers in Immunology / Jun 23, 2021

Peruzzotti-Jametti, L., Willis, C. M., Hamel, R., Krzak, G., & Pluchino, S. (2021). Metabolic Control of Smoldering Neuroinflammation. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.705920

Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice

Molecular Therapy / Dec 01, 2020

Braga, A., Bandiera, S., Verheyen, J., Hamel, R., Rutigliani, C., Edenhofer, F., Smith, J. A., & Pluchino, S. (2020). Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice. Molecular Therapy, 28(12), 2677–2690. https://doi.org/10.1016/j.ymthe.2020.08.001

Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury

Frontiers in Immunology / Aug 24, 2022

Yao, X.-Q., Chen, J.-Y., Yu, Z.-H., Huang, Z.-C., Hamel, R., Zeng, Y.-Q., Huang, Z.-P., Tu, K.-W., Liu, J.-H., Lu, Y.-M., Zhou, Z.-T., Pluchino, S., Zhu, Q.-A., & Chen, J.-T. (2022). Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.964138

Single cell biology—a Keystone Symposia report

Annals of the New York Academy of Sciences / Oct 03, 2021

Cable, J., Elowitz, M. B., Domingos, A. I., Habib, N., Itzkovitz, S., Hamidzada, H., Balzer, M. S., Yanai, I., Liberali, P., Whited, J., Streets, A., Cai, L., Stergachis, A. B., Hong, C. K. Y., Keren, L., Guilliams, M., Alon, U., Shalek, A. K., Hamel, R., … Romeike, M. (2021). Single cell biology—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506(1), 74–97. Portico. https://doi.org/10.1111/nyas.14692

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Sarafa A. Akeem

Benin City
Lecturer and Food Researcher with fifteen peer-reviewed publications in international journal outlets.
Most Relevant Research Expertise
Molecular Biology
Microbiology
Biotechnology
Other Research Expertise (10)
Food Processing and preservation
Food Chemistry and Nutrition
Food Product Development
Food Quality Control
Food Safety
And 5 more
About
Sarafa Adeyemi Akeem is an innovative, creative, highly motivated and result-oriented Food Researcher that is open to job opportunities as well as open to both national and international collaborations in the various areas of Food Chemistry/ biochemistry, Processing, Preservation, Process Engineering, Analysis, Quality Control, Safety, Product Development, Post Harvest Technology and Nutrition with the overall aim of contributing to the global food and nutrition security.
Most Relevant Publications (3+)

11 total publications

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

Journal of Agricultural Sciences – Sri Lanka / May 01, 2017

EFFECTS OF ADDITION OF DIFFERENT SPICES ON THE QUALITY ATTRIBUTES OF TIGER-NUT MILK (KUNUN-AYA) DURING STORAGE

Journal of microbiology, biotechnology and food sciences / Aug 01, 2017

INFLUENCE OF PARTIAL SUBSTITUTION OF SUGAR WITH SERENDIPITY BERRY (DIOSCOREOPHYLLUM CUMMINSII) EXTRACT ON THE QUALITY ATTRIBUTES AND SHELF-LIFE OF WHEAT BREAD

Journal of microbiology, biotechnology and food sciences / Aug 01, 2019

Monday Ojo Kayode, R., Adunni Abiodun, O., Adeyemi Akeem, S., & Omodasola Oyeneye, H. (2019). INFLUENCE OF PARTIAL SUBSTITUTION OF SUGAR WITH SERENDIPITY BERRY (DIOSCOREOPHYLLUM CUMMINSII) EXTRACT ON THE QUALITY ATTRIBUTES AND SHELF-LIFE OF WHEAT BREAD. Journal of Microbiology, Biotechnology and Food Sciences, 9(1), 115–120. https://doi.org/10.15414/jmbfs.2019.9.1.115-120

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Dr. Hannah Actor-Engel, Ph.D.

Brooklyn, New York, United States of America
University of Colorado Anschutz
Most Relevant Research Expertise
Histology
Cell Biology
Molecular Biology
Cellular and Molecular Neuroscience
Other Research Expertise (2)
Molecular neuroscience
Anatomy
About
Biomedical scientist with Ph.D. in Neuroscience. Expertise in neuroscience, molecular biology, neurodegeneration, and fluorescence microscopy. Experienced researcher, problem-solver, and medical writer.
Most Relevant Publications (6+)

8 total publications

NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise

Brain Structure and Function / Dec 03, 2016

Chen, Y.-W., Actor-Engel, H., Sherpa, A. D., Klingensmith, L., Chowdhury, T. G., & Aoki, C. (2016). NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Structure and Function, 222(5), 2271–2294. https://doi.org/10.1007/s00429-016-1341-7

α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males

Molecular and Cellular Neuroscience / Jul 01, 2018

Chen, Y.-W., Actor-Engel, H., & Aoki, C. (2018). α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males. Molecular and Cellular Neuroscience, 90, 33–48. https://doi.org/10.1016/j.mcn.2018.04.008

Suppression of food restriction‐evoked hyperactivity in activity‐based anorexia animal model through glutamate transporters GLT‐1 at excitatory synapses in the hippocampus

Synapse / Mar 16, 2021

Bilash, O. M., Actor‐Engel, H. S., Sherpa, A. D., Chen, Y., & Aoki, C. (2021). Suppression of food restriction‐evoked hyperactivity in activity‐based anorexia animal model through glutamate transporters GLT‐1 at excitatory synapses in the hippocampus. Synapse, 75(7). Portico. https://doi.org/10.1002/syn.22197

Correction to: NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise

Brain Structure and Function / Jan 31, 2020

Chen, Y.-W., Actor-Engel, H., Sherpa, A. D., Klingensmith, L., Chowdhury, T. G., & Aoki, C. (2020). Correction to: NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Structure and Function, 225(3), 1165–1165. https://doi.org/10.1007/s00429-020-02030-9

Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses

Cell Reports / Nov 01, 2023

Olah, S. S., Kareemo, D. J., Buchta, W. C., Sinnen, B. L., Miller, C. N., Actor-Engel, H. S., Gookin, S. E., Winborn, C. S., Kleinjan, M. S., Crosby, K. C., Aoto, J., Smith, K. R., & Kennedy, M. J. (2023). Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Reports, 42(11), 113331. https://doi.org/10.1016/j.celrep.2023.113331

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release

Frontiers in Molecular Neuroscience / Aug 03, 2023

Ramsay, H. J., Gookin, S. E., Ramsey, A. M., Kareemo, D. J., Crosby, K. C., Stich, D. G., Olah, S. S., Actor-Engel, H. S., Smith, K. R., & Kennedy, M. J. (2023). AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. Frontiers in Molecular Neuroscience, 16. https://doi.org/10.3389/fnmol.2023.1232795

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Tali Reiner Brodetzki

Philadelphia , Pennsylvania, United States of America
Assistant Professor at La Salle University
Most Relevant Research Expertise
Genetics
Molecular Biology
Animal Science and Zoology
Behavioral Neuroscience
Other Research Expertise (8)
Evolution
Social insects
Behavioral ecology
Population genetics
Epigenetics
And 3 more
About
Tali Reiner Brodetzki is a highly accomplished scientist with a strong background in zoology. She received her Ph.D. in Zoology from Tel Aviv University in 2018, where she focused on the study of animal behavior and evolutionary ecology. During her graduate studies, she published several papers in top scientific journals and received numerous awards for her research. After completing her Ph.D., Tali went on to work as a Postdoctoral Fellow at both the University of Pennsylvania and Rutgers University. During this time, she continued to conduct research on animal behavior and evolution, and also gained valuable experience in teaching and mentoring students. In 2020, Tali joined the faculty at La Salle University as an Assistant Professor in the Department of Biology. She is currently conducting research on the effects of human activities on animal behavior and adaptation, and is also teaching undergraduate and graduate courses in zoology, bioinformatics, genomics, and evolutionary biology. Tali's research has been widely recognized and she has received numerous grants and awards, including the prestigious European Molecular Biology Organisation's postdoctoral award. She is also a member of several professional organizations, including the Society for Integrative and Comparative Biology and the Animal Behavior Society. In addition to her academic and research accomplishments, Tali is also passionate about science outreach and communication. She regularly presents her research at conferences and seminars, and also participates in science fairs and other community events. She is dedicated to inspiring the next generation of scientists and promoting the importance of studying and protecting our natural world. Overall, Tali Reiner Brodetzki is a highly skilled and dedicated scientist who is making significant contributions to the field of zoology. Her education and experience have prepared her to continue making important discoveries and advancements in the study of animal behavior and evolution.
Most Relevant Publications (3+)

9 total publications

An integrative approach to untangling species delimitation in the Cataglyphis bicolor desert ant complex in Israel

Molecular Phylogenetics and Evolution / Oct 01, 2017

Eyer, P. A., Seltzer, R., Reiner-Brodetzki, T., & Hefetz, A. (2017). An integrative approach to untangling species delimitation in the Cataglyphis bicolor desert ant complex in Israel. Molecular Phylogenetics and Evolution, 115, 128–139. https://doi.org/10.1016/j.ympev.2017.07.024

Lack of subspecies-recognition in breeding Barn Swallows (Hirundo rustica transitiva)

Behavioural Processes / Aug 01, 2021

Reiner Brodetzki, T., Lotem, A., Safran, R. J., & Hauber, M. E. (2021). Lack of subspecies-recognition in breeding Barn Swallows (Hirundo rustica transitiva). Behavioural Processes, 189, 104422. https://doi.org/10.1016/j.beproc.2021.104422

Worker demography and behavior in a supercolonial ant colony: The case of the desert ant Cataglyphis niger

Ethology / Oct 09, 2019

Reiner Brodetzki, T., Brodetzki, G., Feinerman, O., & Hefetz, A. (2019). Worker demography and behavior in a supercolonial ant colony: The case of the desert ant Cataglyphis niger. Ethology, 126(1), 59–67. Portico. https://doi.org/10.1111/eth.12960

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Martin Tsui

San Francisco, California, United States of America
University of California, San Francisco
Most Relevant Research Expertise
Molecular Biology
Cell Biology
Other Research Expertise (14)
Biochemistry
Structural Biology
Cryo-EM
CRISPR
Molecular Assembly and Interaction
And 9 more
About
Martin Tsui is an accomplished scientist with a strong background in biochemistry. He received his Ph.D. in Molecular Biophysics from Florida State University in 2017, where he conducted research on the structure and function of CRISPR proteins. Prior to that, he obtained his B.S. in Chemistry from the University of California, San Diego in 2012. After completing his graduate studies, Martin founded his own company, Stealth, where he serves as a Founder & CEO. Under his leadership, the company has developed innovative solutions for the biotech industry and has gained recognition for its groundbreaking research. Before starting his company, Martin worked as a Senior Scientist at Amazon, where he applied his expertise in protein biochemistry and CRISPR to improve the company's product development processes and creating new products. He also gained valuable experience as a Postdoctoral Scholar at the University of California, San Francisco and Postdoctoral Fellow at the Van Andel Institute, where he studied cancer proteins, SARS-CoV-2, HIV proteins, and the role of proteins in neurodegenerative diseases, respectively. Martin is a highly driven and passionate individual who is dedicated to advancing the field of biotechnology. His impressive education and diverse experience have equipped him with the skills and knowledge to make significant contributions to the scientific community. He continues to pursue new opportunities to further his research and make a positive impact in the world of science.
Most Relevant Publications (4+)

16 total publications

Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification

Briefings in Bioinformatics / Sep 11, 2020

Khan, A. A., & Khan, Z. (2020). Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification. Briefings in Bioinformatics, 22(2), 1206–1214. https://doi.org/10.1093/bib/bbaa207

Structure Principles of CRISPR-Cas Surveillance and Effector Complexes

Annual Review of Biophysics / Jun 22, 2015

Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

Structure / Mar 01, 2023

Remesh, S. G., Merz, G. E., Brilot, A. F., Chio, U. S., Rizo, A. N., Pospiech, T. H., Lui, I., Laurie, M. T., Glasgow, J., Le, C. Q., Zhang, Y., Diwanji, D., Hernandez, E., Lopez, J., Mehmood, H., Pawar, K. I., Pourmal, S., Smith, A. M., Zhou, F., … Verba, K. A. (2023). Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31(3), 253-264.e6. https://doi.org/10.1016/j.str.2023.01.009

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Nature Chemical Biology / Oct 20, 2020

Bracken, C. J., Lim, S. A., Solomon, P., Rettko, N. J., Nguyen, D. P., Zha, B. S., Schaefer, K., Byrnes, J. R., Zhou, J., Lui, I., Liu, J., Pance, K., Azumaya, C. M., Braxton, J. R., Brilot, A. F., Gupta, M., Li, F., Lopez, K. E., … Melo, A. (2020). Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nature Chemical Biology, 17(1), 113–121. https://doi.org/10.1038/s41589-020-00679-1

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Xiaolei Wang

Raleigh, North Carolina, United States of America
R&D Scientist in biomedical imaging and surgical microscope development
Most Relevant Research Expertise
Biotechnology
Molecular Biology
Developmental Biology
Other Research Expertise (17)
Optical imaging system development
image analysis algorithm development
Atomic and Molecular Physics, and Optics
Mechanics of Materials
Mechanical Engineering
And 12 more
About
I am an R&D Optical Scientist and Expert specializing in Optical Imaging and Optical Microscope Development for biomedical and clinical applications. With a background in Physics and over 15 years of experience in optical science and imaging, I am passionate about pushing the boundaries of what light can achieve in the realm of medicine and healthcare. My journey in the world of optics has led me to become a leader in the research and development of next-generation optical imaging products that have a profound impact on surgical procedures and patient outcomes. My areas of expertise encompass optical physics, optical microscopy, optical metrology, photonics, and computational modeling and simulation. I've had the privilege of sharing my insights through multiple peer-reviewed publications in prestigious journals like ACS Nano, Optical Letter, and Advanced Materials. Additionally, I hold certifications in machine learning and deep learning for image analysis, allowing me to harness the power of cutting-edge technology in my work.
Most Relevant Publications (2+)

33 total publications

Computational multifocal microscopy

Biomedical Optics Express / Nov 28, 2018

He, K., Wang, Z., Huang, X., Wang, X., Yoo, S., Ruiz, P., Gdor, I., Selewa, A., Ferrier, N. J., Scherer, N., Hereld, M., Katsaggelos, A. K., & Cossairt, O. (2018). Computational multifocal microscopy. Biomedical Optics Express, 9(12), 6477. https://doi.org/10.1364/boe.9.006477

DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning

Development / Nov 01, 2022

Haertter, D., Wang, X., Fogerson, S. M., Ramkumar, N., Crawford, J. M., Poss, K. D., Di Talia, S., Kiehart, D. P., & Schmidt, C. F. (2022). DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning. Development, 149(21). https://doi.org/10.1242/dev.200621

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Odion Ikhimiukor

Albany, New York, United States of America
Postdoctoral Research Scientist at University at Albany, State University of New York
Most Relevant Research Expertise
Bioinformatics
Molecular Biology
Cell Biology
Microbiology
Applied Microbiology and Biotechnology
Genetics
Microbiology (medical)
Animal Science and Zoology
Physiology
Other Research Expertise (15)
Pathogen Genomics
Epidemiology
Environmental Microbiology
Immunology
Pollution
And 10 more
About
A postdoctoral research scientist with over 9 years experience in bacterial genomics, microbiology, bioinformatics and antimicrobial resistance research. I’m seeking a Research Scientist or Epidemiologist role at public health genomics laboratories and I am the perfect fit for these roles because I have the following skills: molecular biology, research & development, strategic planning, project management, documentation, outbreak investigation, and cross-functional collaboration skills. I have leveraged my skills to work in a collaborative team-oriented environment to accomplish project goals related to examining the evolution of antimicrobial resistance as evidenced by over 7 national and international collaborations including the New York State Department of Health. I am also a proactive problem-solver adopting innovative and scientific thinking strategies in molecular biology to fulfill project objectives resulting in scientific discoveries including uncovering 1 novel hotspot for the dissemination of resistance in bacteria. I have gained mentorship expertise in promoting data reproducibility, and innovative research methodology in antimicrobial resistance research as evidenced by mentoring 10 professionals on evolutionary genomics, epidemiological statistics, and antimicrobial stewardship. I have also worked collaboratively with a team to apply pathogen genomics, bioinformatics, and leadership skills as demonstrated by working with over 10 highly collaborative teams including the Africa CDC. In addition, I have the following qualifications: Cross-functional collaborator and experience elucidating methods and frequencies of horizontal gene transfer and antimicrobial resistance spread in bacterial species, as demonstrated by 26 peer-reviewed publications including 1 in Nature Microbiology. Experience in leading and managing project details and tasks as evidenced by over 20 projects in pathogen genomics, epidemiology, antimicrobial resistance surveillance, and global health. Astute communication skills in bacterial epidemiology and antimicrobial resistance research resulting in 20 presentations and 6 travel awards to deliver such presentations, including the Bill and Melinda Gates Foundation. I want to serve an organization that prizes community, collaboration and humility among its employees. I’m excited to be on a team built around impact, innovation and a strong, positive reputation. I know I will thrive at a company where responsibility is valued, as well as self-improvement and time-management. I want to be a part of an organization that infuses growth into their brand, culture and market and who I can help make a difference in the world.
Most Relevant Publications (10+)

27 total publications

A bottom-up view of antimicrobial resistance transmission in developing countries

Nature Microbiology / May 30, 2022

Ikhimiukor, O. O., Odih, E. E., Donado-Godoy, P., & Okeke, I. N. (2022). A bottom-up view of antimicrobial resistance transmission in developing countries. Nature Microbiology, 7(6), 757–765. https://doi.org/10.1038/s41564-022-01124-w

A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex

Nature Communications / Jul 07, 2021

Lam, M. M. C., Wick, R. R., Watts, S. C., Cerdeira, L. T., Wyres, K. L., & Holt, K. E. (2021). A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24448-3

Evolutionary dynamics of the accessory genomes of Staphylococcus aureus

mSphere / Mar 19, 2024

Piper, K. R., Ikhimiukor, O. O., Souza, S. S. R., Garcia-Aroca, T., & Andam, C. P. (2024). Evolutionary dynamics of the accessory genomes of Staphylococcus aureus. MSphere. https://doi.org/10.1128/msphere.00751-23

Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales

Microbiology Spectrum / Oct 17, 2023

Ikhimiukor, O. O., Souza, S. S. R., Akintayo, I. J., Marcovici, M. M., Workman, A., Martin, I. W., & Andam, C. P. (2023). Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales. Microbiology Spectrum, 11(5). https://doi.org/10.1128/spectrum.00549-23

Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species

Communications Biology / May 03, 2023

Ikhimiukor, O. O., Souza, S. S. R., Marcovici, M. M., Nye, G. J., Gibson, R., & Andam, C. P. (2023). Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species. Communications Biology, 6(1). https://doi.org/10.1038/s42003-023-04877-0

Genome Sequencing of Methicillin-Resistant and Methicillin-Susceptible Mammaliicoccus sciuri from Diseased Animals

Microbiology Resource Announcements / Oct 20, 2022

Garcia-Aroca, T., Souza, S. S. R., Ikhimiukor, O. O., Marcovici, M. M., Smith, J. T., Amador, S., McGonagle, C. J., Nye, G. J., Needle, D. B., Gibson, R., & Andam, C. P. (2022). Genome Sequencing of Methicillin-Resistant and Methicillin-Susceptible Mammaliicoccus sciuri from Diseased Animals. Microbiology Resource Announcements, 11(10). https://doi.org/10.1128/mra.00714-22

Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria’s experience

Microbiology / Sep 22, 2022

Okeke, I. N., Aboderin, A. O., Egwuenu, A., Underwood, A., Afolayan, A. O., Kekre, M., Oaikhena, A. O., Odih, E. E., Omotayo, H. T., Dada-Adegbola, H., Ogunleye, V. O., Ikhimiukor, O. O., Aanensen, D. M., & Ihekweazu, C. (2022). Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria’s experience. Microbiology, 168(8). https://doi.org/10.1099/mic.0.001208

Draft Genome Sequences of Multidrug-Resistant Shiga Toxin-Producing Escherichia coli O116:H25 Strains from Ready-to-Eat Foods Sold in Lagos, Nigeria

Microbiology Resource Announcements / Aug 18, 2022

Makinde, O. M., Van Wyk, D., Ikhimiukor, O. O., Bezuidenhout, C., Adeleke, R. A., & Ezekiel, C. N. (2022). Draft Genome Sequences of Multidrug-Resistant Shiga Toxin-Producing Escherichia coli O116:H25 Strains from Ready-to-Eat Foods Sold in Lagos, Nigeria. Microbiology Resource Announcements, 11(8). https://doi.org/10.1128/mra.00314-22

Genetic variation and cryptic lineage diversity of the Nigerian red-headed rock agama Agama agama associate with eco-geographic zones

Current Zoology / Mar 08, 2019

Nneji, L. M., Adeola, A. C., Yan, F., Okeyoyin, A. O., Oladipo, O. C., Saidu, Y., Samuel, D., Nneji, I. C., Adeyi, A. O., Onadeko, A. B., Olagunju, T. E., Omotoso, O., Oladipo, S. O., Iyiola, O. A., Usongo, J. Y., Auta, T., Usman, A. D., Abdullahi, H., Ikhimiukor, O. O., … Che, J. (2019). Genetic variation and cryptic lineage diversity of the Nigerian red-headed rock agama Agama agama associate with eco-geographic zones. Current Zoology, 65(6), 713–724. https://doi.org/10.1093/cz/zoz002

Selective metal accumulation by metal-resistant bacteria growing on spent engine oil in single and ternary metal mixtures

International Journal of Environmental Science and Technology / Dec 08, 2018

Ikhimiukor, O. O., & Adelowo, O. O. (2018). Selective metal accumulation by metal-resistant bacteria growing on spent engine oil in single and ternary metal mixtures. International Journal of Environmental Science and Technology, 16(8), 4945–4954. https://doi.org/10.1007/s13762-018-2137-5

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Boris Leibovitch

New York, New York, United States of America
Experienced wet lab and in teaching Molecular Cell biologist, geneticist, cancer biologist in Academia
Most Relevant Research Expertise
Cell Biology
Developmental Biology
Molecular Biology
Genetics
Other Research Expertise (5)
Cancer Research
Hematology
Immunology
Biochemistry
Oncology
About
I am experienced molecular and cell biologist with deep genetics background who worked many years in USA and Russia on the bench and as teacher. Both types of work had demanded extremely broad knowledge and understanding of developments in the fields. Participation in grant writing, editorial/reviewer work for scientific journals and consulting colleagues on these subjects added a lot to my broad experience as the scientist.
Most Relevant Publications (13+)

22 total publications

Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors

Developmental Biology / Jan 01, 2011

Marzan, C. V., Kupumbati, T. S., Bertran, S. P., Samuels, T., Leibovitch, B., Mira-y-Lopez, R., Ossowski, L., & Farias, E. F. (2011). Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors. Developmental Biology, 349(2), 125–136. https://doi.org/10.1016/j.ydbio.2010.10.018

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

Blood / Mar 15, 2008

Marango, J., Shimoyama, M., Nishio, H., Meyer, J. A., Min, D.-J., Sirulnik, A., Martinez-Martinez, Y., Chesi, M., Bergsagel, P. L., Zhou, M.-M., Waxman, S., Leibovitch, B. A., Walsh, M. J., & Licht, J. D. (2008). The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood, 111(6), 3145–3154. https://doi.org/10.1182/blood-2007-06-092122

Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster

Cold Spring Harbor Symposia on Quantitative Biology / Jan 01, 2004

HAYNES, K. A., LEIBOVITCH, B. A., RANGWALA, S. H., CRAIG, C., & ELGIN, S. C. R. (2004). Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster. Cold Spring Harbor Symposia on Quantitative Biology, 69(0), 267–272. https://doi.org/10.1101/sqb.2004.69.267

GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter

Molecular and Cellular Biology / Sep 01, 2002

Leibovitch, B. A., Lu, Q., Benjamin, L. R., Liu, Y., Gilmour, D. S., & Elgin, S. C. R. (2002). GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter. Molecular and Cellular Biology, 22(17), 6148–6157. https://doi.org/10.1128/mcb.22.17.6148-6157.2002

A heat-shock-activated cDNA encoding GAGA factor rescues some lethal mutations in the Drosophila melanogaster Trithorax-like gene

Genetical Research / Aug 01, 2001

GRANOK, H., LEIBOVITCH, B. A., & ELGIN, S. C. R. (2001). A heat-shock-activated cDNA encoding GAGA factor rescues some lethal mutations in the Drosophila melanogaster Trithorax-like gene. Genetical Research, 78(1), 13–21. https://doi.org/10.1017/s0016672301005122

Chromatin organization and transcriptional control of gene expression in Drosophila

Gene / Aug 01, 2000

Farkas, G., Leibovitch, B. A., & Elgin, S. C. R. (2000). Chromatin organization and transcriptional control of gene expression in Drosophila. Gene, 253(2), 117–136. https://doi.org/10.1016/s0378-1119(00)00240-7

Chromatin: Ga-ga over GAGA factor

Current Biology / Mar 01, 1995

Granok, H., Leibovitch, B. A., Shaffer, C. D., & Elgin, S. C. R. (1995). Chromatin: Ga-ga over GAGA factor. Current Biology, 5(3), 238–241. https://doi.org/10.1016/s0960-9822(95)00048-0

Mutations That Affect Ion Channels Change the Sensitivity ofDrosophila Melanogasterto Volatile Anesthetics

Journal of Neurogenetics / Jan 01, 1995

Leibovitch, B. A., Campbell, D. B., Krishnan, K. S., & Nash, H. A. (1995). Mutations That Affect Ion Channels Change the Sensitivity ofDrosophila Melanogasterto Volatile Anesthetics. Journal of Neurogenetics, 10(1), 1–13. https://doi.org/10.3109/01677069509083455

Telomeres and P-element of Drosophila melanogaster contain sequences that replicate autonomously in Saccharomyces cerevisiae

Molecular and General Genetics MGG / Nov 01, 1984

Danilevskaya, O. N., Kurenova, E. V., Leibovitch, B. A., Shevelev, A. Ya., Bass, I. A., & Khesin, R. B. (1984). Telomeres and P-element of Drosophila melanogaster contain sequences that replicate autonomously in Saccharomyces cerevisiae. Molecular and General Genetics MGG, 197(2), 342–344. https://doi.org/10.1007/bf00330983

Increase in the number of histone genes in case of their deficiency in Drosophila melanogaster

Molecular and General Genetics MGG / Jul 01, 1980

Chernyshev, A. I., Bashkirov, V. N., Leibovitch, B. A., & Khesin, R. B. (1980). Increase in the number of histone genes in case of their deficiency in Drosophila melanogaster. Molecular and General Genetics MGG, 178(3), 663–668. https://doi.org/10.1007/bf00337876

Influence of deficiency of the histone gene-containing 38B-40 region on X-chromosome template activity and the White gene position effect variegation in Drosophila melanogaster

Molecular and General Genetics MGG / Jan 01, 1978

Khesin, R. B., & Leibovitch, B. A. (1978). Influence of deficiency of the histone gene-containing 38B-40 region on X-chromosome template activity and the White gene position effect variegation in Drosophila melanogaster. Molecular and General Genetics MGG, 162(3), 323–328. https://doi.org/10.1007/bf00268858

Comparison of in vivo and in vitro RNA synthesis on polytene chromosomes of Drosophila

Chromosoma / Jan 01, 1976

Leibovitch, B. A., Belyaeva, E. S., Zhimulev, I. F., & Khesin, R. B. (1976). Comparison of in vivo and in vitro RNA synthesis on polytene chromosomes of Drosophila. Chromosoma, 54(4), 349–362. https://doi.org/10.1007/bf00292815

Synthesis of RNA by Escherichia coli RNA polymerase on the chromosomes of Drosophila melanogaster

Chromosoma / Jan 01, 1974

Khesin, R. B., & Leibovitch, B. A. (1974). Synthesis of RNA by Escherichia coli RNA polymerase on the chromosomes of Drosophila melanogaster. Chromosoma, 46(2), 161–172. https://doi.org/10.1007/bf00332514

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Luca Delfinis

Toronto, Ontario, Canada
PhD candidate in physiology researching the mechanisms that drive muscle dysfunction in cancer
Most Relevant Research Expertise
Physiology
Cell Biology
Other Research Expertise (1)
Physiology (medical)
About
Luca Delfinis is a PhD candidate at York University where his research focuses on muscle dysfunction in cancer. Luca has been a part of several research collaborations both nationally and internationally throughout his PhD that has helped him gain unique perspectives in physiology, especially in the context of metabolism. He has also presented at several conferences where he has discussed data with leaders in cachexia, metabolism, exercise and more.
Most Relevant Publications (2+)

4 total publications

Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation

Journal of Cachexia, Sarcopenia and Muscle / Apr 02, 2019

Hughes, M. C., Ramos, S. V., Turnbull, P. C., Rebalka, I. A., Cao, A., Monaco, C. M. F., Varah, N. E., Edgett, B. A., Huber, J. S., Tadi, P., Delfinis, L. J., Schlattner, U., Simpson, J. A., Hawke, T. J., & Perry, C. G. R. (2019). Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation. Journal of Cachexia, Sarcopenia and Muscle, 10(3), 643–661. Portico. https://doi.org/10.1002/jcsm.12405

Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime

American Journal of Physiology-Cell Physiology / May 01, 2023

Bellissimo, C. A., Delfinis, L. J., Hughes, M. C., Turnbull, P. C., Gandhi, S., DiBenedetto, S. N., Rahman, F. A., Tadi, P., Amaral, C. A., Dehghani, A., Cobley, J. N., Quadrilatero, J., Schlattner, U., & Perry, C. G. R. (2023). Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime. American Journal of Physiology-Cell Physiology, 324(5), C1141–C1157. https://doi.org/10.1152/ajpcell.00377.2022

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