Experts and Thought Leaders in Life Sciences
Martin Tsui
University of California, San Francisco
Education
Florida State University
Ph.D., Molecular Biophysics / July, 2017
University of California, San Diego
B.S., Chemistry / June, 2012
Experience
Stealth
Founder & CEO / January, 2023 — Present
Genome engineering
Amazon
Senior Scientist / December, 2021 — February, 2023
Molecular Diagnostics
Van Andel Institute
Postdoctoral Fellow / September, 2020 — April, 2021
Cryo-EM of membrane proteins
Most Relevant Research Expertise
Other Research Expertise (14)
About
Most Relevant Publications (4+)
16 total publications
Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification
Briefings in Bioinformatics / Sep 11, 2020
Khan, A. A., & Khan, Z. (2020). Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification. Briefings in Bioinformatics, 22(2), 1206–1214. https://doi.org/10.1093/bib/bbaa207
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes
Annual Review of Biophysics / Jun 22, 2015
Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Structure / Mar 01, 2023
Remesh, S. G., Merz, G. E., Brilot, A. F., Chio, U. S., Rizo, A. N., Pospiech, T. H., Lui, I., Laurie, M. T., Glasgow, J., Le, C. Q., Zhang, Y., Diwanji, D., Hernandez, E., Lopez, J., Mehmood, H., Pawar, K. I., Pourmal, S., Smith, A. M., Zhou, F., … Verba, K. A. (2023). Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31(3), 253-264.e6. https://doi.org/10.1016/j.str.2023.01.009
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2
Nature Chemical Biology / Oct 20, 2020
Bracken, C. J., Lim, S. A., Solomon, P., Rettko, N. J., Nguyen, D. P., Zha, B. S., Schaefer, K., Byrnes, J. R., Zhou, J., Lui, I., Liu, J., Pance, K., Azumaya, C. M., Braxton, J. R., Brilot, A. F., Gupta, M., Li, F., Lopez, K. E., … Melo, A. (2020). Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nature Chemical Biology, 17(1), 113–121. https://doi.org/10.1038/s41589-020-00679-1
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Xiaolei Wang
R&D Scientist in biomedical imaging and surgical microscope development
Education
University of Science and Technology of China
Ph.D., Optics / June, 2011
Anhui Normal University
Bachelor, Physics / July, 2006
Experience
Duke University
Research Scientist/Manager / June, 2019 — May, 2022
University of Chicago
Research Professional / April, 2016 — May, 2019
True Digital Surgery
Principal R&D Scientist / July, 2022 — January, 2024
Most Relevant Research Expertise
Other Research Expertise (17)
About
Most Relevant Publications (2+)
33 total publications
Computational multifocal microscopy
Biomedical Optics Express / Nov 28, 2018
He, K., Wang, Z., Huang, X., Wang, X., Yoo, S., Ruiz, P., Gdor, I., Selewa, A., Ferrier, N. J., Scherer, N., Hereld, M., Katsaggelos, A. K., & Cossairt, O. (2018). Computational multifocal microscopy. Biomedical Optics Express, 9(12), 6477. https://doi.org/10.1364/boe.9.006477
DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning
Development / Nov 01, 2022
Haertter, D., Wang, X., Fogerson, S. M., Ramkumar, N., Crawford, J. M., Poss, K. D., Di Talia, S., Kiehart, D. P., & Schmidt, C. F. (2022). DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning. Development, 149(21). https://doi.org/10.1242/dev.200621
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Odion Ikhimiukor
Postdoctoral Research Scientist at University at Albany, State University of New York
Education
University of Ibadan
PhD Microbiology, Bacterial genomics, Bioinformatics, Microbiology
University of Ibadan
Master of Science (M. Sc.), Environmental Microbiology / April, 2015
University of Abuja
Bachelor of Science (B.Sc.), Microbiology / March, 2011
Experience
University at Albany, State University of New York
Postdoctoral Associate
National Institute for Pharmaceutical Research and Development
FCT Emergency Services, Asokoro District Hospital
Most Relevant Research Expertise
Other Research Expertise (15)
About
Most Relevant Publications (10+)
27 total publications
A bottom-up view of antimicrobial resistance transmission in developing countries
Nature Microbiology / May 30, 2022
Ikhimiukor, O. O., Odih, E. E., Donado-Godoy, P., & Okeke, I. N. (2022). A bottom-up view of antimicrobial resistance transmission in developing countries. Nature Microbiology, 7(6), 757–765. https://doi.org/10.1038/s41564-022-01124-w
A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex
Nature Communications / Jul 07, 2021
Lam, M. M. C., Wick, R. R., Watts, S. C., Cerdeira, L. T., Wyres, K. L., & Holt, K. E. (2021). A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24448-3
Evolutionary dynamics of the accessory genomes of Staphylococcus aureus
mSphere / Mar 19, 2024
Piper, K. R., Ikhimiukor, O. O., Souza, S. S. R., Garcia-Aroca, T., & Andam, C. P. (2024). Evolutionary dynamics of the accessory genomes of Staphylococcus aureus. MSphere. https://doi.org/10.1128/msphere.00751-23
Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales
Microbiology Spectrum / Oct 17, 2023
Ikhimiukor, O. O., Souza, S. S. R., Akintayo, I. J., Marcovici, M. M., Workman, A., Martin, I. W., & Andam, C. P. (2023). Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales. Microbiology Spectrum, 11(5). https://doi.org/10.1128/spectrum.00549-23
Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species
Communications Biology / May 03, 2023
Ikhimiukor, O. O., Souza, S. S. R., Marcovici, M. M., Nye, G. J., Gibson, R., & Andam, C. P. (2023). Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species. Communications Biology, 6(1). https://doi.org/10.1038/s42003-023-04877-0
Genome Sequencing of Methicillin-Resistant and Methicillin-Susceptible Mammaliicoccus sciuri from Diseased Animals
Microbiology Resource Announcements / Oct 20, 2022
Garcia-Aroca, T., Souza, S. S. R., Ikhimiukor, O. O., Marcovici, M. M., Smith, J. T., Amador, S., McGonagle, C. J., Nye, G. J., Needle, D. B., Gibson, R., & Andam, C. P. (2022). Genome Sequencing of Methicillin-Resistant and Methicillin-Susceptible Mammaliicoccus sciuri from Diseased Animals. Microbiology Resource Announcements, 11(10). https://doi.org/10.1128/mra.00714-22
Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria’s experience
Microbiology / Sep 22, 2022
Okeke, I. N., Aboderin, A. O., Egwuenu, A., Underwood, A., Afolayan, A. O., Kekre, M., Oaikhena, A. O., Odih, E. E., Omotayo, H. T., Dada-Adegbola, H., Ogunleye, V. O., Ikhimiukor, O. O., Aanensen, D. M., & Ihekweazu, C. (2022). Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria’s experience. Microbiology, 168(8). https://doi.org/10.1099/mic.0.001208
Draft Genome Sequences of Multidrug-Resistant Shiga Toxin-Producing Escherichia coli O116:H25 Strains from Ready-to-Eat Foods Sold in Lagos, Nigeria
Microbiology Resource Announcements / Aug 18, 2022
Makinde, O. M., Van Wyk, D., Ikhimiukor, O. O., Bezuidenhout, C., Adeleke, R. A., & Ezekiel, C. N. (2022). Draft Genome Sequences of Multidrug-Resistant Shiga Toxin-Producing Escherichia coli O116:H25 Strains from Ready-to-Eat Foods Sold in Lagos, Nigeria. Microbiology Resource Announcements, 11(8). https://doi.org/10.1128/mra.00314-22
Genetic variation and cryptic lineage diversity of the Nigerian red-headed rock agama Agama agama associate with eco-geographic zones
Current Zoology / Mar 08, 2019
Nneji, L. M., Adeola, A. C., Yan, F., Okeyoyin, A. O., Oladipo, O. C., Saidu, Y., Samuel, D., Nneji, I. C., Adeyi, A. O., Onadeko, A. B., Olagunju, T. E., Omotoso, O., Oladipo, S. O., Iyiola, O. A., Usongo, J. Y., Auta, T., Usman, A. D., Abdullahi, H., Ikhimiukor, O. O., … Che, J. (2019). Genetic variation and cryptic lineage diversity of the Nigerian red-headed rock agama Agama agama associate with eco-geographic zones. Current Zoology, 65(6), 713–724. https://doi.org/10.1093/cz/zoz002
Selective metal accumulation by metal-resistant bacteria growing on spent engine oil in single and ternary metal mixtures
International Journal of Environmental Science and Technology / Dec 08, 2018
Ikhimiukor, O. O., & Adelowo, O. O. (2018). Selective metal accumulation by metal-resistant bacteria growing on spent engine oil in single and ternary metal mixtures. International Journal of Environmental Science and Technology, 16(8), 4945–4954. https://doi.org/10.1007/s13762-018-2137-5
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Dushani L. Palliyaguru, Ph.D.
Toxicologist | Aging, Nutrition and Metabolism Research Scientist | Systems Biologist
Education
University of Pittsburgh
Ph.D., Environmental and Occupational Health (Toxicology) / May, 2016
Clark University
B.A., Biochemistry and Molecular Biology, Mathematics / May, 2009
Experience
National Institute on Aging Intramural Research Program, Translational Gerontology Branch
IRTA Postdoctoral Fellow, K99/R00 Grant Recipient / September, 2018 — Present
-Leading, managing and coordinating large population longitudinal studies within US Federal Government and Industry partnerships - Successfully writing, submitting, and managing grants and manuscripts to ensure continuity of research initiatives -Hiring, mentoring, and supervising research fellows and technicians -Applying epidemiological, machine learning and data science methods to multi-omics data to characterize biomarkers of aging and aging-related diseases -Testing nutritional and pharmacological compounds for lifespan extension, and prevention of chronic diseases (eg. Alzheimer’s)
University of Pittsburgh, Department of Pharmacology and Chemical Biology
Postdoctoral Fellow / May, 2016 — September, 2018
Identified a novel urinary biomarker of cruciferous vegetable intake in cancer prevention clinical trials using liquid chromatography mass spectrometry -Led and managed project that showed broccoli-derived sulforaphane prevented breast cancer through altering gene expression and lipidomics profiles
Healthcare Ready
Health Policy Fellow / January, 2017 — January, 2018
-Synthesized data, mined literature and wrote Toolkits/ Issue Brief on “Pharmacy and Emergency Preparedness: A Landscape Analysis”
Most Relevant Research Expertise
Other Research Expertise (10)
About
Most Relevant Publications (12+)
20 total publications
Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling
Molecular and Cellular Biology / Feb 15, 2014
Wakabayashi, N., Skoko, J. J., Chartoumpekis, D. V., Kimura, S., Slocum, S. L., Noda, K., Palliyaguru, D. L., Fujimuro, M., Boley, P. A., Tanaka, Y., Shigemura, N., Biswal, S., Yamamoto, M., & Kensler, T. W. (2014). Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling. Molecular and Cellular Biology, 34(4), 653–663. https://doi.org/10.1128/mcb.01408-13
Isothiocyanates: Translating the Power of Plants to People
Molecular Nutrition & Food Research / Mar 26, 2018
Palliyaguru, D. L., Yuan, J.-M., Kensler, T. W., & Fahey, J. W. (2018). Isothiocyanates: Translating the Power of Plants to People. Molecular Nutrition & Food Research, 62(18), 1700965. Portico. https://doi.org/10.1002/mnfr.201700965
Withania somnifera : From prevention to treatment of cancer
Molecular Nutrition & Food Research / Jan 29, 2016
Palliyaguru, D. L., Singh, S. V., & Kensler, T. W. (2016). Withania somnifera : From prevention to treatment of cancer. Molecular Nutrition & Food Research, 60(6), 1342–1353. Portico. https://doi.org/10.1002/mnfr.201500756
Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions
Mechanisms of Ageing and Development / Jun 01, 2019
Palliyaguru, D. L., Moats, J. M., Di Germanio, C., Bernier, M., & de Cabo, R. (2019). Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions. Mechanisms of Ageing and Development, 180, 42–48. https://doi.org/10.1016/j.mad.2019.03.005
Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide
Food Additives & Contaminants: Part A / Mar 01, 2013
Palliyaguru, D. L., & Wu, F. (2013). Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide. Food Additives & Contaminants: Part A, 30(3), 534–540. https://doi.org/10.1080/19440049.2012.751630
Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice
American Journal of Physiology-Endocrinology and Metabolism / Aug 01, 2018
Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Fazzari, M., Khoo, N. K. H., Schopfer, F. J., Sipula, I., Yagishita, Y., Michalopoulos, G. K., O’Doherty, R. M., & Kensler, T. W. (2018). Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. American Journal of Physiology-Endocrinology and Metabolism, 315(2), E180–E195. https://doi.org/10.1152/ajpendo.00311.2017
Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice
Molecular Metabolism / Jul 01, 2015
Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Khoo, N. K. H., Schoiswohl, G., O’Doherty, R. M., & Kensler, T. W. (2015). Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice. Molecular Metabolism, 4(7), 543–550. https://doi.org/10.1016/j.molmet.2015.04.004
Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques
The Journals of Gerontology: Series A / Dec 18, 2020
Palliyaguru, D. L., Vieira Ligo Teixeira, C., Duregon, E., di Germanio, C., Alfaras, I., Mitchell, S. J., Navas-Enamorado, I., Shiroma, E. J., Studenski, S., Bernier, M., Camandola, S., Price, N. L., Ferrucci, L., & de Cabo, R. (2020). Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques. The Journals of Gerontology: Series A, 76(4), 552–560. https://doi.org/10.1093/gerona/glaa285
Fasting blood glucose as a predictor of mortality: Lost in translation
Cell Metabolism / Nov 01, 2021
Palliyaguru, D. L., Shiroma, E. J., Nam, J. K., Duregon, E., Vieira Ligo Teixeira, C., Price, N. L., Bernier, M., Camandola, S., Vaughan, K. L., Colman, R. J., Deighan, A., Korstanje, R., Peters, L. L., Dickinson, S. L., Ejima, K., Simonsick, E. M., Launer, L. J., Chia, C. W., Egan, J., … de Cabo, R. (2021). Fasting blood glucose as a predictor of mortality: Lost in translation. Cell Metabolism, 33(11), 2189-2200.e3. https://doi.org/10.1016/j.cmet.2021.08.013
Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet
The Journals of Gerontology: Series A / Jun 18, 2020
Palliyaguru, D. L., Minor, R. K., Mitchell, S. J., Palacios, H. H., Licata, J. J., Ward, T. M., Abulwerdi, G., Elliott, P., Westphal, C., Ellis, J. L., Sinclair, D. A., Price, N. L., Bernier, M., & de Cabo, R. (2020). Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet. The Journals of Gerontology: Series A, 75(11), 2037–2041. https://doi.org/10.1093/gerona/glaa148
Perinatal diet influences health and survival in a mouse model of leukemia
GeroScience / May 11, 2020
Palliyaguru, D. L., Rudderow, A. L., Sossong, A. M., Lewis, K. N., Younts, C., Pearson, K. J., Bernier, M., & de Cabo, R. (2020). Perinatal diet influences health and survival in a mouse model of leukemia. GeroScience, 42(4), 1147–1155. https://doi.org/10.1007/s11357-020-00199-9
Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake
Molecular Nutrition & Food Research / Nov 22, 2018
Palliyaguru, D. L., Salvatore, S. R., Schopfer, F. J., Cheng, X., Zhou, J., Kensler, T. W., & Wendell, S. G. (2018). Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake. Molecular Nutrition & Food Research, 63(3), 1801029. Portico. https://doi.org/10.1002/mnfr.201801029
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Sarafa A. Akeem
Lecturer and Food Researcher with fifteen peer-reviewed publications in international journal outlets.
Education
University of Ibadan
Ph.D, Food Technology / October, 2025 (anticipated)
University of Ibadan
M.Sc, Food Technology / February, 2018
University of Ilorin
B.Sc, Food Science / July, 2014
Experience
Edo State College of Agriculture and Natural Resources
Lecturer III / August, 2023 — Present
Teaching courses in Food Processing, Postharvest Technology and General Biology. Carrying out research, analysing data, writing manuscript, presenting the output and publishing the output in reputable peer-reviewed high impact factor journals. Engaging in community services.
Dayntee Farms Limited
Quality Control and Assurance Lead / April, 2022 — July, 2023
Most Relevant Research Expertise
Other Research Expertise (10)
About
Most Relevant Publications (3+)
11 total publications
Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour
Journal of Agricultural Sciences – Sri Lanka / May 01, 2017
EFFECTS OF ADDITION OF DIFFERENT SPICES ON THE QUALITY ATTRIBUTES OF TIGER-NUT MILK (KUNUN-AYA) DURING STORAGE
Journal of microbiology, biotechnology and food sciences / Aug 01, 2017
INFLUENCE OF PARTIAL SUBSTITUTION OF SUGAR WITH SERENDIPITY BERRY (DIOSCOREOPHYLLUM CUMMINSII) EXTRACT ON THE QUALITY ATTRIBUTES AND SHELF-LIFE OF WHEAT BREAD
Journal of microbiology, biotechnology and food sciences / Aug 01, 2019
Monday Ojo Kayode, R., Adunni Abiodun, O., Adeyemi Akeem, S., & Omodasola Oyeneye, H. (2019). INFLUENCE OF PARTIAL SUBSTITUTION OF SUGAR WITH SERENDIPITY BERRY (DIOSCOREOPHYLLUM CUMMINSII) EXTRACT ON THE QUALITY ATTRIBUTES AND SHELF-LIFE OF WHEAT BREAD. Journal of Microbiology, Biotechnology and Food Sciences, 9(1), 115–120. https://doi.org/10.15414/jmbfs.2019.9.1.115-120
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Dr. Hannah Actor-Engel, Ph.D.
University of Colorado Anschutz
Education
University of Colorado Denver
PhD, Neuroscience / 2023
New York University
Bachelor of Science, Neural Science / May, 2015
Experience
New York University
Junior Research Scientist / August, 2015 — May, 2017
Most Relevant Research Expertise
Other Research Expertise (2)
About
Most Relevant Publications (6+)
8 total publications
NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise
Brain Structure and Function / Dec 03, 2016
Chen, Y.-W., Actor-Engel, H., Sherpa, A. D., Klingensmith, L., Chowdhury, T. G., & Aoki, C. (2016). NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Structure and Function, 222(5), 2271–2294. https://doi.org/10.1007/s00429-016-1341-7
α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males
Molecular and Cellular Neuroscience / Jul 01, 2018
Chen, Y.-W., Actor-Engel, H., & Aoki, C. (2018). α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males. Molecular and Cellular Neuroscience, 90, 33–48. https://doi.org/10.1016/j.mcn.2018.04.008
Suppression of food restriction‐evoked hyperactivity in activity‐based anorexia animal model through glutamate transporters GLT‐1 at excitatory synapses in the hippocampus
Synapse / Mar 16, 2021
Bilash, O. M., Actor‐Engel, H. S., Sherpa, A. D., Chen, Y., & Aoki, C. (2021). Suppression of food restriction‐evoked hyperactivity in activity‐based anorexia animal model through glutamate transporters GLT‐1 at excitatory synapses in the hippocampus. Synapse, 75(7). Portico. https://doi.org/10.1002/syn.22197
Correction to: NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise
Brain Structure and Function / Jan 31, 2020
Chen, Y.-W., Actor-Engel, H., Sherpa, A. D., Klingensmith, L., Chowdhury, T. G., & Aoki, C. (2020). Correction to: NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Structure and Function, 225(3), 1165–1165. https://doi.org/10.1007/s00429-020-02030-9
Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses
Cell Reports / Nov 01, 2023
Olah, S. S., Kareemo, D. J., Buchta, W. C., Sinnen, B. L., Miller, C. N., Actor-Engel, H. S., Gookin, S. E., Winborn, C. S., Kleinjan, M. S., Crosby, K. C., Aoto, J., Smith, K. R., & Kennedy, M. J. (2023). Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Reports, 42(11), 113331. https://doi.org/10.1016/j.celrep.2023.113331
AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release
Frontiers in Molecular Neuroscience / Aug 03, 2023
Ramsay, H. J., Gookin, S. E., Ramsey, A. M., Kareemo, D. J., Crosby, K. C., Stich, D. G., Olah, S. S., Actor-Engel, H. S., Smith, K. R., & Kennedy, M. J. (2023). AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. Frontiers in Molecular Neuroscience, 16. https://doi.org/10.3389/fnmol.2023.1232795
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Tali Reiner Brodetzki
Assistant Professor at La Salle University
Education
Tel Aviv University
Ph.D., Zoology / December, 2018
Experience
University of Pennsylvania
Postdoctoral Fellow / January, 2019 — August, 2021
Rutgers university
Postdoctoral Fellow / September, 2021 — August, 2022
La Salle University
Assistant Professor / August, 2022 — Present
Most Relevant Research Expertise
Other Research Expertise (8)
About
Most Relevant Publications (3+)
9 total publications
An integrative approach to untangling species delimitation in the Cataglyphis bicolor desert ant complex in Israel
Molecular Phylogenetics and Evolution / Oct 01, 2017
Eyer, P. A., Seltzer, R., Reiner-Brodetzki, T., & Hefetz, A. (2017). An integrative approach to untangling species delimitation in the Cataglyphis bicolor desert ant complex in Israel. Molecular Phylogenetics and Evolution, 115, 128–139. https://doi.org/10.1016/j.ympev.2017.07.024
Lack of subspecies-recognition in breeding Barn Swallows (Hirundo rustica transitiva)
Behavioural Processes / Aug 01, 2021
Reiner Brodetzki, T., Lotem, A., Safran, R. J., & Hauber, M. E. (2021). Lack of subspecies-recognition in breeding Barn Swallows (Hirundo rustica transitiva). Behavioural Processes, 189, 104422. https://doi.org/10.1016/j.beproc.2021.104422
Worker demography and behavior in a supercolonial ant colony: The case of the desert ant Cataglyphis niger
Ethology / Oct 09, 2019
Reiner Brodetzki, T., Brodetzki, G., Feinerman, O., & Hefetz, A. (2019). Worker demography and behavior in a supercolonial ant colony: The case of the desert ant Cataglyphis niger. Ethology, 126(1), 59–67. Portico. https://doi.org/10.1111/eth.12960
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Aayudh Das, Ph.D.
Scientist at Garuda therapeutics, specialized in Genomics and Computational Biology
Education
University of Vermont
PhD, Plant Biology / April, 2022
Texas A&M University
Master's in Biochemistry, Biochemistry & Biophysics / May, 2016
University of Calcutta
Master's, Biotechnology
Experience
Garuda therapeutics
Scientist / July, 2023 — Present
The Pennsylvania State University - University Park Campus
Postdoctoral Researcher / June, 2022 — July, 2023
University of Vermont
Research Assistant / May, 2016 — May, 2022
Most Relevant Research Expertise
Other Research Expertise (7)
About
Most Relevant Publications (8+)
10 total publications
Metabolomic Profiling of Soybeans (Glycine max L.) Reveals the Importance of Sugar and Nitrogen Metabolism under Drought and Heat Stress
Plants / May 25, 2017
Das, A., Rushton, P., & Rohila, J. (2017). Metabolomic Profiling of Soybeans (Glycine max L.) Reveals the Importance of Sugar and Nitrogen Metabolism under Drought and Heat Stress. Plants, 6(4), 21. https://doi.org/10.3390/plants6020021
Leaf Proteome Analysis Reveals Prospective Drought and Heat Stress Response Mechanisms in Soybean
BioMed Research International / Jan 01, 2016
Das, A., Eldakak, M., Paudel, B., Kim, D.-W., Hemmati, H., Basu, C., & Rohila, J. S. (2016). Leaf Proteome Analysis Reveals Prospective Drought and Heat Stress Response Mechanisms in Soybean. BioMed Research International, 2016, 1–23. https://doi.org/10.1155/2016/6021047
Unraveling Key Metabolomic Alterations in Wheat Embryos Derived from Freshly Harvested and Water-Imbibed Seeds of Two Wheat Cultivars with Contrasting Dormancy Status
Frontiers in Plant Science / Jul 12, 2017
Das, A., Kim, D.-W., Khadka, P., Rakwal, R., & Rohila, J. S. (2017). Unraveling Key Metabolomic Alterations in Wheat Embryos Derived from Freshly Harvested and Water-Imbibed Seeds of Two Wheat Cultivars with Contrasting Dormancy Status. Frontiers in Plant Science, 8. https://doi.org/10.3389/fpls.2017.01203
A Quantitative Proteomics View on the Function of Qfhb1, a Major QTL for Fusarium Head Blight Resistance in Wheat
Pathogens / Jun 22, 2018
Eldakak, M., Das, A., Zhuang, Y., Rohila, J., Glover, K., & Yen, Y. (2018). A Quantitative Proteomics View on the Function of Qfhb1, a Major QTL for Fusarium Head Blight Resistance in Wheat. Pathogens, 7(3), 58. https://doi.org/10.3390/pathogens7030058
Proteomic Responses of Switchgrass and Prairie Cordgrass to Senescence
Frontiers in Plant Science / Mar 14, 2016
Paudel, B., Das, A., Tran, M., Boe, A., Palmer, N. A., Sarath, G., Gonzalez-Hernandez, J. L., Rushton, P. J., & Rohila, J. S. (2016). Proteomic Responses of Switchgrass and Prairie Cordgrass to Senescence. Frontiers in Plant Science, 7. https://doi.org/10.3389/fpls.2016.00293
Variation in climatic tolerance, but not stomatal traits, partially explains Pooideae grass species distributions
Annals of Botany / Mar 27, 2021
Das, A., Prakash, A., Dedon, N., Doty, A., Siddiqui, M., & Preston, J. C. (2021). Variation in climatic tolerance, but not stomatal traits, partially explains Pooideae grass species distributions. Annals of Botany, 128(1), 83–95. https://doi.org/10.1093/aob/mcab046
Investigation of the Cardiotonic Steroids, Marinobufagenin and Resibufogenin, in the Acute Respiratory Distress Syndrome
The FASEB Journal / Apr 01, 2016
Abbas, M. M. K., Chen, Q., Das, A., Oliver, J., Jiang, W., Moorthy, B., Patel, B., Morin, K., & Puschett, J. (2016). Investigation of the Cardiotonic Steroids, Marinobufagenin and Resibufogenin, in the Acute Respiratory Distress Syndrome. The FASEB Journal, 30(S1). Portico. https://doi.org/10.1096/fasebj.30.1_supplement.982.4
Testing the chilling‐ before drought‐tolerance hypothesis in Pooideae grasses
Molecular Ecology / Dec 07, 2022
Das, A., Dedon, N., Enders, D. J., Fjellheim, S., & Preston, J. C. (2022). Testing the chilling‐ before drought‐tolerance hypothesis in Pooideae grasses. Molecular Ecology, 32(4), 772–785. Portico. https://doi.org/10.1111/mec.16794
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Elena Shersher, Ph.D.
Cancer researcher at University of Miami
Education
Florida International University
Ph.D., Biochemistry / May, 2016
Experience
University of Miami
Cancer researcher / March, 2017 — Present
I study cell signaling mechanisms to identify the most promising molecular targets for therapeutic intervention in cancer.
Most Relevant Research Expertise
Other Research Expertise (4)
About
Most Relevant Publications (1+)
4 total publications
NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis
Cell Communication and Signaling / Sep 22, 2021
Shersher, E., Lahiry, M., Alvarez-Trotta, A., Diluvio, G., Robbins, D. J., Shiekhattar, R., & Capobianco, A. J. (2021). NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis. Cell Communication and Signaling, 19(1). https://doi.org/10.1186/s12964-021-00776-1
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Susan Song, MD/PhD
Research Assistant Professor in Neuroscience at University of Pittsburgh
Education
Southern Medical University
MD/PhD, Neurology, Neuroscience / June, 2015
University of Pittsburgh
Post-doc, Neuroscience / December, 2019
Experience
University of Pittsburgh
Research Assistant Professor / January, 2022 — Present
Research Instructor / January, 2020 — December, 2021
Postdoctoral Scholar / October, 2015 — December, 2019
Most Relevant Research Expertise
Other Research Expertise (12)
About
Most Relevant Publications (13+)
20 total publications
Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke
Glia / Sep 19, 2017
Begum, G., Song, S., Wang, S., Zhao, H., Bhuiyan, M. I. H., Li, E., Nepomuceno, R., Ye, Q., Sun, M., Calderon, M. J., Stolz, D. B., St. Croix, C., Watkins, S. C., Chen, Y., He, P., Shull, G. E., & Sun, D. (2017). Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia, 66(1), 126–144. Portico. https://doi.org/10.1002/glia.23232
Ion channels and transporters in microglial function in physiology and brain diseases
Neurochemistry International / Jan 01, 2021
Luo, L., Song, S., Ezenwukwa, C. C., Jalali, S., Sun, B., & Sun, D. (2021). Ion channels and transporters in microglial function in physiology and brain diseases. Neurochemistry International, 142, 104925. https://doi.org/10.1016/j.neuint.2020.104925
Roles of glial ion transporters in brain diseases
Glia / Aug 16, 2019
Song, S., Luo, L., Sun, B., & Sun, D. (2019). Roles of glial ion transporters in brain diseases. Glia, 68(3), 472–494. Portico. https://doi.org/10.1002/glia.23699
Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery
Glia / Jul 25, 2018
Song, S., Wang, S., Pigott, V. M., Jiang, T., Foley, L. M., Mishra, A., Nayak, R., Zhu, W., Begum, G., Shi, Y., Carney, K. E., Hitchens, T. K., Shull, G. E., & Sun, D. (2018). Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery. Glia, 66(11), 2279–2298. Portico. https://doi.org/10.1002/glia.23456
Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function
Journal of Neuroinflammation / Aug 28, 2021
Liu, Q., Bhuiyan, M. I. H., Liu, R., Song, S., Begum, G., Young, C. B., Foley, L. M., Chen, F., Hitchens, T. K., Cao, G., Chattopadhyay, A., He, L., & Sun, D. (2021). Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function. Journal of Neuroinflammation, 18(1). https://doi.org/10.1186/s12974-021-02234-8
The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases
Aging and disease / Jan 01, 2019
Huang, H., Song, S., Banerjee, S., Jiang, T., Zhang, J., Kahle, K. T., Sun, D., & Zhang, Z. (2019). The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases. Aging and Disease, 10(3), 626. https://doi.org/10.14336/ad.2018.0928
Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice
Communications Biology / Jan 11, 2022
Song, S., Yu, L., Hasan, M. N., Paruchuri, S. S., Mullett, S. J., Sullivan, M. L. G., Fiesler, V. M., Young, C. B., Stolz, D. B., Wendell, S. G., & Sun, D. (2022). Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice. Communications Biology, 5(1). https://doi.org/10.1038/s42003-021-02984-4
Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury
Journal of Neuroinflammation / Oct 05, 2022
Song, S., Hasan, M. N., Yu, L., Paruchuri, S. S., Bielanin, J. P., Metwally, S., Oft, H. C. M., Fischer, S. G., Fiesler, V. M., Sen, T., Gupta, R. K., Foley, L. M., Hitchens, T. K., Dixon, C. E., Cambi, F., Sen, N., & Sun, D. (2022). Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury. Journal of Neuroinflammation, 19(1). https://doi.org/10.1186/s12974-022-02608-6
Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation
Journal of Neural Engineering / Mar 19, 2021
Dubaniewicz, M., Eles, J. R., Lam, S., Song, S., Cambi, F., Sun, D., Wellman, S. M., & Kozai, T. D. Y. (2021). Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation. Journal of Neural Engineering, 18(4), 045001. https://doi.org/10.1088/1741-2552/abe8f1
Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke
International Journal of Molecular Sciences / Aug 27, 2023
Metwally, S. A. H., Paruchuri, S. S., Yu, L., Capuk, O., Pennock, N., Sun, D., & Song, S. (2023). Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke. International Journal of Molecular Sciences, 24(17), 13289. https://doi.org/10.3390/ijms241713289
Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells
Neural Regeneration Research / Jan 01, 2014
Jin, B., Jiang, X., Chang, H., Song, S., Chen, Z., Wang, Y., Yang, L., Du, M., Ke, Y., & Xu, R. (2014). Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells. Neural Regeneration Research, 9(5), 519. https://doi.org/10.4103/1673-5374.130079
Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier
Frontiers in Cellular Neuroscience / Dec 01, 2023
Chen, Y., Lin, L., Bhuiyan, M. I. H., He, K., Jha, R., Song, S., Fiesler, V. M., Begum, G., Yin, Y., & Sun, D. (2023). Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1279385
Does Adjuvant Gamma Knife Stereotactic Radiosurgery Have a Role in Treating Optic Nerve Sheath Meningiomas?
Journal of Neuro-Ophthalmology / Jul 05, 2023
Wei, Z., Taori, S., Song, S., Deng, H., Niranjan, A., & Lunsford, L. D. (2023). Does Adjuvant Gamma Knife Stereotactic Radiosurgery Have a Role in Treating Optic Nerve Sheath Meningiomas? Journal of Neuro-Ophthalmology. https://doi.org/10.1097/wno.0000000000001914
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Shariq Usmani, PhD
Massachusetts General Hospital, Harvard Medical School
Education
University of Konstanz
PhD, Molecular and Cell Biology / May, 2011
Harvard University
Postdoctoral fellow, Virology/Immunology / 2019
Experience
Cabaletta Bio
Scientific Director / 2024 — Present
I lead a research team in the preclinical R&D organization at Cabaletta bio. I directly manage a talented group of Senior Scientists, Scientists and Research Associates to spearhead and drive innovation in cell therapies and biologics in autoimmune disease indications.
Sana Biotechnology
Principal Scientist / 2022 — 2023
As a team lead, I led efforts to establish in vivo genome editing platform, vector design/engineering and optimization, with a broader goal to develop innovative and effective genomic medicine for unmet medical needs.
Zohdan Bio
Consultant / 2024 — Present
Providing strategic support for all aspects of preclinical, R&D programs in gene therapy, genome editing and virology and immunology space.
Most Relevant Research Expertise
Other Research Expertise (4)
About
Most Relevant Publications (16+)
22 total publications
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen
Nature Communications / Apr 01, 2014
Usmani, S. M., Zirafi, O., Müller, J. A., Sandi-Monroy, N. L., Yadav, J. K., Meier, C., Weil, T., Roan, N. R., Greene, W. C., Walther, P., Nilsson, K. P. R., Hammarström, P., Wetzel, R., Pilcher, C. D., Gagsteiger, F., Fändrich, M., Kirchhoff, F., & Münch, J. (2014). Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nature Communications, 5(1). https://doi.org/10.1038/ncomms4508
Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin
Cell Host & Microbe / Nov 01, 2014
Kluge, S. F., Mack, K., Iyer, S. S., Pujol, F. M., Heigele, A., Learn, G. H., Usmani, S. M., Sauter, D., Joas, S., Hotter, D., Bibollet-Ruche, F., Plenderleith, L. J., Peeters, M., Geyer, M., Sharp, P. M., Fackler, O. T., Hahn, B. H., & Kirchhoff, F. (2014). Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin. Cell Host & Microbe, 16(5), 639–650. https://doi.org/10.1016/j.chom.2014.10.002
Human Tetherin Exerts Strong Selection Pressure on the HIV-1 Group N Vpu Protein
PLoS Pathogens / Dec 20, 2012
Sauter, D., Unterweger, D., Vogl, M., Usmani, S. M., Heigele, A., Kluge, S. F., Hermkes, E., Moll, M., Barker, E., Peeters, M., Learn, G. H., Bibollet-Ruche, F., Fritz, J. V., Fackler, O. T., Hahn, B. H., & Kirchhoff, F. (2012). Human Tetherin Exerts Strong Selection Pressure on the HIV-1 Group N Vpu Protein. PLoS Pathogens, 8(12), e1003093. https://doi.org/10.1371/journal.ppat.1003093
A molecular tweezer antagonizes seminal amyloids and HIV infection
eLife / Aug 18, 2015
Lump, E., Castellano, L. M., Meier, C., Seeliger, J., Erwin, N., Sperlich, B., Stürzel, C. M., Usmani, S., Hammond, R. M., von Einem, J., Gerold, G., Kreppel, F., Bravo-Rodriguez, K., Pietschmann, T., Holmes, V. M., Palesch, D., Zirafi, O., Weissman, D., Sowislok, A., … Münch, J. (2015). A molecular tweezer antagonizes seminal amyloids and HIV infection. ELife, 4. CLOCKSS. https://doi.org/10.7554/elife.05397
Semen amyloids participate in spermatozoa selection and clearance
eLife / Jun 27, 2017
Roan, N. R., Sandi-Monroy, N., Kohgadai, N., Usmani, S. M., Hamil, K. G., Neidleman, J., Montano, M., Ständker, L., Röcker, A., Cavrois, M., Rosen, J., Marson, K., Smith, J. F., Pilcher, C. D., Gagsteiger, F., Sakk, O., O’Rand, M., Lishko, P. V., Kirchhoff, F., … Greene, W. C. (2017). Semen amyloids participate in spermatozoa selection and clearance. ELife, 6. CLOCKSS. https://doi.org/10.7554/elife.24888
Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection
Journal of Virology / Jul 01, 2014
Roan, N. R., Liu, H., Usmani, S. M., Neidleman, J., Müller, J. A., Avila-Herrera, A., Gawanbacht, A., Zirafi, O., Chu, S., Dong, M., Kumar, S. T., Smith, J. F., Pollard, K. S., Fändrich, M., Kirchhoff, F., Münch, J., Witkowska, H. E., & Greene, W. C. (2014). Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection. Journal of Virology, 88(13), 7221–7234. https://doi.org/10.1128/jvi.00269-14
Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4 + T Cell Counts in Viremic HIV-2 Infection
Journal of Virology / May 01, 2012
Khalid, M., Yu, H., Sauter, D., Usmani, S. M., Schmokel, J., Feldman, J., Gruters, R. A., van der Ende, M. E., Geyer, M., Rowland-Jones, S., Osterhaus, A. D., & Kirchhoff, F. (2012). Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4 + T Cell Counts in Viremic HIV-2 Infection. Journal of Virology, 86(9), 4906–4920. https://doi.org/10.1128/jvi.06856-11
Reacquisition of Nef-Mediated Tetherin Antagonism in a Single In Vivo Passage of HIV-1 through Its Original Chimpanzee Host
Cell Host & Microbe / Sep 01, 2012
Götz, N., Sauter, D., Usmani, S. M., Fritz, J. V., Goffinet, C., Heigele, A., Geyer, M., Bibollet-Ruche, F., Learn, G. H., Fackler, O. T., Hahn, B. H., & Kirchhoff, F. (2012). Reacquisition of Nef-Mediated Tetherin Antagonism in a Single In Vivo Passage of HIV-1 through Its Original Chimpanzee Host. Cell Host & Microbe, 12(3), 373–380. https://doi.org/10.1016/j.chom.2012.07.008
HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission
Cell Host & Microbe / Jan 01, 2019
Usmani, S. M., Murooka, T. T., Deruaz, M., Koh, W. H., Sharaf, R. R., Di Pilato, M., Power, K. A., Lopez, P., Hnatiuk, R., Vrbanac, V. D., Tager, A. M., Allen, T. M., Luster, A. D., & Mempel, T. R. (2019). HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission. Cell Host & Microbe, 25(1), 73-86.e5. https://doi.org/10.1016/j.chom.2018.12.008
The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals
Retrovirology / Mar 05, 2013
Yu, H., Usmani, S. M., Borch, A., Krämer, J., Stürzel, C. M., Khalid, M., Li, X., Krnavek, D., van der Ende, M. E., Osterhaus, A. D., Gruters, R. A., & Kirchhoff, F. (2013). The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals. Retrovirology, 10(1). https://doi.org/10.1186/1742-4690-10-27
Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins
Cellular Microbiology / Dec 13, 2011
Usmani, S. M., von Einem, J., Frick, M., Miklavc, P., Mayenburg, M., Husmann, M., Dietl, P., & Wittekindt, O. H. (2011). Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins: Streptolysin O activates SOC entry. Cellular Microbiology, 14(3), 299–315. https://doi.org/10.1111/j.1462-5822.2011.01724.x
2-APB and Capsazepine-induced Ca<sup>2+</sup> Influx Stimulates Clathrin-dependent Endocytosis in Alveolar Epithelial Cells
Cellular Physiology and Biochemistry / Jan 01, 2010
Usmani, S., Fois, G., Albrecht, S., von Aulock, S., Dietl, P., & Wittekindt, O. (2010). 2-APB and Capsazepine-induced Ca<sup>2+</sup> Influx Stimulates Clathrin-dependent Endocytosis in Alveolar Epithelial Cells. Cellular Physiology and Biochemistry, 25(001), 091–102. https://doi.org/10.1159/000272064
Lentiviral Nef Proteins Manipulate T Cells in a Subset-Specific Manner
Journal of Virology / Feb 15, 2015
Yu, H., Khalid, M., Heigele, A., Schmökel, J., M. Usmani, S., van der Merwe, J., Münch, J., Silvestri, G., & Kirchhoff, F. (2015). Lentiviral Nef Proteins Manipulate T Cells in a Subset-Specific Manner. Journal of Virology, 89(4), 1986–2001. https://doi.org/10.1128/jvi.03104-14
Plasma Membrane Trafficking in Alveolar Type II Cells
Cellular Physiology and Biochemistry / Jan 01, 2010
Albrecht, S., Usmani, S., Dietl, P., & Wittekindt, O. (2010). Plasma Membrane Trafficking in Alveolar Type II Cells. Cellular Physiology and Biochemistry, 25(001), 081–090. https://doi.org/10.1159/000272053
Cancer cells relax and resist cytotoxic attack
Immunity / May 01, 2021
Usmani, S. M., & Mempel, T. R. (2021). Cancer cells relax and resist cytotoxic attack. Immunity, 54(5), 853–855. https://doi.org/10.1016/j.immuni.2021.04.017
HIV-enhancing Amyloids Are Prevalent in Fresh Semen and Are a Determinant for Semen's Ability to Enhance HIV Infection: Relevance for HIV Transmission
AIDS Research and Human Retroviruses / Oct 01, 2014
Usmani, S., Liu, H., Pilcher, C. D., Witkowska, H. E., Kirchhoff, F., Greene, W. C., Münch, J., & Roan, N. R. (2014). HIV-enhancing Amyloids Are Prevalent in Fresh Semen and Are a Determinant for Semen’s Ability to Enhance HIV Infection: Relevance for HIV Transmission. AIDS Research and Human Retroviruses, 30(S1), A183–A184. https://doi.org/10.1089/aid.2014.5392.abstract
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Regan Hamel
Senior bioinformatics scientist, specializing in single cell omics in the context of cellular reprogramming and neuroinflammation
Education
University of Cambridge
PhD, Clinical Neurosciences / September, 2021
University of Cambridge
MPhil, Clinical Neurosciences / September, 2018
McGill University
Bachelor of Science, Neurosciences / June, 2017
Experience
Mogrify Ltd
Bioinformatics scientist / August, 2021 — June, 2023
Senior Bioinformatics Scientist / July, 2023 — Present
Most Relevant Research Expertise
Other Research Expertise (7)
About
Most Relevant Publications (6+)
12 total publications
Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology
Frontiers in Cellular Neuroscience / Nov 05, 2020
Willis, C. M., Nicaise, A. M., Hamel, R., Pappa, V., Peruzzotti-Jametti, L., & Pluchino, S. (2020). Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology. Frontiers in Cellular Neuroscience, 14. https://doi.org/10.3389/fncel.2020.590960
Stem Cell Therapies for Progressive Multiple Sclerosis
Frontiers in Cell and Developmental Biology / Jul 09, 2021
Smith, J. A., Nicaise, A. M., Ionescu, R.-B., Hamel, R., Peruzzotti-Jametti, L., & Pluchino, S. (2021). Stem Cell Therapies for Progressive Multiple Sclerosis. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.696434
Metabolic Control of Smoldering Neuroinflammation
Frontiers in Immunology / Jun 23, 2021
Peruzzotti-Jametti, L., Willis, C. M., Hamel, R., Krzak, G., & Pluchino, S. (2021). Metabolic Control of Smoldering Neuroinflammation. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.705920
Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice
Molecular Therapy / Dec 01, 2020
Braga, A., Bandiera, S., Verheyen, J., Hamel, R., Rutigliani, C., Edenhofer, F., Smith, J. A., & Pluchino, S. (2020). Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice. Molecular Therapy, 28(12), 2677–2690. https://doi.org/10.1016/j.ymthe.2020.08.001
Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury
Frontiers in Immunology / Aug 24, 2022
Yao, X.-Q., Chen, J.-Y., Yu, Z.-H., Huang, Z.-C., Hamel, R., Zeng, Y.-Q., Huang, Z.-P., Tu, K.-W., Liu, J.-H., Lu, Y.-M., Zhou, Z.-T., Pluchino, S., Zhu, Q.-A., & Chen, J.-T. (2022). Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.964138
Single cell biology—a Keystone Symposia report
Annals of the New York Academy of Sciences / Oct 03, 2021
Cable, J., Elowitz, M. B., Domingos, A. I., Habib, N., Itzkovitz, S., Hamidzada, H., Balzer, M. S., Yanai, I., Liberali, P., Whited, J., Streets, A., Cai, L., Stergachis, A. B., Hong, C. K. Y., Keren, L., Guilliams, M., Alon, U., Shalek, A. K., Hamel, R., … Romeike, M. (2021). Single cell biology—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506(1), 74–97. Portico. https://doi.org/10.1111/nyas.14692
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Luca Delfinis
PhD candidate in physiology researching the mechanisms that drive muscle dysfunction in cancer
Education
Wilfrid Laurier University
BSc, Kinesiology & Physical Education / April, 2018
York University
MSc, Molecular, Cellular and Integrative Physiology / August, 2020
York University
PhD, Molecular, Cellular and Integrative Physiology / August, 2024 (anticipated)
Experience
York University
Teaching Assistant / September, 2018 — Present
KINE 2049 (Research Methods in Kinesiology) and KINE 3012 (Human Physiology II)
Wilfrid Laurier University
Supplemental Instruction Senior Mentor / April, 2017 — April, 2018
Oversee teaching assistants with their teaching programs
Most Relevant Research Expertise
Other Research Expertise (1)
About
Most Relevant Publications (2+)
4 total publications
Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation
Journal of Cachexia, Sarcopenia and Muscle / Apr 02, 2019
Hughes, M. C., Ramos, S. V., Turnbull, P. C., Rebalka, I. A., Cao, A., Monaco, C. M. F., Varah, N. E., Edgett, B. A., Huber, J. S., Tadi, P., Delfinis, L. J., Schlattner, U., Simpson, J. A., Hawke, T. J., & Perry, C. G. R. (2019). Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation. Journal of Cachexia, Sarcopenia and Muscle, 10(3), 643–661. Portico. https://doi.org/10.1002/jcsm.12405
Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime
American Journal of Physiology-Cell Physiology / May 01, 2023
Bellissimo, C. A., Delfinis, L. J., Hughes, M. C., Turnbull, P. C., Gandhi, S., DiBenedetto, S. N., Rahman, F. A., Tadi, P., Amaral, C. A., Dehghani, A., Cobley, J. N., Quadrilatero, J., Schlattner, U., & Perry, C. G. R. (2023). Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime. American Journal of Physiology-Cell Physiology, 324(5), C1141–C1157. https://doi.org/10.1152/ajpcell.00377.2022
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Gwendolyn Thomas, Ph.D., CSCS, USAW-L1
Resistance Exercise Physiologist/Performance Enhancement/Optimizing RE Prescription
Education
University of Connecticut
Ph.D., Kinesiology (Exercise Endocrinology, Exercise Physiology, Resistance Exercise) / May, 2010
University of Connecticut
M.A., Strength and Conditioning / May, 2007
Experience
Penn State University
Assistant Research Professor / September, 2019 — August, 2023
Principal Investigator of the Exercise Prescription Lab. The lab (PI: Thomas) conducts interdisciplinary and translational research on chronic diseases, publishing in peer-reviewed journals. Transform population health outcomes through data, analytics, and actionable insights. Chair the regulatory review board, overseeing IRB Administration, running meetings, and approving research protocols. Expertise in institutional, FDA, and Federal regulatory work.
Penn State Integrative Physiology
Faculty Member / September, 2019 — Present
Faculty Member In Integrative Physiology
Syracuse University
Assistant Professor / August, 2016 — August, 2019
Independent Principal Investigator: Assumed responsibility for all research studies conducted in my lab, including but not limited to oversight and training of research assistants (25), training of research assistants (30), and generating independent, high quality, reproducible results. Responsible for the management and integrity of design, conduct and reporting of the research project and for managing, monitoring and ensuring the integrity of collaborative relationships. Curriculum Committee Chair:Led Curriculum Committee and Departmental Leadership to develop Master’s Degree in Strength and Conditioning through certifying agency, the National Strength and Conditioning Association (NSCA).
Most Relevant Research Expertise
Other Research Expertise (23)
About
Most Relevant Publications (31+)
51 total publications
Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation
BMC Cancer / Jan 22, 2019
van Rooijen, S., Carli, F., Dalton, S., Thomas, G., Bojesen, R., Le Guen, M., Barizien, N., Awasthi, R., Minnella, E., Beijer, S., Martínez-Palli, G., van Lieshout, R., Gögenur, I., Feo, C., Johansen, C., Scheede-Bergdahl, C., Roumen, R., Schep, G., & Slooter, G. (2019). Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation. BMC Cancer, 19(1). https://doi.org/10.1186/s12885-018-5232-6
Effects of a Whole Body Compression Garment on Markers of Recovery After a Heavy Resistance Workout in Men and Women
Journal of Strength and Conditioning Research / Mar 01, 2010
Kraemer, W. J., Flanagan, S. D., Comstock, B. A., Fragala, M. S., Earp, J. E., Dunn-Lewis, C., Ho, J.-Y., Thomas, G. A., Solomon-Hill, G., Penwell, Z. R., Powell, M. D., Wolf, M. R., Volek, J. S., Denegar, C. R., & Maresh, C. M. (2010). Effects of a Whole Body Compression Garment on Markers of Recovery After a Heavy Resistance Workout in Men and Women. Journal of Strength and Conditioning Research, 24(3), 804–814. https://doi.org/10.1519/jsc.0b013e3181d33025
MAXIMAL POWER AT DIFFERENT PERCENTAGES OF ONE REPETITION MAXIMUM
Journal of Strength and Conditioning Research / May 01, 2007
THOMAS, G. A., KRAEMER, W. J., SPIERING, B. A., VOLEK, J. S., ANDERSON, J. M., & MARESH, C. M. (2007). MAXIMAL POWER AT DIFFERENT PERCENTAGES OF ONE REPETITION MAXIMUM: INFLUENCE OF RESISTANCE AND GENDER. Journal of Strength and Conditioning Research, 21(2), 336–342. https://doi.org/10.1519/00124278-200705000-00008
Effects of Stretching on Upper-Body Muscular Performance
Journal of Strength and Conditioning Research / Jul 01, 2008
Torres, E. M., Kraemer, W. J., Vingren, J. L., Volek, J. S., Hatfield, D. L., Spiering, B. A., Ho, J. Y., Fragala, M. S., Thomas, G. A., Anderson, J. M., Häkkinen, K., & Maresh, C. M. (2008). Effects of Stretching on Upper-Body Muscular Performance. Journal of Strength and Conditioning Research, 22(4), 1279–1285. https://doi.org/10.1519/jsc.0b013e31816eb501
Effects of Amino Acids Supplement on Physiological Adaptations to Resistance Training
Medicine & Science in Sports & Exercise / May 01, 2009
KRAEMER, W. J., HATFIELD, D. L., VOLEK, J. S., FRAGALA, M. S., VINGREN, J. L., ANDERSON, J. M., SPIERING, B. A., THOMAS, G. A., HO, J. Y., QUANN, E. E., IZQUIERDO, M., HÄKKINEN, K., & MARESH, C. M. (2009). Effects of Amino Acids Supplement on Physiological Adaptations to Resistance Training. Medicine & Science in Sports & Exercise, 41(5), 1111–1121. https://doi.org/10.1249/mss.0b013e318194cc75
Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women
Steroids / Nov 01, 2009
Vingren, J. L., Kraemer, W. J., Hatfield, D. L., Volek, J. S., Ratamess, N. A., Anderson, J. M., Häkkinen, K., Ahtiainen, J., Fragala, M. S., & Thomas, G. A. (2009). Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women. Steroids, 74(13–14), 1033–1039. https://doi.org/10.1016/j.steroids.2009.08.002
Recovery From a National Collegiate Athletic Association Division I Football Game: Muscle Damage and Hormonal Status
Journal of Strength and Conditioning Research / Jan 01, 2009
Kraemer, W. J., Spiering, B. A., Volek, J. S., Martin, G. J., Howard, R. L., Ratamess, N. A., Hatfield, D. L., Vingren, J. L., Ho, J. Y., Fragala, M. S., Thomas, G. A., French, D. N., Anderson, J. M., Häkkinen, K., & Maresh, C. M. (2009). Recovery From a National Collegiate Athletic Association Division I Football Game: Muscle Damage and Hormonal Status. Journal of Strength and Conditioning Research, 23(1), 2–10. https://doi.org/10.1519/jsc.0b013e31819306f2
The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors
Obesity / Dec 27, 2016
Thomas, G. A., Cartmel, B., Harrigan, M., Fiellin, M., Capozza, S., Zhou, Y., Ercolano, E., Gross, C. P., Hershman, D., Ligibel, J., Schmitz, K., Li, F., Sanft, T., & Irwin, M. L. (2016). The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors. Obesity, 25(2), 346–351. Portico. https://doi.org/10.1002/oby.21729
l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women
Metabolism / Aug 01, 2010
Ho, J.-Y., Kraemer, W. J., Volek, J. S., Fragala, M. S., Thomas, G. A., Dunn-Lewis, C., Coday, M., Häkkinen, K., & Maresh, C. M. (2010). l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism, 59(8), 1190–1199. https://doi.org/10.1016/j.metabol.2009.11.012
Effects of L-Carnitine L-Tartrate Supplementation on Muscle Oxygenation Responses to Resistance Exercise
Journal of Strength and Conditioning Research / Jul 01, 2008
Spiering, B. A., Kraemer, W. J., Hatfield, D. L., Vingren, J. L., Fragala, M. S., Ho, J.-Y., Thomas, G. A., Häkkinen, K., & Volek, J. S. (2008). Effects of L-Carnitine L-Tartrate Supplementation on Muscle Oxygenation Responses to Resistance Exercise. Journal of Strength and Conditioning Research, 22(4), 1130–1135. https://doi.org/10.1519/jsc.0b013e31817d48d9
Endocrine Response Patterns to Acute Unilateral and Bilateral Resistance Exercise in Men
Journal of Strength and Conditioning Research / Jan 01, 2010
Migiano, M. J., Vingren, J. L., Volek, J. S., Maresh, C. M., Fragala, M. S., Ho, J.-Y., Thomas, G. A., Hatfield, D. L., Häkkinen, K., Ahtiainen, J., Earp, J. E., & Kraemer, W. J. (2010). Endocrine Response Patterns to Acute Unilateral and Bilateral Resistance Exercise in Men. Journal of Strength and Conditioning Research, 24(1), 128–134. https://doi.org/10.1519/jsc.0b013e3181a92dc5
Growth Hormone, Exercise, and Athletic Performance
Current Sports Medicine Reports / Jul 01, 2010
Kraemer, W. J., Dunn-Lewis, C., Comstock, B. A., Thomas, G. A., Clark, J. E., & Nindl, B. C. (2010). Growth Hormone, Exercise, and Athletic Performance: A Continued Evolution of Complexity. Current Sports Medicine Reports, 9(4), 242–252. https://doi.org/10.1249/jsr.0b013e3181e976df
Effect of resistance exercise on muscle steroidogenesis
Journal of Applied Physiology / Dec 01, 2008
Vingren, J. L., Kraemer, W. J., Hatfield, D. L., Anderson, J. M., Volek, J. S., Ratamess, N. A., Thomas, G. A., Ho, J.-Y., Fragala, M. S., & Maresh, C. M. (2008). Effect of resistance exercise on muscle steroidogenesis. Journal of Applied Physiology, 105(6), 1754–1760. https://doi.org/10.1152/japplphysiol.91235.2008
Obesity, Growth Hormone and Exercise
Sports Medicine / Jun 30, 2013
Thomas, G. A., Kraemer, W. J., Comstock, B. A., Dunn-Lewis, C., Maresh, C. M., & Volek, J. S. (2013). Obesity, Growth Hormone and Exercise. Sports Medicine, 43(9), 839–849. https://doi.org/10.1007/s40279-013-0064-7
Effect of Exercise on Metabolic Syndrome Variables in Breast Cancer Survivors
International Journal of Endocrinology / Jan 01, 2013
Thomas, G. A., Alvarez-Reeves, M., Lu, L., Yu, H., & Irwin, M. L. (2013). Effect of Exercise on Metabolic Syndrome Variables in Breast Cancer Survivors. International Journal of Endocrinology, 2013, 1–8. https://doi.org/10.1155/2013/168797
Factors Affecting Flutter Kicking Speed in Women Who Are Competitive and Recreational Swimmers
Journal of Strength and Conditioning Research / Oct 01, 2009
McCullough, A. S., Kraemer, W. J., Volek, J. S., Solomon-Hill, G. F., Hatfield, D. L., Vingren, J. L., Ho, J.-Y., Fragala, M. S., Thomas, G. A., Häkkinen, K., & Maresh, C. M. (2009). Factors Affecting Flutter Kicking Speed in Women Who Are Competitive and Recreational Swimmers. Journal of Strength and Conditioning Research, 23(7), 2130–2136. https://doi.org/10.1519/jsc.0b013e31819ab977
Immunoreactive and bioactive growth hormone responses to resistance exercise in men who are lean or obese
Journal of Applied Physiology / Aug 01, 2011
Thomas, G. A., Kraemer, W. J., Kennett, M. J., Comstock, B. A., Maresh, C. M., Denegar, C. R., Volek, J. S., & Hymer, W. C. (2011). Immunoreactive and bioactive growth hormone responses to resistance exercise in men who are lean or obese. Journal of Applied Physiology, 111(2), 465–472. https://doi.org/10.1152/japplphysiol.00157.2011
Relationship Between Off-Ice Testing Variables and On-Ice Speed in Women's Collegiate Synchronized Figure Skaters: Implications for Training
Journal of Strength and Conditioning Research / Mar 01, 2010
Bower, M. E., Kraemer, W. J., Potteiger, J. A., Volek, J. S., Hatfield, D. A., Vingren, J. L., Spiering, B. A., Fragala, M. S., Ho, J.-Y., Thomas, G. A., Earp, J. E., Häkkinen, K., & Maresh, C. M. (2010). Relationship Between Off-Ice Testing Variables and On-Ice Speed in Women’s Collegiate Synchronized Figure Skaters: Implications for Training. Journal of Strength and Conditioning Research, 24(3), 831–839. https://doi.org/10.1519/jsc.0b013e3181a59a5c
Effects of resistance exercise and obesity level on ghrelin and cortisol in men
Metabolism / Jun 01, 2012
Thomas, G. A., Kraemer, W. J., Comstock, B. A., Dunn-Lewis, C., Volek, J. S., Denegar, C. R., & Maresh, C. M. (2012). Effects of resistance exercise and obesity level on ghrelin and cortisol in men. Metabolism, 61(6), 860–868. https://doi.org/10.1016/j.metabol.2011.10.015
Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight
European Journal of Applied Physiology / Dec 02, 2008
Fragala, M. S., Kraemer, W. J., Volek, J. S., Maresh, C. M., Puglisi, M. J., Vingren, J. L., Ho, J.-Y., Hatfield, D. L., Spiering, B. A., Forsythe, C. E., Thomas, G. A., Quann, E. E., Anderson, J. M., & Hesslink, R. L. (2008). Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight. European Journal of Applied Physiology, 105(5). https://doi.org/10.1007/s00421-008-0944-y
Implementation of a Postoperative Screening and Treatment Guidance for the Low Anterior Resection Syndrome: Preliminary Results
Diseases of the Colon & Rectum / Sep 01, 2019
van der Heijden, J. A. G., van Heinsbergen, M., Thomas, G., Caers, F., Slooter, G. D., & Maaskant-Braat, A. J. G. (2019). Implementation of a Postoperative Screening and Treatment Guidance for the Low Anterior Resection Syndrome: Preliminary Results. Diseases of the Colon & Rectum, 62(9), 1033–1042. https://doi.org/10.1097/dcr.0000000000001428
Effects of Acute Resistance Exercise on Muscle Damage and Perceptual Measures Between Men Who Are Lean and Obese
Journal of Strength and Conditioning Research / Dec 01, 2013
Comstock, B. A., Thomas, G. A., Dunn-Lewis, C., Volek, J. S., Szivak, T. K., Hooper, D. R., Kupchak, B. R., Flanagan, S. D., Denegar, C. R., & Kraemer, W. J. (2013). Effects of Acute Resistance Exercise on Muscle Damage and Perceptual Measures Between Men Who Are Lean and Obese. Journal of Strength and Conditioning Research, 27(12), 3488–3494. https://doi.org/10.1519/jsc.0b013e31828f8202
Endogenous opioid peptide responses to opioid and anti-inflammatory medications following eccentric exercise-induced muscle damage
Peptides / Jan 01, 2010
Kraemer, W. J., Joseph, M. F., Volek, J. S., Hoffman, J. R., Ratamess, N. A., Newton, R. U., Fragala, M. S., French, D. N., Rubin, M. A., Scheett, T. P., McGuigan, M. R., Thomas, G. A., Gomez, A. L., Häkkinen, K., & Maresh, C. M. (2010). Endogenous opioid peptide responses to opioid and anti-inflammatory medications following eccentric exercise-induced muscle damage. Peptides, 31(1), 88–93. https://doi.org/10.1016/j.peptides.2009.09.031
Effect of circulating growth hormone on muscle IGF-I protein concentration in female mice with growth hormone receptor gene disruption
Growth Hormone & IGF Research / Jun 01, 2009
Kraemer, W. J., Vingren, J. L., Schuenke, M. D., Kopchick, J. J., Volek, J. S., Fragala, M. S., Häkkinen, K., Jen-Ho, Thomas, G. A., & Staron, R. S. (2009). Effect of circulating growth hormone on muscle IGF-I protein concentration in female mice with growth hormone receptor gene disruption. Growth Hormone & IGF Research, 19(3), 242–244. https://doi.org/10.1016/j.ghir.2008.10.006
The Effects Of An Acute Resistance Exercise Bout On Insulin Like Growth Factor-I And 3 Binding Proteins In Well-Trained Men And Women
Journal of Strength and Conditioning Research / Jan 01, 2010
Hatfield, D. L., Kraemer, W. J., Vingren, J. L., Anderson, J. M., Volek, J. S., Nindl, B. C., Thomas, G. A., Ho, J. Y., Fragala, M. S., & Maresh, C. M. (2010). The Effects Of An Acute Resistance Exercise Bout On Insulin Like Growth Factor-I And 3 Binding Proteins In Well-Trained Men And Women. Journal of Strength and Conditioning Research, 24, 1. https://doi.org/10.1097/01.jsc.0000367124.12392.bb
Effects of a Smartphone Based Exercise Intervention on Quality of Life in Breast Cancer Survivors
Medicine & Science in Sports & Exercise / Jun 01, 2019
Bedillion, M. F., Ansell, E. B., & Thomas, G. A. (2019). Effects of a Smartphone Based Exercise Intervention on Quality of Life in Breast Cancer Survivors: 927 Board #161 May 29 3:30 PM - 5:00 PM. Medicine & Science in Sports & Exercise, 51(6S), 237–237. https://doi.org/10.1249/01.mss.0000561217.04972.38
Differences by Activity Level in Barriers and Benefits of Exercise in Breast Cancer Survivors
Medicine & Science in Sports & Exercise / Jun 01, 2019
Thomas, G. A., & Bedillion, M. F. (2019). Differences by Activity Level in Barriers and Benefits of Exercise in Breast Cancer Survivors: 3277 Board #5 June 1 9:00 AM - 11:00 AM. Medicine & Science in Sports & Exercise, 51(6S), 900–900. https://doi.org/10.1249/01.mss.0000563194.81354.46
Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors
Medicine & Science in Sports & Exercise / May 01, 2016
Thomas, G. A., Cartmel, B., Harrigan, M., Fiellin, M., Capozza, S., Zhou, Y., Ercolano, E., Gross, C., Hershman, D., Ligibel, J., Schmitz, K., Li, F., Sanft, T., & Irwin, M. L. (2016). Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors: 1285 Board #6 June 2, 8. Medicine & Science in Sports & Exercise, 48, 334. https://doi.org/10.1249/01.mss.0000486010.57056.60
LOW INTENSITY RESISTANCE EXERCISE FOLLOWING HIGH INTENSITY RESISTANCE EXERCISE STIMULATES GROWTH HORMONE SECRETION IN MEN
Medicine & Science in Sports & Exercise / May 01, 2001
Goto, K., & Takamatsu, K. (2001). LOW INTENSITY RESISTANCE EXERCISE FOLLOWING HIGH INTENSITY RESISTANCE EXERCISE STIMULATES GROWTH HORMONE SECRETION IN MEN. Medicine & Science in Sports & Exercise, 33(5), S287. https://doi.org/10.1097/00005768-200105001-01614
Maximal Force Generation In The Bench Press During Concentric And Eccentric Actions
Medicine & Science in Sports & Exercise / May 01, 2009
Ho, J. Y., Fragala, M. S., Thomas, G. A., Volek, J. S., & Kraemer, W. J. (2009). Maximal Force Generation In The Bench Press During Concentric And Eccentric Actions: 728 May 28 9:15 AM - 9:30 AM. Medicine & Science in Sports & Exercise, 41(5), 63. https://doi.org/10.1249/01.mss.0000353462.75436.37
The Effect of Growth Hormone Receptor Deficiency on Skeletal Muscle Insulin-like Growth Factor-I Protein Expression
Medicine & Science in Sports & Exercise / May 01, 2008
Hatfield, D. L., Kraemer, W. J., Vingren, J. L., Fragala, M. S., Ho, J.-Y., Thomas, G. A., Volek, J. S., Maresh, C. M., Spiering, B. A., Schuenke, M., Kopchick, J. J., & Staron, R. S. (2008). The Effect of Growth Hormone Receptor Deficiency on Skeletal Muscle Insulin-like Growth Factor-I Protein Expression: 2482 Board #65 May 31 9:30 AM - 11:00 AM. Medicine & Science in Sports & Exercise, 40(5), S470. https://doi.org/10.1249/01.mss.0000322995.34725.36
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Burcu Vitrinel, Ph.D.
Cross-functional life sciences strategy professional with a Ph.D. in genetics
Education
New York University
Ph.D., Developmental Genetics / May, 2021
M.Sc., Molecular Medicine / September, 2015
Sabancı University
B.Sc., Bioengineering / May, 2013
Experience
Putnam Associates
Life Sciences Consultant / July, 2021 — November, 2023
Most Relevant Research Expertise
Other Research Expertise (11)
About
Most Relevant Publications (5+)
10 total publications
Exploiting Interdata Relationships in Next-generation Proteomics Analysis
Molecular & Cellular Proteomics / Aug 01, 2019
Vitrinel, B., Koh, H. W. L., Mujgan Kar, F., Maity, S., Rendleman, J., Choi, H., & Vogel, C. (2019). Exploiting Interdata Relationships in Next-generation Proteomics Analysis. Molecular & Cellular Proteomics, 18(8), S5–S14. https://doi.org/10.1074/mcp.mr118.001246
Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity
Cell Systems / Dec 01, 2020
Shim, W. J., Sinniah, E., Xu, J., Vitrinel, B., Alexanian, M., Andreoletti, G., Shen, S., Sun, Y., Balderson, B., Boix, C., Peng, G., Jing, N., Wang, Y., Kellis, M., Tam, P. P. L., Smith, A., Piper, M., Christiaen, L., Nguyen, Q., … Palpant, N. J. (2020). Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity. Cell Systems, 11(6), 625-639.e13. https://doi.org/10.1016/j.cels.2020.11.001
The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans
Aging Cell / Aug 09, 2019
Müthel, S., Uyar, B., He, M., Krause, A., Vitrinel, B., Bulut, S., Vasiljevic, D., Marchal, I., Kempa, S., Akalin, A., & Tursun, B. (2019). The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Aging Cell, 18(6). Portico. https://doi.org/10.1111/acel.13012
Ring Finger 149-Related Is an FGF/MAPK-Independent Regulator of Pharyngeal Muscle Fate Specification
International Journal of Molecular Sciences / May 16, 2023
Vitrinel, B., Vogel, C., & Christiaen, L. (2023). Ring Finger 149-Related Is an FGF/MAPK-Independent Regulator of Pharyngeal Muscle Fate Specification. International Journal of Molecular Sciences, 24(10), 8865. https://doi.org/10.3390/ijms24108865
Proteomic Signatures of the Serological Response to Influenza Vaccination in a Large Human Cohort Study
Viruses / Nov 09, 2022
Wu, S., Pushalkar, S., Maity, S., Pressler, M., Rendleman, J., Vitrinel, B., Carlock, M., Ross, T., Choi, H., & Vogel, C. (2022). Proteomic Signatures of the Serological Response to Influenza Vaccination in a Large Human Cohort Study. Viruses, 14(11), 2479. https://doi.org/10.3390/v14112479
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Dr. Everson A Nunes, Ph.D.
Post-Doctoral Fellow at McMaster University | former Associate Professor - Physiological Sciences
Education
Universidade Federal do Paraná - Campus Centro Politécnico
PhD, Physiological Sciences / December, 2009
Universidade Federal do Paraná - Campus Centro Politécnico
BSc - Human Nutrition / December, 2007
Universidade Federal do Paraná - Campus Centro Politécnico
MSc, Physiological Sciences / March, 2005
Experience
McMaster University
Post Doctoral Fellow / September, 2019 — Present
Post-Doctoral Research Fellow / September, 2015 — August, 2016
Universidade Federal de Santa Catarina
Associate professor / October, 2013 — April, 2022
Assistant Professor / October, 2010 — September, 2013
Universidade Federal do Paraná
Post-Doctoral Fellow / December, 2009 — September, 2010
Most Relevant Research Expertise
Other Research Expertise (29)
About
Most Relevant Publications (52+)
97 total publications
The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease
Frontiers in Nutrition / Sep 06, 2019
McGlory, C., Calder, P. C., & Nunes, E. A. (2019). The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease. Frontiers in Nutrition, 6. https://doi.org/10.3389/fnut.2019.00144
Systematic review and meta‐analysis of protein intake to support muscle mass and function in healthy adults
Journal of Cachexia, Sarcopenia and Muscle / Feb 20, 2022
Nunes, E. A., Colenso‐Semple, L., McKellar, S. R., Yau, T., Ali, M. U., Fitzpatrick‐Lewis, D., Sherifali, D., Gaudichon, C., Tomé, D., Atherton, P. J., Robles, M. C., Naranjo‐Modad, S., Braun, M., Landi, F., & Phillips, S. M. (2022). Systematic review and meta‐analysis of protein intake to support muscle mass and function in healthy adults. Journal of Cachexia, Sarcopenia and Muscle, 13(2), 795–810. Portico. https://doi.org/10.1002/jcsm.12922
Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients
Lipids / Jul 26, 2013
Mocellin, M. C., Pastore e Silva, J. de A., Camargo, C. de Q., Fabre, M. E. de S., Gevaerd, S., Naliwaiko, K., Moreno, Y. M. F., Nunes, E. A., & Trindade, E. B. S. de M. (2013). Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients. Lipids, 48(9), 879–888. Portico. https://doi.org/10.1007/s11745-013-3816-0
Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats
European Journal of Applied Physiology / Aug 08, 2008
de Lima, C., Alves, L. E., Iagher, F., Machado, A. F., Bonatto, S. J., Kuczera, D., de Souza, C. F., Pequito, D. C., Muritiba, A. L., Nunes, E. A., & Fernandes, L. C. (2008). Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats. European Journal of Applied Physiology, 104(6), 957–964. https://doi.org/10.1007/s00421-008-0849-9
Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy
Lipids / Dec 11, 2011
Bonatto, S. J. R., Oliveira, H. H. P., Nunes, E. A., Pequito, D., Iagher, F., Coelho, I., Naliwaiko, K., Kryczyk, M., Brito, G. A. P., Repka, J., Sabóia, L. V., Fukujima, G., Calder, P. C., & Fernandes, L. C. (2011). Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy. Lipids, 47(4), 383–389. Portico. https://doi.org/10.1007/s11745-011-3643-0
β-Hydroxy-β-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-κB expression
Nutrition Research / Jul 01, 2008
Nunes, E. A., Kuczera, D., Brito, G. A. P., Bonatto, S. J. R., Yamazaki, R. K., Tanhoffer, R. A., Mund, R. C., Kryczyk, M., & Fernandes, L. C. (2008). β-Hydroxy-β-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-κB expression. Nutrition Research, 28(7), 487–493. https://doi.org/10.1016/j.nutres.2008.04.006
Effects of Prebiotic and Synbiotic Supplementation on Inflammatory Markers and Anthropometric Indices After Roux-en-Y Gastric Bypass
Journal of Clinical Gastroenterology / Mar 01, 2016
Fernandes, R., Beserra, B. T. S., Mocellin, M. C., Kuntz, M. G. F., da Rosa, J. S., de Miranda, R. C. D., Schreiber, C. S. O., Fröde, T. S., Nunes, E. A., & Trindade, E. B. S. M. (2016). Effects of Prebiotic and Synbiotic Supplementation on Inflammatory Markers and Anthropometric Indices After Roux-en-Y Gastric Bypass: A Randomized, Triple-blind, Placebo-controlled Pilot Study. Journal of Clinical Gastroenterology, 50(3), 208–217. https://doi.org/10.1097/mcg.0000000000000328
Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats
Lipids in Health and Disease / Jan 01, 2011
Yamazaki, R. K., Brito, G. A., Coelho, I., Pequitto, D. C., Yamaguchi, A. A., Borghetti, G., Schiessel, D., Kryczyk, M., Machado, J., Rocha, R. E., Aikawa, J., Iagher, F., Naliwaiko, K., Tanhoffer, R. A., Nunes, E. A., & Fernandes, L. (2011). Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats. Lipids in Health and Disease, 10(1), 66. https://doi.org/10.1186/1476-511x-10-66
Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men
Medicine & Science in Sports & Exercise / Jan 01, 2019
JAKUBOWSKI, J. S., WONG, E. P. T., NUNES, E. A., NOGUCHI, K. S., VANDEWEERD, J. K., MURPHY, K. T., MORTON, R. W., MCGLORY, C., & PHILLIPS, S. M. (2019). Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men. Medicine & Science in Sports & Exercise, 51(1), 65–74. https://doi.org/10.1249/mss.0000000000001752
An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy
Medicine & Science in Sports & Exercise / Apr 06, 2022
LIM, C., NUNES, E. A., CURRIER, B. S., MCLEOD, J. C., THOMAS, A. C. Q., & PHILLIPS, S. M. (2022). An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy. Medicine & Science in Sports & Exercise, 54(9), 1546–1559. https://doi.org/10.1249/mss.0000000000002929
In vitro ketone‐supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle
The Journal of Physiology / Aug 19, 2020
Petrick, H. L., Brunetta, H. S., Pignanelli, C., Nunes, E. A., van Loon, L. J. C., Burr, J. F., & Holloway, G. P. (2020). In vitro ketone‐supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle. The Journal of Physiology, 598(21), 4869–4885. Portico. https://doi.org/10.1113/jp280032
Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats
Lipids in Health and Disease / Oct 16, 2013
Iagher, F., de Brito Belo, S. R., Souza, W. M., Nunes, J. R., Naliwaiko, K., Sassaki, G. L., Bonatto, S. J. R., de Oliveira, H. H. P., Brito, G. A. P., de Lima, C., Kryczyk, M., de Souza, C. F., Steffani, J. A., Nunes, E. A., & Fernandes, L. C. (2013). Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats. Lipids in Health and Disease, 12(1). https://doi.org/10.1186/1476-511x-12-146
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model
Arquivos Brasileiros de Endocrinologia & Metabologia / Nov 01, 2013
Rocha, R. E. R., Coelho, I., Pequito, D. C. T., Yamagushi, A., Borghetti, G., Yamazaki, R. K., Brito, G. A. P. de, Machado, J., Kryczyk, M., Nunes, E. A., Venera, G., & Fernandes, L. C. (2013). Interval training attenuates the metabolic disturbances in type 1 diabetes rat model. Arquivos Brasileiros de Endocrinologia & Metabologia, 57(8), 594–602. https://doi.org/10.1590/s0004-27302013000800003
Decrement in resting and insulin‐stimulated soleus muscle mitochondrial respiration is an early event in diet‐induced obesity in mice
Experimental Physiology / Jan 24, 2019
Brunetta, H. S., de Paula, G. C., de Oliveira, J., Martins, E. L., dos Santos, G. J., Galina, A., Rafacho, A., de Bem, A. F., & Nunes, E. A. (2019). Decrement in resting and insulin‐stimulated soleus muscle mitochondrial respiration is an early event in diet‐induced obesity in mice. Experimental Physiology, 104(3), 306–321. Portico. https://doi.org/10.1113/ep087317
Nitrate attenuates high fat diet‐induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission
The Journal of Physiology / Jun 16, 2020
Brunetta, H. S., Politis‐Barber, V., Petrick, H. L., Dennis, K. M. J. H., Kirsh, A. J., Barbeau, P., Nunes, E. A., & Holloway, G. P. (2020). Nitrate attenuates high fat diet‐induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission. The Journal of Physiology, 598(16), 3357–3371. Portico. https://doi.org/10.1113/jp279455
Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats
Canadian Journal of Physiology and Pharmacology / Oct 01, 2014
dos Santos, C., Ferreira, F. B. D., Gonçalves-Neto, L. M., Taboga, S. R., Boschero, A. C., & Rafacho, A. (2014). Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats. Canadian Journal of Physiology and Pharmacology, 92(10), 867–878. https://doi.org/10.1139/cjpp-2014-0259
Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment
Biochemical Journal / Jul 09, 2021
Brunetta, H. S., Petrick, H. L., Vachon, B., Nunes, E. A., & Holloway, G. P. (2021). Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment. Biochemical Journal, 478(13), 2539–2553. https://doi.org/10.1042/bcj20210264
An umbrella review of systematic reviews of β‐hydroxy‐β‐methyl butyrate supplementation in ageing and clinical practice
Journal of Cachexia, Sarcopenia and Muscle / Jul 12, 2022
Phillips, S. M., Lau, K. J., D’Souza, A. C., & Nunes, E. A. (2022). An umbrella review of systematic reviews of β‐hydroxy‐β‐methyl butyrate supplementation in ageing and clinical practice. Journal of Cachexia, Sarcopenia and Muscle, 13(5), 2265–2275. Portico. https://doi.org/10.1002/jcsm.13030
Heart rate reactivity to acute mental stress is associated with adiposity, carotid distensibility, sleep efficiency, and autonomic modulation in young men
Physiology & Behavior / Oct 01, 2022
Formolo, N. P. S., Filipini, R. E., Macedo, E. F. O., Corrêa, C. R., Nunes, E. A., Lima, L. R. A., & Speretta, G. F. (2022). Heart rate reactivity to acute mental stress is associated with adiposity, carotid distensibility, sleep efficiency, and autonomic modulation in young men. Physiology & Behavior, 254, 113908. https://doi.org/10.1016/j.physbeh.2022.113908
Increased protein intake derived from leucine-enriched protein enhances the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women: a 4-day randomized controlled trial
Applied Physiology, Nutrition, and Metabolism / Nov 01, 2022
Lim, C., Traylor, D. A., McGlory, C., Joanisse, S., McKendry, J., Grewal, T., Mcleod, J. C., Prior, T., Nunes, E. A., Lees, M., & Phillips, S. M. (2022). Increased protein intake derived from leucine-enriched protein enhances the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women: a 4-day randomized controlled trial. Applied Physiology, Nutrition, and Metabolism, 47(11), 1104–1114. https://doi.org/10.1139/apnm-2022-0164
Mixed-meal test reveals a worsen phenotypic flexibility correlated to central adiposity in clinically healthy young males
Clinical Nutrition ESPEN / Dec 01, 2020
Corrêa, C. R., Filipini, R. E., Mazera, M. S., Rafacho, A., & Nunes, E. A. (2020). Mixed-meal test reveals a worsen phenotypic flexibility correlated to central adiposity in clinically healthy young males. Clinical Nutrition ESPEN, 40, 622. https://doi.org/10.1016/j.clnesp.2020.09.650
Associação da atividade física, consumo de álcool e índice de massa corporal com a qualidade de vida de adolescentes
Revista Brasileira de Cineantropometria e Desempenho Humano / Jul 18, 2008
Gordia, A. P. (2008). Associação da atividade física, consumo de álcool e índice de massa corporal com a qualidade de vida de adolescentes. Revista Brasileira de Cineantropometria e Desempenho Humano, 10(3), 313. https://doi.org/10.5007/1980-0037.2008v10n3p313
β-hydroxy-β-methylbutyrate (HMB) Does Not Improve Resistance Exercise-Induced Changes In Body Composition: A Systematic-review And Meta-analysis
Medicine & Science in Sports & Exercise / Jul 01, 2020
Nunes, E. A., Jakubowski, J., Teixeira, F. J., Vescio, V., Morton, R. W., & Phillips, S. M. (2020). β-hydroxy-β-methylbutyrate (HMB) Does Not Improve Resistance Exercise-Induced Changes In Body Composition: A Systematic-review And Meta-analysis: 1698 Board #292 May 28 9:30 AM - 11:00 AM. Medicine & Science in Sports & Exercise, 52(7S), 456–457. https://doi.org/10.1249/01.mss.0000678888.31639.48
1739-P: Insulin Rapidly Increases Skeletal Muscle Mitochondrial ADP Sensitivity, Mitigating HFD-Induced Mitochondrial Dysfunction
Diabetes / Jun 01, 2020
BRUNETTA, H., PETRICK, H. L., NUNES, E. A., & HOLLOWAY, G. (2020). 1739-P: Insulin Rapidly Increases Skeletal Muscle Mitochondrial ADP Sensitivity, Mitigating HFD-Induced Mitochondrial Dysfunction. Diabetes, 69(Supplement_1). https://doi.org/10.2337/db20-1739-p
Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies
American Journal of Physiology-Cell Physiology / Jun 01, 2022
Nunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022). Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies. American Journal of Physiology-Cell Physiology, 322(6), C1068–C1084. https://doi.org/10.1152/ajpcell.00425.2021
Dietary acid load is positively associated with insulin resistance: a population-based study
Clinical Nutrition ESPEN / Jun 01, 2022
Smeha, L., Fassula, A. S., Franco Moreno, Y. M., Gonzalez-Chica, D. A., & Nunes, E. A. (2022). Dietary acid load is positively associated with insulin resistance: a population-based study. Clinical Nutrition ESPEN, 49, 341–347. https://doi.org/10.1016/j.clnesp.2022.03.025
Relative fat mass is a better tool to diagnose high adiposity when compared to body mass index in young male adults: A cross-section study
Clinical Nutrition ESPEN / Feb 01, 2021
Corrêa, C. R., Formolo, N. P. S., Dezanetti, T., Speretta, G. F. F., & Nunes, E. A. (2021). Relative fat mass is a better tool to diagnose high adiposity when compared to body mass index in young male adults: A cross-section study. Clinical Nutrition ESPEN, 41, 225–233. https://doi.org/10.1016/j.clnesp.2020.12.009
Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration
The Journal of Nutritional Biochemistry / Apr 01, 2021
Santos, C. dos, da Silva, J. S., Brunetta, H. S., Chagas, T. R., Zoccal, D. B., Nunes, E. A., & Rafacho, A. (2021). Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration. The Journal of Nutritional Biochemistry, 90, 108572. https://doi.org/10.1016/j.jnutbio.2020.108572
Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies
Clinical Nutrition Open Science / Apr 01, 2021
Joanisse, S., McKendry, J., Lim, C., Nunes, E. A., Stokes, T., Mcleod, J. C., & Phillips, S. M. (2021). Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies. Clinical Nutrition Open Science, 36, 56–77. https://doi.org/10.1016/j.nutos.2021.01.005
Effect of mate tea consumption on rapid force production after eccentric exercise: a randomized, controlled, crossover study
Sport Sciences for Health / Jul 09, 2020
Moura, B. M., Panza, V. P., Brunetta, H. S., Tamborindeguy, A. C., de Oliveira, M. V., Sakugawa, R. L., Nunes, E. A., da Silva, E. L., & Diefenthaeler, F. (2020). Effect of mate tea consumption on rapid force production after eccentric exercise: a randomized, controlled, crossover study. Sport Sciences for Health, 16(3), 571–581. https://doi.org/10.1007/s11332-020-00669-9
Association of physical activity and sedentary behavior at school with cardiovascular risk factors in adolescents
Revista Brasileira de Cineantropometria & Desempenho Humano / Jan 01, 2020
Santos, P. C. dos, Lima, L. R. A. de, Costa, B. G. G. da, Martins, C. R., Minatto, G., Berria, J., Nunes, E. A., Petroski, E. L., & Silva, K. S. da. (2020). Association of physical activity and sedentary behavior at school with cardiovascular risk factors in adolescents. Revista Brasileira de Cineantropometria & Desempenho Humano, 22. https://doi.org/10.1590/1980-0037.2020v22e72397
Behavioral, cardiovascular and endocrine alterations induced by chronic stress in rats fed a high-fat diet
Physiology & Behavior / Sep 01, 2020
Batschauer, T., Cordeiro, J. M., Simas, B. B., Brunetta, H. S., Souza, R. M., Nunes, E. A., Reis, W. L., Moreira, E. L. G., Crestani, C. C., Santos, A. R. S., & Speretta, G. F. (2020). Behavioral, cardiovascular and endocrine alterations induced by chronic stress in rats fed a high-fat diet. Physiology & Behavior, 223, 113013. https://doi.org/10.1016/j.physbeh.2020.113013
Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice
Neurochemical Research / Sep 23, 2020
dos Santos, B., Schmitz, A. E., de Almeida, G. R. L., de Souza, L. F., Szczepanik, J. C., Nunes, E. A., Brunetta, H. S., Mack, J. M., Prediger, R. D., Cunha, M. P., & Dafre, A. L. (2020). Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice. Neurochemical Research, 45(12), 2868–2883. https://doi.org/10.1007/s11064-020-03135-7
Fish oil decreases the severity of treatment-related adverse events in gastrointestinal cancer patients undergoing chemotherapy: A randomized, placebo-controlled, triple-blind clinical trial
Clinical Nutrition ESPEN / Jun 01, 2019
Camargo, C. de Q., Mocellin, M. C., Brunetta, H. S., Chagas, T. R., Fabre, M. E. de S., Trindade, E. B. S. de M., Silva, E. L. da, & Nunes, E. A. (2019). Fish oil decreases the severity of treatment-related adverse events in gastrointestinal cancer patients undergoing chemotherapy: A randomized, placebo-controlled, triple-blind clinical trial. Clinical Nutrition ESPEN, 31, 61–70. https://doi.org/10.1016/j.clnesp.2019.02.015
Aerobic fitness and physical activity are inversely associated with body fat, dyslipidemia and inflammatory mediators in children and adolescents living with HIV
Journal of Sports Sciences / Jun 08, 2018
de Lima, L. R. A., Back, I. de C., Nunes, E. A., Silva, D. A. S., & Petroski, E. L. (2018). Aerobic fitness and physical activity are inversely associated with body fat, dyslipidemia and inflammatory mediators in children and adolescents living with HIV. Journal of Sports Sciences, 37(1), 50–58. https://doi.org/10.1080/02640414.2018.1481724
Assessing the mechanistic target of rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay
Applied Physiology, Nutrition, and Metabolism / Sep 01, 2018
McGlory, C., Nunes, E. A., Oikawa, S. Y., Tsakiridis, E., & Phillips, S. M. (2018). Assessing the mechanistic target of rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay. Applied Physiology, Nutrition, and Metabolism, 43(9), 945–949. https://doi.org/10.1139/apnm-2017-0852
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats
Stress / Feb 10, 2018
Simas, B. B., Nunes, E. A., Crestani, C. C., & Speretta, G. F. (2018). Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats. Stress, 21(3), 247–256. https://doi.org/10.1080/10253890.2018.1437413
Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice
International Journal of Experimental Pathology / Dec 01, 2017
Ferreira, F. B. D., dos Santos, C., Bruxel, M. A., Nunes, E. A., Spiller, F., & Rafacho, A. (2017). Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice. International Journal of Experimental Pathology, 98(6), 329–340. Portico. https://doi.org/10.1111/iep.12255
Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose
BioMed Research International / Jan 01, 2017
Sulis, P. M., Motta, K., Barbosa, A. M., Besen, M. H., da Silva, J. S., Nunes, E. A., & Rafacho, A. (2017). Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose. BioMed Research International, 2017, 1–16. https://doi.org/10.1155/2017/4378328
Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats
Applied Physiology, Nutrition, and Metabolism / Apr 01, 2016
Barbosa, A. M., Francisco, P. de C., Motta, K., Chagas, T. R., dos Santos, C., Rafacho, A., & Nunes, E. A. (2016). Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats. Applied Physiology, Nutrition, and Metabolism, 41(4), 382–390. https://doi.org/10.1139/apnm-2015-0487
INTERVAL TRAINING IS INSUFFICIENT TO ATTENUATE METABOLIC DISTURBANCES IN DIABETIC RATS
Revista Brasileira de Medicina do Esporte / Oct 01, 2016
Rocha, R. E. R. da, Nunes, E. A., Venera, G. D., & Fernandes, L. C. (2016). INTERVAL TRAINING IS INSUFFICIENT TO ATTENUATE METABOLIC DISTURBANCES IN DIABETIC RATS. Revista Brasileira de Medicina Do Esporte, 22(5), 393–397. https://doi.org/10.1590/1517-869220162205154777
Glucose homoeostasis in rats exposed to acute intermittent hypoxia
Acta Physiologica / Jun 08, 2013
Rafacho, A., Gonçalves-Neto, L. M., Ferreira, F. B. D., Protzek, A. O. P., Boschero, A. C., Nunes, E. A., & Zoccal, D. B. (2013). Glucose homoeostasis in rats exposed to acute intermittent hypoxia. Acta Physiologica, 209(1), 77–89. https://doi.org/10.1111/apha.12118
Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats
Applied Physiology, Nutrition, and Metabolism / Nov 01, 2013
Nunes, E. A., Gonçalves-Neto, L. M., Ferreira, F. B. D., dos Santos, C., Fernandes, L. C., Boschero, A. C., Calder, P. C., & Rafacho, A. (2013). Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats. Applied Physiology, Nutrition, and Metabolism, 38(11), 1137–1146. https://doi.org/10.1139/apnm-2012-0456
Relationship between Acute Phase Proteins and Serum Fatty Acid Composition in Morbidly Obese Patients
Disease Markers / Jan 01, 2013
Fernandes, R., Beserra, B. T. S., Cunha, R. S. G., Hillesheim, E., Camargo, C. de Q., Pequito, D. C. T., de Castro, I. C., Fernandes, L. C., Nunes, E. A., & Trindade, E. B. S. de M. (2013). Relationship between Acute Phase Proteins and Serum Fatty Acid Composition in Morbidly Obese Patients. Disease Markers, 35, 105–112. https://doi.org/10.1155/2013/913715
β-Hydroxy-β-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro
Nutrition / Jan 01, 2011
Nunes, E. A., Lomax, A. R., Noakes, P. S., Miles, E. A., Fernandes, L. C., & Calder, P. C. (2011). β-Hydroxy-β-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro. Nutrition, 27(1), 92–99. https://doi.org/10.1016/j.nut.2009.12.008
Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise
Cell Biochemistry and Function / May 26, 2010
Brito, G. A. P., Nunes, E. A., Nogata, C., Yamazaky, R. K., Naliwaiko, K., Curi, R., & Fernandes, L. C. (2010). Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise. Cell Biochemistry and Function, 28(4), 278–282. Portico. https://doi.org/10.1002/cbf.1652
Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats
Nutrition Research / Nov 01, 2010
Belo, S. R. B., Iagher, F., Bonatto, S. J., Naliwaiko, K., Calder, P. C., Nunes, E. A., & Fernandes, L. C. (2010). Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats. Nutrition Research, 30(11), 770–776. https://doi.org/10.1016/j.nutres.2010.09.015
Neutrophil response of anaerobic jump trained diabetic rats
European Journal of Applied Physiology / Sep 10, 2008
de Souza, C. F., Machado, A. F., Bonatto, S. J. R., Grando, F. C. C., Pessini, C., Alves, L. E., de Lima, C., de Brito, G. A. P., Nunes, E. A., & Fernandes, L. C. (2008). Neutrophil response of anaerobic jump trained diabetic rats. European Journal of Applied Physiology, 104(6), 1079–1086. https://doi.org/10.1007/s00421-008-0865-9
Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation
Prostaglandins, Leukotrienes and Essential Fatty Acids / Feb 01, 2007
Mund, R. C., Pizato, N., Bonatto, S., Nunes, E. A., Vicenzi, T., Tanhoffer, R., de Oliveira, H. H. P., Curi, R., Calder, P. C., & Fernandes, L. C. (2007). Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation. Prostaglandins, Leukotrienes and Essential Fatty Acids, 76(2), 113–120. https://doi.org/10.1016/j.plefa.2006.11.008
Fish oil alters T-lymphocyte proliferation and macrophage responses in Walker 256 tumor-bearing rats
Nutrition / Apr 01, 2006
Pizato, N., Bonatto, S., Piconcelli, M., de Souza, L. M., Sassaki, G. L., Naliwaiko, K., Nunes, E. A., Curi, R., Calder, P. C., & Fernandes, L. C. (2006). Fish oil alters T-lymphocyte proliferation and macrophage responses in Walker 256 tumor-bearing rats. Nutrition, 22(4), 425–432. https://doi.org/10.1016/j.nut.2005.11.001
The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle
Molecular and Cellular Biochemistry / May 01, 2005
Yamazaki, R. K., Hirabara, S. M., Tchaikovski, O., Lopes, M. C. P., Nogata, C., Aikawa, J., Nunes, E. A., Tanhoffer, R. A., Lissa, M. D., & Fernandes, L. C. (2005). The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle. Molecular and Cellular Biochemistry, 273(1–2), 145–150. https://doi.org/10.1007/s11010-005-8265-5
Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation
Applied Physiology, Nutrition, and Metabolism / Aug 01, 2011
de Lima, C., Alves, L., Iagher, F., Machado, A. F., Kryczyk, M., Yamazaki, R. K., Brito, G. A. P., Nunes, E. A., Naliwaiko, K., & Fernandes, L. C. (2011). Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation. Applied Physiology, Nutrition, and Metabolism, 36(4), 533–538. https://doi.org/10.1139/h11-047
See Full Profile
Dr. Shilpa Patil, Ph.D
PhD & Postdoc level expertise in Cancer Research
Education
University of Göttingen
Ph.D, Cancer Research / June, 2020
Manipal Academy of Higher Education
MSc, Regenerative Medicine / August, 2014
Manipal Academy of Higher Education
BSc, Biotechnology / August, 2012
Experience
University of British Columbia
Postdoctoral Research Fellow / January, 2021 — July, 2023
University of Gottingen
Postdoctoral Researcher / July, 2020 — December, 2020
JNCASR
Research Assistant / September, 2014 — February, 2016
Most Relevant Research Expertise
Other Research Expertise (9)
About
Most Relevant Publications (9+)
20 total publications
Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
EBioMedicine / Feb 01, 2019
Patzak, M. S., Kari, V., Patil, S., Hamdan, F. H., Goetze, R. G., Brunner, M., Gaedcke, J., Kitz, J., Jodrell, D. I., Richards, F. M., Pilarsky, C., Gruetzmann, R., Rümmele, P., Knösel, T., Hessmann, E., Ellenrieder, V., Johnsen, S. A., & Neesse, A. (2019). Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites. EBioMedicine, 40, 394–405. https://doi.org/10.1016/j.ebiom.2019.01.037
Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models
Journal of Visualized Experiments / Apr 07, 2018
Goetze, R.-G., Buchholz, S. M., Patil, S., Petzold, G., Ellenrieder, V., Hessmann, E., & Neesse, A. (2018). Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models. Journal of Visualized Experiments, 134. https://doi.org/10.3791/56979-v
Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation
Biochimica et Biophysica Acta (BBA) - General Subjects / Aug 01, 2018
Kaypee, S., Sahadevan, S. A., Sudarshan, D., Halder Sinha, S., Patil, S., Senapati, P., Kodaganur, G. S., Mohiyuddin, A., Dasgupta, D., & Kundu, T. K. (2018). Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation. Biochimica et Biophysica Acta (BBA) - General Subjects, 1862(8), 1729–1741. https://doi.org/10.1016/j.bbagen.2018.05.003
Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes
Visceral Medicine / Dec 27, 2021
Patil, S., Dou, Y., & Kopp, J. L. (2021). Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes. Visceral Medicine, 38(1), 4–10. Portico. https://doi.org/10.1159/000520946
NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming
Cellular and Molecular Gastroenterology and Hepatology / Jan 01, 2023
Zhang, Z., Wang, X., Hamdan, F. H., Likhobabina, A., Patil, S., Aperdannier, L., Sen, M., Traub, J., Neesse, A., Fischer, A., Papantonis, A., Singh, S. K., Ellenrieder, V., Johnsen, S. A., & Hessmann, E. (2023). NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming. Cellular and Molecular Gastroenterology and Hepatology, 15(5), 1219–1246. https://doi.org/10.1016/j.jcmgh.2023.01.015
EZH2 controls PDAC plasticity by regulating differentiation genes
Pancreatology / Jun 01, 2019
Patil, S., Najafova, Z., Kari, V., Wang, X., Bohnenberger, H., Kopp, W., Spitalieri, J., Neesse, A., Ellenrieder, V., Johnsen, S., & Hessmann, E. (2019). EZH2 controls PDAC plasticity by regulating differentiation genes. Pancreatology, 19, S11. https://doi.org/10.1016/j.pan.2019.05.021
Impact of cytosolic 5'-nucleotidase 1A on chemotherapeutic resistance in pancreatic cancer
Pancreatology / Jun 01, 2018
Patzak, M. S., Hessmann, E., Kari, V., Kitz, J., Patil, S., Richards, F. M., Jodrell, D. I., Johnsen, S. A., Ellenrieder, V., & Neesse, A. (2018). Impact of cytosolic 5’-nucleotidase 1A on chemotherapeutic resistance in pancreatic cancer. Pancreatology, 18(4), S91. https://doi.org/10.1016/j.pan.2018.05.247
Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity
Pancreatology / Jul 01, 2017
Patil, S., Witte, H., Neesse, A., Johnsen, S., Ellenrieder, V., & Hessmann, E. (2017). Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity. Pancreatology, 17(3), S41. https://doi.org/10.1016/j.pan.2017.05.128
Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models
Journal of Visualized Experiments / Apr 07, 2018
Goetze, R.-G., Buchholz, S. M., Patil, S., Petzold, G., Ellenrieder, V., Hessmann, E., & Neesse, A. (2018). Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models. Journal of Visualized Experiments, 134. https://doi.org/10.3791/56979
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Joshua adekunle Babalola, Ph.D.
A scientist interested in translating life science skills into solving real life problems relating to microbes, aging, neurodegenerative and metabolic diseases. An advocate of inclusive science and life style changes.
Education
Medical University of Graz
PhD, Human Medicine / December, 2023
Experience
Medical University of Graz
Doctoral Researcher / November, 2019 — December, 2023
I investigated the contribution of metabolic dysfunctions to the progression of degenerative diseases of the brain
Hallym University, South Korea
Research Fellow / February, 2016 — September, 2019
I investigated the specie transmissibility of animal prions from one host to another. I also investigated the genotype frequency of prion protein polymorphism among healthy Nigerians.
Most Relevant Research Expertise
Other Research Expertise (5)
About
Most Relevant Publications (4+)
9 total publications
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation
Brain Research / Nov 01, 2023
Babalola, J. A., Lang, M., George, M., Stracke, A., Tam-Amersdorfer, C., Itxaso, I., Lucija, D., Tadic, J., Schilcher, I., Loeffler, T., Flunkert, S., Prokesch, M., Leitinger, G., Lass, A., Hutter-Paier, B., Panzenboeck, U., & Hoefler, G. (2023). Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation. Brain Research, 1819, 148518. https://doi.org/10.1016/j.brainres.2023.148518
Sex and genotype dependent differences in amyloid beta levels and lipid metabolism in type 2 diabetic APPxhQC transgenic mice
Alzheimer's & Dementia / Dec 01, 2023
Babalola, J. A., Lang, M., George, M., Stracke, A., Loeffler, T., Schilcher, I., Flunkert, S., Neddens, J., Prokesch, M., Leitinger, G., Lass, A., Hoefler, G., & Hutter‐Paier, B. (2023). Sex and genotype dependent differences in amyloid beta levels and lipid metabolism in type 2 diabetic APPxhQC transgenic mice. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.079077
Establishing a Type 2 Diabetes phenotype in APPxhQC transgenic mice expressing N‐terminally modified pGlu Aβ peptides.
Alzheimer's & Dementia / Dec 01, 2022
Babalola, J. A., Loeffler, T., Schilcher, I., Breznik, L., Rabl, R., Sideromenos, S., Flunkert, S., Prokesch, M., Hoefler, G., & Hutter‐Paier, B. (2022). Establishing a Type 2 Diabetes phenotype in APPxhQC transgenic mice expressing N‐terminally modified pGlu Aβ peptides. Alzheimer’s & Dementia, 18(S3). Portico. https://doi.org/10.1002/alz.066646
Liver-X receptor activation attenuates oxysterol induced inflammatory response in human feto-placental endothelial cells in gestational diabetes mellitus
Placenta / Sep 01, 2021
Geroge, M., Lang, M., Tam-Amersdorfer, C., Joshua, B., & Wadsack, C. (2021). Liver-X receptor activation attenuates oxysterol induced inflammatory response in human feto-placental endothelial cells in gestational diabetes mellitus. Placenta, 112, e37. https://doi.org/10.1016/j.placenta.2021.07.121
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