Experts and Thought Leaders in Life Sciences

Martin Tsui

San Francisco, California, United States of America
7 Years Experience
University of California, San Francisco
Education

Florida State University

Ph.D., Molecular Biophysics / July, 2017

Tallahassee, Florida, United States of America

University of California, San Diego

B.S., Chemistry / June, 2012

San Diego, California, United States of America
Experience

Stealth

Founder & CEO / January, 2023Present

Genome engineering

Amazon

Senior Scientist / December, 2021February, 2023

Molecular Diagnostics

Van Andel Institute

Postdoctoral Fellow / September, 2020April, 2021

Cryo-EM of membrane proteins

Most Relevant Research Expertise
Molecular Biology
Cell Biology
Other Research Expertise (14)
Biochemistry
Structural Biology
Cryo-EM
CRISPR
Molecular Assembly and Interaction
And 9 more
About
Martin Tsui is an accomplished scientist with a strong background in biochemistry. He received his Ph.D. in Molecular Biophysics from Florida State University in 2017, where he conducted research on the structure and function of CRISPR proteins. Prior to that, he obtained his B.S. in Chemistry from the University of California, San Diego in 2012. After completing his graduate studies, Martin founded his own company, Stealth, where he serves as a Founder & CEO. Under his leadership, the company has developed innovative solutions for the biotech industry and has gained recognition for its groundbreaking research. Before starting his company, Martin worked as a Senior Scientist at Amazon, where he applied his expertise in protein biochemistry and CRISPR to improve the company's product development processes and creating new products. He also gained valuable experience as a Postdoctoral Scholar at the University of California, San Francisco and Postdoctoral Fellow at the Van Andel Institute, where he studied cancer proteins, SARS-CoV-2, HIV proteins, and the role of proteins in neurodegenerative diseases, respectively. Martin is a highly driven and passionate individual who is dedicated to advancing the field of biotechnology. His impressive education and diverse experience have equipped him with the skills and knowledge to make significant contributions to the scientific community. He continues to pursue new opportunities to further his research and make a positive impact in the world of science.
Most Relevant Publications (4+)

16 total publications

Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification

Briefings in Bioinformatics / Sep 11, 2020

Khan, A. A., & Khan, Z. (2020). Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification. Briefings in Bioinformatics, 22(2), 1206–1214. https://doi.org/10.1093/bib/bbaa207

Structure Principles of CRISPR-Cas Surveillance and Effector Complexes

Annual Review of Biophysics / Jun 22, 2015

Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

Structure / Mar 01, 2023

Remesh, S. G., Merz, G. E., Brilot, A. F., Chio, U. S., Rizo, A. N., Pospiech, T. H., Lui, I., Laurie, M. T., Glasgow, J., Le, C. Q., Zhang, Y., Diwanji, D., Hernandez, E., Lopez, J., Mehmood, H., Pawar, K. I., Pourmal, S., Smith, A. M., Zhou, F., … Verba, K. A. (2023). Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31(3), 253-264.e6. https://doi.org/10.1016/j.str.2023.01.009

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Nature Chemical Biology / Oct 20, 2020

Bracken, C. J., Lim, S. A., Solomon, P., Rettko, N. J., Nguyen, D. P., Zha, B. S., Schaefer, K., Byrnes, J. R., Zhou, J., Lui, I., Liu, J., Pance, K., Azumaya, C. M., Braxton, J. R., Brilot, A. F., Gupta, M., Li, F., Lopez, K. E., … Melo, A. (2020). Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nature Chemical Biology, 17(1), 113–121. https://doi.org/10.1038/s41589-020-00679-1

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Xiaolei Wang

Raleigh, North Carolina, United States of America
8 Years Experience
R&D Scientist in biomedical imaging and surgical microscope development
Education

University of Science and Technology of China

Ph.D., Optics / June, 2011

Hefei

Anhui Normal University

Bachelor, Physics / July, 2006

Wuhu
Experience

Duke University

Research Scientist/Manager / June, 2019May, 2022

University of Chicago

Research Professional / April, 2016May, 2019

True Digital Surgery

Principal R&D Scientist / July, 2022January, 2024

Most Relevant Research Expertise
Biotechnology
Molecular Biology
Developmental Biology
Other Research Expertise (17)
Optical imaging system development
image analysis algorithm development
Atomic and Molecular Physics, and Optics
Mechanics of Materials
Mechanical Engineering
And 12 more
About
I am an R&D Optical Scientist and Expert specializing in Optical Imaging and Optical Microscope Development for biomedical and clinical applications. With a background in Physics and over 15 years of experience in optical science and imaging, I am passionate about pushing the boundaries of what light can achieve in the realm of medicine and healthcare. My journey in the world of optics has led me to become a leader in the research and development of next-generation optical imaging products that have a profound impact on surgical procedures and patient outcomes. My areas of expertise encompass optical physics, optical microscopy, optical metrology, photonics, and computational modeling and simulation. I've had the privilege of sharing my insights through multiple peer-reviewed publications in prestigious journals like ACS Nano, Optical Letter, and Advanced Materials. Additionally, I hold certifications in machine learning and deep learning for image analysis, allowing me to harness the power of cutting-edge technology in my work.
Most Relevant Publications (2+)

33 total publications

Computational multifocal microscopy

Biomedical Optics Express / Nov 28, 2018

He, K., Wang, Z., Huang, X., Wang, X., Yoo, S., Ruiz, P., Gdor, I., Selewa, A., Ferrier, N. J., Scherer, N., Hereld, M., Katsaggelos, A. K., & Cossairt, O. (2018). Computational multifocal microscopy. Biomedical Optics Express, 9(12), 6477. https://doi.org/10.1364/boe.9.006477

DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning

Development / Nov 01, 2022

Haertter, D., Wang, X., Fogerson, S. M., Ramkumar, N., Crawford, J. M., Poss, K. D., Di Talia, S., Kiehart, D. P., & Schmidt, C. F. (2022). DeepProjection: specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning. Development, 149(21). https://doi.org/10.1242/dev.200621

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Odion Ikhimiukor

Albany, New York, United States of America
6 Years Experience
Postdoctoral Research Scientist at University at Albany, State University of New York
Education

University of Ibadan

PhD Microbiology, Bacterial genomics, Bioinformatics, Microbiology

Ibadan

University of Ibadan

Master of Science (M. Sc.), Environmental Microbiology / April, 2015

Ibadan

University of Abuja

Bachelor of Science (B.Sc.), Microbiology / March, 2011

Abuja
Experience

University at Albany, State University of New York

Postdoctoral Associate

National Institute for Pharmaceutical Research and Development

FCT Emergency Services, Asokoro District Hospital

Most Relevant Research Expertise
Bioinformatics
Molecular Biology
Cell Biology
Microbiology
Applied Microbiology and Biotechnology
Genetics
Microbiology (medical)
Animal Science and Zoology
Physiology
Other Research Expertise (15)
Pathogen Genomics
Epidemiology
Environmental Microbiology
Immunology
Pollution
And 10 more
About
A postdoctoral research scientist with over 9 years experience in bacterial genomics, microbiology, bioinformatics and antimicrobial resistance research. I’m seeking a Research Scientist or Epidemiologist role at public health genomics laboratories and I am the perfect fit for these roles because I have the following skills: molecular biology, research & development, strategic planning, project management, documentation, outbreak investigation, and cross-functional collaboration skills. I have leveraged my skills to work in a collaborative team-oriented environment to accomplish project goals related to examining the evolution of antimicrobial resistance as evidenced by over 7 national and international collaborations including the New York State Department of Health. I am also a proactive problem-solver adopting innovative and scientific thinking strategies in molecular biology to fulfill project objectives resulting in scientific discoveries including uncovering 1 novel hotspot for the dissemination of resistance in bacteria. I have gained mentorship expertise in promoting data reproducibility, and innovative research methodology in antimicrobial resistance research as evidenced by mentoring 10 professionals on evolutionary genomics, epidemiological statistics, and antimicrobial stewardship. I have also worked collaboratively with a team to apply pathogen genomics, bioinformatics, and leadership skills as demonstrated by working with over 10 highly collaborative teams including the Africa CDC. In addition, I have the following qualifications: Cross-functional collaborator and experience elucidating methods and frequencies of horizontal gene transfer and antimicrobial resistance spread in bacterial species, as demonstrated by 26 peer-reviewed publications including 1 in Nature Microbiology. Experience in leading and managing project details and tasks as evidenced by over 20 projects in pathogen genomics, epidemiology, antimicrobial resistance surveillance, and global health. Astute communication skills in bacterial epidemiology and antimicrobial resistance research resulting in 20 presentations and 6 travel awards to deliver such presentations, including the Bill and Melinda Gates Foundation. I want to serve an organization that prizes community, collaboration and humility among its employees. I’m excited to be on a team built around impact, innovation and a strong, positive reputation. I know I will thrive at a company where responsibility is valued, as well as self-improvement and time-management. I want to be a part of an organization that infuses growth into their brand, culture and market and who I can help make a difference in the world.
Most Relevant Publications (10+)

27 total publications

A bottom-up view of antimicrobial resistance transmission in developing countries

Nature Microbiology / May 30, 2022

Ikhimiukor, O. O., Odih, E. E., Donado-Godoy, P., & Okeke, I. N. (2022). A bottom-up view of antimicrobial resistance transmission in developing countries. Nature Microbiology, 7(6), 757–765. https://doi.org/10.1038/s41564-022-01124-w

A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex

Nature Communications / Jul 07, 2021

Lam, M. M. C., Wick, R. R., Watts, S. C., Cerdeira, L. T., Wyres, K. L., & Holt, K. E. (2021). A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24448-3

Evolutionary dynamics of the accessory genomes of Staphylococcus aureus

mSphere / Mar 19, 2024

Piper, K. R., Ikhimiukor, O. O., Souza, S. S. R., Garcia-Aroca, T., & Andam, C. P. (2024). Evolutionary dynamics of the accessory genomes of Staphylococcus aureus. MSphere. https://doi.org/10.1128/msphere.00751-23

Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales

Microbiology Spectrum / Oct 17, 2023

Ikhimiukor, O. O., Souza, S. S. R., Akintayo, I. J., Marcovici, M. M., Workman, A., Martin, I. W., & Andam, C. P. (2023). Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales. Microbiology Spectrum, 11(5). https://doi.org/10.1128/spectrum.00549-23

Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species

Communications Biology / May 03, 2023

Ikhimiukor, O. O., Souza, S. S. R., Marcovici, M. M., Nye, G. J., Gibson, R., & Andam, C. P. (2023). Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species. Communications Biology, 6(1). https://doi.org/10.1038/s42003-023-04877-0

Genome Sequencing of Methicillin-Resistant and Methicillin-Susceptible Mammaliicoccus sciuri from Diseased Animals

Microbiology Resource Announcements / Oct 20, 2022

Garcia-Aroca, T., Souza, S. S. R., Ikhimiukor, O. O., Marcovici, M. M., Smith, J. T., Amador, S., McGonagle, C. J., Nye, G. J., Needle, D. B., Gibson, R., & Andam, C. P. (2022). Genome Sequencing of Methicillin-Resistant and Methicillin-Susceptible Mammaliicoccus sciuri from Diseased Animals. Microbiology Resource Announcements, 11(10). https://doi.org/10.1128/mra.00714-22

Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria’s experience

Microbiology / Sep 22, 2022

Okeke, I. N., Aboderin, A. O., Egwuenu, A., Underwood, A., Afolayan, A. O., Kekre, M., Oaikhena, A. O., Odih, E. E., Omotayo, H. T., Dada-Adegbola, H., Ogunleye, V. O., Ikhimiukor, O. O., Aanensen, D. M., & Ihekweazu, C. (2022). Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria’s experience. Microbiology, 168(8). https://doi.org/10.1099/mic.0.001208

Draft Genome Sequences of Multidrug-Resistant Shiga Toxin-Producing Escherichia coli O116:H25 Strains from Ready-to-Eat Foods Sold in Lagos, Nigeria

Microbiology Resource Announcements / Aug 18, 2022

Makinde, O. M., Van Wyk, D., Ikhimiukor, O. O., Bezuidenhout, C., Adeleke, R. A., & Ezekiel, C. N. (2022). Draft Genome Sequences of Multidrug-Resistant Shiga Toxin-Producing Escherichia coli O116:H25 Strains from Ready-to-Eat Foods Sold in Lagos, Nigeria. Microbiology Resource Announcements, 11(8). https://doi.org/10.1128/mra.00314-22

Genetic variation and cryptic lineage diversity of the Nigerian red-headed rock agama Agama agama associate with eco-geographic zones

Current Zoology / Mar 08, 2019

Nneji, L. M., Adeola, A. C., Yan, F., Okeyoyin, A. O., Oladipo, O. C., Saidu, Y., Samuel, D., Nneji, I. C., Adeyi, A. O., Onadeko, A. B., Olagunju, T. E., Omotoso, O., Oladipo, S. O., Iyiola, O. A., Usongo, J. Y., Auta, T., Usman, A. D., Abdullahi, H., Ikhimiukor, O. O., … Che, J. (2019). Genetic variation and cryptic lineage diversity of the Nigerian red-headed rock agama Agama agama associate with eco-geographic zones. Current Zoology, 65(6), 713–724. https://doi.org/10.1093/cz/zoz002

Selective metal accumulation by metal-resistant bacteria growing on spent engine oil in single and ternary metal mixtures

International Journal of Environmental Science and Technology / Dec 08, 2018

Ikhimiukor, O. O., & Adelowo, O. O. (2018). Selective metal accumulation by metal-resistant bacteria growing on spent engine oil in single and ternary metal mixtures. International Journal of Environmental Science and Technology, 16(8), 4945–4954. https://doi.org/10.1007/s13762-018-2137-5

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Dushani L. Palliyaguru, Ph.D.

Baltimore, MD, Maryland, United States of America
16 Years Experience
Toxicologist | Aging, Nutrition and Metabolism Research Scientist | Systems Biologist
Education

University of Pittsburgh

Ph.D., Environmental and Occupational Health (Toxicology) / May, 2016

Pittsburgh, Pennsylvania, United States of America

Clark University

B.A., Biochemistry and Molecular Biology, Mathematics / May, 2009

Worcester, Massachusetts, United States of America
Experience

National Institute on Aging Intramural Research Program, Translational Gerontology Branch

IRTA Postdoctoral Fellow, K99/R00 Grant Recipient / September, 2018Present

-Leading, managing and coordinating large population longitudinal studies within US Federal Government and Industry partnerships - Successfully writing, submitting, and managing grants and manuscripts to ensure continuity of research initiatives -Hiring, mentoring, and supervising research fellows and technicians -Applying epidemiological, machine learning and data science methods to multi-omics data to characterize biomarkers of aging and aging-related diseases -Testing nutritional and pharmacological compounds for lifespan extension, and prevention of chronic diseases (eg. Alzheimer’s)

University of Pittsburgh, Department of Pharmacology and Chemical Biology

Postdoctoral Fellow / May, 2016September, 2018

Identified a novel urinary biomarker of cruciferous vegetable intake in cancer prevention clinical trials using liquid chromatography mass spectrometry -Led and managed project that showed broccoli-derived sulforaphane prevented breast cancer through altering gene expression and lipidomics profiles

Healthcare Ready

Health Policy Fellow / January, 2017January, 2018

-Synthesized data, mined literature and wrote Toolkits/ Issue Brief on “Pharmacy and Emergency Preparedness: A Landscape Analysis”

Most Relevant Research Expertise
aging
Molecular Biology
Biotechnology
Toxicology
Physiology
Endocrinology, Diabetes and Metabolism
Geriatrics and Gerontology
Other Research Expertise (10)
Nutrition
Oncology
Hematology
Food Science
Biochemistry
And 5 more
About
·   Highly productive scientist with 13 years of multidisciplinary experience in toxicology, molecular nutrition, and aging/ disease biomarkers ·   Excellent communicator with proven record of advanced writing and presentation skills - manuscripts, conference presentations, and grants ·   Extensive experience in large study design, supervision and coordination, big data analysis, and management of junior scientists
Most Relevant Publications (12+)

20 total publications

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

Molecular and Cellular Biology / Feb 15, 2014

Wakabayashi, N., Skoko, J. J., Chartoumpekis, D. V., Kimura, S., Slocum, S. L., Noda, K., Palliyaguru, D. L., Fujimuro, M., Boley, P. A., Tanaka, Y., Shigemura, N., Biswal, S., Yamamoto, M., & Kensler, T. W. (2014). Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling. Molecular and Cellular Biology, 34(4), 653–663. https://doi.org/10.1128/mcb.01408-13

Isothiocyanates: Translating the Power of Plants to People

Molecular Nutrition & Food Research / Mar 26, 2018

Palliyaguru, D. L., Yuan, J.-M., Kensler, T. W., & Fahey, J. W. (2018). Isothiocyanates: Translating the Power of Plants to People. Molecular Nutrition & Food Research, 62(18), 1700965. Portico. https://doi.org/10.1002/mnfr.201700965

Withania somnifera : From prevention to treatment of cancer

Molecular Nutrition & Food Research / Jan 29, 2016

Palliyaguru, D. L., Singh, S. V., & Kensler, T. W. (2016). Withania somnifera : From prevention to treatment of cancer. Molecular Nutrition & Food Research, 60(6), 1342–1353. Portico. https://doi.org/10.1002/mnfr.201500756

Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions

Mechanisms of Ageing and Development / Jun 01, 2019

Palliyaguru, D. L., Moats, J. M., Di Germanio, C., Bernier, M., & de Cabo, R. (2019). Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions. Mechanisms of Ageing and Development, 180, 42–48. https://doi.org/10.1016/j.mad.2019.03.005

Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide

Food Additives & Contaminants: Part A / Mar 01, 2013

Palliyaguru, D. L., & Wu, F. (2013). Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide. Food Additives & Contaminants: Part A, 30(3), 534–540. https://doi.org/10.1080/19440049.2012.751630

Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice

American Journal of Physiology-Endocrinology and Metabolism / Aug 01, 2018

Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Fazzari, M., Khoo, N. K. H., Schopfer, F. J., Sipula, I., Yagishita, Y., Michalopoulos, G. K., O’Doherty, R. M., & Kensler, T. W. (2018). Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. American Journal of Physiology-Endocrinology and Metabolism, 315(2), E180–E195. https://doi.org/10.1152/ajpendo.00311.2017

Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice

Molecular Metabolism / Jul 01, 2015

Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Khoo, N. K. H., Schoiswohl, G., O’Doherty, R. M., & Kensler, T. W. (2015). Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice. Molecular Metabolism, 4(7), 543–550. https://doi.org/10.1016/j.molmet.2015.04.004

Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques

The Journals of Gerontology: Series A / Dec 18, 2020

Palliyaguru, D. L., Vieira Ligo Teixeira, C., Duregon, E., di Germanio, C., Alfaras, I., Mitchell, S. J., Navas-Enamorado, I., Shiroma, E. J., Studenski, S., Bernier, M., Camandola, S., Price, N. L., Ferrucci, L., & de Cabo, R. (2020). Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques. The Journals of Gerontology: Series A, 76(4), 552–560. https://doi.org/10.1093/gerona/glaa285

Fasting blood glucose as a predictor of mortality: Lost in translation

Cell Metabolism / Nov 01, 2021

Palliyaguru, D. L., Shiroma, E. J., Nam, J. K., Duregon, E., Vieira Ligo Teixeira, C., Price, N. L., Bernier, M., Camandola, S., Vaughan, K. L., Colman, R. J., Deighan, A., Korstanje, R., Peters, L. L., Dickinson, S. L., Ejima, K., Simonsick, E. M., Launer, L. J., Chia, C. W., Egan, J., … de Cabo, R. (2021). Fasting blood glucose as a predictor of mortality: Lost in translation. Cell Metabolism, 33(11), 2189-2200.e3. https://doi.org/10.1016/j.cmet.2021.08.013

Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet

The Journals of Gerontology: Series A / Jun 18, 2020

Palliyaguru, D. L., Minor, R. K., Mitchell, S. J., Palacios, H. H., Licata, J. J., Ward, T. M., Abulwerdi, G., Elliott, P., Westphal, C., Ellis, J. L., Sinclair, D. A., Price, N. L., Bernier, M., & de Cabo, R. (2020). Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet. The Journals of Gerontology: Series A, 75(11), 2037–2041. https://doi.org/10.1093/gerona/glaa148

Perinatal diet influences health and survival in a mouse model of leukemia

GeroScience / May 11, 2020

Palliyaguru, D. L., Rudderow, A. L., Sossong, A. M., Lewis, K. N., Younts, C., Pearson, K. J., Bernier, M., & de Cabo, R. (2020). Perinatal diet influences health and survival in a mouse model of leukemia. GeroScience, 42(4), 1147–1155. https://doi.org/10.1007/s11357-020-00199-9

Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake

Molecular Nutrition & Food Research / Nov 22, 2018

Palliyaguru, D. L., Salvatore, S. R., Schopfer, F. J., Cheng, X., Zhou, J., Kensler, T. W., & Wendell, S. G. (2018). Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake. Molecular Nutrition & Food Research, 63(3), 1801029. Portico. https://doi.org/10.1002/mnfr.201801029

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Sarafa A. Akeem

Benin City
9 Years Experience
Lecturer and Food Researcher with fifteen peer-reviewed publications in international journal outlets.
Education

University of Ibadan

Ph.D, Food Technology / October, 2025 (anticipated)

Ibadan

University of Ibadan

M.Sc, Food Technology / February, 2018

Ibadan

University of Ilorin

B.Sc, Food Science / July, 2014

Ilorin
Experience

Edo State College of Agriculture and Natural Resources

Lecturer III / August, 2023Present

Teaching courses in Food Processing, Postharvest Technology and General Biology. Carrying out research, analysing data, writing manuscript, presenting the output and publishing the output in reputable peer-reviewed high impact factor journals. Engaging in community services.

Dayntee Farms Limited

Quality Control and Assurance Lead / April, 2022July, 2023

Most Relevant Research Expertise
Molecular Biology
Microbiology
Biotechnology
Other Research Expertise (10)
Food Processing and preservation
Food Chemistry and Nutrition
Food Product Development
Food Quality Control
Food Safety
And 5 more
About
Sarafa Adeyemi Akeem is an innovative, creative, highly motivated and result-oriented Food Researcher that is open to job opportunities as well as open to both national and international collaborations in the various areas of Food Chemistry/ biochemistry, Processing, Preservation, Process Engineering, Analysis, Quality Control, Safety, Product Development, Post Harvest Technology and Nutrition with the overall aim of contributing to the global food and nutrition security.
Most Relevant Publications (3+)

11 total publications

INFLUENCE OF PARTIAL SUBSTITUTION OF SUGAR WITH SERENDIPITY BERRY (DIOSCOREOPHYLLUM CUMMINSII) EXTRACT ON THE QUALITY ATTRIBUTES AND SHELF-LIFE OF WHEAT BREAD

Journal of microbiology, biotechnology and food sciences / Aug 01, 2019

Monday Ojo Kayode, R., Adunni Abiodun, O., Adeyemi Akeem, S., & Omodasola Oyeneye, H. (2019). INFLUENCE OF PARTIAL SUBSTITUTION OF SUGAR WITH SERENDIPITY BERRY (DIOSCOREOPHYLLUM CUMMINSII) EXTRACT ON THE QUALITY ATTRIBUTES AND SHELF-LIFE OF WHEAT BREAD. Journal of Microbiology, Biotechnology and Food Sciences, 9(1), 115–120. https://doi.org/10.15414/jmbfs.2019.9.1.115-120

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Dr. Hannah Actor-Engel, Ph.D.

Brooklyn, New York, United States of America
10 Years Experience
University of Colorado Anschutz
Education

University of Colorado Denver

PhD, Neuroscience / 2023

Denver, Colorado, United States of America

New York University

Bachelor of Science, Neural Science / May, 2015

New York, New York, United States of America
Experience

New York University

Junior Research Scientist / August, 2015May, 2017

Most Relevant Research Expertise
Histology
Cell Biology
Molecular Biology
Cellular and Molecular Neuroscience
Other Research Expertise (2)
Molecular neuroscience
Anatomy
About
Biomedical scientist with Ph.D. in Neuroscience. Expertise in neuroscience, molecular biology, neurodegeneration, and fluorescence microscopy. Experienced researcher, problem-solver, and medical writer.
Most Relevant Publications (6+)

8 total publications

NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise

Brain Structure and Function / Dec 03, 2016

Chen, Y.-W., Actor-Engel, H., Sherpa, A. D., Klingensmith, L., Chowdhury, T. G., & Aoki, C. (2016). NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Structure and Function, 222(5), 2271–2294. https://doi.org/10.1007/s00429-016-1341-7

α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males

Molecular and Cellular Neuroscience / Jul 01, 2018

Chen, Y.-W., Actor-Engel, H., & Aoki, C. (2018). α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males. Molecular and Cellular Neuroscience, 90, 33–48. https://doi.org/10.1016/j.mcn.2018.04.008

Suppression of food restriction‐evoked hyperactivity in activity‐based anorexia animal model through glutamate transporters GLT‐1 at excitatory synapses in the hippocampus

Synapse / Mar 16, 2021

Bilash, O. M., Actor‐Engel, H. S., Sherpa, A. D., Chen, Y., & Aoki, C. (2021). Suppression of food restriction‐evoked hyperactivity in activity‐based anorexia animal model through glutamate transporters GLT‐1 at excitatory synapses in the hippocampus. Synapse, 75(7). Portico. https://doi.org/10.1002/syn.22197

Correction to: NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise

Brain Structure and Function / Jan 31, 2020

Chen, Y.-W., Actor-Engel, H., Sherpa, A. D., Klingensmith, L., Chowdhury, T. G., & Aoki, C. (2020). Correction to: NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Structure and Function, 225(3), 1165–1165. https://doi.org/10.1007/s00429-020-02030-9

Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses

Cell Reports / Nov 01, 2023

Olah, S. S., Kareemo, D. J., Buchta, W. C., Sinnen, B. L., Miller, C. N., Actor-Engel, H. S., Gookin, S. E., Winborn, C. S., Kleinjan, M. S., Crosby, K. C., Aoto, J., Smith, K. R., & Kennedy, M. J. (2023). Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Reports, 42(11), 113331. https://doi.org/10.1016/j.celrep.2023.113331

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release

Frontiers in Molecular Neuroscience / Aug 03, 2023

Ramsay, H. J., Gookin, S. E., Ramsey, A. M., Kareemo, D. J., Crosby, K. C., Stich, D. G., Olah, S. S., Actor-Engel, H. S., Smith, K. R., & Kennedy, M. J. (2023). AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. Frontiers in Molecular Neuroscience, 16. https://doi.org/10.3389/fnmol.2023.1232795

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Tali Reiner Brodetzki

Philadelphia , Pennsylvania, United States of America
5 Years Experience
Assistant Professor at La Salle University
Education

Tel Aviv University

Ph.D., Zoology / December, 2018

Tel Aviv
Experience

University of Pennsylvania

Postdoctoral Fellow / January, 2019August, 2021

Rutgers university

Postdoctoral Fellow / September, 2021August, 2022

La Salle University

Assistant Professor / August, 2022Present

Most Relevant Research Expertise
Genetics
Molecular Biology
Animal Science and Zoology
Behavioral Neuroscience
Other Research Expertise (8)
Evolution
Social insects
Behavioral ecology
Population genetics
Epigenetics
And 3 more
About
Tali Reiner Brodetzki is a highly accomplished scientist with a strong background in zoology. She received her Ph.D. in Zoology from Tel Aviv University in 2018, where she focused on the study of animal behavior and evolutionary ecology. During her graduate studies, she published several papers in top scientific journals and received numerous awards for her research. After completing her Ph.D., Tali went on to work as a Postdoctoral Fellow at both the University of Pennsylvania and Rutgers University. During this time, she continued to conduct research on animal behavior and evolution, and also gained valuable experience in teaching and mentoring students. In 2020, Tali joined the faculty at La Salle University as an Assistant Professor in the Department of Biology. She is currently conducting research on the effects of human activities on animal behavior and adaptation, and is also teaching undergraduate and graduate courses in zoology, bioinformatics, genomics, and evolutionary biology. Tali's research has been widely recognized and she has received numerous grants and awards, including the prestigious European Molecular Biology Organisation's postdoctoral award. She is also a member of several professional organizations, including the Society for Integrative and Comparative Biology and the Animal Behavior Society. In addition to her academic and research accomplishments, Tali is also passionate about science outreach and communication. She regularly presents her research at conferences and seminars, and also participates in science fairs and other community events. She is dedicated to inspiring the next generation of scientists and promoting the importance of studying and protecting our natural world. Overall, Tali Reiner Brodetzki is a highly skilled and dedicated scientist who is making significant contributions to the field of zoology. Her education and experience have prepared her to continue making important discoveries and advancements in the study of animal behavior and evolution.
Most Relevant Publications (3+)

9 total publications

An integrative approach to untangling species delimitation in the Cataglyphis bicolor desert ant complex in Israel

Molecular Phylogenetics and Evolution / Oct 01, 2017

Eyer, P. A., Seltzer, R., Reiner-Brodetzki, T., & Hefetz, A. (2017). An integrative approach to untangling species delimitation in the Cataglyphis bicolor desert ant complex in Israel. Molecular Phylogenetics and Evolution, 115, 128–139. https://doi.org/10.1016/j.ympev.2017.07.024

Lack of subspecies-recognition in breeding Barn Swallows (Hirundo rustica transitiva)

Behavioural Processes / Aug 01, 2021

Reiner Brodetzki, T., Lotem, A., Safran, R. J., & Hauber, M. E. (2021). Lack of subspecies-recognition in breeding Barn Swallows (Hirundo rustica transitiva). Behavioural Processes, 189, 104422. https://doi.org/10.1016/j.beproc.2021.104422

Worker demography and behavior in a supercolonial ant colony: The case of the desert ant Cataglyphis niger

Ethology / Oct 09, 2019

Reiner Brodetzki, T., Brodetzki, G., Feinerman, O., & Hefetz, A. (2019). Worker demography and behavior in a supercolonial ant colony: The case of the desert ant Cataglyphis niger. Ethology, 126(1), 59–67. Portico. https://doi.org/10.1111/eth.12960

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Aayudh Das, Ph.D.

Boston, Massachusetts, United States of America
10 Years Experience
Scientist at Garuda therapeutics, specialized in Genomics and Computational Biology
Education

University of Vermont

PhD, Plant Biology / April, 2022

Burlington, Vermont, United States of America

Texas A&M University

Master's in Biochemistry, Biochemistry & Biophysics / May, 2016

College Station, Texas, United States of America

University of Calcutta

Master's, Biotechnology

Kolkata
Experience

Garuda therapeutics

Scientist / July, 2023Present

The Pennsylvania State University - University Park Campus

Postdoctoral Researcher / June, 2022July, 2023

University of Vermont

Research Assistant / May, 2016May, 2022

Most Relevant Research Expertise
Genomics
Computational Biology
Plant Science
Immunology and Allergy
Molecular Biology
Microbiology (medical)
Genetics
Biotechnology
Other Research Expertise (7)
Transcriptomics
Proteomics
Metabolomics
Ecology, Evolution, Behavior and Systematics
Ecology
And 2 more
About
I am a dedicated Scientist-I at Garuda Therapeutics, where I specialize in computational biology and genomics within the R&D department. My work primarily revolves around developing and optimizing pipelines for variant calling using Strelka2 and GATK4 with Whole Genome Sequencing (WGS) to identify oncogenes in human induced pluripotent stem cells (iPSCs). This involves extensive work in the qualification and validation of these pipelines for regulatory filings, as well as leveraging databases such as ClinVar, COSMIC, and DepMap to craft targeted oncogenes panels for deep sequencing. I also apply Next-Generation Sequencing (NGS) for downstream sequencing to validate CRISPR knockouts, including the identification and validation of CRISPR off-targets using techniques like rhAMPseq and Induce-seq. Additionally, my expertise extends to single-cell sequencing analysis and understanding structural variants with Optical Genome Mapping (Bionano). Prior to joining Garuda Therapeutics, I completed a postdoctoral fellowship in computational biology at Pennsylvania State University, where I honed my skills in identifying climate-adaptive variants and conducted Genome-Wide Association Studies (GWAS) to uncover resistance genes against parasites and other stressors. My academic journey began at the University of Vermont, where I explored abiotic stress resistance genes using transcriptomics and developed a robust understanding of RNA-seq data analysis, from assembly to gene annotation. My work is driven by a passion for leveraging computational and genomics tools to address pressing challenges in biology and healthcare, combining my rigorous academic training with a practical, solution-oriented approach to research and development.
Most Relevant Publications (8+)

10 total publications

Metabolomic Profiling of Soybeans (Glycine max L.) Reveals the Importance of Sugar and Nitrogen Metabolism under Drought and Heat Stress

Plants / May 25, 2017

Das, A., Rushton, P., & Rohila, J. (2017). Metabolomic Profiling of Soybeans (Glycine max L.) Reveals the Importance of Sugar and Nitrogen Metabolism under Drought and Heat Stress. Plants, 6(4), 21. https://doi.org/10.3390/plants6020021

Leaf Proteome Analysis Reveals Prospective Drought and Heat Stress Response Mechanisms in Soybean

BioMed Research International / Jan 01, 2016

Das, A., Eldakak, M., Paudel, B., Kim, D.-W., Hemmati, H., Basu, C., & Rohila, J. S. (2016). Leaf Proteome Analysis Reveals Prospective Drought and Heat Stress Response Mechanisms in Soybean. BioMed Research International, 2016, 1–23. https://doi.org/10.1155/2016/6021047

Unraveling Key Metabolomic Alterations in Wheat Embryos Derived from Freshly Harvested and Water-Imbibed Seeds of Two Wheat Cultivars with Contrasting Dormancy Status

Frontiers in Plant Science / Jul 12, 2017

Das, A., Kim, D.-W., Khadka, P., Rakwal, R., & Rohila, J. S. (2017). Unraveling Key Metabolomic Alterations in Wheat Embryos Derived from Freshly Harvested and Water-Imbibed Seeds of Two Wheat Cultivars with Contrasting Dormancy Status. Frontiers in Plant Science, 8. https://doi.org/10.3389/fpls.2017.01203

A Quantitative Proteomics View on the Function of Qfhb1, a Major QTL for Fusarium Head Blight Resistance in Wheat

Pathogens / Jun 22, 2018

Eldakak, M., Das, A., Zhuang, Y., Rohila, J., Glover, K., & Yen, Y. (2018). A Quantitative Proteomics View on the Function of Qfhb1, a Major QTL for Fusarium Head Blight Resistance in Wheat. Pathogens, 7(3), 58. https://doi.org/10.3390/pathogens7030058

Proteomic Responses of Switchgrass and Prairie Cordgrass to Senescence

Frontiers in Plant Science / Mar 14, 2016

Paudel, B., Das, A., Tran, M., Boe, A., Palmer, N. A., Sarath, G., Gonzalez-Hernandez, J. L., Rushton, P. J., & Rohila, J. S. (2016). Proteomic Responses of Switchgrass and Prairie Cordgrass to Senescence. Frontiers in Plant Science, 7. https://doi.org/10.3389/fpls.2016.00293

Variation in climatic tolerance, but not stomatal traits, partially explains Pooideae grass species distributions

Annals of Botany / Mar 27, 2021

Das, A., Prakash, A., Dedon, N., Doty, A., Siddiqui, M., & Preston, J. C. (2021). Variation in climatic tolerance, but not stomatal traits, partially explains Pooideae grass species distributions. Annals of Botany, 128(1), 83–95. https://doi.org/10.1093/aob/mcab046

Investigation of the Cardiotonic Steroids, Marinobufagenin and Resibufogenin, in the Acute Respiratory Distress Syndrome

The FASEB Journal / Apr 01, 2016

Abbas, M. M. K., Chen, Q., Das, A., Oliver, J., Jiang, W., Moorthy, B., Patel, B., Morin, K., & Puschett, J. (2016). Investigation of the Cardiotonic Steroids, Marinobufagenin and Resibufogenin, in the Acute Respiratory Distress Syndrome. The FASEB Journal, 30(S1). Portico. https://doi.org/10.1096/fasebj.30.1_supplement.982.4

Testing the chilling‐ before drought‐tolerance hypothesis in Pooideae grasses

Molecular Ecology / Dec 07, 2022

Das, A., Dedon, N., Enders, D. J., Fjellheim, S., & Preston, J. C. (2022). Testing the chilling‐ before drought‐tolerance hypothesis in Pooideae grasses. Molecular Ecology, 32(4), 772–785. Portico. https://doi.org/10.1111/mec.16794

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Elena Shersher, Ph.D.

Miami
7 Years Experience
Cancer researcher at University of Miami
Education

Florida International University

Ph.D., Biochemistry / May, 2016

Miami, Florida, United States of America
Experience

University of Miami

Cancer researcher / March, 2017Present

I study cell signaling mechanisms to identify the most promising molecular targets for therapeutic intervention in cancer.

Most Relevant Research Expertise
Molecular Biology
Cell Biology
Other Research Expertise (4)
Cancer Research
Biochemistry
Drug discovery
Cancer cell signaling
About
Elena Shersher, Ph.D. is a highly skilled and experienced biochemist with a strong background in cancer research. She received her Ph.D. in Biochemistry from Florida International University in 2016, where she was a recipient of a prestigious Presidential fellowship. After completing her Ph.D., Elena continued her career as a clinical program development lead and coordinator at a CRO. In 2017, Elena joined a cancer research team at the University of Miami as a researcher. In this role, she utilized her expertise in advanced laboratory techniques and data analysis to study the role of specific proteins in cancer cell signaling in order to identify promising molecular targets for therapeutic intervention. Elena's research has been published in several prestigious scientific journals, and she has presented her findings at numerous conferences. In addition to her research, Elena is also passionate about mentoring and teaching the next generation of scientists. She has served as a mentor and advisor to undergraduate and graduate students, helping them develop their research skills and guiding them in their academic and career paths. Elena's dedication and contributions to the field of cancer research have made her a valuable asset to the scientific community. With her expertise and experience, she continues to make significant advancements in understanding and treating cancer, bringing hope to those affected by this devastating disease.
Most Relevant Publications (1+)

4 total publications

NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis

Cell Communication and Signaling / Sep 22, 2021

Shersher, E., Lahiry, M., Alvarez-Trotta, A., Diluvio, G., Robbins, D. J., Shiekhattar, R., & Capobianco, A. J. (2021). NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis. Cell Communication and Signaling, 19(1). https://doi.org/10.1186/s12964-021-00776-1

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Susan Song, MD/PhD

Pittsburgh, Pennsylvania, United States of America
9 Years Experience
Research Assistant Professor in Neuroscience at University of Pittsburgh
Education

Southern Medical University

MD/PhD, Neurology, Neuroscience / June, 2015

Guangzhou

University of Pittsburgh

Post-doc, Neuroscience / December, 2019

Pittsburgh, Pennsylvania, United States of America
Experience

University of Pittsburgh

Research Assistant Professor / January, 2022Present

Research Instructor / January, 2020December, 2021

Postdoctoral Scholar / October, 2015December, 2019

Most Relevant Research Expertise
Cellular and Molecular Neuroscience
Cell Biology
Molecular Biology
Developmental Neuroscience
Other Research Expertise (12)
microglia
white matter
neurodegenerative disease
Neurology
Neurology (clinical)
And 7 more
About
Susan Song, MD/PhD, is a highly accomplished neuroscientist, with extensive education and experience in the field. She received her MD/PhD in Neurology and Neuroscience from Southern Medical University in 2015, where she conducted groundbreaking research on the molecular mechanisms of neurodegenerative diseases. Following this, she completed a post-doctoral fellowship in Neuroscience at the University of Pittsburgh, where she continued to excel in her research and received numerous awards and grants for her work. Dr. Song's expertise lies in studying the underlying causes and potential treatments for various neurological diseases, such as ischemic stroke, traumatic brain injury, glioblastoma, Alzheimer's disease, and multiple sclerosis. She has a deep understanding of the brain and nervous system, and is constantly seeking new ways to unravel the complexities of these diseases. Dr. Song has held several prestigious positions throughout her career, including her current position as Research Assistant Professor at the University of Pittsburgh. She has published numerous articles in top scientific journals and presented her research at international conferences. Her findings have contributed greatly to the field of neurology and have the potential to improve the lives of millions of people suffering from neurological disorders. Overall, Dr. Song is a highly respected and accomplished physician-scientist who is making significant contributions to the field of neurology. With her extensive education, diverse experience, and unwavering dedication to her patients, she is a true leader in the field and a valuable asset to the medical community.
Most Relevant Publications (13+)

20 total publications

Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke

Glia / Sep 19, 2017

Begum, G., Song, S., Wang, S., Zhao, H., Bhuiyan, M. I. H., Li, E., Nepomuceno, R., Ye, Q., Sun, M., Calderon, M. J., Stolz, D. B., St. Croix, C., Watkins, S. C., Chen, Y., He, P., Shull, G. E., & Sun, D. (2017). Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia, 66(1), 126–144. Portico. https://doi.org/10.1002/glia.23232

Ion channels and transporters in microglial function in physiology and brain diseases

Neurochemistry International / Jan 01, 2021

Luo, L., Song, S., Ezenwukwa, C. C., Jalali, S., Sun, B., & Sun, D. (2021). Ion channels and transporters in microglial function in physiology and brain diseases. Neurochemistry International, 142, 104925. https://doi.org/10.1016/j.neuint.2020.104925

Roles of glial ion transporters in brain diseases

Glia / Aug 16, 2019

Song, S., Luo, L., Sun, B., & Sun, D. (2019). Roles of glial ion transporters in brain diseases. Glia, 68(3), 472–494. Portico. https://doi.org/10.1002/glia.23699

Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery

Glia / Jul 25, 2018

Song, S., Wang, S., Pigott, V. M., Jiang, T., Foley, L. M., Mishra, A., Nayak, R., Zhu, W., Begum, G., Shi, Y., Carney, K. E., Hitchens, T. K., Shull, G. E., & Sun, D. (2018). Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery. Glia, 66(11), 2279–2298. Portico. https://doi.org/10.1002/glia.23456

Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

Journal of Neuroinflammation / Aug 28, 2021

Liu, Q., Bhuiyan, M. I. H., Liu, R., Song, S., Begum, G., Young, C. B., Foley, L. M., Chen, F., Hitchens, T. K., Cao, G., Chattopadhyay, A., He, L., & Sun, D. (2021). Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function. Journal of Neuroinflammation, 18(1). https://doi.org/10.1186/s12974-021-02234-8

The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases

Aging and disease / Jan 01, 2019

Huang, H., Song, S., Banerjee, S., Jiang, T., Zhang, J., Kahle, K. T., Sun, D., & Zhang, Z. (2019). The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases. Aging and Disease, 10(3), 626. https://doi.org/10.14336/ad.2018.0928

Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Communications Biology / Jan 11, 2022

Song, S., Yu, L., Hasan, M. N., Paruchuri, S. S., Mullett, S. J., Sullivan, M. L. G., Fiesler, V. M., Young, C. B., Stolz, D. B., Wendell, S. G., & Sun, D. (2022). Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice. Communications Biology, 5(1). https://doi.org/10.1038/s42003-021-02984-4

Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury

Journal of Neuroinflammation / Oct 05, 2022

Song, S., Hasan, M. N., Yu, L., Paruchuri, S. S., Bielanin, J. P., Metwally, S., Oft, H. C. M., Fischer, S. G., Fiesler, V. M., Sen, T., Gupta, R. K., Foley, L. M., Hitchens, T. K., Dixon, C. E., Cambi, F., Sen, N., & Sun, D. (2022). Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury. Journal of Neuroinflammation, 19(1). https://doi.org/10.1186/s12974-022-02608-6

Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation

Journal of Neural Engineering / Mar 19, 2021

Dubaniewicz, M., Eles, J. R., Lam, S., Song, S., Cambi, F., Sun, D., Wellman, S. M., & Kozai, T. D. Y. (2021). Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation. Journal of Neural Engineering, 18(4), 045001. https://doi.org/10.1088/1741-2552/abe8f1

Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke

International Journal of Molecular Sciences / Aug 27, 2023

Metwally, S. A. H., Paruchuri, S. S., Yu, L., Capuk, O., Pennock, N., Sun, D., & Song, S. (2023). Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke. International Journal of Molecular Sciences, 24(17), 13289. https://doi.org/10.3390/ijms241713289

Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells

Neural Regeneration Research / Jan 01, 2014

Jin, B., Jiang, X., Chang, H., Song, S., Chen, Z., Wang, Y., Yang, L., Du, M., Ke, Y., & Xu, R. (2014). Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells. Neural Regeneration Research, 9(5), 519. https://doi.org/10.4103/1673-5374.130079

Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier

Frontiers in Cellular Neuroscience / Dec 01, 2023

Chen, Y., Lin, L., Bhuiyan, M. I. H., He, K., Jha, R., Song, S., Fiesler, V. M., Begum, G., Yin, Y., & Sun, D. (2023). Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1279385

Does Adjuvant Gamma Knife Stereotactic Radiosurgery Have a Role in Treating Optic Nerve Sheath Meningiomas?

Journal of Neuro-Ophthalmology / Jul 05, 2023

Wei, Z., Taori, S., Song, S., Deng, H., Niranjan, A., & Lunsford, L. D. (2023). Does Adjuvant Gamma Knife Stereotactic Radiosurgery Have a Role in Treating Optic Nerve Sheath Meningiomas? Journal of Neuro-Ophthalmology. https://doi.org/10.1097/wno.0000000000001914

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Shariq Usmani, PhD

Boston, Massachusetts, United States of America
15 Years Experience
Massachusetts General Hospital, Harvard Medical School
Education

University of Konstanz

PhD, Molecular and Cell Biology / May, 2011

Konstanz

Harvard University

Postdoctoral fellow, Virology/Immunology / 2019

Cambridge, Massachusetts, United States of America
Experience

Cabaletta Bio

Scientific Director / 2024Present

I lead a research team in the preclinical R&D organization at Cabaletta bio. I directly manage a talented group of Senior Scientists, Scientists and Research Associates to spearhead and drive innovation in cell therapies and biologics in autoimmune disease indications.

Sana Biotechnology

Principal Scientist / 20222023

As a team lead, I led efforts to establish in vivo genome editing platform, vector design/engineering and optimization, with a broader goal to develop innovative and effective genomic medicine for unmet medical needs.

Zohdan Bio

Consultant / 2024Present

Providing strategic support for all aspects of preclinical, R&D programs in gene therapy, genome editing and virology and immunology space.

Most Relevant Research Expertise
Microbiology
Virology
Molecular Biology
Genetics
Physiology
Immunology and Allergy
Other Research Expertise (4)
Immunology
Biochemistry
Analytical Chemistry
Infectious Diseases
About
Dr. Shariq Usmani is scientific director at Cabaletta bio, a leader in cell therapy for autoimmune diseases (https://www.cabalettabio.com). He leads a research team in preclinical R&D organization at Cabaletta bio. He directly manage a talented group of Senior Scientists, Scientists and Research Associates to spearhead and drive innovation in cell therapies and biologics in autoimmune disease indications. <br> He is also serves as consultant at Zohdan Bio, where he provides strategic support for preclinical R&D programs focused on gene therapy, genome editing, and virology. With a deep foundation in oncology and biologics, Dr. Usmani has led groundbreaking work in both academia and industry, including his tenures at Sana Biotechnology, Harvard Medical School and Massachusetts General Hospital. He's led and spearheaded the development of innovative in vivo genome editing platforms, optimized viral vectors, and engineered cutting-edge reporter assays.
Most Relevant Publications (16+)

22 total publications

Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen

Nature Communications / Apr 01, 2014

Usmani, S. M., Zirafi, O., Müller, J. A., Sandi-Monroy, N. L., Yadav, J. K., Meier, C., Weil, T., Roan, N. R., Greene, W. C., Walther, P., Nilsson, K. P. R., Hammarström, P., Wetzel, R., Pilcher, C. D., Gagsteiger, F., Fändrich, M., Kirchhoff, F., & Münch, J. (2014). Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nature Communications, 5(1). https://doi.org/10.1038/ncomms4508

Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin

Cell Host &amp; Microbe / Nov 01, 2014

Kluge, S. F., Mack, K., Iyer, S. S., Pujol, F. M., Heigele, A., Learn, G. H., Usmani, S. M., Sauter, D., Joas, S., Hotter, D., Bibollet-Ruche, F., Plenderleith, L. J., Peeters, M., Geyer, M., Sharp, P. M., Fackler, O. T., Hahn, B. H., & Kirchhoff, F. (2014). Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin. Cell Host &amp; Microbe, 16(5), 639–650. https://doi.org/10.1016/j.chom.2014.10.002

Human Tetherin Exerts Strong Selection Pressure on the HIV-1 Group N Vpu Protein

PLoS Pathogens / Dec 20, 2012

Sauter, D., Unterweger, D., Vogl, M., Usmani, S. M., Heigele, A., Kluge, S. F., Hermkes, E., Moll, M., Barker, E., Peeters, M., Learn, G. H., Bibollet-Ruche, F., Fritz, J. V., Fackler, O. T., Hahn, B. H., & Kirchhoff, F. (2012). Human Tetherin Exerts Strong Selection Pressure on the HIV-1 Group N Vpu Protein. PLoS Pathogens, 8(12), e1003093. https://doi.org/10.1371/journal.ppat.1003093

A molecular tweezer antagonizes seminal amyloids and HIV infection

eLife / Aug 18, 2015

Lump, E., Castellano, L. M., Meier, C., Seeliger, J., Erwin, N., Sperlich, B., Stürzel, C. M., Usmani, S., Hammond, R. M., von Einem, J., Gerold, G., Kreppel, F., Bravo-Rodriguez, K., Pietschmann, T., Holmes, V. M., Palesch, D., Zirafi, O., Weissman, D., Sowislok, A., … Münch, J. (2015). A molecular tweezer antagonizes seminal amyloids and HIV infection. ELife, 4. CLOCKSS. https://doi.org/10.7554/elife.05397

Semen amyloids participate in spermatozoa selection and clearance

eLife / Jun 27, 2017

Roan, N. R., Sandi-Monroy, N., Kohgadai, N., Usmani, S. M., Hamil, K. G., Neidleman, J., Montano, M., Ständker, L., Röcker, A., Cavrois, M., Rosen, J., Marson, K., Smith, J. F., Pilcher, C. D., Gagsteiger, F., Sakk, O., O’Rand, M., Lishko, P. V., Kirchhoff, F., … Greene, W. C. (2017). Semen amyloids participate in spermatozoa selection and clearance. ELife, 6. CLOCKSS. https://doi.org/10.7554/elife.24888

Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection

Journal of Virology / Jul 01, 2014

Roan, N. R., Liu, H., Usmani, S. M., Neidleman, J., Müller, J. A., Avila-Herrera, A., Gawanbacht, A., Zirafi, O., Chu, S., Dong, M., Kumar, S. T., Smith, J. F., Pollard, K. S., Fändrich, M., Kirchhoff, F., Münch, J., Witkowska, H. E., & Greene, W. C. (2014). Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection. Journal of Virology, 88(13), 7221–7234. https://doi.org/10.1128/jvi.00269-14

Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4 + T Cell Counts in Viremic HIV-2 Infection

Journal of Virology / May 01, 2012

Khalid, M., Yu, H., Sauter, D., Usmani, S. M., Schmokel, J., Feldman, J., Gruters, R. A., van der Ende, M. E., Geyer, M., Rowland-Jones, S., Osterhaus, A. D., & Kirchhoff, F. (2012). Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4 + T Cell Counts in Viremic HIV-2 Infection. Journal of Virology, 86(9), 4906–4920. https://doi.org/10.1128/jvi.06856-11

Reacquisition of Nef-Mediated Tetherin Antagonism in a Single In Vivo Passage of HIV-1 through Its Original Chimpanzee Host

Cell Host &amp; Microbe / Sep 01, 2012

Götz, N., Sauter, D., Usmani, S. M., Fritz, J. V., Goffinet, C., Heigele, A., Geyer, M., Bibollet-Ruche, F., Learn, G. H., Fackler, O. T., Hahn, B. H., & Kirchhoff, F. (2012). Reacquisition of Nef-Mediated Tetherin Antagonism in a Single In Vivo Passage of HIV-1 through Its Original Chimpanzee Host. Cell Host &amp; Microbe, 12(3), 373–380. https://doi.org/10.1016/j.chom.2012.07.008

HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission

Cell Host &amp; Microbe / Jan 01, 2019

Usmani, S. M., Murooka, T. T., Deruaz, M., Koh, W. H., Sharaf, R. R., Di Pilato, M., Power, K. A., Lopez, P., Hnatiuk, R., Vrbanac, V. D., Tager, A. M., Allen, T. M., Luster, A. D., & Mempel, T. R. (2019). HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission. Cell Host &amp; Microbe, 25(1), 73-86.e5. https://doi.org/10.1016/j.chom.2018.12.008

The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals

Retrovirology / Mar 05, 2013

Yu, H., Usmani, S. M., Borch, A., Krämer, J., Stürzel, C. M., Khalid, M., Li, X., Krnavek, D., van der Ende, M. E., Osterhaus, A. D., Gruters, R. A., & Kirchhoff, F. (2013). The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals. Retrovirology, 10(1). https://doi.org/10.1186/1742-4690-10-27

Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins

Cellular Microbiology / Dec 13, 2011

Usmani, S. M., von Einem, J., Frick, M., Miklavc, P., Mayenburg, M., Husmann, M., Dietl, P., & Wittekindt, O. H. (2011). Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins: Streptolysin O activates SOC entry. Cellular Microbiology, 14(3), 299–315. https://doi.org/10.1111/j.1462-5822.2011.01724.x

2-APB and Capsazepine-induced Ca<sup>2+</sup> Influx Stimulates Clathrin-dependent Endocytosis in Alveolar Epithelial Cells

Cellular Physiology and Biochemistry / Jan 01, 2010

Usmani, S., Fois, G., Albrecht, S., von Aulock, S., Dietl, P., & Wittekindt, O. (2010). 2-APB and Capsazepine-induced Ca&lt;sup&gt;2+&lt;/sup&gt; Influx Stimulates Clathrin-dependent Endocytosis in Alveolar Epithelial Cells. Cellular Physiology and Biochemistry, 25(001), 091–102. https://doi.org/10.1159/000272064

Lentiviral Nef Proteins Manipulate T Cells in a Subset-Specific Manner

Journal of Virology / Feb 15, 2015

Yu, H., Khalid, M., Heigele, A., Schmökel, J., M. Usmani, S., van der Merwe, J., Münch, J., Silvestri, G., & Kirchhoff, F. (2015). Lentiviral Nef Proteins Manipulate T Cells in a Subset-Specific Manner. Journal of Virology, 89(4), 1986–2001. https://doi.org/10.1128/jvi.03104-14

Plasma Membrane Trafficking in Alveolar Type II Cells

Cellular Physiology and Biochemistry / Jan 01, 2010

Albrecht, S., Usmani, S., Dietl, P., & Wittekindt, O. (2010). Plasma Membrane Trafficking in Alveolar Type II Cells. Cellular Physiology and Biochemistry, 25(001), 081–090. https://doi.org/10.1159/000272053

Cancer cells relax and resist cytotoxic attack

Immunity / May 01, 2021

Usmani, S. M., & Mempel, T. R. (2021). Cancer cells relax and resist cytotoxic attack. Immunity, 54(5), 853–855. https://doi.org/10.1016/j.immuni.2021.04.017

HIV-enhancing Amyloids Are Prevalent in Fresh Semen and Are a Determinant for Semen's Ability to Enhance HIV Infection: Relevance for HIV Transmission

AIDS Research and Human Retroviruses / Oct 01, 2014

Usmani, S., Liu, H., Pilcher, C. D., Witkowska, H. E., Kirchhoff, F., Greene, W. C., Münch, J., & Roan, N. R. (2014). HIV-enhancing Amyloids Are Prevalent in Fresh Semen and Are a Determinant for Semen’s Ability to Enhance HIV Infection: Relevance for HIV Transmission. AIDS Research and Human Retroviruses, 30(S1), A183–A184. https://doi.org/10.1089/aid.2014.5392.abstract

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Fayth Tan, Ph.D.

Pasadena, California, United States of America
7 Years Experience
Science Communicator · Biologist
Education

California Institute of Technology

Ph.D. Biology, Biology and Bioengineering / June, 2023

Pasadena, California, United States of America

University of California San Diego

B.S Marine Biology, Scripps Institution of Oceanography / June, 2018

La Jolla, California, United States of America
Experience

California Institute of Technology

Graduate Researcher / September, 2018June, 2023

Independent/Freelance

Science Writer / December, 2021Present

Write features, profiles, essay, reportage and creative non-fiction. Bylines in Nature, Electric Literature, The Xylom etc.

Schmidt Sciences

Science Writer / October, 2023Present

Interview and profile Schmidt Sciences AI 2050 Initiative Fellows, collectively elevating research agendas in the use, development or impacts of AI worth >$12 million

Most Relevant Research Expertise
Developmental Biology
Molecular Biology
Physiology
Science Communication
Other Research Expertise (4)
Regeneration Biology
Evolutionary Biology
Science Writing
Inflammation
About
Award-winning science writer and communicator with >7 years of experience as an academic biologist. Available for opportunities to consult on topics including regeneration biology, inflammation and fibrosis, aging, stem cell biology, metabolic disease, and animal physiology—or how best to communicate them to your target audience. I can also speak on effective science communication for researchers. My graduate research was in animal regeneration, using mouse models to investigate how physiology affects regenerative ability in the mouse digit tip and the neonatal mouse heart. I've published on novel methods to induce mouse digit regeneration, and analyzed the single-cell transcriptome of neonatal cardiac stem cells to identify potential developmental changes that may cause the loss of regenerative ability in older mice. As a science writer and communicator, I write about how science and technology impact and are impacted by society and culture. My work was recognized by the National Academy of Sciences in 2022, winning the Schmidt Prize for Excellence in Science Communication—an award of $20,000 that was given to 24 scientists and journalists from over 550 submissions. I've been commissioned by companies and non-profits to write about subjects from AI-powered drug discovery to the use of metaphor in neuroscience—my work doesn't shy away from niche, interdisciplinary and unexpected topics. <br> <br> <br> <br>

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Regan Hamel

Cambridge
6 Years Experience
Senior bioinformatics scientist, specializing in single cell omics in the context of cellular reprogramming and neuroinflammation
Education

University of Cambridge

PhD, Clinical Neurosciences / September, 2021

Cambridge

University of Cambridge

MPhil, Clinical Neurosciences / September, 2018

Cambridge

McGill University

Bachelor of Science, Neurosciences / June, 2017

Montreal
Experience

Mogrify Ltd

Bioinformatics scientist / August, 2021June, 2023

Senior Bioinformatics Scientist / July, 2023Present

Most Relevant Research Expertise
Cellular and Molecular Neuroscience
Cell Biology
Developmental Biology
Immunology and Allergy
Genetics
Molecular Biology
Other Research Expertise (7)
single cell biology
transcriptomics
Immunology
Drug Discovery
Pharmacology
And 2 more
About
Regan Hamel has an MPhil and PhD in Clinical Neurosciences from University of Cambridge. She also has a Bachelor of Science in Neurosciences from McGill University. Her PhD with Stefano Pluchino and John Marioni focused on single cell transcriptomics in the context of neuroinflammation. Since 2021 she has worked as a Bioinformatics scientist at Mogrify Ltd, applying a multitude of computational biology techniques (including single cell omics, bulk RNAseq, and predictive modelling) in the context of cell reprogramming
Most Relevant Publications (6+)

12 total publications

Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology

Frontiers in Cellular Neuroscience / Nov 05, 2020

Willis, C. M., Nicaise, A. M., Hamel, R., Pappa, V., Peruzzotti-Jametti, L., & Pluchino, S. (2020). Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology. Frontiers in Cellular Neuroscience, 14. https://doi.org/10.3389/fncel.2020.590960

Stem Cell Therapies for Progressive Multiple Sclerosis

Frontiers in Cell and Developmental Biology / Jul 09, 2021

Smith, J. A., Nicaise, A. M., Ionescu, R.-B., Hamel, R., Peruzzotti-Jametti, L., & Pluchino, S. (2021). Stem Cell Therapies for Progressive Multiple Sclerosis. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.696434

Metabolic Control of Smoldering Neuroinflammation

Frontiers in Immunology / Jun 23, 2021

Peruzzotti-Jametti, L., Willis, C. M., Hamel, R., Krzak, G., & Pluchino, S. (2021). Metabolic Control of Smoldering Neuroinflammation. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.705920

Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice

Molecular Therapy / Dec 01, 2020

Braga, A., Bandiera, S., Verheyen, J., Hamel, R., Rutigliani, C., Edenhofer, F., Smith, J. A., & Pluchino, S. (2020). Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice. Molecular Therapy, 28(12), 2677–2690. https://doi.org/10.1016/j.ymthe.2020.08.001

Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury

Frontiers in Immunology / Aug 24, 2022

Yao, X.-Q., Chen, J.-Y., Yu, Z.-H., Huang, Z.-C., Hamel, R., Zeng, Y.-Q., Huang, Z.-P., Tu, K.-W., Liu, J.-H., Lu, Y.-M., Zhou, Z.-T., Pluchino, S., Zhu, Q.-A., & Chen, J.-T. (2022). Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.964138

Single cell biology—a Keystone Symposia report

Annals of the New York Academy of Sciences / Oct 03, 2021

Cable, J., Elowitz, M. B., Domingos, A. I., Habib, N., Itzkovitz, S., Hamidzada, H., Balzer, M. S., Yanai, I., Liberali, P., Whited, J., Streets, A., Cai, L., Stergachis, A. B., Hong, C. K. Y., Keren, L., Guilliams, M., Alon, U., Shalek, A. K., Hamel, R., … Romeike, M. (2021). Single cell biology—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506(1), 74–97. Portico. https://doi.org/10.1111/nyas.14692

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Luca Delfinis

Toronto, Ontario, Canada
6 Years Experience
PhD candidate in physiology researching the mechanisms that drive muscle dysfunction in cancer
Education

Wilfrid Laurier University

BSc, Kinesiology & Physical Education / April, 2018

Waterloo, Ontario, Canada

York University

MSc, Molecular, Cellular and Integrative Physiology / August, 2020

Toronto, Ontario, Canada

York University

PhD, Molecular, Cellular and Integrative Physiology / August, 2024 (anticipated)

Toronto, Ontario, Canada
Experience

York University

Teaching Assistant / September, 2018Present

KINE 2049 (Research Methods in Kinesiology) and KINE 3012 (Human Physiology II)

Wilfrid Laurier University

Supplemental Instruction Senior Mentor / April, 2017April, 2018

Oversee teaching assistants with their teaching programs

Most Relevant Research Expertise
Physiology
Cell Biology
Other Research Expertise (1)
Physiology (medical)
About
Luca Delfinis is a PhD candidate at York University where his research focuses on muscle dysfunction in cancer. Luca has been a part of several research collaborations both nationally and internationally throughout his PhD that has helped him gain unique perspectives in physiology, especially in the context of metabolism. He has also presented at several conferences where he has discussed data with leaders in cachexia, metabolism, exercise and more.
Most Relevant Publications (2+)

4 total publications

Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation

Journal of Cachexia, Sarcopenia and Muscle / Apr 02, 2019

Hughes, M. C., Ramos, S. V., Turnbull, P. C., Rebalka, I. A., Cao, A., Monaco, C. M. F., Varah, N. E., Edgett, B. A., Huber, J. S., Tadi, P., Delfinis, L. J., Schlattner, U., Simpson, J. A., Hawke, T. J., & Perry, C. G. R. (2019). Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation. Journal of Cachexia, Sarcopenia and Muscle, 10(3), 643–661. Portico. https://doi.org/10.1002/jcsm.12405

Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime

American Journal of Physiology-Cell Physiology / May 01, 2023

Bellissimo, C. A., Delfinis, L. J., Hughes, M. C., Turnbull, P. C., Gandhi, S., DiBenedetto, S. N., Rahman, F. A., Tadi, P., Amaral, C. A., Dehghani, A., Cobley, J. N., Quadrilatero, J., Schlattner, U., & Perry, C. G. R. (2023). Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime. American Journal of Physiology-Cell Physiology, 324(5), C1141–C1157. https://doi.org/10.1152/ajpcell.00377.2022

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Gwendolyn Thomas, Ph.D., CSCS, USAW-L1

Philadelphia, Pennsylvania, United States of America
17 Years Experience
Resistance Exercise Physiologist/Performance Enhancement/Optimizing RE Prescription
Education

University of Connecticut

Ph.D., Kinesiology (Exercise Endocrinology, Exercise Physiology, Resistance Exercise) / May, 2010

Storrs, Connecticut, United States of America

University of Connecticut

M.A., Strength and Conditioning / May, 2007

Storrs, Connecticut, United States of America
Experience

Penn State University

Assistant Research Professor / September, 2019August, 2023

Principal Investigator of the Exercise Prescription Lab. The lab (PI: Thomas) conducts interdisciplinary and translational research on chronic diseases, publishing in peer-reviewed journals. Transform population health outcomes through data, analytics, and actionable insights. Chair the regulatory review board, overseeing IRB Administration, running meetings, and approving research protocols. Expertise in institutional, FDA, and Federal regulatory work.

Penn State Integrative Physiology

Faculty Member / September, 2019Present

Faculty Member In Integrative Physiology

Syracuse University

Assistant Professor / August, 2016August, 2019

Independent Principal Investigator: Assumed responsibility for all research studies conducted in my lab, including but not limited to oversight and training of research assistants (25), training of research assistants (30), and generating independent, high quality, reproducible results. Responsible for the management and integrity of design, conduct and reporting of the research project and for managing, monitoring and ensuring the integrity of collaborative relationships. Curriculum Committee Chair:Led Curriculum Committee and Departmental Leadership to develop Master’s Degree in Strength and Conditioning through certifying agency, the National Strength and Conditioning Association (NSCA).

Most Relevant Research Expertise
Genetics
Orthopedics and Sports Medicine
Endocrinology
Molecular Biology
Endocrinology, Diabetes and Metabolism
Physiology
Gastroenterology
Cellular and Molecular Neuroscience
Other Research Expertise (23)
resistance exercise
obesity
breast cancer
chronic disease
inflammation
And 18 more
About
My work has focused on how we can use data to support decisions to individualize monitoring to optimize human performance.  My work has demonstrated that a one size fits all approach is not the way to optimize performance in any setting.  My monitoring approach is one that utilizes a network physiology paradigm, which focuses on nonlinear dynamic interactions. In my athlete monitoring I focus on leveraging EMA and wearables; biological sampling and resistance exercise and conditioning prescribed to elicit a specific biological response.    Additionally, as a practitioner it is important to understand the limitations of athlete monitoring, which is another area research and practice has focused.  This is an important skillset that is currently being utilized by the in a project entitled “Integrating mHealth and Physical Function to Develop a Predictors of Injury and Optimal Performance Model in Special Military Operators “with the Rangers in the 3/75 Ranger Battalion.  This approach is one that quantifies factors such as dosage variables of training and lifestyle factors (sleep, nutrition, life stress).  Using this data, we are working on individualizing acute training sessions to optimize readiness and performance enhancement.   During my time at Syracuse University, I was the professor of record to teach the NSCA CSCS preparation course and lead the strength and conditioning program.  We were developing a master’s in exercise science and I was in the process of working on certification with the NSCA.  We also worked closely with athletics to secure strength and conditioning assistantships to allow for student funding.  I am currently on several NSCA committees, which include the Education and Women’s Committee (next certification cycle).    I am particularly adept at all phases of the athletic performance enhancement and these experiences have given me expertise in evidence based program design, linear and non-linear periodization, exercise endocrinology, resistance exercise physiology and acute and chronic training readiness and non-training parameters
Most Relevant Publications (31+)

51 total publications

Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation

BMC Cancer / Jan 22, 2019

van Rooijen, S., Carli, F., Dalton, S., Thomas, G., Bojesen, R., Le Guen, M., Barizien, N., Awasthi, R., Minnella, E., Beijer, S., Martínez-Palli, G., van Lieshout, R., Gögenur, I., Feo, C., Johansen, C., Scheede-Bergdahl, C., Roumen, R., Schep, G., & Slooter, G. (2019). Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation. BMC Cancer, 19(1). https://doi.org/10.1186/s12885-018-5232-6

Effects of a Whole Body Compression Garment on Markers of Recovery After a Heavy Resistance Workout in Men and Women

Journal of Strength and Conditioning Research / Mar 01, 2010

Kraemer, W. J., Flanagan, S. D., Comstock, B. A., Fragala, M. S., Earp, J. E., Dunn-Lewis, C., Ho, J.-Y., Thomas, G. A., Solomon-Hill, G., Penwell, Z. R., Powell, M. D., Wolf, M. R., Volek, J. S., Denegar, C. R., & Maresh, C. M. (2010). Effects of a Whole Body Compression Garment on Markers of Recovery After a Heavy Resistance Workout in Men and Women. Journal of Strength and Conditioning Research, 24(3), 804–814. https://doi.org/10.1519/jsc.0b013e3181d33025

MAXIMAL POWER AT DIFFERENT PERCENTAGES OF ONE REPETITION MAXIMUM

Journal of Strength and Conditioning Research / May 01, 2007

THOMAS, G. A., KRAEMER, W. J., SPIERING, B. A., VOLEK, J. S., ANDERSON, J. M., & MARESH, C. M. (2007). MAXIMAL POWER AT DIFFERENT PERCENTAGES OF ONE REPETITION MAXIMUM: INFLUENCE OF RESISTANCE AND GENDER. Journal of Strength and Conditioning Research, 21(2), 336–342. https://doi.org/10.1519/00124278-200705000-00008

Effects of Stretching on Upper-Body Muscular Performance

Journal of Strength and Conditioning Research / Jul 01, 2008

Torres, E. M., Kraemer, W. J., Vingren, J. L., Volek, J. S., Hatfield, D. L., Spiering, B. A., Ho, J. Y., Fragala, M. S., Thomas, G. A., Anderson, J. M., Häkkinen, K., & Maresh, C. M. (2008). Effects of Stretching on Upper-Body Muscular Performance. Journal of Strength and Conditioning Research, 22(4), 1279–1285. https://doi.org/10.1519/jsc.0b013e31816eb501

Effects of Amino Acids Supplement on Physiological Adaptations to Resistance Training

Medicine &amp; Science in Sports &amp; Exercise / May 01, 2009

KRAEMER, W. J., HATFIELD, D. L., VOLEK, J. S., FRAGALA, M. S., VINGREN, J. L., ANDERSON, J. M., SPIERING, B. A., THOMAS, G. A., HO, J. Y., QUANN, E. E., IZQUIERDO, M., HÄKKINEN, K., & MARESH, C. M. (2009). Effects of Amino Acids Supplement on Physiological Adaptations to Resistance Training. Medicine &amp; Science in Sports &amp; Exercise, 41(5), 1111–1121. https://doi.org/10.1249/mss.0b013e318194cc75

Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women

Steroids / Nov 01, 2009

Vingren, J. L., Kraemer, W. J., Hatfield, D. L., Volek, J. S., Ratamess, N. A., Anderson, J. M., Häkkinen, K., Ahtiainen, J., Fragala, M. S., & Thomas, G. A. (2009). Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women. Steroids, 74(13–14), 1033–1039. https://doi.org/10.1016/j.steroids.2009.08.002

Recovery From a National Collegiate Athletic Association Division I Football Game: Muscle Damage and Hormonal Status

Journal of Strength and Conditioning Research / Jan 01, 2009

Kraemer, W. J., Spiering, B. A., Volek, J. S., Martin, G. J., Howard, R. L., Ratamess, N. A., Hatfield, D. L., Vingren, J. L., Ho, J. Y., Fragala, M. S., Thomas, G. A., French, D. N., Anderson, J. M., Häkkinen, K., & Maresh, C. M. (2009). Recovery From a National Collegiate Athletic Association Division I Football Game: Muscle Damage and Hormonal Status. Journal of Strength and Conditioning Research, 23(1), 2–10. https://doi.org/10.1519/jsc.0b013e31819306f2

The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors

Obesity / Dec 27, 2016

Thomas, G. A., Cartmel, B., Harrigan, M., Fiellin, M., Capozza, S., Zhou, Y., Ercolano, E., Gross, C. P., Hershman, D., Ligibel, J., Schmitz, K., Li, F., Sanft, T., & Irwin, M. L. (2016). The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors. Obesity, 25(2), 346–351. Portico. https://doi.org/10.1002/oby.21729

l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women

Metabolism / Aug 01, 2010

Ho, J.-Y., Kraemer, W. J., Volek, J. S., Fragala, M. S., Thomas, G. A., Dunn-Lewis, C., Coday, M., Häkkinen, K., & Maresh, C. M. (2010). l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism, 59(8), 1190–1199. https://doi.org/10.1016/j.metabol.2009.11.012

Effects of L-Carnitine L-Tartrate Supplementation on Muscle Oxygenation Responses to Resistance Exercise

Journal of Strength and Conditioning Research / Jul 01, 2008

Spiering, B. A., Kraemer, W. J., Hatfield, D. L., Vingren, J. L., Fragala, M. S., Ho, J.-Y., Thomas, G. A., Häkkinen, K., & Volek, J. S. (2008). Effects of L-Carnitine L-Tartrate Supplementation on Muscle Oxygenation Responses to Resistance Exercise. Journal of Strength and Conditioning Research, 22(4), 1130–1135. https://doi.org/10.1519/jsc.0b013e31817d48d9

Endocrine Response Patterns to Acute Unilateral and Bilateral Resistance Exercise in Men

Journal of Strength and Conditioning Research / Jan 01, 2010

Migiano, M. J., Vingren, J. L., Volek, J. S., Maresh, C. M., Fragala, M. S., Ho, J.-Y., Thomas, G. A., Hatfield, D. L., Häkkinen, K., Ahtiainen, J., Earp, J. E., & Kraemer, W. J. (2010). Endocrine Response Patterns to Acute Unilateral and Bilateral Resistance Exercise in Men. Journal of Strength and Conditioning Research, 24(1), 128–134. https://doi.org/10.1519/jsc.0b013e3181a92dc5

Growth Hormone, Exercise, and Athletic Performance

Current Sports Medicine Reports / Jul 01, 2010

Kraemer, W. J., Dunn-Lewis, C., Comstock, B. A., Thomas, G. A., Clark, J. E., & Nindl, B. C. (2010). Growth Hormone, Exercise, and Athletic Performance: A Continued Evolution of Complexity. Current Sports Medicine Reports, 9(4), 242–252. https://doi.org/10.1249/jsr.0b013e3181e976df

Effect of resistance exercise on muscle steroidogenesis

Journal of Applied Physiology / Dec 01, 2008

Vingren, J. L., Kraemer, W. J., Hatfield, D. L., Anderson, J. M., Volek, J. S., Ratamess, N. A., Thomas, G. A., Ho, J.-Y., Fragala, M. S., & Maresh, C. M. (2008). Effect of resistance exercise on muscle steroidogenesis. Journal of Applied Physiology, 105(6), 1754–1760. https://doi.org/10.1152/japplphysiol.91235.2008

Obesity, Growth Hormone and Exercise

Sports Medicine / Jun 30, 2013

Thomas, G. A., Kraemer, W. J., Comstock, B. A., Dunn-Lewis, C., Maresh, C. M., & Volek, J. S. (2013). Obesity, Growth Hormone and Exercise. Sports Medicine, 43(9), 839–849. https://doi.org/10.1007/s40279-013-0064-7

Effect of Exercise on Metabolic Syndrome Variables in Breast Cancer Survivors

International Journal of Endocrinology / Jan 01, 2013

Thomas, G. A., Alvarez-Reeves, M., Lu, L., Yu, H., & Irwin, M. L. (2013). Effect of Exercise on Metabolic Syndrome Variables in Breast Cancer Survivors. International Journal of Endocrinology, 2013, 1–8. https://doi.org/10.1155/2013/168797

Factors Affecting Flutter Kicking Speed in Women Who Are Competitive and Recreational Swimmers

Journal of Strength and Conditioning Research / Oct 01, 2009

McCullough, A. S., Kraemer, W. J., Volek, J. S., Solomon-Hill, G. F., Hatfield, D. L., Vingren, J. L., Ho, J.-Y., Fragala, M. S., Thomas, G. A., Häkkinen, K., & Maresh, C. M. (2009). Factors Affecting Flutter Kicking Speed in Women Who Are Competitive and Recreational Swimmers. Journal of Strength and Conditioning Research, 23(7), 2130–2136. https://doi.org/10.1519/jsc.0b013e31819ab977

Immunoreactive and bioactive growth hormone responses to resistance exercise in men who are lean or obese

Journal of Applied Physiology / Aug 01, 2011

Thomas, G. A., Kraemer, W. J., Kennett, M. J., Comstock, B. A., Maresh, C. M., Denegar, C. R., Volek, J. S., & Hymer, W. C. (2011). Immunoreactive and bioactive growth hormone responses to resistance exercise in men who are lean or obese. Journal of Applied Physiology, 111(2), 465–472. https://doi.org/10.1152/japplphysiol.00157.2011

Relationship Between Off-Ice Testing Variables and On-Ice Speed in Women's Collegiate Synchronized Figure Skaters: Implications for Training

Journal of Strength and Conditioning Research / Mar 01, 2010

Bower, M. E., Kraemer, W. J., Potteiger, J. A., Volek, J. S., Hatfield, D. A., Vingren, J. L., Spiering, B. A., Fragala, M. S., Ho, J.-Y., Thomas, G. A., Earp, J. E., Häkkinen, K., & Maresh, C. M. (2010). Relationship Between Off-Ice Testing Variables and On-Ice Speed in Women’s Collegiate Synchronized Figure Skaters: Implications for Training. Journal of Strength and Conditioning Research, 24(3), 831–839. https://doi.org/10.1519/jsc.0b013e3181a59a5c

Effects of resistance exercise and obesity level on ghrelin and cortisol in men

Metabolism / Jun 01, 2012

Thomas, G. A., Kraemer, W. J., Comstock, B. A., Dunn-Lewis, C., Volek, J. S., Denegar, C. R., & Maresh, C. M. (2012). Effects of resistance exercise and obesity level on ghrelin and cortisol in men. Metabolism, 61(6), 860–868. https://doi.org/10.1016/j.metabol.2011.10.015

Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight

European Journal of Applied Physiology / Dec 02, 2008

Fragala, M. S., Kraemer, W. J., Volek, J. S., Maresh, C. M., Puglisi, M. J., Vingren, J. L., Ho, J.-Y., Hatfield, D. L., Spiering, B. A., Forsythe, C. E., Thomas, G. A., Quann, E. E., Anderson, J. M., & Hesslink, R. L. (2008). Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight. European Journal of Applied Physiology, 105(5). https://doi.org/10.1007/s00421-008-0944-y

Implementation of a Postoperative Screening and Treatment Guidance for the Low Anterior Resection Syndrome: Preliminary Results

Diseases of the Colon &amp; Rectum / Sep 01, 2019

van der Heijden, J. A. G., van Heinsbergen, M., Thomas, G., Caers, F., Slooter, G. D., & Maaskant-Braat, A. J. G. (2019). Implementation of a Postoperative Screening and Treatment Guidance for the Low Anterior Resection Syndrome: Preliminary Results. Diseases of the Colon &amp; Rectum, 62(9), 1033–1042. https://doi.org/10.1097/dcr.0000000000001428

Effects of Acute Resistance Exercise on Muscle Damage and Perceptual Measures Between Men Who Are Lean and Obese

Journal of Strength and Conditioning Research / Dec 01, 2013

Comstock, B. A., Thomas, G. A., Dunn-Lewis, C., Volek, J. S., Szivak, T. K., Hooper, D. R., Kupchak, B. R., Flanagan, S. D., Denegar, C. R., & Kraemer, W. J. (2013). Effects of Acute Resistance Exercise on Muscle Damage and Perceptual Measures Between Men Who Are Lean and Obese. Journal of Strength and Conditioning Research, 27(12), 3488–3494. https://doi.org/10.1519/jsc.0b013e31828f8202

Endogenous opioid peptide responses to opioid and anti-inflammatory medications following eccentric exercise-induced muscle damage

Peptides / Jan 01, 2010

Kraemer, W. J., Joseph, M. F., Volek, J. S., Hoffman, J. R., Ratamess, N. A., Newton, R. U., Fragala, M. S., French, D. N., Rubin, M. A., Scheett, T. P., McGuigan, M. R., Thomas, G. A., Gomez, A. L., Häkkinen, K., & Maresh, C. M. (2010). Endogenous opioid peptide responses to opioid and anti-inflammatory medications following eccentric exercise-induced muscle damage. Peptides, 31(1), 88–93. https://doi.org/10.1016/j.peptides.2009.09.031

Effect of circulating growth hormone on muscle IGF-I protein concentration in female mice with growth hormone receptor gene disruption

Growth Hormone &amp; IGF Research / Jun 01, 2009

Kraemer, W. J., Vingren, J. L., Schuenke, M. D., Kopchick, J. J., Volek, J. S., Fragala, M. S., Häkkinen, K., Jen-Ho, Thomas, G. A., & Staron, R. S. (2009). Effect of circulating growth hormone on muscle IGF-I protein concentration in female mice with growth hormone receptor gene disruption. Growth Hormone &amp; IGF Research, 19(3), 242–244. https://doi.org/10.1016/j.ghir.2008.10.006

The Effects Of An Acute Resistance Exercise Bout On Insulin Like Growth Factor-I And 3 Binding Proteins In Well-Trained Men And Women

Journal of Strength and Conditioning Research / Jan 01, 2010

Hatfield, D. L., Kraemer, W. J., Vingren, J. L., Anderson, J. M., Volek, J. S., Nindl, B. C., Thomas, G. A., Ho, J. Y., Fragala, M. S., & Maresh, C. M. (2010). The Effects Of An Acute Resistance Exercise Bout On Insulin Like Growth Factor-I And 3 Binding Proteins In Well-Trained Men And Women. Journal of Strength and Conditioning Research, 24, 1. https://doi.org/10.1097/01.jsc.0000367124.12392.bb

Effects of a Smartphone Based Exercise Intervention on Quality of Life in Breast Cancer Survivors

Medicine &amp; Science in Sports &amp; Exercise / Jun 01, 2019

Bedillion, M. F., Ansell, E. B., & Thomas, G. A. (2019). Effects of a Smartphone Based Exercise Intervention on Quality of Life in Breast Cancer Survivors: 927 Board #161 May 29 3:30 PM - 5:00 PM. Medicine &amp; Science in Sports &amp; Exercise, 51(6S), 237–237. https://doi.org/10.1249/01.mss.0000561217.04972.38

Differences by Activity Level in Barriers and Benefits of Exercise in Breast Cancer Survivors

Medicine &amp; Science in Sports &amp; Exercise / Jun 01, 2019

Thomas, G. A., & Bedillion, M. F. (2019). Differences by Activity Level in Barriers and Benefits of Exercise in Breast Cancer Survivors: 3277 Board #5 June 1 9:00 AM - 11:00 AM. Medicine &amp; Science in Sports &amp; Exercise, 51(6S), 900–900. https://doi.org/10.1249/01.mss.0000563194.81354.46

Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors

Medicine &amp; Science in Sports &amp; Exercise / May 01, 2016

Thomas, G. A., Cartmel, B., Harrigan, M., Fiellin, M., Capozza, S., Zhou, Y., Ercolano, E., Gross, C., Hershman, D., Ligibel, J., Schmitz, K., Li, F., Sanft, T., & Irwin, M. L. (2016). Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors: 1285 Board #6 June 2, 8. Medicine &amp; Science in Sports &amp; Exercise, 48, 334. https://doi.org/10.1249/01.mss.0000486010.57056.60

LOW INTENSITY RESISTANCE EXERCISE FOLLOWING HIGH INTENSITY RESISTANCE EXERCISE STIMULATES GROWTH HORMONE SECRETION IN MEN

Medicine &amp; Science in Sports &amp; Exercise / May 01, 2001

Goto, K., & Takamatsu, K. (2001). LOW INTENSITY RESISTANCE EXERCISE FOLLOWING HIGH INTENSITY RESISTANCE EXERCISE STIMULATES GROWTH HORMONE SECRETION IN MEN. Medicine &amp; Science in Sports &amp; Exercise, 33(5), S287. https://doi.org/10.1097/00005768-200105001-01614

Maximal Force Generation In The Bench Press During Concentric And Eccentric Actions

Medicine &amp; Science in Sports &amp; Exercise / May 01, 2009

Ho, J. Y., Fragala, M. S., Thomas, G. A., Volek, J. S., & Kraemer, W. J. (2009). Maximal Force Generation In The Bench Press During Concentric And Eccentric Actions: 728 May 28 9:15 AM - 9:30 AM. Medicine &amp; Science in Sports &amp; Exercise, 41(5), 63. https://doi.org/10.1249/01.mss.0000353462.75436.37

The Effect of Growth Hormone Receptor Deficiency on Skeletal Muscle Insulin-like Growth Factor-I Protein Expression

Medicine &amp; Science in Sports &amp; Exercise / May 01, 2008

Hatfield, D. L., Kraemer, W. J., Vingren, J. L., Fragala, M. S., Ho, J.-Y., Thomas, G. A., Volek, J. S., Maresh, C. M., Spiering, B. A., Schuenke, M., Kopchick, J. J., & Staron, R. S. (2008). The Effect of Growth Hormone Receptor Deficiency on Skeletal Muscle Insulin-like Growth Factor-I Protein Expression: 2482 Board #65 May 31 9:30 AM - 11:00 AM. Medicine &amp; Science in Sports &amp; Exercise, 40(5), S470. https://doi.org/10.1249/01.mss.0000322995.34725.36

See Full Profile

Burcu Vitrinel, Ph.D.

San Francisco
11 Years Experience
Cross-functional life sciences strategy professional with a Ph.D. in genetics
Education

New York University

Ph.D., Developmental Genetics / May, 2021

New York, New York, United States of America

M.Sc., Molecular Medicine / September, 2015

Berlin

Sabancı University

B.Sc., Bioengineering / May, 2013

Istanbul
Experience

Putnam Associates

Life Sciences Consultant / July, 2021November, 2023

Most Relevant Research Expertise
Molecular Biology
Cell Biology
Aging
Virology
Developmental Biology
Other Research Expertise (11)
Biochemistry
Computer Science Applications
Mass spectrometry
Transcriptomics
Proteomics
And 6 more
About
Cross-functional life sciences **strategy** professional with a doctoral degree in **genetics**; worked on 16+ projects in collaboration with 7+ big pharma clients as the lead consultant in a **client-facing** role. Exceptional understanding of current life sciences **market trends**. Scientist with 10+ years of wet-lab with hands-on **CRISPR-Cas9 gene** **editing and tandem mass-spectrometry** experience with 3 first-author papers. Experienced primary market researcher for pharmaceutical companies. Award-winning science communicator for a wide range of audiences tailored to different internal and external stakeholders.
Most Relevant Publications (5+)

10 total publications

Exploiting Interdata Relationships in Next-generation Proteomics Analysis

Molecular &amp; Cellular Proteomics / Aug 01, 2019

Vitrinel, B., Koh, H. W. L., Mujgan Kar, F., Maity, S., Rendleman, J., Choi, H., & Vogel, C. (2019). Exploiting Interdata Relationships in Next-generation Proteomics Analysis. Molecular &amp; Cellular Proteomics, 18(8), S5–S14. https://doi.org/10.1074/mcp.mr118.001246

Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity

Cell Systems / Dec 01, 2020

Shim, W. J., Sinniah, E., Xu, J., Vitrinel, B., Alexanian, M., Andreoletti, G., Shen, S., Sun, Y., Balderson, B., Boix, C., Peng, G., Jing, N., Wang, Y., Kellis, M., Tam, P. P. L., Smith, A., Piper, M., Christiaen, L., Nguyen, Q., … Palpant, N. J. (2020). Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity. Cell Systems, 11(6), 625-639.e13. https://doi.org/10.1016/j.cels.2020.11.001

The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans

Aging Cell / Aug 09, 2019

Müthel, S., Uyar, B., He, M., Krause, A., Vitrinel, B., Bulut, S., Vasiljevic, D., Marchal, I., Kempa, S., Akalin, A., & Tursun, B. (2019). The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Aging Cell, 18(6). Portico. https://doi.org/10.1111/acel.13012

Ring Finger 149-Related Is an FGF/MAPK-Independent Regulator of Pharyngeal Muscle Fate Specification

International Journal of Molecular Sciences / May 16, 2023

Vitrinel, B., Vogel, C., & Christiaen, L. (2023). Ring Finger 149-Related Is an FGF/MAPK-Independent Regulator of Pharyngeal Muscle Fate Specification. International Journal of Molecular Sciences, 24(10), 8865. https://doi.org/10.3390/ijms24108865

Proteomic Signatures of the Serological Response to Influenza Vaccination in a Large Human Cohort Study

Viruses / Nov 09, 2022

Wu, S., Pushalkar, S., Maity, S., Pressler, M., Rendleman, J., Vitrinel, B., Carlock, M., Ross, T., Choi, H., & Vogel, C. (2022). Proteomic Signatures of the Serological Response to Influenza Vaccination in a Large Human Cohort Study. Viruses, 14(11), 2479. https://doi.org/10.3390/v14112479

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Dr. Everson A Nunes, Ph.D.

Hamilton, Ontario, Canada
19 Years Experience
Post-Doctoral Fellow at McMaster University | former Associate Professor - Physiological Sciences
Education

Universidade Federal do Paraná - Campus Centro Politécnico

PhD, Physiological Sciences / December, 2009

Curitiba

Universidade Federal do Paraná - Campus Centro Politécnico

BSc - Human Nutrition / December, 2007

Curitiba

Universidade Federal do Paraná - Campus Centro Politécnico

MSc, Physiological Sciences / March, 2005

Curitiba
Experience

McMaster University

Post Doctoral Fellow / September, 2019Present

Post-Doctoral Research Fellow / September, 2015August, 2016

Universidade Federal de Santa Catarina

Associate professor / October, 2013April, 2022

Assistant Professor / October, 2010September, 2013

Universidade Federal do Paraná

Post-Doctoral Fellow / December, 2009September, 2010

Most Relevant Research Expertise
Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Cell Biology
Physiology
Endocrinology
Gastroenterology
Behavioral Neuroscience
Pathology and Forensic Medicine
Molecular Biology
Genetics
Cellular and Molecular Neuroscience
Other Research Expertise (29)
skeletal muscle
nutrition
physical activity
obesity
cancer
And 24 more
About
Dr. Everson A Nunes is a highly accomplished researcher and educator in the field of physiological sciences. He received his Ph.D. in Cellular and Molecular Biology with a focus on Physiological Sciences from Universidade Federal do Paraná in 2009, after completing a BSc in Human Nutrition and an MSc in Physiological Sciences. He also holds a specialization in Exercise Physiology and a BSc in Biological Sciences from Universidade Federal do Paraná. Dr. Nunes has a strong background in research, having completed two post-doctoral fellowships at McMaster University and Universidade Federal do Paraná. He has also held positions as an associate professor and assistant professor at Universidade Federal de Santa Catarina. He has published numerous articles in peer-reviewed journals, and his research focuses on the effects of exercise and nutrition on physiological processes in the human body. In addition to his research, Dr. Nunes is also a dedicated educator. He has taught at various universities in Brazil, including Universidade Federal de Santa Catarina, Universidade Gama Filho, Faculdades Integradas Espírita, Pontificia Universidade Católica do Paraná, and Faculdade do Litoral Sul. He is known for his dynamic teaching style and his ability to engage students in complex physiological concepts. Dr. Nunes is a member of several professional organizations, including the American Society for Nutrition, the Canadian Society of Exercise Physiology, the Canadian Nutrition Society and the Brazilian Society of Physiology. He is also a regular speaker at national and international conferences, sharing his expertise and research findings with colleagues and students. Overall, Dr. Nunes is a highly qualified and experienced professional in physiological sciences, metabolism, cancer and nutrition. His dedication to research and education makes him a valuable asset to any institution.
Most Relevant Publications (52+)

97 total publications

The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease

Frontiers in Nutrition / Sep 06, 2019

McGlory, C., Calder, P. C., & Nunes, E. A. (2019). The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease. Frontiers in Nutrition, 6. https://doi.org/10.3389/fnut.2019.00144

Systematic review and meta‐analysis of protein intake to support muscle mass and function in healthy adults

Journal of Cachexia, Sarcopenia and Muscle / Feb 20, 2022

Nunes, E. A., Colenso‐Semple, L., McKellar, S. R., Yau, T., Ali, M. U., Fitzpatrick‐Lewis, D., Sherifali, D., Gaudichon, C., Tomé, D., Atherton, P. J., Robles, M. C., Naranjo‐Modad, S., Braun, M., Landi, F., & Phillips, S. M. (2022). Systematic review and meta‐analysis of protein intake to support muscle mass and function in healthy adults. Journal of Cachexia, Sarcopenia and Muscle, 13(2), 795–810. Portico. https://doi.org/10.1002/jcsm.12922

Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients

Lipids / Jul 26, 2013

Mocellin, M. C., Pastore e Silva, J. de A., Camargo, C. de Q., Fabre, M. E. de S., Gevaerd, S., Naliwaiko, K., Moreno, Y. M. F., Nunes, E. A., & Trindade, E. B. S. de M. (2013). Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients. Lipids, 48(9), 879–888. Portico. https://doi.org/10.1007/s11745-013-3816-0

Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats

European Journal of Applied Physiology / Aug 08, 2008

de Lima, C., Alves, L. E., Iagher, F., Machado, A. F., Bonatto, S. J., Kuczera, D., de Souza, C. F., Pequito, D. C., Muritiba, A. L., Nunes, E. A., & Fernandes, L. C. (2008). Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats. European Journal of Applied Physiology, 104(6), 957–964. https://doi.org/10.1007/s00421-008-0849-9

Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy

Lipids / Dec 11, 2011

Bonatto, S. J. R., Oliveira, H. H. P., Nunes, E. A., Pequito, D., Iagher, F., Coelho, I., Naliwaiko, K., Kryczyk, M., Brito, G. A. P., Repka, J., Sabóia, L. V., Fukujima, G., Calder, P. C., & Fernandes, L. C. (2011). Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy. Lipids, 47(4), 383–389. Portico. https://doi.org/10.1007/s11745-011-3643-0

β-Hydroxy-β-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-κB expression

Nutrition Research / Jul 01, 2008

Nunes, E. A., Kuczera, D., Brito, G. A. P., Bonatto, S. J. R., Yamazaki, R. K., Tanhoffer, R. A., Mund, R. C., Kryczyk, M., & Fernandes, L. C. (2008). β-Hydroxy-β-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-κB expression. Nutrition Research, 28(7), 487–493. https://doi.org/10.1016/j.nutres.2008.04.006

Effects of Prebiotic and Synbiotic Supplementation on Inflammatory Markers and Anthropometric Indices After Roux-en-Y Gastric Bypass

Journal of Clinical Gastroenterology / Mar 01, 2016

Fernandes, R., Beserra, B. T. S., Mocellin, M. C., Kuntz, M. G. F., da Rosa, J. S., de Miranda, R. C. D., Schreiber, C. S. O., Fröde, T. S., Nunes, E. A., & Trindade, E. B. S. M. (2016). Effects of Prebiotic and Synbiotic Supplementation on Inflammatory Markers and Anthropometric Indices After Roux-en-Y Gastric Bypass: A Randomized, Triple-blind, Placebo-controlled Pilot Study. Journal of Clinical Gastroenterology, 50(3), 208–217. https://doi.org/10.1097/mcg.0000000000000328

Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats

Lipids in Health and Disease / Jan 01, 2011

Yamazaki, R. K., Brito, G. A., Coelho, I., Pequitto, D. C., Yamaguchi, A. A., Borghetti, G., Schiessel, D., Kryczyk, M., Machado, J., Rocha, R. E., Aikawa, J., Iagher, F., Naliwaiko, K., Tanhoffer, R. A., Nunes, E. A., & Fernandes, L. (2011). Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats. Lipids in Health and Disease, 10(1), 66. https://doi.org/10.1186/1476-511x-10-66

Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men

Medicine &amp; Science in Sports &amp; Exercise / Jan 01, 2019

JAKUBOWSKI, J. S., WONG, E. P. T., NUNES, E. A., NOGUCHI, K. S., VANDEWEERD, J. K., MURPHY, K. T., MORTON, R. W., MCGLORY, C., & PHILLIPS, S. M. (2019). Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men. Medicine &amp; Science in Sports &amp; Exercise, 51(1), 65–74. https://doi.org/10.1249/mss.0000000000001752

An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

Medicine &amp; Science in Sports &amp; Exercise / Apr 06, 2022

LIM, C., NUNES, E. A., CURRIER, B. S., MCLEOD, J. C., THOMAS, A. C. Q., & PHILLIPS, S. M. (2022). An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy. Medicine &amp; Science in Sports &amp; Exercise, 54(9), 1546–1559. https://doi.org/10.1249/mss.0000000000002929

In vitro ketone‐supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle

The Journal of Physiology / Aug 19, 2020

Petrick, H. L., Brunetta, H. S., Pignanelli, C., Nunes, E. A., van Loon, L. J. C., Burr, J. F., & Holloway, G. P. (2020). In vitro ketone‐supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle. The Journal of Physiology, 598(21), 4869–4885. Portico. https://doi.org/10.1113/jp280032

Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats

Lipids in Health and Disease / Oct 16, 2013

Iagher, F., de Brito Belo, S. R., Souza, W. M., Nunes, J. R., Naliwaiko, K., Sassaki, G. L., Bonatto, S. J. R., de Oliveira, H. H. P., Brito, G. A. P., de Lima, C., Kryczyk, M., de Souza, C. F., Steffani, J. A., Nunes, E. A., & Fernandes, L. C. (2013). Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats. Lipids in Health and Disease, 12(1). https://doi.org/10.1186/1476-511x-12-146

Interval training attenuates the metabolic disturbances in type 1 diabetes rat model

Arquivos Brasileiros de Endocrinologia &amp; Metabologia / Nov 01, 2013

Rocha, R. E. R., Coelho, I., Pequito, D. C. T., Yamagushi, A., Borghetti, G., Yamazaki, R. K., Brito, G. A. P. de, Machado, J., Kryczyk, M., Nunes, E. A., Venera, G., & Fernandes, L. C. (2013). Interval training attenuates the metabolic disturbances in type 1 diabetes rat model. Arquivos Brasileiros de Endocrinologia &amp; Metabologia, 57(8), 594–602. https://doi.org/10.1590/s0004-27302013000800003

Decrement in resting and insulin‐stimulated soleus muscle mitochondrial respiration is an early event in diet‐induced obesity in mice

Experimental Physiology / Jan 24, 2019

Brunetta, H. S., de Paula, G. C., de Oliveira, J., Martins, E. L., dos Santos, G. J., Galina, A., Rafacho, A., de Bem, A. F., & Nunes, E. A. (2019). Decrement in resting and insulin‐stimulated soleus muscle mitochondrial respiration is an early event in diet‐induced obesity in mice. Experimental Physiology, 104(3), 306–321. Portico. https://doi.org/10.1113/ep087317

Nitrate attenuates high fat diet‐induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission

The Journal of Physiology / Jun 16, 2020

Brunetta, H. S., Politis‐Barber, V., Petrick, H. L., Dennis, K. M. J. H., Kirsh, A. J., Barbeau, P., Nunes, E. A., & Holloway, G. P. (2020). Nitrate attenuates high fat diet‐induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission. The Journal of Physiology, 598(16), 3357–3371. Portico. https://doi.org/10.1113/jp279455

Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats

Canadian Journal of Physiology and Pharmacology / Oct 01, 2014

dos Santos, C., Ferreira, F. B. D., Gonçalves-Neto, L. M., Taboga, S. R., Boschero, A. C., & Rafacho, A. (2014). Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats. Canadian Journal of Physiology and Pharmacology, 92(10), 867–878. https://doi.org/10.1139/cjpp-2014-0259

Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment

Biochemical Journal / Jul 09, 2021

Brunetta, H. S., Petrick, H. L., Vachon, B., Nunes, E. A., & Holloway, G. P. (2021). Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment. Biochemical Journal, 478(13), 2539–2553. https://doi.org/10.1042/bcj20210264

An umbrella review of systematic reviews of β‐hydroxy‐β‐methyl butyrate supplementation in ageing and clinical practice

Journal of Cachexia, Sarcopenia and Muscle / Jul 12, 2022

Phillips, S. M., Lau, K. J., D’Souza, A. C., & Nunes, E. A. (2022). An umbrella review of systematic reviews of β‐hydroxy‐β‐methyl butyrate supplementation in ageing and clinical practice. Journal of Cachexia, Sarcopenia and Muscle, 13(5), 2265–2275. Portico. https://doi.org/10.1002/jcsm.13030

Heart rate reactivity to acute mental stress is associated with adiposity, carotid distensibility, sleep efficiency, and autonomic modulation in young men

Physiology &amp; Behavior / Oct 01, 2022

Formolo, N. P. S., Filipini, R. E., Macedo, E. F. O., Corrêa, C. R., Nunes, E. A., Lima, L. R. A., & Speretta, G. F. (2022). Heart rate reactivity to acute mental stress is associated with adiposity, carotid distensibility, sleep efficiency, and autonomic modulation in young men. Physiology &amp; Behavior, 254, 113908. https://doi.org/10.1016/j.physbeh.2022.113908

Increased protein intake derived from leucine-enriched protein enhances the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women: a 4-day randomized controlled trial

Applied Physiology, Nutrition, and Metabolism / Nov 01, 2022

Lim, C., Traylor, D. A., McGlory, C., Joanisse, S., McKendry, J., Grewal, T., Mcleod, J. C., Prior, T., Nunes, E. A., Lees, M., & Phillips, S. M. (2022). Increased protein intake derived from leucine-enriched protein enhances the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women: a 4-day randomized controlled trial. Applied Physiology, Nutrition, and Metabolism, 47(11), 1104–1114. https://doi.org/10.1139/apnm-2022-0164

Mixed-meal test reveals a worsen phenotypic flexibility correlated to central adiposity in clinically healthy young males

Clinical Nutrition ESPEN / Dec 01, 2020

Corrêa, C. R., Filipini, R. E., Mazera, M. S., Rafacho, A., & Nunes, E. A. (2020). Mixed-meal test reveals a worsen phenotypic flexibility correlated to central adiposity in clinically healthy young males. Clinical Nutrition ESPEN, 40, 622. https://doi.org/10.1016/j.clnesp.2020.09.650

Associação da atividade física, consumo de álcool e índice de massa corporal com a qualidade de vida de adolescentes

Revista Brasileira de Cineantropometria e Desempenho Humano / Jul 18, 2008

Gordia, A. P. (2008). Associação da atividade física, consumo de álcool e índice de massa corporal com a qualidade de vida de adolescentes. Revista Brasileira de Cineantropometria e Desempenho Humano, 10(3), 313. https://doi.org/10.5007/1980-0037.2008v10n3p313

β-hydroxy-β-methylbutyrate (HMB) Does Not Improve Resistance Exercise-Induced Changes In Body Composition: A Systematic-review And Meta-analysis

Medicine &amp; Science in Sports &amp; Exercise / Jul 01, 2020

Nunes, E. A., Jakubowski, J., Teixeira, F. J., Vescio, V., Morton, R. W., & Phillips, S. M. (2020). β-hydroxy-β-methylbutyrate (HMB) Does Not Improve Resistance Exercise-Induced Changes In Body Composition: A Systematic-review And Meta-analysis: 1698 Board #292 May 28 9:30 AM - 11:00 AM. Medicine &amp; Science in Sports &amp; Exercise, 52(7S), 456–457. https://doi.org/10.1249/01.mss.0000678888.31639.48

1739-P: Insulin Rapidly Increases Skeletal Muscle Mitochondrial ADP Sensitivity, Mitigating HFD-Induced Mitochondrial Dysfunction

Diabetes / Jun 01, 2020

BRUNETTA, H., PETRICK, H. L., NUNES, E. A., & HOLLOWAY, G. (2020). 1739-P: Insulin Rapidly Increases Skeletal Muscle Mitochondrial ADP Sensitivity, Mitigating HFD-Induced Mitochondrial Dysfunction. Diabetes, 69(Supplement_1). https://doi.org/10.2337/db20-1739-p

Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies

American Journal of Physiology-Cell Physiology / Jun 01, 2022

Nunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022). Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies. American Journal of Physiology-Cell Physiology, 322(6), C1068–C1084. https://doi.org/10.1152/ajpcell.00425.2021

Dietary acid load is positively associated with insulin resistance: a population-based study

Clinical Nutrition ESPEN / Jun 01, 2022

Smeha, L., Fassula, A. S., Franco Moreno, Y. M., Gonzalez-Chica, D. A., & Nunes, E. A. (2022). Dietary acid load is positively associated with insulin resistance: a population-based study. Clinical Nutrition ESPEN, 49, 341–347. https://doi.org/10.1016/j.clnesp.2022.03.025

Relative fat mass is a better tool to diagnose high adiposity when compared to body mass index in young male adults: A cross-section study

Clinical Nutrition ESPEN / Feb 01, 2021

Corrêa, C. R., Formolo, N. P. S., Dezanetti, T., Speretta, G. F. F., & Nunes, E. A. (2021). Relative fat mass is a better tool to diagnose high adiposity when compared to body mass index in young male adults: A cross-section study. Clinical Nutrition ESPEN, 41, 225–233. https://doi.org/10.1016/j.clnesp.2020.12.009

Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration

The Journal of Nutritional Biochemistry / Apr 01, 2021

Santos, C. dos, da Silva, J. S., Brunetta, H. S., Chagas, T. R., Zoccal, D. B., Nunes, E. A., & Rafacho, A. (2021). Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration. The Journal of Nutritional Biochemistry, 90, 108572. https://doi.org/10.1016/j.jnutbio.2020.108572

Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies

Clinical Nutrition Open Science / Apr 01, 2021

Joanisse, S., McKendry, J., Lim, C., Nunes, E. A., Stokes, T., Mcleod, J. C., & Phillips, S. M. (2021). Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies. Clinical Nutrition Open Science, 36, 56–77. https://doi.org/10.1016/j.nutos.2021.01.005

Effect of mate tea consumption on rapid force production after eccentric exercise: a randomized, controlled, crossover study

Sport Sciences for Health / Jul 09, 2020

Moura, B. M., Panza, V. P., Brunetta, H. S., Tamborindeguy, A. C., de Oliveira, M. V., Sakugawa, R. L., Nunes, E. A., da Silva, E. L., & Diefenthaeler, F. (2020). Effect of mate tea consumption on rapid force production after eccentric exercise: a randomized, controlled, crossover study. Sport Sciences for Health, 16(3), 571–581. https://doi.org/10.1007/s11332-020-00669-9

Association of physical activity and sedentary behavior at school with cardiovascular risk factors in adolescents

Revista Brasileira de Cineantropometria &amp; Desempenho Humano / Jan 01, 2020

Santos, P. C. dos, Lima, L. R. A. de, Costa, B. G. G. da, Martins, C. R., Minatto, G., Berria, J., Nunes, E. A., Petroski, E. L., & Silva, K. S. da. (2020). Association of physical activity and sedentary behavior at school with cardiovascular risk factors in adolescents. Revista Brasileira de Cineantropometria &amp; Desempenho Humano, 22. https://doi.org/10.1590/1980-0037.2020v22e72397

Behavioral, cardiovascular and endocrine alterations induced by chronic stress in rats fed a high-fat diet

Physiology &amp; Behavior / Sep 01, 2020

Batschauer, T., Cordeiro, J. M., Simas, B. B., Brunetta, H. S., Souza, R. M., Nunes, E. A., Reis, W. L., Moreira, E. L. G., Crestani, C. C., Santos, A. R. S., & Speretta, G. F. (2020). Behavioral, cardiovascular and endocrine alterations induced by chronic stress in rats fed a high-fat diet. Physiology &amp; Behavior, 223, 113013. https://doi.org/10.1016/j.physbeh.2020.113013

Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice

Neurochemical Research / Sep 23, 2020

dos Santos, B., Schmitz, A. E., de Almeida, G. R. L., de Souza, L. F., Szczepanik, J. C., Nunes, E. A., Brunetta, H. S., Mack, J. M., Prediger, R. D., Cunha, M. P., & Dafre, A. L. (2020). Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice. Neurochemical Research, 45(12), 2868–2883. https://doi.org/10.1007/s11064-020-03135-7

Fish oil decreases the severity of treatment-related adverse events in gastrointestinal cancer patients undergoing chemotherapy: A randomized, placebo-controlled, triple-blind clinical trial

Clinical Nutrition ESPEN / Jun 01, 2019

Camargo, C. de Q., Mocellin, M. C., Brunetta, H. S., Chagas, T. R., Fabre, M. E. de S., Trindade, E. B. S. de M., Silva, E. L. da, & Nunes, E. A. (2019). Fish oil decreases the severity of treatment-related adverse events in gastrointestinal cancer patients undergoing chemotherapy: A randomized, placebo-controlled, triple-blind clinical trial. Clinical Nutrition ESPEN, 31, 61–70. https://doi.org/10.1016/j.clnesp.2019.02.015

Aerobic fitness and physical activity are inversely associated with body fat, dyslipidemia and inflammatory mediators in children and adolescents living with HIV

Journal of Sports Sciences / Jun 08, 2018

de Lima, L. R. A., Back, I. de C., Nunes, E. A., Silva, D. A. S., & Petroski, E. L. (2018). Aerobic fitness and physical activity are inversely associated with body fat, dyslipidemia and inflammatory mediators in children and adolescents living with HIV. Journal of Sports Sciences, 37(1), 50–58. https://doi.org/10.1080/02640414.2018.1481724

Assessing the mechanistic target of rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay

Applied Physiology, Nutrition, and Metabolism / Sep 01, 2018

McGlory, C., Nunes, E. A., Oikawa, S. Y., Tsakiridis, E., & Phillips, S. M. (2018). Assessing the mechanistic target of rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay. Applied Physiology, Nutrition, and Metabolism, 43(9), 945–949. https://doi.org/10.1139/apnm-2017-0852

Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats

Stress / Feb 10, 2018

Simas, B. B., Nunes, E. A., Crestani, C. C., & Speretta, G. F. (2018). Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats. Stress, 21(3), 247–256. https://doi.org/10.1080/10253890.2018.1437413

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice

International Journal of Experimental Pathology / Dec 01, 2017

Ferreira, F. B. D., dos Santos, C., Bruxel, M. A., Nunes, E. A., Spiller, F., & Rafacho, A. (2017). Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice. International Journal of Experimental Pathology, 98(6), 329–340. Portico. https://doi.org/10.1111/iep.12255

Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose

BioMed Research International / Jan 01, 2017

Sulis, P. M., Motta, K., Barbosa, A. M., Besen, M. H., da Silva, J. S., Nunes, E. A., & Rafacho, A. (2017). Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose. BioMed Research International, 2017, 1–16. https://doi.org/10.1155/2017/4378328

Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats

Applied Physiology, Nutrition, and Metabolism / Apr 01, 2016

Barbosa, A. M., Francisco, P. de C., Motta, K., Chagas, T. R., dos Santos, C., Rafacho, A., & Nunes, E. A. (2016). Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats. Applied Physiology, Nutrition, and Metabolism, 41(4), 382–390. https://doi.org/10.1139/apnm-2015-0487

INTERVAL TRAINING IS INSUFFICIENT TO ATTENUATE METABOLIC DISTURBANCES IN DIABETIC RATS

Revista Brasileira de Medicina do Esporte / Oct 01, 2016

Rocha, R. E. R. da, Nunes, E. A., Venera, G. D., & Fernandes, L. C. (2016). INTERVAL TRAINING IS INSUFFICIENT TO ATTENUATE METABOLIC DISTURBANCES IN DIABETIC RATS. Revista Brasileira de Medicina Do Esporte, 22(5), 393–397. https://doi.org/10.1590/1517-869220162205154777

Glucose homoeostasis in rats exposed to acute intermittent hypoxia

Acta Physiologica / Jun 08, 2013

Rafacho, A., Gonçalves-Neto, L. M., Ferreira, F. B. D., Protzek, A. O. P., Boschero, A. C., Nunes, E. A., & Zoccal, D. B. (2013). Glucose homoeostasis in rats exposed to acute intermittent hypoxia. Acta Physiologica, 209(1), 77–89. https://doi.org/10.1111/apha.12118

Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats

Applied Physiology, Nutrition, and Metabolism / Nov 01, 2013

Nunes, E. A., Gonçalves-Neto, L. M., Ferreira, F. B. D., dos Santos, C., Fernandes, L. C., Boschero, A. C., Calder, P. C., & Rafacho, A. (2013). Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats. Applied Physiology, Nutrition, and Metabolism, 38(11), 1137–1146. https://doi.org/10.1139/apnm-2012-0456

Relationship between Acute Phase Proteins and Serum Fatty Acid Composition in Morbidly Obese Patients

Disease Markers / Jan 01, 2013

Fernandes, R., Beserra, B. T. S., Cunha, R. S. G., Hillesheim, E., Camargo, C. de Q., Pequito, D. C. T., de Castro, I. C., Fernandes, L. C., Nunes, E. A., & Trindade, E. B. S. de M. (2013). Relationship between Acute Phase Proteins and Serum Fatty Acid Composition in Morbidly Obese Patients. Disease Markers, 35, 105–112. https://doi.org/10.1155/2013/913715

β-Hydroxy-β-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro

Nutrition / Jan 01, 2011

Nunes, E. A., Lomax, A. R., Noakes, P. S., Miles, E. A., Fernandes, L. C., & Calder, P. C. (2011). β-Hydroxy-β-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro. Nutrition, 27(1), 92–99. https://doi.org/10.1016/j.nut.2009.12.008

Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise

Cell Biochemistry and Function / May 26, 2010

Brito, G. A. P., Nunes, E. A., Nogata, C., Yamazaky, R. K., Naliwaiko, K., Curi, R., & Fernandes, L. C. (2010). Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise. Cell Biochemistry and Function, 28(4), 278–282. Portico. https://doi.org/10.1002/cbf.1652

Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats

Nutrition Research / Nov 01, 2010

Belo, S. R. B., Iagher, F., Bonatto, S. J., Naliwaiko, K., Calder, P. C., Nunes, E. A., & Fernandes, L. C. (2010). Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats. Nutrition Research, 30(11), 770–776. https://doi.org/10.1016/j.nutres.2010.09.015

Neutrophil response of anaerobic jump trained diabetic rats

European Journal of Applied Physiology / Sep 10, 2008

de Souza, C. F., Machado, A. F., Bonatto, S. J. R., Grando, F. C. C., Pessini, C., Alves, L. E., de Lima, C., de Brito, G. A. P., Nunes, E. A., & Fernandes, L. C. (2008). Neutrophil response of anaerobic jump trained diabetic rats. European Journal of Applied Physiology, 104(6), 1079–1086. https://doi.org/10.1007/s00421-008-0865-9

Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation

Prostaglandins, Leukotrienes and Essential Fatty Acids / Feb 01, 2007

Mund, R. C., Pizato, N., Bonatto, S., Nunes, E. A., Vicenzi, T., Tanhoffer, R., de Oliveira, H. H. P., Curi, R., Calder, P. C., & Fernandes, L. C. (2007). Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation. Prostaglandins, Leukotrienes and Essential Fatty Acids, 76(2), 113–120. https://doi.org/10.1016/j.plefa.2006.11.008

Fish oil alters T-lymphocyte proliferation and macrophage responses in Walker 256 tumor-bearing rats

Nutrition / Apr 01, 2006

Pizato, N., Bonatto, S., Piconcelli, M., de Souza, L. M., Sassaki, G. L., Naliwaiko, K., Nunes, E. A., Curi, R., Calder, P. C., & Fernandes, L. C. (2006). Fish oil alters T-lymphocyte proliferation and macrophage responses in Walker 256 tumor-bearing rats. Nutrition, 22(4), 425–432. https://doi.org/10.1016/j.nut.2005.11.001

The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle

Molecular and Cellular Biochemistry / May 01, 2005

Yamazaki, R. K., Hirabara, S. M., Tchaikovski, O., Lopes, M. C. P., Nogata, C., Aikawa, J., Nunes, E. A., Tanhoffer, R. A., Lissa, M. D., & Fernandes, L. C. (2005). The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle. Molecular and Cellular Biochemistry, 273(1–2), 145–150. https://doi.org/10.1007/s11010-005-8265-5

Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation

Applied Physiology, Nutrition, and Metabolism / Aug 01, 2011

de Lima, C., Alves, L., Iagher, F., Machado, A. F., Kryczyk, M., Yamazaki, R. K., Brito, G. A. P., Nunes, E. A., Naliwaiko, K., & Fernandes, L. C. (2011). Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation. Applied Physiology, Nutrition, and Metabolism, 36(4), 533–538. https://doi.org/10.1139/h11-047

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Dr. Shilpa Patil, Ph.D

Vancouver, British Columbia, Canada
10 Years Experience
PhD & Postdoc level expertise in Cancer Research
Education

University of Göttingen

Ph.D, Cancer Research / June, 2020

Göttingen

Manipal Academy of Higher Education

MSc, Regenerative Medicine / August, 2014

Manipal

Manipal Academy of Higher Education

BSc, Biotechnology / August, 2012

Manipal
Experience

University of British Columbia

Postdoctoral Research Fellow / January, 2021July, 2023

University of Gottingen

Postdoctoral Researcher / July, 2020December, 2020

JNCASR

Research Assistant / September, 2014February, 2016

Most Relevant Research Expertise
Molecular Biology
Gastroenterology
Endocrinology, Diabetes and Metabolism
Other Research Expertise (9)
Cancer
epigenetics
development
Oncology
Cancer Research
And 4 more
About
Dr. Shilpa Patil is a highly experienced cancer researcher with a strong background in Preclinical studies. She received her Ph.D. in Molecular Medicine from the University of Göttingen in 2020, where she focused on developing novel treatments for pancreatic cancer. Prior to that, she completed her MSc in Regenerative Medicine from Manipal University in 2014 and her BSc in Biotechnology from the same institution in 2012. With over 6 years of research experience, Dr. Patil has worked at prestigious institutions such as the University of British Columbia, University of Göttingen and JNCASR. Her expertise lies in the areas of cancer biology, epigenetics, cell and molecular biology, and regenerative medicine. She has published numerous research articles in reputed journals and has presented her work at various international conferences. Dr. Patil is a dedicated and passionate scientist, committed to using her knowledge and skills to contribute to the fight against cancer. She is driven by her curiosity to unravel complex biological processes and her desire to make a positive impact in the field of cancer research. She is also driven to bridge the academia-industry gap.
Most Relevant Publications (9+)

20 total publications

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

EBioMedicine / Feb 01, 2019

Patzak, M. S., Kari, V., Patil, S., Hamdan, F. H., Goetze, R. G., Brunner, M., Gaedcke, J., Kitz, J., Jodrell, D. I., Richards, F. M., Pilarsky, C., Gruetzmann, R., Rümmele, P., Knösel, T., Hessmann, E., Ellenrieder, V., Johnsen, S. A., & Neesse, A. (2019). Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites. EBioMedicine, 40, 394–405. https://doi.org/10.1016/j.ebiom.2019.01.037

Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models

Journal of Visualized Experiments / Apr 07, 2018

Goetze, R.-G., Buchholz, S. M., Patil, S., Petzold, G., Ellenrieder, V., Hessmann, E., & Neesse, A. (2018). Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models. Journal of Visualized Experiments, 134. https://doi.org/10.3791/56979-v

Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation

Biochimica et Biophysica Acta (BBA) - General Subjects / Aug 01, 2018

Kaypee, S., Sahadevan, S. A., Sudarshan, D., Halder Sinha, S., Patil, S., Senapati, P., Kodaganur, G. S., Mohiyuddin, A., Dasgupta, D., & Kundu, T. K. (2018). Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation. Biochimica et Biophysica Acta (BBA) - General Subjects, 1862(8), 1729–1741. https://doi.org/10.1016/j.bbagen.2018.05.003

Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes

Visceral Medicine / Dec 27, 2021

Patil, S., Dou, Y., & Kopp, J. L. (2021). Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes. Visceral Medicine, 38(1), 4–10. Portico. https://doi.org/10.1159/000520946

NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming

Cellular and Molecular Gastroenterology and Hepatology / Jan 01, 2023

Zhang, Z., Wang, X., Hamdan, F. H., Likhobabina, A., Patil, S., Aperdannier, L., Sen, M., Traub, J., Neesse, A., Fischer, A., Papantonis, A., Singh, S. K., Ellenrieder, V., Johnsen, S. A., & Hessmann, E. (2023). NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming. Cellular and Molecular Gastroenterology and Hepatology, 15(5), 1219–1246. https://doi.org/10.1016/j.jcmgh.2023.01.015

EZH2 controls PDAC plasticity by regulating differentiation genes

Pancreatology / Jun 01, 2019

Patil, S., Najafova, Z., Kari, V., Wang, X., Bohnenberger, H., Kopp, W., Spitalieri, J., Neesse, A., Ellenrieder, V., Johnsen, S., & Hessmann, E. (2019). EZH2 controls PDAC plasticity by regulating differentiation genes. Pancreatology, 19, S11. https://doi.org/10.1016/j.pan.2019.05.021

Impact of cytosolic 5'-nucleotidase 1A on chemotherapeutic resistance in pancreatic cancer

Pancreatology / Jun 01, 2018

Patzak, M. S., Hessmann, E., Kari, V., Kitz, J., Patil, S., Richards, F. M., Jodrell, D. I., Johnsen, S. A., Ellenrieder, V., & Neesse, A. (2018). Impact of cytosolic 5’-nucleotidase 1A on chemotherapeutic resistance in pancreatic cancer. Pancreatology, 18(4), S91. https://doi.org/10.1016/j.pan.2018.05.247

Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity

Pancreatology / Jul 01, 2017

Patil, S., Witte, H., Neesse, A., Johnsen, S., Ellenrieder, V., & Hessmann, E. (2017). Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity. Pancreatology, 17(3), S41. https://doi.org/10.1016/j.pan.2017.05.128

Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models

Journal of Visualized Experiments / Apr 07, 2018

Goetze, R.-G., Buchholz, S. M., Patil, S., Petzold, G., Ellenrieder, V., Hessmann, E., & Neesse, A. (2018). Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models. Journal of Visualized Experiments, 134. https://doi.org/10.3791/56979

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Joshua adekunle Babalola, Ph.D.

Graz
8 Years Experience
A scientist interested in translating life science skills into solving real life problems relating to microbes, aging, neurodegenerative and metabolic diseases. An advocate of inclusive science and life style changes.
Education

Medical University of Graz

PhD, Human Medicine / December, 2023

Graz
Experience

Medical University of Graz

Doctoral Researcher / November, 2019December, 2023

I investigated the contribution of metabolic dysfunctions to the progression of degenerative diseases of the brain

Hallym University, South Korea

Research Fellow / February, 2016September, 2019

I investigated the specie transmissibility of animal prions from one host to another. I also investigated the genotype frequency of prion protein polymorphism among healthy Nigerians.

Most Relevant Research Expertise
Aging
Neurodegeneration
Molecular Biology
Developmental Neuroscience
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Other Research Expertise (5)
Dementia
Life style changes
Metabolic dysfunction
Neurology (clinical)
Epidemiology
About
Joshua Babalola  completed his doctoral studies recently during which he investigated the combinational effects of Type 2 diabetes and protein post translational modification in the pathophysiology of Alzheimer's disease. <br> Joshua is interested in translating life science skills into solving real life problems relating to microbial infections, aging, metabolic dysfunctions and neurodegenerative diseases. Aside these, he advocates for inclusive science and lifestyle changes. Joshua's educational background includes an MSc in Medical Microbiology from Hallym University, South Korea and a PhD in Human Medicine from Medical University of Graz, Austria. He also holds a BSc in Microbiology from Ekiti State University, Nigeria. In Joshua's leisure, he communicates science relating to healthy lifestyle modifications and Dementia via his social media handles.
Most Relevant Publications (4+)

9 total publications

Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation

Brain Research / Nov 01, 2023

Babalola, J. A., Lang, M., George, M., Stracke, A., Tam-Amersdorfer, C., Itxaso, I., Lucija, D., Tadic, J., Schilcher, I., Loeffler, T., Flunkert, S., Prokesch, M., Leitinger, G., Lass, A., Hutter-Paier, B., Panzenboeck, U., & Hoefler, G. (2023). Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation. Brain Research, 1819, 148518. https://doi.org/10.1016/j.brainres.2023.148518

Sex and genotype dependent differences in amyloid beta levels and lipid metabolism in type 2 diabetic APPxhQC transgenic mice

Alzheimer's &amp; Dementia / Dec 01, 2023

Babalola, J. A., Lang, M., George, M., Stracke, A., Loeffler, T., Schilcher, I., Flunkert, S., Neddens, J., Prokesch, M., Leitinger, G., Lass, A., Hoefler, G., & Hutter‐Paier, B. (2023). Sex and genotype dependent differences in amyloid beta levels and lipid metabolism in type 2 diabetic APPxhQC transgenic mice. Alzheimer’s &amp; Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.079077

Establishing a Type 2 Diabetes phenotype in APPxhQC transgenic mice expressing N‐terminally modified pGlu Aβ peptides.

Alzheimer's &amp; Dementia / Dec 01, 2022

Babalola, J. A., Loeffler, T., Schilcher, I., Breznik, L., Rabl, R., Sideromenos, S., Flunkert, S., Prokesch, M., Hoefler, G., & Hutter‐Paier, B. (2022). Establishing a Type 2 Diabetes phenotype in APPxhQC transgenic mice expressing N‐terminally modified pGlu Aβ peptides. Alzheimer’s &amp; Dementia, 18(S3). Portico. https://doi.org/10.1002/alz.066646

Liver-X receptor activation attenuates oxysterol induced inflammatory response in human feto-placental endothelial cells in gestational diabetes mellitus

Placenta / Sep 01, 2021

Geroge, M., Lang, M., Tam-Amersdorfer, C., Joshua, B., & Wadsack, C. (2021). Liver-X receptor activation attenuates oxysterol induced inflammatory response in human feto-placental endothelial cells in gestational diabetes mellitus. Placenta, 112, e37. https://doi.org/10.1016/j.placenta.2021.07.121

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Subdisciplines